Current issue

Vol. 36 No. s1 (2026): 40° CONGRESSO NAZIONALE SISC

130 articles Published 3 November 2026

CEFALEE 50 ANNI DOPO: DALLA TRADIZIONE ALL'INNOVAZIONE, 5-7 novembre 2026, Lecce

Congresso Nazionale SISC

130 articles

OC01 | DECODING THE BIOCHEMICAL SIGNATURE OF TREATMENT-RESISTANT MIGRAINE: SEARCHING FOR DISEASE PHENOTYPES AND NOVEL THERAPEUTIC TARGETS

B. Agostini^1|2, R. Greco², G. Vaghi^1|2, V. Grillo^1|2, M. Corrado², F. Cammarota^1|2, C. Angeli^1|2, F. Muscariello^1|2, M. Giraudo^1|2, M. Allena², E. Guaschino², N. Ghiotto², C. Demartini², M. Francavilla^1|2, S. Facchetti^1|2, V. Franco^2|3, G. Sances², C. Tassorelli^1|2, R. De Icco^1|2 | ¹Department of Brain and Behavioral Sciences, University of Pavia, Italy; ²Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy; ³Department of Internal Medicine and Therapeutics, University of Pavia, Italy

DOI https://doi.org/10.4081/cc.2026.15939
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OC02 | MULTICENTER STUDY ON THE THERAPEUTIC MANAGEMENT OF PEDIATRIC MIGRAINE IN SISC PEDIATRIC HEADACHE CENTERS

B. Baldo¹, A. Versace², L. Papetti³, E. Parolin¹, A. Bonuccelli⁴, E. Correnti⁵, A. Passarini⁶, A. Ferretti⁷, M. Morelli⁸, C. Termine⁹, P. Diana¹⁰, V. Sciruicchio¹¹, I. Toldo¹ | ¹Juvenile Headache Center, Department of Woman’s and Child’s Health, University of Padua, Italy; ²Pediatric Headache Center, Department of Pediatric Emergency, Regina Margherita Children’s Hospital, Turin, Italy; ³Developmental Neurology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy; ⁴Pediatric Neurology, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; ⁵Child Neuropsychiatry Unit, Civico Di Cristina Benfratelli Hospital, Palermo, Italy; ⁶Child Neuropsychiatry Unit, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy; ⁷Pediatrics Unit, Neuroscience, Mental Health and Sense Organs (NESMOS) Department, Faculty of Medicine and Psychology, Sapienza University of Rome, Italy; ⁸Institute for Maternal and Child Health Burlo Garofolo (IRCCS), Trieste, Italy; ⁹Child Neuropsychiatry Unit, Department of Medicine and Technological Innovation, University of Insubria, Varese, Italy; ¹⁰Department of Neuropsychiatry of Childhood and Adolescence, S. Marta and S. Venera Hospital, ASP Catania, Italy; ¹¹Children Epilepsy and EEG Center, San Paolo Hospital, ASL Bari, Italy

DOI https://doi.org/10.4081/cc.2026.15940
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OC03 | PLASMA PACAP-38 IS INCREASED IN MIGRAINE REGARDLESS OF CLINICAL PHENOTYPE: A CASE-CONTROL STUDY

S. Boschi^1|2, A. Agostinelli^1|2, A. Panza^1|2, E. Maria Piella^1|2, V. Batti^1|2, I. Rainero^1|2, E. Rubino^1|2 | ¹Dipartimento di Neuroscienze "Rita Levi Montalcini", Università di Torino, Italy; ²Centro Cefalee, Dipartimento di Neuroscienze e Salute Mentale, AOU Città della Salute e della Scienza di Torino, Italy

DOI https://doi.org/10.4081/cc.2026.15941
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OC04 | MORAL JUDGMENT IN MIGRAINE: A CASE-CONTROL STUDY

S. Bottiroli^1|2, M. Cangelosi¹, G. Curcio³, S. Migliore³, G. Sances², G. Vaghi^1|2, N. Ghiotto², R. De Icco^1|2, C. Tassorelli^1|2 | ¹Università degli Studi di Pavia, Italy; ²IRCCS Fondazione Mondino, Pavia, Italy; ³Università degli Studi dell’Aquila, Italy

DOI https://doi.org/10.4081/cc.2026.15942
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OC05 | MIGRAINE MONITORING AND ATTACK PREDICTION IN THE PREICTAL PHASE USING MACHINE LEARNING APPROACHES COMBINING E-DIARIES AND BIOLOGICAL VARIABLES COLLECTED THROUGH WEARABLE SENSORS: THE MIGRAMETER STUDY

F. De Santis¹, R. Ornello¹, R. Guido², M. Fiaz², C. Rosignoli¹, A. Onofri¹, F. Gabriele¹, M. Junaid Jawaid¹, G. Scatena³, D. Conforti², S. Sacco¹ | ¹Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, Italy; ²Dipartimento di Ingegneria Meccanica, Energetica e Gestionale - DIMEG, University of Calabria, Italy; ³Mith S.r.l., Capistrello (AQ), Italy

DOI https://doi.org/10.4081/cc.2026.15943
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OC06 | UNRAVELING THE SPECTRUM OF MIGRAINE RESISTANT TO TREATMENT: THE ROLE OF MRI RESTING-STATE FUNCTIONAL CONNECTIVITY IN MIGRAINE SUBJECTS TREATED WITH ANTI-CGRP MONOCLONAL ANTIBODIES

M. Giraudo^1|2, D. Martinelli², G. Vaghi^1|2, G. Castellazzi², M. Corrado², F. Cammarota^1|2, B. Agostini^1|2, F. Muscariello^1|2, C. Angeli^1|2, V. Grillo^1|2, R. Greco², C. Demartini^1|2, M. Francavilla^1|2, S. Facchetti^1|2, A. Pichiecchio^1|3, M. Allena², E. Guaschino², N. Ghiotto², G. Sances², C. Tassorelli^1|2, R. De Icco^1|2 | ¹Department of Brain and Behavioral Sciences, University of Pavia, Italy; ²Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy; ³Neuroradiology Department, IRCCS Mondino Foundation, Pavia, Italy

DOI https://doi.org/10.4081/cc.2026.15944
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OC07 | LONG-TERM COMBINATION WITH ONABOTULINUMTOXINA AND ATOGEPANT TO ACHIEVE HIGHER STANDARDS OF MIGRAINE CONTROL: A 52-WEEK, PROSPECTIVE, REAL-WORLD EVALUATION (SYNERGY STUDY)

L. Francesco Iannone¹, M. Romozzi^2|3, A. Russo⁴, I. Finkelstein⁵, D. Seabi⁶, A. Ahlden⁶, A. Hege Aamodt^7|8|9, P. Calabresi^2|3, C. Vollono³, E. Caronna^10|11, P. Pozo-Rosich^10|11, E. Andreas Tronvik^8|12|13, C. Sundal^6|12 | ¹Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy; ²Dipartimento Universitario di Neuroscienze, Università Cattolica del Sacro Cuore, Rome, Italy; ³Neurologia, Dipartimento di neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; ⁴Inter-departmental Program of Headache Medicine and Primary Pain Syndromes, Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, University of Campania “Luigi Vanvitelli”, Naples, Italy; ⁵Toronto Headache and Pain clinic; Pain Clinic, Toronto, Canada; ⁶NeuroClinicNorway, Lillestrøm, Norway; ⁷Department of Neurology, Oslo University Hospital, Rikshospitalet, Norway; ⁸NorHead, Norwegian Headache Research Centre; NTNU, Norwegian University of Science and Technology, Trondheim, Norway; ⁹Institute of Population Health, Faculty of Health and Life Sciences, University of Liverpool, UK; ¹⁰Headache and Neurological Pain Research Group, Vall d’Hebron Research Institute, Department of Neuroscience, Universitat Autònoma de Barcelona, Spain; ¹¹Headache Clinic, Neurology Department, Vall d’Hebron Hospital, Barcelona, Spain; ¹²Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway; ¹³Neuroclinic, St. Olavs Hospital, Trondheim, Norway

DOI https://doi.org/10.4081/cc.2026.15945
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OC08 | HEADACHE OUTCOME AFTER MIDDLE-MENINGEAL ARTERY EMBOLIZATION IN SUBDURAL HEMATOMA

F. Innocenti^1|3, M. Romozzi^1|3, M. Palermo, F. Tosto⁴, C. Vollono^1|3, P. Calabresi, H. Yuan, L. Francesco Iannone, F. Maria Polli, F. Signorelli, I. Valente, G. Garignano, A. Pedicelli | ¹Neurology Unit, Department of Neurosciences, Sense Organs and Thorax, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Italy; ²Neurosurgery Unit, Department of Neurosciences, Sense Organs and Thorax, Fondazione Policlinico Universitario A. Gemelli IRCCS, Italy; ³Department of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy; ⁴Department of Neuroscience, Giovanni Paolo II Hospital, Catanzaro, Italy

DOI https://doi.org/10.4081/cc.2026.15946
- 4 abstract views
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OC09 | TOBACCO/NICOTINE-RELATED HEADACHE AS A CANDIDATE PHENOTYPE FOR ICHD-4: INSIGHTS FROM THE JASTIS STUDY, A JAPANESE CROSS-SECTIONAL ANALYSIS

M. Katsuki^1|2, M. Romozzi^3|4, Y. Matsumori⁵, K. Moran², T. Ward², T. Tabuchi⁷ | ¹Nagaoka University of Technology, Japan; ²Insight Research Ireland Centre for Data Analytics, Ireland; ³Università Cattolica del Sacro Cuore, Italy; ⁴Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Italy; ⁵Sendai Headache and Neurology Clinic, Japan; ⁶Tohoku University, Japan

DOI https://doi.org/10.4081/cc.2026.15947
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OC10 | EFFECTS OF RECEPTIVE MUSIC THERAPY IN ADDITION TO ONABOTULINUMTOXINA TREATMENT FOR CHRONIC MIGRAINE: A PILOT STUDY

L. La Rocca¹, N. Rini², M. Rizzo³, E. Scarlata¹, F. Brighina² | ¹M.A. in Music Therapy - Conservatorio "A.Scarlatti", Palermo, Italy; ²Dept of Biomedicine, Neuroscience and advanced Diagnostic (BIND) - University of Palermo, Italy; ³Research Office - IRCCS ISMETT Mediterranean Institute for Transplantation and Advanced Specialized Therapies - Palermo, Italy

DOI https://doi.org/10.4081/cc.2026.15948
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OC11 | A CASE REPORT OF GALCANEZUMAB-INDUCED MYASTENIA GRAVIS-LIKE SYMPTOMS

F. Lo Castro, D. Brovia, S. Guerzoni | Digital and Predictive Medicine, Pharmacology and Clinical Metabolic Toxicology-Headache Center and Drug Abuse-Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico di Modena, Italy

DOI https://doi.org/10.4081/cc.2026.15949
- 6 abstract views
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OC12 | HEADACHE-ATTRIBUTED BURDEN IN ITALIAN CHILDREN AND ADOLESCENTS: FINDINGS FROM THE REPICEF SCHOOL-BASED STUDY

A. Onofri, C. Rosignoli, F. De Santis, R. Ornello, S. Sacco | Dipartimento di Scienze Cliniche Applicate e Biotecnologiche, Università degli Studi dell’Aquila, Italy

DOI https://doi.org/10.4081/cc.2026.15950
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OC13 | ABNORMAL NEUROVASCULAR COUPLING IN THE PRECUNEUS–POSTERIOR CINGULATE CORTEX MAY BRIDGE SIMPLE AND COMPLEX AURA PHENOMENA IN THE MIGRAINE BRAIN: AN ARTERIAL SPIN LABELLING INVESTIGATION

I. Orologio, M. Silvestro, F. Esposito, A. Tessitore, M. Cirillo, A. Russo | Programma Interdipartimentale di Medicina delle Cefalee e delle Sindromi Dolorose Primitive, Dipartimento di Scienze Mediche e Chirurgiche Avanzate, Università degli Studi della Campania “Luigi Vanvitelli”, Napoli, Italy

DOI https://doi.org/10.4081/cc.2026.15951
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OC14 | MIGRAINE IN OLDER ADULTS: A MULTICENTER REAL-WORLD ANALYSIS FROM THE ITALIAN RICE REGISTRY

G. Paparella^1|2, L. Iannone³, G. Paparella¹, S. Scannicchio¹, C. Abbatantuono¹, L. Clemente¹, M. Delussi⁴, M. de Tommaso¹ | ¹Neurophysiopathology Unit, Department of Translational Biomedicine and Neuroscience (DiBraiN), University of Bari Aldo Moro, Italy; ²IRCCS Neuromed, Pozzilli (IS), Italy; ³Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy; ⁴Department of Education, Psychology, Communication (For.Psi.Com.), University of Bari Aldo Moro, Italy

DOI https://doi.org/10.4081/cc.2026.15952
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OC15 | CENTRAL AND PERIPHERAL CONTRIBUTIONS TO FIBROMYALGIA PHENOTYPES: ROLE OF MIGRAINE COMORBIDITY AND SMALL FIBRE PATHOLOGY

G. Paparella^1|2, E. Ammendola¹, S. Limitone¹, L. Clemente¹, G. Libro¹, M. de Tommaso¹ | ¹Neurophysiopathology Unit, Department of Translational Biomedicine and Neuroscience (DiBraiN), University of Bari Aldo Moro, Italy; ²IRCCS Neuromed, Pozzilli (IS), Italy

DOI https://doi.org/10.4081/cc.2026.15953
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OC16 | GUT MICROBIOTA FUNCTIONAL REMODELING IN PEDIATRIC MIGRAINE: A MULTI-OMIC INSIGHT INTO NEUROACTIVE AND IMMUNOMETABOLIC PATHWAYS

