“P025 | PAIN RELIEF AFTER 30 MINUTES PREDICTS COMPLETE ACUTE TREATMENT SUCCESS AT 12 HOURS: A REAL-WORLD ANALYSIS OF INTRAVENOUS EPTINEZUMAB INFUSION IN HIGHLY REFRACTORY MIGRAINE PATIENTS: L. Fofi1, C. Altamura1|2, M. Marcosano1|2, L. d’Onofrio2, A. Doretti3, F. Pistoia4, A. Granato5, S. Guerzoni6, M. Trimboli7, L. Grazzi8, D. Antonio Montisano8, G. Avino9, G. Sebastianelli10, C. Fasano11, E. Maria Piella12, P. Geppetti13, N. Brunelli1, S. Lodico2, L. Francesco Iannone14, F. Vernieri1|2 | 1Neurosonology and Headache Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy; 2Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Italy; 3Department of Neurology-Laboratory of Neuroscience, IRCCS, Istituto Auxologico Italiano, Milan, Italy; 4Department of Biotechnological and Applied Clinical Sciences, Neurological Institute, University of L’Aquila, Italy; 5Headache Center, Neurology Clinic, University Hospital of Trieste, University of Trieste, Italy; 6Digital and Predictive Medicine, Pharmacology and Clinical Metabolic Toxicology-Headache Center and Drug Abuse-Laboratory of Clinical Pharmacology and Pharmacogenomics, Department of Specialist Medicines, AOU Policlinico di Modena, Italy; 7Azienda Ospedaliera-Universitaria “Renato Dulbecco”, Catanzaro, Italy; 8Headache Center, Department of Neurology, IRCCS Foundation “Carlo Besta” Neurological Institute, Milan, Italy; 9SOC Neurologia, Ospedale Santo Stefano, USL Toscana Centro, Prato, Italy; 10Department of Medico-Surgical Sciences and Biotechnologies, Polo Pontino ICOT, Sapienza University of Rome, Latina, Italy; 11Headache and Cerebrovascular Diseases Center, Neurology Unit 2, Careggi University Hospital, Florence, Italy; 12Department of Neurosciences ‘Rita Levi Montalcini’, University of Turin, Italy; 13Department of Molecular Pathobiology and Pain Research Center, College of Dentistry, New York University, NY, United States; 14Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy” (2026) Confinia Cephalalgica, 36(s1). doi:10.4081/cc.2026.15981.