Search

Search Results

• P036 | ROLE OF SPECIFIC MICRORNAS IN CLUSTER HEADACHE: ASSOCIATION WITH DISEASE PHENOTYPE AND NEUROPEPTIDE LEVELS

  C. Angeli^1|2, R. De Icco^1|2, M. Corrado², G. Vaghi^1|2, F. Cammarota^1|2, V. Grillo^1|2, M. Giraudo^1|2, B. Agostini^1|2, F. Muscariello^1|2, R. Greco², C. Demartini^1|2, M. Francavilla^1|2, S. Franchini^1|2, M. Allena², G. Sances², C. Tassorelli^1|2 | ¹Department of Brain and Behavioural Sciences, University of Pavia, Italy; ²Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.15992

  • 0 abstract views
  • 0 PDF

• P039 | GUT-BRAIN AXIS ALTERATIONS IN A NITROGLYCERIN MODEL OF MIGRAINE: FROM MICROBIOTA DYSBIOSIS TO TRIGEMINAL SENSITIZATION

  C. Demartini¹, S. Facchetti^1|2, M. Francavilla¹, S. Baldi³, S. Bertorello³, G. Bartolucci⁴, E. Niccolai³, A. Amedei³, R. Greco¹, C. Tassorelli^1|2 | ¹Section of Translational Neurovascular Research, IRCCS Mondino Foundation, Pavia, Italy; ²Department of Brain and Behavioral Sciences, University of Pavia, Italy; ³Department of Experimental and Clinical Medicine, University of Florence, Italy; ⁴Department of Neuroscience, Psychology, Drug Research and Child Health NEUROFARBA, University of Florence, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.15995

  • 0 abstract views
  • 0 PDF

• OC06 | UNRAVELING THE SPECTRUM OF MIGRAINE RESISTANT TO TREATMENT: THE ROLE OF MRI RESTING-STATE FUNCTIONAL CONNECTIVITY IN MIGRAINE SUBJECTS TREATED WITH ANTI-CGRP MONOCLONAL ANTIBODIES

  M. Giraudo^1|2, D. Martinelli², G. Vaghi^1|2, G. Castellazzi², M. Corrado², F. Cammarota^1|2, B. Agostini^1|2, F. Muscariello^1|2, C. Angeli^1|2, V. Grillo^1|2, R. Greco², C. Demartini^1|2, M. Francavilla^1|2, S. Facchetti^1|2, A. Pichiecchio^1|3, M. Allena², E. Guaschino², N. Ghiotto², G. Sances², C. Tassorelli^1|2, R. De Icco^1|2 | ¹Department of Brain and Behavioral Sciences, University of Pavia, Italy; ²Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy; ³Neuroradiology Department, IRCCS Mondino Foundation, Pavia, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.15944

  • 0 abstract views
  • 0 PDF

• OC01 | DECODING THE BIOCHEMICAL SIGNATURE OF TREATMENT-RESISTANT MIGRAINE: SEARCHING FOR DISEASE PHENOTYPES AND NOVEL THERAPEUTIC TARGETS

  B. Agostini^1|2, R. Greco², G. Vaghi^1|2, V. Grillo^1|2, M. Corrado², F. Cammarota^1|2, C. Angeli^1|2, F. Muscariello^1|2, M. Giraudo^1|2, M. Allena², E. Guaschino², N. Ghiotto², C. Demartini², M. Francavilla^1|2, S. Facchetti^1|2, V. Franco^2|3, G. Sances², C. Tassorelli^1|2, R. De Icco^1|2 | ¹Department of Brain and Behavioral Sciences, University of Pavia, Italy; ²Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy; ³Department of Internal Medicine and Therapeutics, University of Pavia, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.15939