L. Papetti¹, S. Levi Mortera^2|3, M. Di Michele^2|3, F. Del Chierico⁴, G. Monte¹, F. Ursitti¹, G. Sforza¹, C. Granata⁵, L. Putignani⁴, M. Valeriani^1|5|6 | ¹Developmental Neurology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy; ²Chromatography and Mass Spectrometry Core Facility, Research Laboratory Platform, Bambino Gesù Children's Hospital, IRCCS Rome, Italy; ³Management and Diagnostic Innovation & Clinical Pathway Research Area, Microbiome Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy; ⁴Unit of Microbiology and Diagnostic Immunology, Unit of Microbiomics and Research Area of Immunology, Rheumatology and Infectious Diseases, Unit of Microbiome, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy; ⁵Systems Medicine Department, Tor Vergata University, Rome, Italy; ⁶Center for Sensory‑Motor Interaction, Aalborg University, Denmark

DOI https://doi.org/10.4081/cc.2026.15954
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OC17 | NEUROPHYSIOLOGICAL EVALUATION IN HEMIPLEGIC MIGRAINE PATIENTS: A STUDY WITH REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION AND SOUND INDUCED FLASH ILLUSIONS

A. Torrente, P. Alonge, V. Gulino, A. Palermo, L. Pilati, C. Camarda, V. Di Stefano, G. Cosentino, F. Brighina | Department of Biomedicine, Neurosciences and advanced Diagnostics, University of Palermo, Italy

DOI https://doi.org/10.4081/cc.2026.15955
- 5 abstract views
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OC18 | LONG-TERM EFFECTIVENESS, SAFETY AND TOLERABILITY OF ATOGEPANT IN THE PREVENTION OF MIGRAINE: A MULTICENTRIC, PROSPECTIVE OBSERVATIONAL, REAL WORLD STUDY (THE 48-WEEK STAR STUDY)

F. Vernieri^1|2, L. Francesco Iannone³, M. Marcosano^1|2, L. Fofi¹, F. Lo Castro⁴, G. Sebastianelli⁵, F. De Santis⁶, M. Corrado⁷, R. Ornello⁶, L. Grazzi⁸, D. Antonio Montisano⁸, F. De Cesaris⁹, A. Munafò⁹, G. Avino¹⁰, M. Trimboli¹¹, M. Albanese¹², A. Russo¹³, M. Silvestro¹³, G. Dalla Volta¹⁴, M. Romozzi¹⁵, P. Calabresi¹⁵, A. Boccalini⁴, P. Merlo¹⁶, M. Pia Prudenzano¹⁷, M. Rosaria Valente¹⁸, I. Rainero¹⁹, G. Giuliani²⁰, M. Altieri²⁰, A. Doretti²¹, G. Vaghi^7|22, F. Pistoia⁶, D. Ferrandi²³, S. Battistini²⁴, G. Coppola⁵, S. Guerzoni⁴, S. Sacco^6|25, C. Tassorelli^7|22, C. Altamura^1|2 | ¹Headache and Neurosonology Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy; ²Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Italy; ³Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy; ⁴Digital and Predictive Medicine, Pharmacology and Clinical Metabolic Toxicology-Headache Center and Drug Abuse-Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico Di Modena, Italy; ⁵Sapienza University of Rome, Department of Medico-Surgical Sciences and Biotechnologies, Polo Pontino, Latina, Italy; ⁶Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, Italy; ⁷Headache Science and Neurorehabilitation Centre, IRCCS Mondino Foundation, Pavia, Italy; ⁸Headache Center IRCCS Fondazione Istituto Neurologico "Carlo Besta", Italy; ⁹Headache center and clinical pharmacology, AOU Careggi, Firenze, Italy; ¹⁰Neurology Unit, Ospedale Santo Stefano, USL Toscana Centro, Prato, Italy; ¹¹Azienda Ospedaliera-universitaria "Renato Dulbecco", Catanzaro, Italy; ¹²Department of Systems Medicine, University of Rome Tor Vergata, Italy; ¹³Headache Center, Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Italy; ¹⁴U.O Neurologia, Istituto Clinico Città di Brescia, Gruppo San Donato, Italy; ¹⁵Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy; ¹⁶UO di Neurologia, Humanitas Gavazzeni, Bergamo, Italy; ¹⁷Clinica Neurologica "L. Amaducci", Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, Italy; ¹⁸Clinica Neurologica ASUFC, Dipartimento di Medicina DMED Università di Udine, Italy; ¹⁹Headache Center, Department of Neuroscience, University of Torino, Italy; ²⁰Department of Human Neuroscience, Sapienza University of Rome, Italy; ²¹IRCCS Istituto Auxologico Italiano, Milano, Italy; ²²Department of Brain and Behavioural Sciences, University of Pavia, Italy; ²³SC Neurologia, Azienda Ospedaliero Universitaria Santi Antonio e Biagio, Alessandria, Italy; ²⁴Department of Medical, Surgical and Neurological Sciences, University of Siena, Italy; ²⁵Neurology and Stroke Unit, ASL 1 Abruzzo, Avezzano-Sulmona-L’Aquila, Italy

DOI https://doi.org/10.4081/cc.2026.15956
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P001 | EFFECTS OF A MINDFULNESS-BASED INTERVENTION ON ADOLESCENTS WITH HIGH FREQUENCY PRIMARY HEADACHES: A PROSPECTIVE MULTICENTER STUDY

I. Bonemazzi¹, B. Baldo¹, S. Contri¹, G. Coser¹, C. Del Vecchio¹, G. De Lorenzi¹, V. Marletta¹, A. Raffagnato², C. Vassia³, E. Serri³, D. D’Agnano⁴, A. Versace³, V. Sciruicchio⁴, L. Grazzi⁵, I. Toldo¹ | ¹Juvenile Headache Center, Department of Woman’s and Child’s Health, University of Padua, Italy; ²Child and Adolescent Neuropsychiatric Unit, Department of Women’s and Children’s Health, University of Padua, Italy; ³Pediatric Headache Center, Department of Pediatric Emergency, Regina Margherita Children’s Hospital, Turin, Italy; ⁴Children Epilepsy and EEG Center, San Paolo Hospital, ASL Bari, Italy; ⁵Neuroalgology Unit and Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy

DOI https://doi.org/10.4081/cc.2026.15957
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P002 | HEADACHE AND FOCAL NEUROLOGICAL DEFICITS: DIAGNOSTIC CHALLENGES BETWEEN HEMIPLEGIC MIGRAINE AND ISCHEMIC EVENTS IN AN ADOLESCENT

C. Brancaccio^1|2, P. Cattabiani^1|2, M. Celario^1|2, S. Genta^1|2, E. Rognone³, A. Pichiecchio^1|3, S. Kalantari^4|5, V. De Giorgis^1|2 | ¹Dipartimento di Scienze del Sistema Nervoso e del Comportamento, Università degli Studi di Pavia, Italy; ²U.O.C. Neuropsichiatria Infantile, Fondazione IRCCS Mondino, Pavia, Italy; ³U.O.C. Neuroradiologia, IRCCS Fondazione Mondino, Pavia, Italy; ⁴Unità di Genetica Medica, IRCCS Fondazione Policlinico San Matteo, Pavia, Italy; ⁵Dipartimento di Medicina Molecolare, Università di Pavia, Italy

DOI https://doi.org/10.4081/cc.2026.15958
- 6 abstract views
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P003 | ATYPICAL AURA IN CHILDHOOD: AN ITALIAN MULTICENTER CASE SERIES AND NARRATIVE REVIEW

E. Correnti¹, B. Bovolenta², A. Di Gioia³, V. Sinisi⁴, B. Baldo⁵, F. Antonelli⁵, C. Gaspari⁶, R. Rossi⁷, C. Vassia⁷, V. Raieli¹, A. Ferretti², V. Sciruicchio³, I. Toldo⁵, A. Versace⁷ | ¹U.O. Child Neuropsychiatry-ISMEP, “G.Di Cristina” Hospital ARNAS Civico, Palermo, Italy; ²Pediatrics Unit, Faculty of Medicine and Psychology, Neuroscience, Mental Health and Sense Organs (NESMOS) Department, Sapienza University of Rome, Italy; ³U.O.S.V.D. Departmental Unit of Epilepsy and Electroencephalography, San Paolo Hospital, Bari, Italy; ⁴U.O.C. Neurology, Pediatric Hospital Giovanni XXIII, AOU Policlinico of Bari, Italy; ⁵Juvenile Headache Centre, Pediatric Neurology and Neurophysiology, Department of Women's and Children's Health, University of Padua, Italy; ⁶Department of Science for Health promotion and Mother and Child Care, University of Palermo, Italy; ⁷Department of Pediatric Emergency Pediatric Headache Centre, Regina Margherita Children’s Hospital, Turin, Italy

DOI https://doi.org/10.4081/cc.2026.15959
- 6 abstract views
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P004 | SECONDARY HEADACHE IN THE PEDIATRIC EMERGENCY DEPARTEMENT: THE CRUCIAL ROLE OF MEDICAL HISTORY

C. Ferraris¹, C. Minero², S. Belluca², B. Lauria², G. Grasso², R. Rossi², C. Vassia², P. Lacroce³, C. Bondone², A. Versace² | ¹Department of Public Health and Pediatrics, Residency Program in Pediatrics, University of Turin, Italy; ²Department of Pediatric Emergency – Pediatric Headache Center, Regina Margherita Children's Hospital, Turin, Italy; ³Department of Pediatric Neurosurgery, Regina Margherita Children's Hospital, Turin, Italy

DOI https://doi.org/10.4081/cc.2026.15960
- 5 abstract views
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P005 | TOLOSA–HUNT SYNDROME IN ADOLESCENCE: A RARE CAUSE OF SECONDARY HEADACHE AND PAINFUL OPHTHALMOPLEGIA

C. Granata¹, G. Sforza², C. Trovato¹, G. Monte², F. Ursitti², M. Valeriani^1|2|3, L. Papetti² | ¹Unit of Child Neurology and Psychiatry, Department of Systems Medicine, Tor Vergata University of Rome, Italy; ²Developmental Neurology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy; ³Translational Pain Neuroscience and Precision Medicine, CNAP, Department of Health Science and Technology, School of Medicine, Aalborg University, Copenhagen, Denmark

DOI https://doi.org/10.4081/cc.2026.15961
- 4 abstract views
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P006 | PAIN MANAGEMENT FOR ACUTE PRIMARY HEADACHE IN A PEDIATRIC EMERGENCY DEPARTMENT: A RETROSPECTIVE STUDY

G. Monte¹, M. Roversi², L. Papetti¹, F. Ursitti¹, G. Sforza¹, S. Cristaldi², U. Raucci⁴, M. Valeriani¹ | ¹Developmental Neurology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy; ²Pediatric Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy; ³Institute for the Child and Adolescent Health, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy

DOI https://doi.org/10.4081/cc.2026.15962
- 4 abstract views
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P007 | PRIMARY HEADACHES IN ITALIAN CHILDREN AND ADOLESCENTS: EPIDEMIOLOGY AND CLINICAL PROFILE FROM THE REPICEF STUDY

A. Onofri, C. Rosignoli, F. De Santis, R. Ornello, S. Sacco | Dipartimento di Scienze Cliniche Applicate e Biotecnologiche, Università degli Studi dell’Aquila, Italy

DOI https://doi.org/10.4081/cc.2026.15963
- 5 abstract views
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P008 | DEVELOPMENTAL DIFFERENCES IN COPING AND PAIN CATASTROPHIZING IN PEDIATRIC MIGRAINE: HOW PATIENTS AND THEIR MOTHERS CHANGE ACROSS AGE

M. Proietti Checchi¹, S. Tarantino¹, F. Ursitti¹, G. Sforza¹, G. Monte¹, M. Valeriani^1|2|3, L. Papetti¹ | ¹Developmental Neurology, Bambino Gesù Children Hospital, IRCCS, Rome, Italy; ²System Medicine Department, Tor Vergata University of Rome, Italy; ³Translational Pain Neuroscience and Precision Medicine, CNAP, Dept. of Health Science and Technology, School of Medicine, Aalborg University, Denmark

DOI https://doi.org/10.4081/cc.2026.15964
- 5 abstract views
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P009 | THE USE OF DRAWING IN PEDIATRIC HEADACHES: A CROSS-CULTURAL ANALYSIS OF THE LITERATURE

V. Raieli¹, F. Cernigliaro², E. Correnti¹, D. Lopes¹, A. Messina³, C. Balzanelli⁴, G. Santangelo¹, R. Nardello⁵ | ¹Child Neuropsychitry Unit – h. “Di Cristina “Arnas civico”, Palermo, Italy; ²Child neuropsychiatry unit – asp 6 -Palermo, Italy; ³Neurotologic Center “Regina Margherita” Palermo, Italy; ⁴Vertigo Center at San Bernardino Outpatient Clinic, Salò, Italy; ⁵Child neuropsychiatry dept. – University of Palermo, Italy

DOI https://doi.org/10.4081/cc.2026.15965
- 4 abstract views
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P010 | APPROPRIATENESS AND EFFECTIVENESS OF FIRST-LINE ANALGESICS IN CHILDREN WITH HEADACHE ADMITTED TO THE PEDIATRIC EMERGENCY DEPARTMENT

R. Rossi, M. Cherubini Scarafoni, G. Grasso, B. Lauria, C. Vassia, C. Minero, E. Castagno, A. Versace, C. Bondone | Department of Pediatric Emergency Pediatric Headache Centre, Regina Margherita Children’s Hospital, Turin, Italy

DOI https://doi.org/10.4081/cc.2026.15966
- 4 abstract views
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P011 | PSYCHOLOGICAL CORRELATES IN ADOLESCENTS WITH CHRONIC AND NON-CHRONIC HEADACHE ATTENDING THE REGINA MARGHERITA CHILDREN’S HOSPITAL HEADACHE CENTER OF TURIN, ITALY (OIRM): A PRELIMINARY ANALYSIS

S. Serri¹, A. Lamberti Zanardi¹, R. Mascolo¹, E. Agosto², A. Fera², E. Martinotti², R. Rossi¹, C. Bondone¹, A. Versace¹, S. Racalbuto¹ | ¹Department of Pediatric Emergency Pediatric Headache Centre, Regina Margherita Children’ s Hospital, Turin, Italy; ²Department of Public Health and Pediatrics, Postgraduate School of Pediatrics, University of Turin, Italy

DOI https://doi.org/10.4081/cc.2026.15967
- 4 abstract views
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P012 | BEYOND WORDS: MIGRAINE PHENOTYPE IN CHILDREN AND ADOLESCENTS WITH AUTISM SPECTRUM DISORDER

