“OC16 | GUT MICROBIOTA FUNCTIONAL REMODELING IN PEDIATRIC MIGRAINE: A MULTI-OMIC INSIGHT INTO NEUROACTIVE AND IMMUNOMETABOLIC PATHWAYS: L. Papetti1, S. Levi Mortera2|3, M. Di Michele2|3, F. Del Chierico4, G. Monte1, F. Ursitti1, G. Sforza1, C. Granata5, L. Putignani4, M. Valeriani1|5|6 | 1Developmental Neurology Unit, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy; 2Chromatography and Mass Spectrometry Core Facility, Research Laboratory Platform, Bambino Gesù Children’s Hospital, IRCCS Rome, Italy; 3Management and Diagnostic Innovation & Clinical Pathway Research Area, Microbiome Unit, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy; 4Unit of Microbiology and Diagnostic Immunology, Unit of Microbiomics and Research Area of Immunology, Rheumatology and Infectious Diseases, Unit of Microbiome, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy; 5Systems Medicine Department, Tor Vergata University, Rome, Italy; 6Center for Sensory‑Motor Interaction, Aalborg University, Denmark” (2026) Confinia Cephalalgica, 36(s1). doi:10.4081/cc.2026.15954.