  • 0 abstract views
  • 0 PDF

• P042 | INHIBITION OF PEA DEGRADATION VIA NAAA BLOCKADE MODULATES MIGRAINE-RELATED PATHWAYS WITHOUT REVERSED TRIGEMINAL HYPERALGESIA IN FEMALE RATS IN THE NTG-BASED MIGRAINE MODEL

  M. Francavilla¹, S. Facchetti^1|2, C. Demartini¹, J. Stefania Cusme Valle^1|2, R. Greco¹, C. Tassorelli^1|2 | ¹Section of Translational Neurovascular Research, IRCCS Mondino Foundation, Pavia, Italy; ²Department of Brain and Behavioral Sciences, University of Pavia, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.15998

  • 0 abstract views
  • 0 PDF

• P032 | IMPROVEMENT IN DEPRESSIVE AND ANXIETY SYMPTOMS DURING EPTINEZUMAB TREATMENT: A POST-HOC ANALYSIS FROM THE TACHIS STUDY

  E.M. Piella¹, A.M. Chiarandon¹, V. Batti¹, D.A. Montisano², L. F. Iannone³, C. Fasano⁴, G. Sebastianelli⁵, G. Coppola⁵, D. Ferrandi⁶, C. Lanni⁷, M.P. Prudenzano⁸, M. De Tommaso⁹, P. Merlo¹⁰, A. Viganò¹⁰, F. De Cesaris¹¹, A. Chiarugi¹¹, A. Munafò¹¹, F. Pistoia¹², R. Ornello¹², S. Sacco¹², A. Doretti¹³, L. Grazzi², F. Lo Castro¹⁴, R. Allamprese¹⁴, R. De Icco^15|16, G. Vaghi^15|16, C. Tassorelli^15|16, G. Avino¹⁷, M. Romozzi¹⁸, C. Vollono¹⁸, P. Calabresi¹⁸, S. Battistini¹⁹, A. Rufa¹⁹, M. Albanese²⁰, M. Trimboli²¹, G. Carlucci⁴, M. Silvestro²², A. Russo²², M. Valente²³, L. Fofi²⁴, M. Marcosano²⁴, P. Geppetti²⁵, C. Altamura²⁴, F. Vernieri²⁴, E. Rubino¹, I. Rainero¹, S. Guerzoni¹⁴ | ¹Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Italy; ²Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy; ³Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy; ⁴NEUROFARBA Department, University of Florence - Neurologia, AOU Careggi, Italy; ⁵Sapienza University of Rome, Department of Medico-Surgical Sciences and Biotechnologies, Polo Pontino, Latina, Italy; ⁶AOU Alessandria, SC Neurologia, Italy; ⁷Psicologia AOU Alessandria, Italy; ⁸Clinica Neurologica "L. Amaducci", Azienda Ospedaliero-Universitaria Consorziale di Bari, Italy; ⁹Neurophysiopathology Unit, Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Italy; ¹⁰UO di Neurologia, Humanitas Gavazzeni, Bergamo, Italy; ¹¹Headache center and Clinical pharmacology unit, AOU Careggi, Florence, Italy; ¹²Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy; ¹³Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milano, Italy; ¹⁴Digital and Predictive Medicine, Pharmacology, Clinical Metabolic Toxicology-Headache Center and Drug Abuse, Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico, Modena, Italy; ¹⁵Department of Brain and Behavioral Sciences, University of Pavia, Italy; ¹⁶Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy; ¹⁷SOC Neurologia, Ospedale di Prato, Italy; ¹⁸Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy; ¹⁹Department of Medical, Surgical and Neurological Sciences, University of Siena, Italy; ²⁰Unit of Neurology, Department of Systems Medicine, University of Rome Tor Vergata, Italy; ²¹Headache Center, Unit of Neurology, AOU Renato Dulbecco, Catanzaro, Italy; ²²Inter-departmental Program of Headache Medicine and Primary Pain Syndromes, Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Naples, Italy; ²³DMED, University of Udine and Clinical Neurology, Udine University Hospital, Italy; ²⁴Fondazione Policlinico Universitario Campus Bio-Medico, Roma e Università Campus Bio-Medico di Roma, Italy; ²⁵Department of Molecular Pathobiology and Pain Research Center, College of Dentistry, New York University, NY, USA