G. Sforza¹, C. Maritato², F. Ursitti¹, G. Monte¹, S. Tarantino¹, M. Proietti Checchi¹, M. Valeriani^1|3|4, L. Papetti¹ | ¹Developmental Neurology, Bambino Gesù Children Hospital, Rome, Italy; ²Department of Maternal, Infantile and Urological Sciences, Sapienza University of Rome, Italy; ³System Medicine Department, Tor Vergata University of Rome, Italy; ⁴Translational Pain Neuroscience and Precision Medicine, CNAP, Department of Health Science and Technology, School of Medicine, Aalborg Aalborg, Denmark University

DOI https://doi.org/10.4081/cc.2026.15968
- 6 abstract views
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P013 | EARLY CHILDHOOD HEADACHE: MAPPING PSYCHOLOGICAL, COGNITIVE, AND FUNCTIONAL IMPACT

S. Tarantino¹, G. Pagano², M. Proietti Checchi¹, F. Ursitti¹, G. Monte¹, G. Sforza¹, L. Mazzone², M. Valeriani^1|2|3, L. Papetti¹ | ¹Developmental Neurology Unit, Bambino Gesù Children’s Hospital, Rome, Italy; ²Child Neurology and Psychiatry Unit, Systems Medicine Department, Tor Vergata University of Rome, Italy; ³Translational Pain Neuroscience and Precision Medicine, CNAP, Dept. of Health Science and Technology, School of Medicine, Aalborg University, Denmark

DOI https://doi.org/10.4081/cc.2026.15969
- 5 abstract views
- 0 PDF
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P014 | HOW LONG DO MIGRAINE ATTACKS LAST IN CHILDREN AND ADOLESCENTS? INSIGHTS FROM A COHORT OF PATIENTS AGED 6–18 YEARS

F. Ursitti¹, C. Maritato², G. Rossetto³, G. Sforza¹, G. Monte¹, R. Mariani⁴, N. Olivini⁴, G. Spina⁴, V. De Giorgis⁵, M. Valeriani^1|6|7, L. Papetti¹ | ¹Developmental Neurology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy; ²Departement of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Italy; ³Department of Brain and Behavioural Sciences, University of Pavia, Italy; ⁴Pediatric Unit, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy; ⁵Department of Brain and Behavioural Sciences, University of Pavia, Italy; Child Neurology and Psychiatry Unit, IRCCS Mondino Foundation, Pavia, Italy; ⁶Child Neurology Unit, Systems Medicine Department, Tor Vergata University Hospital of Rome, Italy; ⁷Translational Pain Neuroscience and Precision Medicine, CNAP, Department of Health Science and Technology, School of Medicine, Aalborg University, Denmark

DOI https://doi.org/10.4081/cc.2026.15970
- 5 abstract views
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P015 | IMPROVING DISTRESS PERCEPTION IN CAREGIVERS OF MIGRAINE PATIENTS WITH DEPRESSIVE SYMPTOMS TREATED WITH FREMANEZUMAB. THE OBSERVATIONAL PROSPECTIVE REAL-LIFE MI-DEAR STUDY

C. Altamura^1|2, L. Fofi¹, C. Aurilia³, E. Cresta⁴, A. Onofri⁵, A. Montisano⁶, M. Silvastro⁷, V. Favoni⁸, G. Viticchi⁹, M. Marcosano¹, G. Egeo³, M. Bartolini⁹, M. Peresson¹⁰, M. Cepparulo¹¹, A. Russo⁷, S. Cevoli⁸, R. Rao^4|12, L. Grazzi⁶, S. Sacco⁵, F. Vernieri^1|2 | ¹Neurosonology and Headache Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy; ²Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Italy; ³Headache and Pain Unit, IRCCS San Raffaele Roma, Italy; ⁴Department of Frailty and Care, Neurology Unit, Headache Center, ASST Spedali Civili, Brescia, Italy; ⁵Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy; ⁶Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy; ⁷Inter-departmental Program of Headache Medicine and Primary Pain Syndromes, Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, University of Campania “Luigi Vanvitelli”, Naples, Italy; ⁸Programma cefalee e algie facciali, IRCCS Istituto delle Scienze Neurologiche di Bologna, Italy; ⁹Neurological Clinic, Marche Polytechnic University, Ancona, Italy; ¹⁰Headache Unit, San Pietro Fatebenefratelli Hospital, Rome, Italy; ¹¹Teva Italia Srl, Milan, Italy; ¹²Department of Clinical and Experimental Sciences (DSCS), University of Brescia, Italy

DOI https://doi.org/10.4081/cc.2026.15971
- 5 abstract views
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P016 | EFFECTIVENESS AND SAFETY OF MONTHLY VERSUS QUARTERLY FREMANEZUMAB FOR MIGRAINE PREVENTION: A 12 MONTHS ITALIAN, MULTICENTER, REAL-LIFE STUDY

A. Antoniazzi¹, E. Ratto¹, I. Cetta¹, A. Visentini^1|2, L. Consuma^1|2, F. Genovese^1|2, L. Zanandrea^1|2, C. Lovati³, S. Cevoli⁴, V. Favoni⁴, F. Vernieri^5|6, C. Altamura^5|6, B. Colombo¹, M. Filippi^1|2, R. Messina^1|2 | ¹Headache Center, Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy; ²Vita-Salute San Raffaele University, Milan, Italy; ³Headache Center, L. Sacco University Hospital, Milan, Italy; ⁴IRCCS Istituto delle Scienze Neurologiche di Bologna, Italy; ⁵Unit of Headache and Neurosonology, Department of Medicine and Surgery, University Campus Bio-Medico di Roma, Italy; ⁶Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy

DOI https://doi.org/10.4081/cc.2026.15972
- 5 abstract views
- 0 PDF
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P017 | LONG-TERM EFFECTIVENESS AND PERSISTENCE OF ANTI-CGRP MONOCLONAL ANTIBODIES IN MIGRAINE: A PROSPECTIVE REAL-WORLD STUDY

F. Brighina, P. Alonge, A. Torrente, V. Portera, I. Cutrò, A. Meli, A. Vignoli, C. Camarda | Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.) - Section of Neurology - University of Palermo, Italy

DOI https://doi.org/10.4081/cc.2026.15973
- 5 abstract views
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P018 | LOOKING AT ADHERENCE TO TREATMENTS TARGETING THE CALCITONIN GENE-RELATED PEPTIDE PATHWAY FROM THE LENS OF PHARMACOUTILIZATION: REAL-WORLD DATA

A. Cipriano, E. Sciarretta, F. Gabriele, F. de Santis, A. Onofri, E. Piizzi, U. Coppola, C. Tiseo, R. Ornello, S. Sacco | Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy

DOI https://doi.org/10.4081/cc.2026.15974
- 6 abstract views
- 0 PDF
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P019 | FAMILIAL AGGREGATION OF RESPONSE TO CGRP MONOCLONAL ANTIBODIES IN MIGRAINE: PRELIMINARY CLINICAL EVIDENCE OF INHERITED TREATMENT SUSCEPTIBILITY

F. Maurizio Chianese, M. Silvestro, I. Orologio, V. Dortucci, A. Tessitore, A. Russo | Inter-departmental Program of Headache Medicine and Primary Pain Syndromes, Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Naples, Italy

DOI https://doi.org/10.4081/cc.2026.15975
- 6 abstract views
- 0 PDF
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P020 | ATOGEPANT AS ADD-ON THERAPY TO ONABOTULINUMTOXINA IN CHRONIC MIGRAINE: A REAL-WORLD STUDY

E. Cresta, A. Lanfranchi, M. Di Pasquale, K. Eshja, I. Zani, R. Rao, A. Padovani | Neurology Unit, Headache Centre, Department of Continuity of Care and Frailty, ASST Spedali Civili; Clinical Neurology, Department of Clinical and Experimental Sciences, University of Brescia, Italy

DOI https://doi.org/10.4081/cc.2026.15976
- 4 abstract views
- 0 PDF
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P021 | FIVE-YEAR REAL-WORLD EFFECTIVENESS AND TREATMENT PERSISTENCE OF ERENUMAB IN MIGRAINE

M. De Luca¹, L. Ferraù¹, M. Stella Adragna¹, A. Cafarchio², M. Autunno¹ | ¹Dipartimento di medicina clinica e sperimentale, Università degli studi di Messina, Italy; ²Centro interdipartimentale della ricerca sui biomateriali, università degli studi di Napoli Federico II, Italy

DOI https://doi.org/10.4081/cc.2026.15977
- 5 abstract views
- 0 PDF
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P022 | REAL-WORLD CGRP-TARGETED THERAPY OUTCOMES IN HIGH-FREQUENCY MIGRAINE: IMPLICATIONS FOR THE 2025 POSITION STATEMENT OF HIS

A. D'Amico^1|2, B. Pitzalis³, C. Zilli³, G. Giuliani⁴, M. Di Giulio³, F. Traccitto³, M. Altieri³ | ¹Istituto Neurotraumatologico Italiano - Roma, Italy; ²Dipartimento di Medicina, Chirurgia e Odontoiatria "Scuola Medica Salernitana", Università degli Studi di Salerno - Baronissi, Italy; ³Dipartimento di Neuroscienze Umane, Università degli Studi di Roma "La Sapienza", Italy; ⁴Centro Cefalee, Ospedale "San Giovanni Addolorata", Roma, Italy

DOI https://doi.org/10.4081/cc.2026.15978
- 12 abstract views
- 0 PDF
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P023 | SUSTAINED CLINICAL RESPONSE TO ATOGEPANT AFTER FAILURE OF FOUR ANTI-CGRP MONOCLONAL ANTIBODIES IN HIGHLY RESISTANT CHRONIC MIGRAINE

G. Difonzo, C. Rita Tamborino, F. Domenico Pellicano, A. Fallacara, D. Paolicelli, M. Pia Prudenzano | Headache Center, “L. Amaducci” Neurological Clinic, Policlinico General Hospital, Bari, Italy

DOI https://doi.org/10.4081/cc.2026.15979
- 5 abstract views
- 0 PDF
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P024 | PROFILING EPTINEZUMAB LONG-TERM EFFECTIVENESS AND DOSE-RESPONSE IN PATIENTS WITH CHRONIC MIGRAINE AND MEDICATION OVERUSE HEADACHE: A REAL-WORLD LONGITUDINAL STUDY

K. Eshja^1|2, A. Lanfranchi¹, A. Rizzardi², E. Cresta^1|2, M. Di Pasquale^1|2, A. Rondina², R. Rao^1|2, A. Padovani^1|2 | ¹Neurology Unit, Headache Centre, Department of “Continuità di Cura e Fragilità”, ASST Spedali Civili, Italy; ²Clinical Neurology, Department of Clinical and Experimental Sciences, University of Brescia, Italy

DOI https://doi.org/10.4081/cc.2026.15980
- 4 abstract views
- 0 PDF
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P025 | PAIN RELIEF AFTER 30 MINUTES PREDICTS COMPLETE ACUTE TREATMENT SUCCESS AT 12 HOURS: A REAL-WORLD ANALYSIS OF INTRAVENOUS EPTINEZUMAB INFUSION IN HIGHLY REFRACTORY MIGRAINE PATIENTS

L. Fofi¹, C. Altamura^1|2, M. Marcosano^1|2, L. d’Onofrio², A. Doretti³, F. Pistoia⁴, A. Granato⁵, S. Guerzoni⁶, M. Trimboli⁷, L. Grazzi⁸, D. Antonio Montisano⁸, G. Avino⁹, G. Sebastianelli¹⁰, C. Fasano¹¹, E. Maria Piella¹², P. Geppetti¹³, N. Brunelli¹, S. Lodico², L. Francesco Iannone¹⁴, F. Vernieri^1|2 | ¹Neurosonology and Headache Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy; ²Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Italy; ³Department of Neurology-Laboratory of Neuroscience, IRCCS, Istituto Auxologico Italiano, Milan, Italy; ⁴Department of Biotechnological and Applied Clinical Sciences, Neurological Institute, University of L’Aquila, Italy; ⁵Headache Center, Neurology Clinic, University Hospital of Trieste, University of Trieste, Italy; ⁶Digital and Predictive Medicine, Pharmacology and Clinical Metabolic Toxicology-Headache Center and Drug Abuse-Laboratory of Clinical Pharmacology and Pharmacogenomics, Department of Specialist Medicines, AOU Policlinico di Modena, Italy; ⁷Azienda Ospedaliera-Universitaria “Renato Dulbecco”, Catanzaro, Italy; ⁸Headache Center, Department of Neurology, IRCCS Foundation “Carlo Besta” Neurological Institute, Milan, Italy; ⁹SOC Neurologia, Ospedale Santo Stefano, USL Toscana Centro, Prato, Italy; ¹⁰Department of Medico-Surgical Sciences and Biotechnologies, Polo Pontino ICOT, Sapienza University of Rome, Latina, Italy; ¹¹Headache and Cerebrovascular Diseases Center, Neurology Unit 2, Careggi University Hospital, Florence, Italy; ¹²Department of Neurosciences “Rita Levi Montalcini”, University of Turin, Italy; ¹³Department of Molecular Pathobiology and Pain Research Center, College of Dentistry, New York University, NY, United States; ¹⁴Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy

DOI https://doi.org/10.4081/cc.2026.15981
- 16 abstract views
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P026 | ATOGEPANT IN CLINICAL PRACTICE: 6-MONTH REAL-WORLD DATA ON EFFECTIVENESS AND SAFETY IN MIGRAINE PREVENTION FROM A THIRD LEVEL HEADACHE CENTER

E. Giacopuzzi Grigoli¹, D. Antonio Montisano¹, A. Parisi¹, A. Raggi², L. Grazzi¹ | ¹Centro Cefalee, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy; ²Unità di Neurologia, Salute Pubblica e Disabilità, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy

DOI https://doi.org/10.4081/cc.2026.15982
- 73 abstract views
- 0 PDF
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P027 | LONG-TERM RESPONSE AND TREATMENT PERSISTENCE IN THE ANTI-CGRP ERA: A REAL-WORLD STUDY

