“P105 | PATIENT DEPRESSIVE SYMPTOMS AND RECIPROCITY INFLUENCE DISTRESS IN THE CAREGIVER OF PATIENTS WITH MIGRAINE: INSIGHTS FROM THE MIDEAR OBSERVATIONAL COHORT STUDY: C. Altamura1|2, L. Fofi1, C. Aurilia3, E. Cresta4, A. Onofri5, A. Montisano6, M. Silvastro7, V. Favoni8, G. Viticchi9, M. Marcosano1, G. Egeo3, M. Bartolini9, M. Peresson10, M. Cepparulo11, A. Russo7, S. Cevoli8, R. Rao4|12, L. Grazzi6, S. Sacco5, F. Vernieri1|2 | 1Neurosonology and Headache Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy; 2Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Italy; 3Headache and Pain Unit, IRCCS San Raffaele Roma, Italy; 4Department of Frailty and Care, Neurology Unit, Headache Center, ASST Spedali Civili, Brescia, Italy; 5Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, Italy; 6Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy; 7Inter-departmental Program of Headache Medicine and Primary Pain Syndromes, Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, University of Campania ‘Luigi Vanvitelli’, Naples, Italy; 8Programma cefalee e algie facciali, IRCCS Istituto delle Scienze Neurologiche di Bologna, Italy; 9Neurological Clinic, Marche Polytechnic University, Ancona, Italy; 10Headache Unit, San Pietro Fatebenefratelli Hospital, Rome, Italy; 11Teva Italia Srl, Milan, Italy; 12Department of Clinical and Experimental Sciences (DSCS), University of Brescia, Italy” (2026) Confinia Cephalalgica, 36(s1). doi:10.4081/cc.2026.16061.