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.15988

  • 0 abstract views
  • 0 PDF

• OC04 | MORAL JUDGMENT IN MIGRAINE: A CASE-CONTROL STUDY

  S. Bottiroli^1|2, M. Cangelosi¹, G. Curcio³, S. Migliore³, G. Sances², G. Vaghi^1|2, N. Ghiotto², R. De Icco^1|2, C. Tassorelli^1|2 | ¹Università degli Studi di Pavia, Italy; ²IRCCS Fondazione Mondino, Pavia, Italy; ³Università degli Studi dell’Aquila, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.15942

  • 0 abstract views
  • 0 PDF

• P093 | GAINER-AI: PREDICTING ACUTE RIMEGEPANT RESPONSE IN MIGRAINE USING MACHINE LEARNING IN A MULTICENTER REAL-WORLD COHORT

  M. Romozzi^1|2, A. Lokhawandala³, G. Vaghi^4|5, G. Sebastianelli⁶, R. Ornello⁷, F. Casillo⁶, A. Russo⁸, M. Silvestro⁸, F. Pistoia⁹, G. Saporito⁹, G. Dalla Volta¹⁰, M. Bolchini¹⁰, A. Burgalassi¹¹, G. Vigani¹¹, D. Antonio Montisano¹², L. Grazzi¹², M. Pia Prudenzano¹³, D. Mascarella¹⁴, E. Mampreso¹⁵, G. Avino¹⁶, M. Valente¹⁷, G. Carlucci¹⁸, S. Guerzoni¹⁹, S. Battistini²⁰, A. Granato²¹, E. Maria Piella²², I. Rainero²², M. Albanese²³, M. Trimboli²⁴, A. Doretti²⁵, F. De Santis⁷, S. Sacco⁷, C. Tassorelli^4|5, S. Di Tella²⁶, C. Vollono^1|2, P. Calabresi^1|2, R. De Icco^4|5, L. Francesco Iannone²⁷ | ¹Dipartimento Universitario di Neuroscienze, Università Cattolica del Sacro Cuore, Rome, Italy; ²Neurologia, Dipartimento di neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; ³Drexel University, Philadelphia, USA; ⁴Department of Brain and Behavioral Sciences, University of Pavia, Italy; ⁵Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy; ⁶Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino, Latina, Italy; ⁷Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, Italy; ⁸Headache Centre, Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy; ⁹Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy; ¹⁰Headache Center of Clinical Neurology of Istituto Clinico Città Di Brescia, Italy; ¹¹Department of Health Sciences, University of Florence, Italy; ¹²Neuroalgology Unit and Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy; ¹³Headache Center, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, Italy; ¹⁴IRCCS Istituto Di Scienze Neurologiche Di Bologna, Programma Cefalee e Algie Facciali, Italy; ¹⁵Headache Centre, Neurology - Euganea, Health Unit, Padua, Italy; ¹⁶Neurology Unit, Ospedale Santo Stefano, USL Toscana Centro, Prato, Italy; ¹⁷Clinical Neurology, Azienda Sanitaria Universitaria Friuli Centrale, Presidio Ospedaliero Santa Maria Della Misericordia, Udine, Italy; ¹⁸NEUROFARBA Department, University of Florence - AOU Careggi, Italy; ¹⁹Digital and Predictive Medicine, Pharmacology, Clinical Metabolic Toxicology-Headache Center and Drug Abuse, Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico, Modena, Italy; ²⁰Department of Medical, Surgical and Neurological Sciences, University of Siena, Italy; ²¹Headache Centre, Clinical Unit of Neurology, School of Neurology, Department of Medicine, Surgery and Health Sciences, University Hospital and Health Services of Trieste, ASUGI, University of Trieste, Italy; ²²Department of Neurosciences “Rita Levi Montalcini”, University of Turin, Italy; ²³Unit of Neurology, Department of Systems Medicine, Tor Vergata University, Rome, Italy; Unit of Neurology - IRCCS Neuromed, Pozzilli (IS), Italy; ²⁴Headache Centre, Neurology Unit, AOU Renato Dulbecco, Catanzaro, Italy; ²⁵Department of Neurology- Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy; ²⁶Dipartimento di Psicologia, Università Cattolica del Sacro Cuore, Milan, Italy; ²⁷Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.16049