G. Giuliani, C. Cutrona, A. Salerno | Headache Center, San Giovanni Addolorata Hospital, Rome, Italy

DOI https://doi.org/10.4081/cc.2026.15983
- 6 abstract views
- 0 PDF
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P028 | WORSENING OF MIGRAINE AFTER DISCONTINUATION OF ANTI-CGRP MONOCLONAL ANTIBODIES: PATIENTS WITHOUT RECURRENCE FOR AT LEAST 6 MONTHS

M. Katsuki^1|2, M. Romozzi^3|4, S. Ooba⁵, Y. Matsumori⁶, K. Moran², T. Ward², S. Ishii⁷ | ¹Nagaoka University of Technology, Japan; ²Insight Research Ireland Centre for Data Analytics, Ireland; ³Università Cattolica del Sacro Cuore, Italy; ⁴Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Italy; ⁵Ooba Clinic for Neurosurgery & Headache, Japan; ⁶Sendai Headache and Neurology Clinic, Japan; ⁷Daidai Clinic Kudanshita Headache Clinic, Japan

DOI https://doi.org/10.4081/cc.2026.15984
- 5 abstract views
- 0 PDF
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P029 | SUSTAINED EFFECTIVENESS OF CGRP MONOCLONAL ANTIBODIES OVER FOUR CONSECUTIVE YEARS: A PROSPECTIVE REAL-WORLD STUDY

M. Marziani, M. Silvestro, F. Esposito, I. Orologio, A. Tessitore, M. Cirillo, A. Russo | Inter-departmental Program of Headache Medicine and Primary Pain Syndromes, Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Naples, Italy

DOI https://doi.org/10.4081/cc.2026.15985
- 6 abstract views
- 0 PDF
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P030 | PREMONITORY EPISODES WITHOUT HEADACHE DURING ANTI-CGRP PREVENTIVE TREATMENTS: A CROSS-SECTIONAL MULTICENTER STUDY

A. Munafò¹, G. Sebastianelli^2|3, P. Amarsena², F. Greenwood², S. Maniataki², A. Burgalassi¹, G. Vigani¹, D. Moreno², F. Puledda², N. Karsan², F. De Cesaris¹, A. Chiarugi¹, P. Goadsby^2|4 | ¹Headache Center and Clinical Pharmacology Unit, Careggi University Hospital, Florence, Italy; ²NIHR King’s Clinical Research Facility, SLaM Biomedical Research Centre and Wolfson SPaRC, Institute of Psychiatry, Psychology and Neurosceince, King’s College London, UK; ³Department of Medico-Surgical Sciences and Biotechnologies, Polo Pontino, Sapeinza University of Rome, Latina, Italy; ⁴Division of Biomedcial Sciences, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia

DOI https://doi.org/10.4081/cc.2026.15986
- 5 abstract views
- 0 PDF
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P031 | ANTI-CGRP MONOCLONAL ANTIBODIES FOR CHRONIC MIGRAINE PREVENTION: A CRITICAL SYNTHESIS OF EVIDENCE FROM RANDOMIZED AND REAL-WORLD STUDIES

O. Pardeo, D. Carta, V. Lo Buono, G. Vita, D. Cosenza, R. Lo Presti, A. Quartarone, S. Marino, R. Grugno | Centro per la Diagnosi e Cura delle Cefalee, IRCCS Centro Neurolesi Bonino-Pulejo, Messina, Italy

DOI https://doi.org/10.4081/cc.2026.15987
- 16 abstract views
- 0 PDF
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P032 | IMPROVEMENT IN DEPRESSIVE AND ANXIETY SYMPTOMS DURING EPTINEZUMAB TREATMENT: A POST-HOC ANALYSIS FROM THE TACHIS STUDY

E.M. Piella¹, A.M. Chiarandon¹, V. Batti¹, D.A. Montisano², L. F. Iannone³, C. Fasano⁴, G. Sebastianelli⁵, G. Coppola⁵, D. Ferrandi⁶, C. Lanni⁷, M.P. Prudenzano⁸, M. De Tommaso⁹, P. Merlo¹⁰, A. Viganò¹⁰, F. De Cesaris¹¹, A. Chiarugi¹¹, A. Munafò¹¹, F. Pistoia¹², R. Ornello¹², S. Sacco¹², A. Doretti¹³, L. Grazzi², F. Lo Castro¹⁴, R. Allamprese¹⁴, R. De Icco^15|16, G. Vaghi^15|16, C. Tassorelli^15|16, G. Avino¹⁷, M. Romozzi¹⁸, C. Vollono¹⁸, P. Calabresi¹⁸, S. Battistini¹⁹, A. Rufa¹⁹, M. Albanese²⁰, M. Trimboli²¹, G. Carlucci⁴, M. Silvestro²², A. Russo²², M. Valente²³, L. Fofi²⁴, M. Marcosano²⁴, P. Geppetti²⁵, C. Altamura²⁴, F. Vernieri²⁴, E. Rubino¹, I. Rainero¹, S. Guerzoni¹⁴ | ¹Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Italy; ²Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy; ³Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy; ⁴NEUROFARBA Department, University of Florence - Neurologia, AOU Careggi, Italy; ⁵Sapienza University of Rome, Department of Medico-Surgical Sciences and Biotechnologies, Polo Pontino, Latina, Italy; ⁶AOU Alessandria, SC Neurologia, Italy; ⁷Psicologia AOU Alessandria, Italy; ⁸Clinica Neurologica "L. Amaducci", Azienda Ospedaliero-Universitaria Consorziale di Bari, Italy; ⁹Neurophysiopathology Unit, Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Italy; ¹⁰UO di Neurologia, Humanitas Gavazzeni, Bergamo, Italy; ¹¹Headache center and Clinical pharmacology unit, AOU Careggi, Florence, Italy; ¹²Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy; ¹³Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milano, Italy; ¹⁴Digital and Predictive Medicine, Pharmacology, Clinical Metabolic Toxicology-Headache Center and Drug Abuse, Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico, Modena, Italy; ¹⁵Department of Brain and Behavioral Sciences, University of Pavia, Italy; ¹⁶Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy; ¹⁷SOC Neurologia, Ospedale di Prato, Italy; ¹⁸Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy; ¹⁹Department of Medical, Surgical and Neurological Sciences, University of Siena, Italy; ²⁰Unit of Neurology, Department of Systems Medicine, University of Rome Tor Vergata, Italy; ²¹Headache Center, Unit of Neurology, AOU Renato Dulbecco, Catanzaro, Italy; ²²Inter-departmental Program of Headache Medicine and Primary Pain Syndromes, Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Naples, Italy; ²³DMED, University of Udine and Clinical Neurology, Udine University Hospital, Italy; ²⁴Fondazione Policlinico Universitario Campus Bio-Medico, Roma e Università Campus Bio-Medico di Roma, Italy; ²⁵Department of Molecular Pathobiology and Pain Research Center, College of Dentistry, New York University, NY, USA

DOI https://doi.org/10.4081/cc.2026.15988
- 5 abstract views
- 0 PDF
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P033 | EARLY SUCCESSFUL RESPONSE TO ATOGEPANT IN PHARMACORESISTANT MALE AND FEMALE MIGRAINE PATIENTS IN A REAL-LIFE SETTING

G. Procopio, A. Di Chirico, L. Troilo, S. Cannavò, R. Ceravolo, F. Baldacci, S. Gori | Neurology Unit, Department of Clinical and Experimental Medicine, AOUP, University of Pisa, Italy

DOI https://doi.org/10.4081/cc.2026.15989
- 5 abstract views
- 0 PDF
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P034 | BODY WEIGHT CHANGES DURING ATOGEPANT THERAPY: A CASE REPORT AND NARRATIVE REVIEW OF THE METABOLIC ROLE OF CGRP

C. Rita Tamborino, G. Difonzo, F. Domenico Pellicano, A. Fallacara, D. Paolicelli, M. Pia Prudenzano | Headache Center, “L. Amaducci” Neurological Clinic, Policlinico General Hospital, Bari, Italy

DOI https://doi.org/10.4081/cc.2026.15990
- 10 abstract views
- 0 PDF
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P035 | ATOGEPANT FOR THE PREVENTION OF MIGRAINE IN DIFFICULT-TO-TREAT PATIENTS: MULTIDIMENSIONAL OUTCOMES FROM A SINGLE-CENTER EXPERIENCE

L. Troilo, G. Procopio, A. Di Chirico, S. Cannavò, R. Ceravolo, F. Baldacci, S. Gori | Neurology Unit, University of Pisa, Italy

DOI https://doi.org/10.4081/cc.2026.15991
- 4 abstract views
- 0 PDF
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P036 | ROLE OF SPECIFIC MICRORNAS IN CLUSTER HEADACHE: ASSOCIATION WITH DISEASE PHENOTYPE AND NEUROPEPTIDE LEVELS

C. Angeli^1|2, R. De Icco^1|2, M. Corrado², G. Vaghi^1|2, F. Cammarota^1|2, V. Grillo^1|2, M. Giraudo^1|2, B. Agostini^1|2, F. Muscariello^1|2, R. Greco², C. Demartini^1|2, M. Francavilla^1|2, S. Franchini^1|2, M. Allena², G. Sances², C. Tassorelli^1|2 | ¹Department of Brain and Behavioural Sciences, University of Pavia, Italy; ²Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy

DOI https://doi.org/10.4081/cc.2026.15992
- 5 abstract views
- 0 PDF
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P037 | ACCELERATED DLPFC-TDCS AS AN ADJUNCTIVE TREATMENT FOR CHRONIC MIGRAINE UNRESPONSIVE TO MONOCLONAL ANTIBODIES: PRELIMINARY FINDINGS FROM A SHAM-CONTROLLED PILOT STUDY

L. Clemente¹, G. Paparella^1|2, V. Francabandiera³, A. Telesca^3|4, E. Ammendola^1|5, L. Grazzi³, M. de Tommaso¹ | ¹Neurophysiopathology Unit, Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Italy; ²IRCCS Neuromed, Pozzilli, Italy; ³Neuroalgology Unit, Department of Clinical Neuroscience, IRCCS Carlo Besta Neurological Institute and Foundation, Milan, Italy; ⁴Neurointensive Care Unit, Department of Neurosurgery, IRCCS Carlo Besta Neurological Institute and Foundation, Milan, Italy; ⁵University Niccolò Cusano, Rome, Italy

DOI https://doi.org/10.4081/cc.2026.15993
- 6 abstract views
- 0 PDF
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P038 | REAL-WORLD EFFECTIVENESS AND SAFETY OF RIMEGEPANT AS PREVENTIVE TREATMENT FOR EPISODIC MIGRAINE: STUDY PROTOCOL OF AN ONGOING PROSPECTIVE SINGLE-CENTER OBSERVATIONAL STUDY

R. De Fiores, R. Lucchino, A. Gambardella, M. Trimboli | Institute of Neurology, Department of Medical and Surgical Sciences, University "Magna Graecia" of Catanzaro, Italy

DOI https://doi.org/10.4081/cc.2026.15994
- 6 abstract views
- 0 PDF
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P039 | GUT-BRAIN AXIS ALTERATIONS IN A NITROGLYCERIN MODEL OF MIGRAINE: FROM MICROBIOTA DYSBIOSIS TO TRIGEMINAL SENSITIZATION

C. Demartini¹, S. Facchetti^1|2, M. Francavilla¹, S. Baldi³, S. Bertorello³, G. Bartolucci⁴, E. Niccolai³, A. Amedei³, R. Greco¹, C. Tassorelli^1|2 | ¹Section of Translational Neurovascular Research, IRCCS Mondino Foundation, Pavia, Italy; ²Department of Brain and Behavioral Sciences, University of Pavia, Italy; ³Department of Experimental and Clinical Medicine, University of Florence, Italy; ⁴Department of Neuroscience, Psychology, Drug Research and Child Health NEUROFARBA, University of Florence, Italy

DOI https://doi.org/10.4081/cc.2026.15995
- 5 abstract views
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P040 | PROBIOTIC SUPPLEMENTATION ALLEVIATES MIGRAINE-LIKE PAIN BY RESTORING INTESTINAL BARRIER INTEGRITY AND ENDOCANNABINOID HOMEOSTASIS

S. Facchetti^1|2, C. Demartini¹, M. Francavilla¹, B. Marfella³, L. Cristino³, R. Greco¹, C. Tassorelli^1|2 | ¹Section of Translational Neurovascular Research, IRCCS Mondino Foundation, Pavia, Italy; ²Department of Brain and Behavioral Sciences, University of Pavia, Italy; ³Istituto di Chimica Biomolecolare del CNR, Pozzuoli (NA), Italy

DOI https://doi.org/10.4081/cc.2026.15996
- 5 abstract views
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P041 | WHO TAKES CARE OF PATIENTS SUFFERING FROM MIGRAINE? THE CAREGIVER’S IDENTIKIT STUDY. A MI-DEAR SUB-ANALYSIS

L. Fofi¹, C. Altamura^1|2, L. D'Onofrio¹, C. Aurilia³, E. Cresta⁴, A. Onofri⁵, A. Montisano⁶, M. Silvestro⁷, V. Favoni⁸, G. Viticchi⁹, M. Marcosano¹, G. Egeo³, M. Bartolini⁹, M. Peresson¹⁰, M. Cepparulo¹¹, A. Russo⁷, S. Cevoli⁸, R. Rao^4|12, L. Grazzi⁶, S. Sacco⁵, F. Vernieri^1|2 | ¹Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Italy; ²Neurosonology and Headache Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy; ³Headache and Pain Unit, IRCCS San Raffaele Roma, Italy; ⁴Department of Frailty and Care, Neurology Unit, Headache Center, ASST Spedali Civili, Brescia, Italy; ⁵Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy; ⁶Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy; ⁷Inter-departmental Program of Headache Medicine and Primary Pain Syndromes, Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, University of Campania “Luigi Vanvitelli”, Naples, Italy; ⁸Programma cefalee e algie facciali, IRCCS Istituto delle Scienze Neurologiche di Bologna, Italy; ⁹Neurological Clinic, Marche Polytechnic University, Ancona, Italy; ¹⁰Headache Unit, San Pietro Fatebenefratelli Hospital, Rome, Italy; ¹¹Teva Italia Srl, Milan, Italy; ¹²Department of Clinical and Experimental Sciences (DSCS), University of Brescia, Italy

DOI https://doi.org/10.4081/cc.2026.15997
- 5 abstract views
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P042 | INHIBITION OF PEA DEGRADATION VIA NAAA BLOCKADE MODULATES MIGRAINE-RELATED PATHWAYS WITHOUT REVERSED TRIGEMINAL HYPERALGESIA IN FEMALE RATS IN THE NTG-BASED MIGRAINE MODEL

M. Francavilla¹, S. Facchetti^1|2, C. Demartini¹, J. Stefania Cusme Valle^1|2, R. Greco¹, C. Tassorelli^1|2 | ¹Section of Translational Neurovascular Research, IRCCS Mondino Foundation, Pavia, Italy; ²Department of Brain and Behavioral Sciences, University of Pavia, Italy

DOI https://doi.org/10.4081/cc.2026.15998
- 6 abstract views
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P043 | BEYOND MEDICATIONS: MINDFULNESS PRACTICE FOR PATIENTS WITH HIGH-FREQUENCY MIGRAINE WITHOUT AURA

L. Grazzi¹, D. Montisano¹, E. Giacopuzzi Grigoli¹, A. Parisi¹, A. Raggi², E. Bocchi³, P. Lanteri³ | ¹Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy; ²Neurology, Public Health and Disability Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy; ³Clinical Neurophysiology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy

DOI https://doi.org/10.4081/cc.2026.15999
- 6 abstract views
- 0 PDF
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P044 | COMBINATION THERAPY WITH ATOGEPANT AND ONABOTULINUMTOXINA IN CHRONIC MIGRAINE: PRELIMINARY REAL-WORLD EVIDENCE FROM AN ONGOING STUDY

L. Marino, B. Perri, M. Trimboli | Neurology Institute, Magna Graecia University, Italy

DOI https://doi.org/10.4081/cc.2026.16000
- 5 abstract views
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P045 | CLINICAL AND NEUROPHYSIOLOGICAL EFFECTS OF ANODAL TRANSCRANIAL DIRECT CURRENT STIMULATION IN PATIENTS WITH REFRACTORY CHRONIC CLUSTER HEADACHE

G. Martino^1|2, M. Conti^1|2, V. D'Agostino^1|2, F. Carparelli^1|2, A. Meo^1|2, L. Orsini^1|2, D. Centonze^1|2, M. Albanese^1|2 | ¹Department of Systems Medicine, University of Rome Tor Vergata, Italy; ²Neurology Unit, Tor Vergata University Hospital, Rome, Italy

DOI https://doi.org/10.4081/cc.2026.16001
- 5 abstract views
- 0 PDF
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P046 | FROM TRIGGERS TO PATTERNS: THE ROLE OF NUTRITION IN MIGRAINE SUSCEPTIBILITY — A NARRATIVE REVIEW

D. Pala^1|2, F. Tosto³, A. Munafò^4|5, A. Burgalassi^4|5, M. Romozzi^6|7, L. Francesco Iannone^8|9, C. Vollono^6|7, P. Calabresi^6|7, F. Casillo¹⁰, C. Di Lorenzo¹⁰ | ¹Department of Medical Science and Public Health, University of Cagliari, Italy; ²Department of Biomedical Sciences, University of Cagliari, Italy; ³Department of Neuroscience, Giovanni Paolo II Hospital, Catanzaro, Italy; ⁴Section of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, Italy; ⁵Headache Center and Clinical Pharmacology Unit, Careggi University Hospital, Florence, Italy; ⁶Department of Neurosciences, Università Cattolica del Sacro Cuore, Rome, Italy; ⁷Neurology, Dipartimento di Neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; ⁸Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy; ⁹Digital and Predictive Medicine, Pharmacology, Clinical Metabolic Toxicology - Headache Center and Drug Abuse, Laboratory of Clinical Pharmacology and Pharmacogenomics, Policlinico di Modena, Italy; ¹⁰Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Polo Pontino, ICOT Istituto Marco Pasquali, Latina, Italy

DOI https://doi.org/10.4081/cc.2026.16002
- 5 abstract views
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P047 | ONABOTULINUMTOXIN-A EFFECTIVENESS EVALUATION IN CHRONIC MIGRAINE PATIENTS WITH SHORT OR LONG DISEASE HISTORY AND PSYCHIATRIC COMORBIDITIES: AN ITALIAN MULTICENTRIC STUDY (THE BACH STUDY)

F. Vernieri^1|2, P. Pasqualetti³, M. Marcosano^1|2, N. Brunelli⁴, L. Fofi¹, D. Antonio Montisano⁵, L. Grazzi⁵, R. Ornello⁶, C. Rosignoli⁶, A. Doretti⁷, E. Colombo⁷, M. Albanese⁸, G. Viticchi⁹, S. Migliore⁶, S. Sacco⁶, C. Altamura^1|2 | ¹Headache and Neurosonology Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy; ²Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Italy; ³Section of Health Statistics and Biometry, Department WHES (Wellbeing, Health & Environmental Sustainability), Sapienza University of Rome, Italy; ⁴Department of Neurology, Vall d’Hebron Research Institute, Barcelona, Spain; ⁵Headache Center, IRCCS Fondazione Istituto Neurologico "Carlo Besta", Milano, Italy; ⁶Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, Italy; ⁷Department of Systems Medicine, University of Rome Tor Vergata, Italy; ⁸IRCCS Istituto Auxologico Italiano, Milano, Italy; ⁹Neurological Clinic, Experimental and Clinical Medicine Department, Marche Polytechnic University, Ancona, Italy

DOI https://doi.org/10.4081/cc.2026.16003
- 5 abstract views
- 0 PDF
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P048 | PLASMA GFAP LEVELS IN PATIENTS WITH MIGRAINE: LACK OF ASSOCIATION WITH CLINICAL PHENOTYPE AND DISEASE BURDEN

A. Agostinelli¹, E. Rubino^1|2, S. Boschi¹, E. Maria Piella¹, A. Panza¹, A. Mario Chiarandon¹, F. Roveta¹, G. Gioiello³, S. Limoncelli³, G. Mengozzi³, I. Rainero^1|2 | ¹Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Italy; ²Headache Center, Department of Neuroscience and Mental Health, AOU Città della Salute e della Scienza di Torino, Italy; ³Clinical Biochemistry Laboratory “Baldi e Riberi”, AOU Città della Salute e della Scienza di Torino”, Italy

DOI https://doi.org/10.4081/cc.2026.16004
- 8 abstract views
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P049 | SIFI FISSION PROFILE IN MIGRAINE PROPHYLAXIS: MIXED ANOVA RESULTS

F. Brighina, P. Alonge, A. Torrente, V. Portera, I. Cutrò, A. Meli, A. Vignoli, C. Camarda | Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.) - Section of Neurology - University of Palermo, Italy

DOI https://doi.org/10.4081/cc.2026.16005
- 5 abstract views
- 0 PDF
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P050 | MIGRAINE PRODROMAL SYMPTOMS AND THEIR CLINICAL MANIFESTATIONS, AN OBSERVATIONAL MULTICENTER STUDY

G. Dalla Volta¹, M. Cortinovis¹, P. Merlo², A. Viganò³, V. Rebecchi⁴, S. Mazza⁴, M. Gennuso⁵, N. Ghiotto⁶, E. Guaschino⁶, G. Sances⁶, M. Bolchini¹ | ¹Neurology Unit and Headache Center, Istituto Clinico Città Di Brescia, Italy; ²Neurology Unit, Humanitas Gavazzeni and University HUNIMED, Bergamo, Italy; ³Neurology Unit, Humanitas Gavazzeni, Bergamo, Italy; ⁴Neurology Unit, Ospedale Civile di Voghera – ASST Pavia, Italy; ⁵Casa di Cura Ancelle della Carità, Fondazione Camplani, Cremona, Italy; ⁶Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy

DOI https://doi.org/10.4081/cc.2026.16006
- 11 abstract views
- 0 PDF
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P051 | NEUROVASCULAR DECOUPLING LINKS METABOLIC DEMAND TO CORTICAL SPREADING DEPOLARIZATION SUSCEPTIBILITY IN MIGRAINE WITH AURA

V. Dortucci, M. Silvestro, F. Esposito, I. Orologio, A. Tessitore, M. Cirillo, A. Russo | Inter-departmental Program of Headache Medicine and Primary Pain Syndromes, Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Naples, Italy

DOI https://doi.org/10.4081/cc.2026.16007
- 6 abstract views
- 0 PDF
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P052 | A PATIENT-SPECIFIC HUMAN TRIGEMINAL NEURON MODEL FOR THE STUDY OF MIGRAINE MECHANISMS

R. Greco¹, M. Bordoni², J. Cazzola³, F. De Luca⁴, M. Francavilla¹, C. Demartini¹, S. Facchetti¹, O. Pansarasa², G. Vaghi¹, R. De Icco^1|5, G. Biella³, C. Tassorelli^1|5 | ¹Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy; ²Cellular Models and Neuroepigenetics Section, IRCCS Mondino Foundation, Pavia, Italy; ³Laboratory of Biophysics and Physiology of Ion Channels, University of Pavia, Italy; ⁴Laboratory of Cell Biology and Neurobiology, University of Pavia, Italy; ⁵Behavioral Sciences, Department of Brain, University of Pavia, Italy

DOI https://doi.org/10.4081/cc.2026.16008
- 5 abstract views
- 0 PDF
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P053 | LONG-TERM EFFECTIVENESS AND SAFETY OF FREMANEZUMAB FOR MIGRAINE PREVENTION: 24-MONTH OUTCOMES FROM THE ITALIAN COHORT OF THE PEARL STUDY

S. Guerzoni¹, C. Aurilia², A. Doretti³, E. Maria Piella⁴, R. Ornello⁵, P. Kokturk⁶, M. Cepparulo⁷ | ¹Digital and Predictive Medicine, Pharmacology and Clinical Metabolic Toxicology- Headache Center and Drug Abuse, Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico di Modena, Italy; ²Headache and Pain Unit, IRCCS San Raffaele, Rome, Italy; ³Department of Neurology-Laboratory of Neuroscience, IRCCS, Istituto Auxologico Italiano, Milan, Italy; ⁴Neurosciences Department, University of Turin, Italy; ⁵Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, Italy; ⁶Teva Netherlands B.V., Haarlem, The Netherlands; ⁷Teva Italia Srl, Milan, Italy

DOI https://doi.org/10.4081/cc.2026.16009
- 4 abstract views
- 0 PDF
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P054 | EXCITATION/INHIBITION IMBALANCE IN MIGRAINE PATIENTS ASSESSED BY ELECTROENCEPHALOGRAPHY

D. Litewczuk, G. De Stefano, D. Chiffi, A. Truini, G. Di Stefano | Sapienza University, Rome, Italy

DOI https://doi.org/10.4081/cc.2026.16010
- 5 abstract views
- 0 PDF
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P055 | DELTA-BAND HYPERCONNECTIVITY AS A POTENTIAL MARKER OF MIGRAINE SEVERITY AND CHRONIFICATION: A RESTING-STATE HIGH-DENSITY EEG STUDY

G. Martino^1|2, M. Conti^1|2, V. D'Agostino^1|2, F. Carparelli^1|2, A. Meo^1|2, D. Centonze^1|2, M. Albanese^1|2 | ¹Department of Systems Medicine, University of Rome Tor Vergata, Italy; ²Neurology Unit, Tor Vergata University Hospital, Rome, Italy

DOI https://doi.org/10.4081/cc.2026.16011
- 6 abstract views
- 0 PDF
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P056 | MIGRAINE SUBGROUPS DEFINED BY ASSOCIATED SYMPTOMS AND ALLEVIATING STRATEGIES: A CROSS-SECTIONAL STUDY OF 3275 PATIENTS WITH EPISODIC MIGRAINE

G. Sebastianelli¹, D. Secci², C. Di Lorenzo¹, A. Perrotta³, G. Coppola¹, A. Ambrosini³ | ¹Department of Medico-Surgical Sciences and Biotechnologies, Polo Pontino, Sapienza University of Rome, Latina, Italy; ²Department of Engineering and Architecture, University of Parma, Italy; ³Headache Clinic - IRCCS NEUROMED, Pozzilli, Italy

DOI https://doi.org/10.4081/cc.2026.16012
- 6 abstract views
- 0 PDF
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P057 | MODULATION OF CEREBRAL HEMODYNAMICS BY ATOGEPANT IN EPISODIC MIGRAINE: A TRANSCRANIAL DOPPLER FOLLOW-UP STUDY

V. Teresi, D. Alivernini, A. Spalloni, G. Sette | La Sapienza Università di Roma, Azienda Ospedaliera Universitaria Sant'Andrea, Italy

DOI https://doi.org/10.4081/cc.2026.16013
- 5 abstract views
- 0 PDF
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P058 | AUTONOMIC EVALUATION IN EPISODIC MIGRAINE WITH A COMPREHENSIVE ASSESSMENT

A. Torrente, A. Palermo, V. Portera, P. Alonge, C. Camarda, A. Labate, F. Brighina | Department of Biomedicine, Neuroscience and advanced Diagnostics, University of Palermo, Italy

DOI https://doi.org/10.4081/cc.2026.16014
- 5 abstract views
- 0 PDF
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P059 | SWITCHING BETWEEN ANTI-CGRP MONOCLONAL ANTIBODIES IN A CADASIL PATIENT: FOUR-YEAR EVIDENCE OF SAFETY AND EFFICACY

S. Cannavò, G. Procopio, A. Di Chirico, L. Troilo, R. Ceravolo, F. Baldacci, S. Gori | Neurology Unit, University of Pisa, Italy

DOI https://doi.org/10.4081/cc.2026.16015
- 5 abstract views
- 0 PDF
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P060 | CLINICAL CHARACTERIZATION OF A NOVEL DE NOVO MUTATION IN THE CACNA1A GENE (C.3277DEL) ASSOCIATED WITH MIGRAINE WITHOUT AURA AND EPISODIC ATAXIA