  • 0 abstract views
  • 0 PDF

• P040 | PROBIOTIC SUPPLEMENTATION ALLEVIATES MIGRAINE-LIKE PAIN BY RESTORING INTESTINAL BARRIER INTEGRITY AND ENDOCANNABINOID HOMEOSTASIS

  S. Facchetti^1|2, C. Demartini¹, M. Francavilla¹, B. Marfella³, L. Cristino³, R. Greco¹, C. Tassorelli^1|2 | ¹Section of Translational Neurovascular Research, IRCCS Mondino Foundation, Pavia, Italy; ²Department of Brain and Behavioral Sciences, University of Pavia, Italy; ³Istituto di Chimica Biomolecolare del CNR, Pozzuoli (NA), Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.15996

  • 0 abstract views
  • 0 PDF

• P077 | UNRAVELING THE COMPLEXITY OF MEDICATION-OVERUSE HEADACHE: CLINICAL AND BEHAVIORAL PREDICTORS OF 12-MONTH OUTCOMES

  N. Ghiotto¹, E. Guaschino¹, S. Pazzi¹, L. Toppi², D. Mazzotta², T. Filidei², M. Allena¹, R. De Icco^1|2, D. Martinelli¹, G. Vaghi^1|2, G. Sances¹, C. Tassorelli^1|2 | ¹Headache Science and Neurorehabilitation Unit, IRCCS C. Mondino Foundation, Pavia, Italy; ²Department of Brain and Behavioral Sciences, University of Pavia, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.16033

  • 0 abstract views
  • 0 PDF

• OC18 | LONG-TERM EFFECTIVENESS, SAFETY AND TOLERABILITY OF ATOGEPANT IN THE PREVENTION OF MIGRAINE: A MULTICENTRIC, PROSPECTIVE OBSERVATIONAL, REAL WORLD STUDY (THE 48-WEEK STAR STUDY)