W. Dell'Oste^1|2, M. Romozzi^1|2, S. Spartano³, C. Vollono^1|2, F. Danilo Tiziano³, P. Calabresi^1|2 | ¹University Department of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy; ²Neurology, Department of Neuroscience, Sensory Organs and Thorax, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; ³Section of Genomic Medicine, Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy

DOI https://doi.org/10.4081/cc.2026.16016
- 5 abstract views
- 0 PDF
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P061 | INTRACRANIAL HYPERTENSION MIMICKING PSEUDOTUMOR CEREBRI AS THE PRIMARY MANIFESTATION OF JAK2-POSITIVE MYELOPROLIFERATIVE NEOPLASMS: A TWO-CASE SERIES

A. Di Chirico, G. Procopio, L. Troilo, S. Cannavò, R. Ceravolo, F. Baldacci, S. Gori | Neurology Unit, Department of Neuroscience, AOUP, University of Pisa, Italy

DOI https://doi.org/10.4081/cc.2026.16017
- 5 abstract views
- 0 PDF
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P062 | POST-DURAL PUNCTURE HEADACHE AFTER DIAGNOSTIC LUMBAR PUNCTURE: INCIDENCE, CLINICAL PRESENTATION, AND ASSOCIATED FACTORS IN A NEUROLOGICAL COHORT

F. Innocenti^1|3, M. Romozzi^1|3, C. Vollono^1|3, P. Rossi^1|3, F. Signorelli^2|3, M. Mirabella^1|3, P. Calabresi^1|3, V. Nociti^1|3 | ¹Neurology Unit, Department of Neurosciences, Sense Organs and Thorax, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Italy; ²Neurosurgery Unit, Department of Neurosciences, Sense Organs and Thorax, Fondazione Policlinico Universitario A. Gemelli IRCCS, Italy; ³Department of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy

DOI https://doi.org/10.4081/cc.2026.16018
- 4 abstract views
- 0 PDF
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P063 | INTEGRATED MANAGEMENT AND 24-MONTH FOLLOW-UP OF COMPLEX MEDICATION OVERUSE HEADACHE (MOH): IMPACT OF CONTINUOUS PSYCHOEDUCATIONAL SUPPORT ON RELAPSE PREVENTION

C. Lanni¹, C. Prevost², A. Canessa², L. Testa², M. Valente², D. Ferrandi² | ¹SSA Psicologia IRCCS AOU Al, Italy; ²SC Neurologia IRCCS AOU Al, Italy

DOI https://doi.org/10.4081/cc.2026.16019
- 4 abstract views
- 0 PDF
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P064 | MIGRAINE HISTORY IN PATIENTS WITH ANEURYSMAL SUBARACHNOID HEMORRHAGE DEVELOPING CEREBRAL VASOSPASM AND DELAYED CEREBRAL ISCHEMIA: A CASE SERIES

G. Rosaria Melis¹, F. Marrama², A. Mascolo², V. D'Agostino¹, M. Diomedi², D. Centonze¹, M. Albanese¹ | ¹Headache Center, Department of Systems Medicine, Policlinico Tor Vergata, University of Rome Tor Vergata, Italy; ²Stroke Unit, Department of Systems Medicine, Policlinico Tor Vergata, University of Rome Tor Vergata, Italy

DOI https://doi.org/10.4081/cc.2026.16020
- 5 abstract views
- 0 PDF
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P065 | ANTI-CGRP MONOCLONAL ANTIBODY RESPONSE IN CHRONIC MIGRAINE WITH SEVERE NEUROPSYCHIATRIC COMORBIDITY: A CASE REPORT AND PATHOPHYSIOLOGICAL INSIGHTS

O. Pardeo, A. Anselmo, M. Pagano, F. Corallo, G. Vita, D. Cosenza, R. Lo Presti, D. Cardile, V. Lo Buono, I. Cappadona, R. Grugno | Centro per la Diagnosi e Cura delle Cefalee, IRCCS Centro Neurolesi Bonino-Pulejo, Messina, Italy

DOI https://doi.org/10.4081/cc.2026.16021
- 10 abstract views
- 0 PDF
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P066 | A CAROTID–CAVERNOUS FISTULA MIMICKING HEMICRANIA CONTINUA

G. Pignatiello, M. Silvestro, I. Orologio, V. Dortucci, A. Tessitore, A. Russo | Inter-departmental Program of Headache Medicine and Primary Pain Syndromes, Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Naples, Italy

DOI https://doi.org/10.4081/cc.2026.16022
- 5 abstract views
- 0 PDF
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P067 | FAMILIAL HEMIPLEGIC MIGRAINE TYPE 2 IN AN ITALIAN FAMILY: A COMPLEX PHENOTYPE WITH FOCAL EPILEPSY AND NEURODEVELOPMENTAL DISORDERS

E. Rubino^1|2, E. Piella^1|2, A. Agostinelli^1|2, G. Brodini^1|2, L. Bonino^1|2, S. Boschi^1|2, A. Panza^1|2, I. Rainero^1|2 | ¹Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Italy; ²Headache Center, Department of Neuroscience and Mental Health, AOU Città della Salute e della Scienza di Torino, Italy

DOI https://doi.org/10.4081/cc.2026.16023
- 5 abstract views
- 0 PDF
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P068 | EPISODIC CLUSTER HEADACHE: HIGH EFFICACY OF THE COMBINED THERAPY WITH HIGH-DOSE INTRAMUSCULAR METHYLPREDNISOLONE AND HIGH DOSES OF VERAPAMIL ON STOPPING SINGLE CLUSTERS

A. Terrin¹, C. Disco², M. Bellamio¹, F. Mainardi³, F. Maggioni⁴, G. Zanchin⁴ | ¹Dipartimento Di Scienze Neurologiche, Centro Cefalee dell’Angelo, UOC Di Neurologia, Ospedale Dell'Angelo AULSS 3 Serenissima, Venice Mestre, Italy; ²Dipartimento di Scienze Neurologiche, Centro Cefalee dell’Ospedale Ca’ Foncello, UOC di Neurologia, AULSS2 Treviso, Italy; ³UOC di Neurologia, Ospedale SS Giovanni e Paolo, AULSS 3 Serenissima, Venice, Italy; ⁴Padua University Medical School, Italy

DOI https://doi.org/10.4081/cc.2026.16024
- 5 abstract views
- 0 PDF
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P069 | EARLY REVERSAL OF BRAIN SAGGING AFTER EPIDURAL BLOOD PATCH IN SPONTANEOUS INTRACRANIAL HYPOTENSION: EVIDENCE FROM BASAL CISTERN MORPHOMETRY

M. Trimboli¹, E. Biamonte², C. Tomas¹, R. Lucchino¹, E. Ferrante³ | ¹Intracranial Pressure Disorders Clinic, Headache Center, AOU Renato Dulbecco, Catanzaro, Italy; ²Intensive Care Unit, Department of Medical and Surgical Sciences, AOU Renato Dulbecco, Catanzaro, Italy; ³IRCCS San Camillo Hospital, Venice, Italy

DOI https://doi.org/10.4081/cc.2026.16025
- 4 abstract views
- 0 PDF
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P070 | TRIGEMINAL NEURALGIA SECONDARY TO SOLITARY PONTINE LESION: CASE SERIES OF A PROPOSED NEW DIAGNOSTIC ENTITY

G. De Stefano¹, D. Litewzuk¹, D. Chiffi¹, E. Galosi¹, G. Di Pietro¹, E. Evangelisti¹, P. Falco¹, C. Leone¹, M. Kristt², R. Sekula², F. Caramia¹, A. Truini¹, G. Di Stefano¹ | ¹Department of Human Neuroscience, Sapienza University of Rome, Italy; ²Department of Neurological Surgery, Columbia University Irving Medical Center, New York, USA

DOI https://doi.org/10.4081/cc.2026.16026
- 4 abstract views
- 0 PDF
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P071 | NEUROPATHIC PAIN: THE STIGMATA OF MIGRAINE

M. Nicolodi¹, R. Branchi², A. Caporossi³, M. Pinnarò¹ | ¹Foundation Primary Pai, Headache & Stress, Italy; ²Odontostomatology, Florence University, Italy; ³Ophthalmology Dept A.Gemelli Foudation, Rome Dipartimento Oculistica Fondazione A. Gemelli, Italy

DOI https://doi.org/10.4081/cc.2026.16027
- 4 abstract views
- 0 PDF
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P072 | QZU® IN THE DISSUASION OF THE MISUSE/ABUSE OF ANALGESICS IN A GROUP OF PATIENTS WITH CHRONIC MIGRAINE

E. Pucci¹, L. Pucci², P. Di Fiore³, E. Domina⁴, A. Vercesi⁵ | ¹Department of Nervous System and Behavioral Sciences - University of Pavia, Italy; ²Master's Degree in Dietetics and Clinical Nutrition – University of Pavia, Italy; ³General Practitioner. Neurology Specialist. ASST Milan, Italy; ⁴Neurology Unit. Maggiore Hospital. Lodi, Italy; ⁵Scientific Consultant Biosphaera Pharma

DOI https://doi.org/10.4081/cc.2026.16028
- 9 abstract views
- 0 PDF
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P073 | DOLOMY FIBRO® IN THE PROPHYLAXIS OF FIBROMYALGIA SYNDROME: PRELIMINARY DATA FROM AN OBSERVATIONAL STUDY

E. Pucci¹, G. Arcuri², G. Bellantoni³, L. Pucci⁴, E. Domina⁵, A. Vercesi⁶ | ¹Department of Nervous System and Behavioral Sciences. University of Pavia, Italy; ²Head of the Orthopedic Rehabilitation Complex Unit, "Città di Pavia" Clinical Institute, Italy; ³Head and Neck Department. Neurosurgery Unit. IRCCS Policlinico "S. Matteo". University of Pavia, Italy; ⁴Master’s Degree in Dietetics and Clinical Nutrition. University of Pavia, Italy; ⁵Neurology Unit. Maggiore Hospital. Lodi, Italy; ⁶Scientific Consultant Biosphaera Pharma

DOI https://doi.org/10.4081/cc.2026.16029
- 5 abstract views
- 0 PDF
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P074 | EFFICACY OF REPETITIVE GREAT OCCIPITAL NERVE BLOCKS IN EPISODIC CLUSTER HEADACHE: A RETROSPECTIVE REAL-WORLD STUDY FROM A TERTIARY HEADACHE CENTER

A. Taglialatela¹, E. Belgrado², C. Lettieri¹, G. Merlino^1|3, M. Valente^1|4, Y. Tereshko³ | ¹Clinical Neurology, Udine University Hospital, Italy; ²Neurology Unit, Department of Head-Neck and Neurosciences, Azienda Sanitaria Universitaria Friuli Centrale (ASU FC), Udine, Italy; ³Stroke Unit, Udine University Hospital, Italy; ⁴DMED, Udine University Hospital, Italy

DOI https://doi.org/10.4081/cc.2026.16030
- 4 abstract views
- 0 PDF
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P075 | DOLOMY FIBRO® IN THE TREATMENT OF OROFACIAL PAIN: CASE REPORT

A. Vercesi¹, G. Bellantoni², G. Arcuri³, L. Pucci⁴, E. Domina⁵, E. Pucci⁶ | ¹Scientific Consultant Biosphaera Pharma; ²Head and Neck Department. Neurosurgery Unit. IRCCS Policlinico "S. Matteo". University of Pavia, Italy; ³Head of the Orthopedic Rehabilitation Complex Unit, "Città di Pavia" Clinical Institute, Italy; ⁴Master’s Degree in Dietetics and Clinical Nutrition. University of Pavia, Italy; ⁵Neurology Unit. Maggiore Hospital. Lodi, Italy; ⁶Department of Nervous System and Bahavioral Sciences, University of Pavia, Italy

DOI https://doi.org/10.4081/cc.2026.16031
- 5 abstract views
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P076 | DOLOMY FIBRO® IN THE TREATMENT OF FIBROMYALGIA SYNDROME: CASE REPORT

A. Vercesi¹, G. Bellantoni², G. Arcuri³, L. Pucci⁴, E. Domina⁵, E. Pucci⁶ | ¹Scientific Consultant Biosphaera Pharma; ²Head and Neck Department. Neurosurgery Unit. IRCCS Policlinico "S. Matteo". University of Pavia, Italy; ³Head of the Orthopedic Rehabilitation Complex Unit, "Città di Pavia" Clinical Institute, Italy; ⁴Master’s Degree in Dietetics and Clinical Nutrition. University of Pavia, Italy; ⁵Neurology Unit. Maggiore Hospital. Lodi, Italy; ⁶Department of Nervous System and Bahavioral Sciences. University of Pavia, Italy

DOI https://doi.org/10.4081/cc.2026.16032
- 6 abstract views
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P077 | UNRAVELING THE COMPLEXITY OF MEDICATION-OVERUSE HEADACHE: CLINICAL AND BEHAVIORAL PREDICTORS OF 12-MONTH OUTCOMES

N. Ghiotto¹, E. Guaschino¹, S. Pazzi¹, L. Toppi², D. Mazzotta², T. Filidei², M. Allena¹, R. De Icco^1|2, D. Martinelli¹, G. Vaghi^1|2, G. Sances¹, C. Tassorelli^1|2 | ¹Headache Science and Neurorehabilitation Unit, IRCCS C. Mondino Foundation, Pavia, Italy; ²Department of Brain and Behavioral Sciences, University of Pavia, Italy

DOI https://doi.org/10.4081/cc.2026.16033
- 5 abstract views
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P078 | THE PATIENT JOURNEY OF RESISTANT AND REFRACTORY MIGRAINE: RESULTS FROM THE REFINE STUDY