  F. Vernieri^1|2, L. Francesco Iannone³, M. Marcosano^1|2, L. Fofi¹, F. Lo Castro⁴, G. Sebastianelli⁵, F. De Santis⁶, M. Corrado⁷, R. Ornello⁶, L. Grazzi⁸, D. Antonio Montisano⁸, F. De Cesaris⁹, A. Munafò⁹, G. Avino¹⁰, M. Trimboli¹¹, M. Albanese¹², A. Russo¹³, M. Silvestro¹³, G. Dalla Volta¹⁴, M. Romozzi¹⁵, P. Calabresi¹⁵, A. Boccalini⁴, P. Merlo¹⁶, M. Pia Prudenzano¹⁷, M. Rosaria Valente¹⁸, I. Rainero¹⁹, G. Giuliani²⁰, M. Altieri²⁰, A. Doretti²¹, G. Vaghi^7|22, F. Pistoia⁶, D. Ferrandi²³, S. Battistini²⁴, G. Coppola⁵, S. Guerzoni⁴, S. Sacco^6|25, C. Tassorelli^7|22, C. Altamura^1|2 | ¹Headache and Neurosonology Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy; ²Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Italy; ³Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy; ⁴Digital and Predictive Medicine, Pharmacology and Clinical Metabolic Toxicology-Headache Center and Drug Abuse-Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico Di Modena, Italy; ⁵Sapienza University of Rome, Department of Medico-Surgical Sciences and Biotechnologies, Polo Pontino, Latina, Italy; ⁶Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, Italy; ⁷Headache Science and Neurorehabilitation Centre, IRCCS Mondino Foundation, Pavia, Italy; ⁸Headache Center IRCCS Fondazione Istituto Neurologico "Carlo Besta", Italy; ⁹Headache center and clinical pharmacology, AOU Careggi, Firenze, Italy; ¹⁰Neurology Unit, Ospedale Santo Stefano, USL Toscana Centro, Prato, Italy; ¹¹Azienda Ospedaliera-universitaria "Renato Dulbecco", Catanzaro, Italy; ¹²Department of Systems Medicine, University of Rome Tor Vergata, Italy; ¹³Headache Center, Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Italy; ¹⁴U.O Neurologia, Istituto Clinico Città di Brescia, Gruppo San Donato, Italy; ¹⁵Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy; ¹⁶UO di Neurologia, Humanitas Gavazzeni, Bergamo, Italy; ¹⁷Clinica Neurologica "L. Amaducci", Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, Italy; ¹⁸Clinica Neurologica ASUFC, Dipartimento di Medicina DMED Università di Udine, Italy; ¹⁹Headache Center, Department of Neuroscience, University of Torino, Italy; ²⁰Department of Human Neuroscience, Sapienza University of Rome, Italy; ²¹IRCCS Istituto Auxologico Italiano, Milano, Italy; ²²Department of Brain and Behavioural Sciences, University of Pavia, Italy; ²³SC Neurologia, Azienda Ospedaliero Universitaria Santi Antonio e Biagio, Alessandria, Italy; ²⁴Department of Medical, Surgical and Neurological Sciences, University of Siena, Italy; ²⁵Neurology and Stroke Unit, ASL 1 Abruzzo, Avezzano-Sulmona-L’Aquila, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.15956

  • 0 abstract views
  • 0 PDF

• P052 | A PATIENT-SPECIFIC HUMAN TRIGEMINAL NEURON MODEL FOR THE STUDY OF MIGRAINE MECHANISMS

  R. Greco¹, M. Bordoni², J. Cazzola³, F. De Luca⁴, M. Francavilla¹, C. Demartini¹, S. Facchetti¹, O. Pansarasa², G. Vaghi¹, R. De Icco^1|5, G. Biella³, C. Tassorelli^1|5 | ¹Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy; ²Cellular Models and Neuroepigenetics Section, IRCCS Mondino Foundation, Pavia, Italy; ³Laboratory of Biophysics and Physiology of Ion Channels, University of Pavia, Italy; ⁴Laboratory of Cell Biology and Neurobiology, University of Pavia, Italy; ⁵Behavioral Sciences, Department of Brain, University of Pavia, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.16008

  • 0 abstract views
  • 0 PDF

• P079 | THE ROLE OF GUT MICROBIOTA IN MIGRAINE SUBJECTS TREATED WITH ANTI-CGRP MONOCLONAL ANTIBODIES: RESULTS THE SPHERA PROJECT

  F. Muscariello^1|2, G. Vaghi^1|2, R. Greco², V. Grillo^1|2, M. Corrado², F. Cammarota^1|2, B. Agostini^1|2, M. Giraudo^1|2, C. Angeli^1|2, M. Allena², E. Guaschino², N. Ghiotto², R. Ornello³, S. Sacco³, C. Demartini², M. Francavilla^1|2, S. Facchetti^1|2, V. Pazienza⁴, D. Sproviero², G. Sances², C. Tassorelli^1|2, R. De Icco^1|2 | ¹Department of Brain and Behavioral Sciences, University of Pavia, Italy; ²Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy; ³Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy; ⁴Division of Gastroenterology, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.16035

  • 0 abstract views
  • 0 PDF