I. Gragnaniello¹, S. Sacco¹, A. Onofri¹, C. Rosignoli¹, V. Caponnetto¹, D. Bayar², M. Braschinsky³, M. Carnovali⁴, M. Gentile⁵, R. Gil-Gouveia⁶, G. Iaccarino⁷, C. Lampl⁸, A. Leheste³, P. Martelletti⁹, C. Mazzanti⁹, D. Mitsikostas¹⁰, A. Muñoz-Vendrell¹¹, R. Oliveira⁶, A. Ozge², I. Pavão Martins¹², P. Pozo-Rosich¹¹, M. Prudenzano⁵, K. Ryliskiene¹³, M. Sanchez del Rio¹⁴, J. Vainauskienė¹³, F. Vernieri⁷, M. Waliszewska-Prosół, Z. Katsarava⁴, A. Sinclair¹⁶, R. Ornello¹ | ¹University of L'Aquila, Department of Applied Clinical Sciences and Biotechnology, Italy; ²Mersin University Faculty of Medicine, Department of Neurology, Turkey; ³Headache Clinic, Tartu, Estonia; ⁴Evangelical Hospital, Unna, Germany; ⁵Centro Cefalee - Clinica Neurologica "L. Amaducci", Azienda Ospedaliero-Universitaria Policlinico Consorziale di Bari, Italy; ⁶Hospital da Luz - Center for Interdisciplinary Research in Health, Universidade Católica Portuguesa, Lisbon, Portugal; ⁷Cefalee e Neurosonologia-Policlinico Universitario Campus Bio-medico, Rome, Italy; ⁸Department of Neurology and Headache Medical Centre, Konventhospital Barmherzige Brüder Linz, Austria; ⁹University Sapienza, Rome, Italy; ¹⁰First Neurology Department, Aeginition Hospital, Medical School, National and Kapodistrian University of Athens, Greece; ¹¹Headache Unit and Research Group Vall d'Hebron University Hospital and Institute of Research, Universitat Autonoma de Barcelona, Spain; ¹²Faculdade de Medicine and Hospital Universitário de Santa Maria, Centro Hospitalar; Hospital Cuf Tejo, Lisbon, Portugal; ¹³Vilnius University Centre of Neurology, Kardiolitos klinikos Centre of Neurology, Lithuania; ¹⁴Clinica Universidad de Navarra, Madrid, Spain; ¹⁵Department of Neurology, Wroclaw Medical University, Poland; ¹⁶Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, United Kingdom

DOI https://doi.org/10.4081/cc.2026.16034
- 4 abstract views
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P079 | THE ROLE OF GUT MICROBIOTA IN MIGRAINE SUBJECTS TREATED WITH ANTI-CGRP MONOCLONAL ANTIBODIES: RESULTS THE SPHERA PROJECT

F. Muscariello^1|2, G. Vaghi^1|2, R. Greco², V. Grillo^1|2, M. Corrado², F. Cammarota^1|2, B. Agostini^1|2, M. Giraudo^1|2, C. Angeli^1|2, M. Allena², E. Guaschino², N. Ghiotto², R. Ornello³, S. Sacco³, C. Demartini², M. Francavilla^1|2, S. Facchetti^1|2, V. Pazienza⁴, D. Sproviero², G. Sances², C. Tassorelli^1|2, R. De Icco^1|2 | ¹Department of Brain and Behavioral Sciences, University of Pavia, Italy; ²Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy; ³Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy; ⁴Division of Gastroenterology, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy

DOI https://doi.org/10.4081/cc.2026.16035
- 6 abstract views
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P080 | REFRACTORINESS OF CHRONIC MIGRAINE: POSSIBLE RISK FACTORS AND SOME WAY-OUT

M. Nicolodi¹, M. Pinnarò^1|2, L. Di Puccio Sicuteri^1|3 | ¹Foundation Primary Pain Headache & Stress, Italy; ²Human Nutrition Florence University, Italy; ³Neuropsychology University of Padua, Italy

DOI https://doi.org/10.4081/cc.2026.16036
- 6 abstract views
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P081 | CONNECTOMICS AND PERSONALITY PROFILES IN REFRACTORY MIGRAINE

E. Principe^1|2, R. Iannacchero^2|3, A. Cerasa², D. Bosco^2|4 | ⁴Psychiatric Service for Diagnosis and Care, Catanzaro, Italy; ¹National Research Council, Institute of Bioimaging and Complex Biological Systems, Catanzaro, Italy; ²Headache Center, “Renato Dulbecco” University Hospital, Catanzaro, Italy; ³Complex Operational Unit of Neurology, “Renato Dulbecco” University Hospital, Catanzaro, Italy

DOI https://doi.org/10.4081/cc.2026.16037
- 5 abstract views
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P082 | CHARACTERIZING SOCIAL COGNITION ACROSS MIGRAINE FREQUENCY USING THE STORY-BASED EMPATHY TASK AND THE READING THE MIND IN THE EYES TEST

V. Batti¹, A. Mario Chiarandon¹, E. Maria Piella¹, A. Agostinelli¹, E. Rota³, I. Rainero^1|2, E. Rubino^1|2 | ¹Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Italy; ²Headache Center, Department of Neuroscience and Mental Health, University Hospital Città della Salute e della Scienza of Turin, Italy; ³Neurology Unit, S. Giacomo Hospital, ASL AL, Novi Ligure, Italy

DOI https://doi.org/10.4081/cc.2026.16038
- 4 abstract views
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P083 | EFFECT OF ATOGEPANT ON COGNITIVE FUNCTION FOLLOWING ACUTE TREATMENT OF MIGRAINE ACROSS MULTIPLE ATTACKS: RESULTS FROM THE ECLIPSE TRIAL

R. Masselli¹, A. Van Dycke², G. Ahmadyar³, E. Brand-Schieber³, C. Castro³, R. Ornello⁴, L. Luo³, P. Pozo-Rosich^5|6, U. Reuter^7|8, K. Carr³, R. Gil-Gouveia^9|10 | ¹AbbVie Srl, Rome, Italy; ²Department of Neurology, General Hospital Sint-Jan Bruges, Belgium; ³AbbVie Inc. North Chicago, IL, USA; ⁴Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy; ⁵Headache Unit, Neurology Department, Vall d'Hebron University Hospital, Barcelona, Spain; Headache and Neurological Pain Research; ⁶Headache and Neurological Pain Research Group, Vall d'Hebron Institute of Research, Universitat Autonoma de Barcelona, Spain; ⁷University Hospital Bonn, Germany; ⁸Charité Universitätsmedizin Berlin, Germany; ⁹Neurology Department, Hospital da Luz, Lisboa, Portugal; ¹⁰Center for Interdisciplinary Research in Health, Universidade Católica Portuguesa, Lisboa, Portugal

DOI https://doi.org/10.4081/cc.2026.16039
- 5 abstract views
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P084 | NEUROPSYCHOLOGICAL AND PSYCHOLOGICAL CHARACTERIZATION OF PATIENTS WITH MIGRAINE: PRELIMINARY RESULTS FROM THE COGMIG STUDY

A. Parisi¹, L. Grazzi¹, E. Giacopuzzi Grigoli¹, A. Marcassoli², A. Raggi², D. Antonio Montisano¹ | ¹Fondazione IRCCS Istituto Neurologico Carlo Besta, Headache Center, Italy; ²Fondazione IRCCS Istituto Neurologico Carlo Besta Neurology, Public Health and Disability Unit, Italy

DOI https://doi.org/10.4081/cc.2026.16040
- 6 abstract views
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P085 | IMPACT OF PROPHYLACTIC TREATMENT ON COGNITIVE FUNCTION IN MIGRAINE: A CLINICAL EVALUATION USING THE I-MIG-SCOG SCALE

P. Solla, E. Ogana, F. Gamberoni, S. Terzitta, T. Ercoli | Headache Center, SC Neurolocìgical Clinic, AOU Sassari, Italy

DOI https://doi.org/10.4081/cc.2026.16041
- 4 abstract views
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P086 | BILATERAL CLASSICAL TRIGEMINAL NEURALGIA WITH CONCOMITANT CONTINUOUS PAIN IN CROUZON SYNDROME: A CASE REPORT

M. Adragna, L. Ferraù, M. De Luca, M. Autunno | Unità di Neurologia e Malattie Neuromuscolari, Dipartimento di Medicina Clinica e Sperimentale, Università di Messina, Italy

DOI https://doi.org/10.4081/cc.2026.16042
- 5 abstract views
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P087 | BASELINE SLEEP QUALITY PREDICTS DIFFERENTIAL RESPONSE TO MIGRAINE PROPHYLAXIS: AN INTERACTION ANALYSIS ON MOOD OUTCOMES

P. Alonge, V. Portera, A. Torrente, A. Meli, A. Vignoli, C. Camarda, A. Labate, F. Brighina | Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), University of Palermo, Italy

DOI https://doi.org/10.4081/cc.2026.16043
- 5 abstract views
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P088 | SLEEP-CIRCADIAN MECHANISMS AND CGRP SIGNALING IN TACS AND HYPNIC HEADACHE: A SYSTEMATIC REVIEW

A. Boccalini¹, C. Benatti², L. Pani^2|3, F. Tascedda⁴, L. Francesco Iannone² | ¹Department of Addiction Services, ULSS 9 Scaligera, Verona, Italy; ²Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy; ³Department of Psychiatry and Behavioral Sciences, University of Miami, USA; ⁴Department of Life Sciences, University of Modena and Reggio Emilia, Italy

DOI https://doi.org/10.4081/cc.2026.16044
- 6 abstract views
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P089 | PRELIMINARY VALIDATION OF THE ITALIAN VERSION OF THE UTAH PHOTOPHOBIA SYMPTOM IMPACT SCALE (UPSIS-2) IN PATIENTS WITH MIGRAINE

A.M. Chiarandon¹, E.M. Piella¹, V. Batti¹, G. Sebastianelli², F. Ferrandes¹, M. Corrado³, M. Romozzi⁴, F. De Santis⁵, C. Fasano⁶, F. Lazzerini⁷, L. F. Iannone⁸, A. Munafò⁹, R. Ornello¹⁰, E. Rubino^1|11, I. Rainero^1|11 | ¹Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Italy; ²Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Polo Pontino, Latina, Italy; ³Department of Brain and Behavioral Sciences, University of Pavia, Italy; ⁴Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome; Università Cattolica del Sacro Cuore, Rome, Italy; ⁵Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, Italy; ⁶Headache and Cerebrovascular Diseases Center, Neurology Unit 2, Careggi University Hospital, Florence, Italy; ⁷Department of Humanities, University of Turin, Italy; ⁸Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy; ⁹Headache center and Clinical pharmacology unit, AOU Careggi, Florence, Italy; ¹⁰Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy; ¹¹Headache Center, Department of Neuroscience and Mental Health, City of Health and Science of Turin, Italy, on behalf of SISC Junior Group

DOI https://doi.org/10.4081/cc.2026.16045
- 8 abstract views
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P090 | INTEGRATED MULTIDISCIPLINARY APPROACH IN MIGRAINE MANAGEMENT: A CASE REPORT

S. Galimberti¹, G. Querzola² | ¹Osteopath, BSc in Exercise Science, Private Practice, Milan, Italy; ²Neurology Department, Headache Center, Stroke Unit, San Carlo Borromeo Hospital (ASST Santi Paolo e Carlo), Milan, Italy

DOI https://doi.org/10.4081/cc.2026.16046
- 11 abstract views
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P091 | RELATIONSHIP BETWEEN PAIN PROCESSING AND THALAMOCORTICAL ACTIVITY: A STUDY OF HIGH-FREQUENCY SOMATOSENSORY OSCILLATIONS AND PRESSURE PAIN THRESHOLD

B. Pitzalis¹, G. Sebastianelli², F. Casillo², C. Abagnale², C. Di Lorenzo², G. Coppola² | ¹Department of Human Neurosciences, Sapienza University of Rome, Italy; ²Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino ICOT, Latina, Italy

DOI https://doi.org/10.4081/cc.2026.16047
- 7 abstract views
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P092 | A PRACTICAL DOMAIN-SPECIFIC RETRIEVAL-AUGMENTED GENERATION FRAMEWORK FOR HEADACHE RESEARCH

L. Francesco Iannone¹, M. Lovino², M. Romozzi^3|4, C. Vollono⁴, P. Calabresi^3|4, C. Benatti², L. Pani^2|5, F. Tascedda¹ | ¹Department of Life Sciences, University of Modena and Reggio Emilia, Italy; ²Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy; ³Dipartimento Universitario di Neuroscienze, Università Cattolica del Sacro Cuore, Rome, Italy; ⁴Neurologia, Dipartimento di neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; ⁵Department of Psychiatry and Behavioral Sciences, University of Miami, USA

DOI https://doi.org/10.4081/cc.2026.16048
- 4 abstract views
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P093 | GAINER-AI: PREDICTING ACUTE RIMEGEPANT RESPONSE IN MIGRAINE USING MACHINE LEARNING IN A MULTICENTER REAL-WORLD COHORT

M. Romozzi^1|2, A. Lokhawandala³, G. Vaghi^4|5, G. Sebastianelli⁶, R. Ornello⁷, F. Casillo⁶, A. Russo⁸, M. Silvestro⁸, F. Pistoia⁹, G. Saporito⁹, G. Dalla Volta¹⁰, M. Bolchini¹⁰, A. Burgalassi¹¹, G. Vigani¹¹, D. Antonio Montisano¹², L. Grazzi¹², M. Pia Prudenzano¹³, D. Mascarella¹⁴, E. Mampreso¹⁵, G. Avino¹⁶, M. Valente¹⁷, G. Carlucci¹⁸, S. Guerzoni¹⁹, S. Battistini²⁰, A. Granato²¹, E. Maria Piella²², I. Rainero²², M. Albanese²³, M. Trimboli²⁴, A. Doretti²⁵, F. De Santis⁷, S. Sacco⁷, C. Tassorelli^4|5, S. Di Tella²⁶, C. Vollono^1|2, P. Calabresi^1|2, R. De Icco^4|5, L. Francesco Iannone²⁷ | ¹Dipartimento Universitario di Neuroscienze, Università Cattolica del Sacro Cuore, Rome, Italy; ²Neurologia, Dipartimento di neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; ³Drexel University, Philadelphia, USA; ⁴Department of Brain and Behavioral Sciences, University of Pavia, Italy; ⁵Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy; ⁶Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino, Latina, Italy; ⁷Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, Italy; ⁸Headache Centre, Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy; ⁹Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy; ¹⁰Headache Center of Clinical Neurology of Istituto Clinico Città Di Brescia, Italy; ¹¹Department of Health Sciences, University of Florence, Italy; ¹²Neuroalgology Unit and Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy; ¹³Headache Center, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, Italy; ¹⁴IRCCS Istituto Di Scienze Neurologiche Di Bologna, Programma Cefalee e Algie Facciali, Italy; ¹⁵Headache Centre, Neurology - Euganea, Health Unit, Padua, Italy; ¹⁶Neurology Unit, Ospedale Santo Stefano, USL Toscana Centro, Prato, Italy; ¹⁷Clinical Neurology, Azienda Sanitaria Universitaria Friuli Centrale, Presidio Ospedaliero Santa Maria Della Misericordia, Udine, Italy; ¹⁸NEUROFARBA Department, University of Florence - AOU Careggi, Italy; ¹⁹Digital and Predictive Medicine, Pharmacology, Clinical Metabolic Toxicology-Headache Center and Drug Abuse, Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico, Modena, Italy; ²⁰Department of Medical, Surgical and Neurological Sciences, University of Siena, Italy; ²¹Headache Centre, Clinical Unit of Neurology, School of Neurology, Department of Medicine, Surgery and Health Sciences, University Hospital and Health Services of Trieste, ASUGI, University of Trieste, Italy; ²²Department of Neurosciences “Rita Levi Montalcini”, University of Turin, Italy; ²³Unit of Neurology, Department of Systems Medicine, Tor Vergata University, Rome, Italy; Unit of Neurology - IRCCS Neuromed, Pozzilli (IS), Italy; ²⁴Headache Centre, Neurology Unit, AOU Renato Dulbecco, Catanzaro, Italy; ²⁵Department of Neurology- Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy; ²⁶Dipartimento di Psicologia, Università Cattolica del Sacro Cuore, Milan, Italy; ²⁷Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy

DOI https://doi.org/10.4081/cc.2026.16049
- 60 abstract views
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P094 | SLEEP MACROSTRUCTURE CHANGES ACROSS THE MIGRAINE CYCLE: PRELIMINARY EVIDENCE FROM PROLONGED HOME POLYSOMNOGRAPHIC MONITORING

E. Piizzi, U. Coppola, A. Cipriano, F. Gabriele, F. De Santis, C. Tiseo, R. Ornello, S. Sacco | Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy

DOI https://doi.org/10.4081/cc.2026.16050
- 5 abstract views
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P095 | CLINICAL PREDICTORS OF SECONDARY HEADACHE IN THE EMERGENCY DEPARTMENT: AN EXPLORATORY MODEL OF A FOUR-VARIABLE BEDSIDE MODEL IN THE EMERGENCY DEPARTMENT

V. Portera, P. Alonge, L. Baiamonte, A. Barresi, A. Calì, F. D'amico, A. Fiorentino, G. Giannetto, E. Lo Mauro, V. Di Stefano, C. Camarda, F. Brighina | Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), University of Palermo, Italy

DOI https://doi.org/10.4081/cc.2026.16051
- 5 abstract views
- 0 PDF
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P096 | VALIDATION OF A STRUCTURED PRE-VISIT QUESTIONNAIRE FOR HEADACHE SPECIALIST CONSULTATIONS

V. Portera, P. Alonge, A. Torrente, I. Cutrò, A. Meli, A. Vignoli, C. Camarda, F. Brighina | Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), University of Palermo, Italy

DOI https://doi.org/10.4081/cc.2026.16052
- 4 abstract views
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P097 | SEQUENTIAL MACHINE LEARNING MODELS FOR PREDICTING ONABOTULINUMTOXINA RESPONSE IN CHRONIC MIGRAINE: A COHORT STUDY

G. Vigani¹, M. Romozzi^2|3, A. Burgalassi¹, A. Lokhawandala⁴, C. Vollono^2|3, P. Calabresi^2|3, F. Tascedda⁵, A. Chiarugi^1|6, F. De Cesaris¹, L. Francesco Iannone⁷ | ¹Headache Center and Clinical Pharmacology Unit, Careggi University Hospital, Florence, Italy; ²Dipartimento Universitario di Neuroscienze, Università Cattolica del Sacro Cuore, Rome, Italy; ³Neurologia, Dipartimento di neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; ⁴Drexel University, Philadelphia, USA; ⁵Department of Life Sciences, University of Modena and Reggio Emilia, Italy; ⁶Section of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, Italy; ⁷Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy

DOI https://doi.org/10.4081/cc.2026.16053
- 5 abstract views
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P098 | PHYSIOTHERAPY INTERVENTIONS FOR MIGRAINE: EﬀECT ON FREQUENCY, DURATION, PAIN INTENSITY, USE OF MEDICATION AND DISABILITY. A SYSTEMATIC REVIEW WITH META-ANALYSIS

S. Di Antonio^1|2|3, L. Bottazzi², M. Mazzoni⁵, M. Bandettini³, E. Pelosin², C. Cosentino², M. Castaldo^1|6|7 | ¹Department of Health Science and Technology, Center for Pain and Neuroplasticity (CNAP), SMI, School of Medicine, Aalborg University, Denmark; ²Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Genoa, Italy; ³IRCCS Azienda Ospedaliera Metropolitana, Genoa, Italy; ⁵ATS area 3 (ex ASL3) Health Protection Agency - Rehabilitation Department Genoa, Italy; ⁶Headache Center, Department of Medicine and Surgery, University of Parma, Italy; ⁷Clinical Psychophysiology and Clinical Neuropsychology Labs, University of Parma, Italy

DOI https://doi.org/10.4081/cc.2026.16054
- 4 abstract views
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P099 | PHYSIOTHERAPY INTERVENTIONS FOR TENSION-TYPE HEADACHE: EﬀECT ON FREQUENCY, DURATION, PAIN INTENSITY, USE OF MEDICATION AND DISABILITY. A SYSTEMATIC REVIEW WITH META-ANALYSIS

S. Di Antonio^1|2|3, L. Bottazzi², M. Mazzoni⁵, M. Bandettini³, E. Pelosin², C. Cosentino², M. Castaldo^1|6|7 | ¹Department of Health Science and Technology, Center for Pain and Neuroplasticity (CNAP), SMI, School of Medicine, Aalborg University, Denmark; ²Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Genoa, Italy; ³IRCCS Azienda Ospedaliera Metropolitana, Genoa, Italy; ⁵ATS area 3 (ex ASL3) Health Protection Agency - Rehabilitation Department Genoa, Italy; ⁶Headache Center, Department of Medicine and Surgery, University of Parma, Italy; ⁷Clinical Psychophysiology and Clinical Neuropsychology Labs, University of Parma, Italy

DOI https://doi.org/10.4081/cc.2026.16055
- 4 abstract views
- 0 PDF
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P100 | ATOGEPANT DEMONSTRATES GREATER IMPROVEMENT IN FUNCTION USING THE ACTIVITY IMPAIRMENT IN MIGRAINE-DIARY (AIM-D) DURING INTERICTAL DAYS: POST-HOC ANALYSIS FROM THE PROGRESS CHRONIC MIGRAINE TRIAL

R. Masselli¹, R. B. Lipton², P. Gandhi³, A. Maassen van den Brink⁴, E. Leroux⁵, R. Halker Singh⁶, M. Duan³, B. Dabruzzo³, K. Umashankar³, J. Stokes³, D. C. Buse⁷ | ¹AbbVie Srl, Rome, Italy; ²Department of Neurology, General Hospital Sint-Jan Bruges, Belgium; ³AbbVie Inc. North Chicago, IL, USA; ⁴Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy; ⁵Headache Unit, Neurology Department, Vall d'Hebron University Hospital, Barcelona, Spain; Headache and Neurological Pain Research; ⁶Headache and Neurological Pain Research Group, Vall d'Hebron Institute of Research, Universitat Autonoma de Barcelona, Spain; ⁷University Hospital Bonn, Germany; ⁸Charité Universitätsmedizin Berlin, Germany; ⁹Neurology Department, Hospital da Luz, Lisboa, Portugal; ¹⁰Center for Interdisciplinary Research in Health, Universidade Católica Portuguesa, Lisboa, Portugal

DOI https://doi.org/10.4081/cc.2026.16056
- 6 abstract views
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P101 | CHRONIC MIGRAINE AND RESIDUAL SYMPTOMS: PHYSIOTHERAPY AS AN ALLY OF PREVENTIVE THERAPIES IN PATIENTS WITH CENTRAL SENSITIZATION, CERVICALGIA, AND SLEEP DISTURBANCES

C. Mostardini, P. Farina, G. Giglioni, L. Gigli | Headache and Sleep Center, ASL Roma 3, Italy

DOI https://doi.org/10.4081/cc.2026.16057
- 8 abstract views
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P102 | INFORMATION NEEDS FOR MIGRAINE TREATMENT ACROSS THE REPRODUCTIVE JOURNEY: INSIGHTS FROM A FIVE-YEAR TERATOLOGY INFORMATION SERVICE EXPERIENCE

A. Burgalassi¹, A. Munafò², F. De Cesaris¹, G. Vigani², A. Chiarugi^1|2 | ¹Headache Center and Clinical Pharmacology Unit, Careggi University Hospital, Florence, Italy; ²Section of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, Italy

DOI https://doi.org/10.4081/cc.2026.16058
- 3 abstract views
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P103 | ALEXITHYMIA INCREASES THE RISK OF MIGRAINE CHRONIFICATION IN WOMEN WITHOUT DEPRESSION

E. Rota¹, E. Rubino², V. Batti², M. Trucco¹, S. Bottiroli^3|4, M. Cangelosi^3|4, A. Doretti⁵, F. Govone⁶, D. Ferrandi⁷, C. Lanni⁷, C. Cavestro⁸, M. Demaestri⁸, E. Canale⁹, V. Sciruicchio¹⁰, A. Di Gioia¹⁰, A. Passarini¹¹, I. Toldo¹², S. Di Antonio¹, A. Versace¹³, E. Cavagnetto¹, L. Savi², A. Battaggia¹⁴ | ¹Neurology Unit, San Giacomo Hospital, Novi Ligure, ASL AL, Italy; ²Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Italy; ³Department of Brain and Behavioral Sciences, University of Pavia, Italy; ⁴IRCCS Mondino Foundation, Pavia, Italy; ⁵Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milano, Italy; ⁶Neurology Unit, Regina Montis Regalis Hospital, Mondovì, ASL CN1, Italy; ⁷Neurology Unit, San Biagio e Arrigo Hospital, Alessandria, AOU AL, Italy; ⁸Headache Center, Alba, ASL CN2, Italy; ⁹Child Neuropsychiatry Unit, IRCCS Istituto G. Gaslini, Genoa, Italy; ¹⁰Children Epilepsy and EEG Center, Bari, Italy; ¹¹Child Neuropsychiatry Unit, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy; ¹²Unit of Child Neurology and Neurophysiology, Women’s and Children’s Health Department University of Padova, Italy; ¹³Pediatric Headache Centre, Department of Pediatric Emergency, Regina Margherita Children’s Hospital, Turin, Italy; ¹⁴SVEMG – Scuola Veneta di Medicina Generale, Padova, Italy

DOI https://doi.org/10.4081/cc.2026.16059
- 10 abstract views
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P104 | SEX DIFFERENCES IN THE IMPACT OF TARGETED MIGRAINE TREATMENTS ON ASSOCIATED OBSESSIVE-COMPULSIVE TRAITS

G. Viticchi¹, L. Falsetti², E. Taruchi¹, G. De Vanna¹, S. Salvemini¹, C. De Felice¹, N. Tanuzi¹, E. Beccacece¹, P. Rosettani¹, G. Moroncini², M. Bartolini¹, M. Silvestrini¹ | ¹Neurological Clinic, Marche Polytechnic University, Azienda Ospedaliero-Universitaria delle Marche, Ancona, Italy; ²Clinica Medica, Marche Polytechnic University, Azienda Ospedaliero-Universitaria delle Marche, Ancona, Italy

DOI https://doi.org/10.4081/cc.2026.16060
- 8 abstract views
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P105 | PATIENT DEPRESSIVE SYMPTOMS AND RECIPROCITY INFLUENCE DISTRESS IN THE CAREGIVER OF PATIENTS WITH MIGRAINE: INSIGHTS FROM THE MIDEAR OBSERVATIONAL COHORT STUDY

C. Altamura^1|2, L. Fofi¹, C. Aurilia³, E. Cresta⁴, A. Onofri⁵, A. Montisano⁶, M. Silvastro⁷, V. Favoni⁸, G. Viticchi⁹, M. Marcosano¹, G. Egeo³, M. Bartolini⁹, M. Peresson¹⁰, M. Cepparulo¹¹, A. Russo⁷, S. Cevoli⁸, R. Rao^4|12, L. Grazzi⁶, S. Sacco⁵, F. Vernieri^1|2 | ¹Neurosonology and Headache Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy; ²Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Italy; ³Headache and Pain Unit, IRCCS San Raffaele Roma, Italy; ⁴Department of Frailty and Care, Neurology Unit, Headache Center, ASST Spedali Civili, Brescia, Italy; ⁵Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy; ⁶Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy; ⁷Inter-departmental Program of Headache Medicine and Primary Pain Syndromes, Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, University of Campania “Luigi Vanvitelli”, Naples, Italy; ⁸Programma cefalee e algie facciali, IRCCS Istituto delle Scienze Neurologiche di Bologna, Italy; ⁹Neurological Clinic, Marche Polytechnic University, Ancona, Italy; ¹⁰Headache Unit, San Pietro Fatebenefratelli Hospital, Rome, Italy; ¹¹Teva Italia Srl, Milan, Italy; ¹²Department of Clinical and Experimental Sciences (DSCS), University of Brescia, Italy

DOI https://doi.org/10.4081/cc.2026.16061
- 9 abstract views
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P106 | ASSESSMENT OF PERSONALITY TRAITS IN PATIENTS WITH CHRONIC MIGRAINE AND ANALGESIC OVERUSE ACCORDING TO THE ALTERNATIVE DSM-5-TR MODEL: AN OBSERVATIONAL STUDY

E. Principe^1|2, M. Pirrotta¹, N. Fava¹, C. Marchio¹, L. Maria Catalano¹, A. Barberi¹, R. Iannacchero^2|3, D. Bosco^2|4 | ¹National Research Council, Institute of Bioimaging and Complex Biological Systems, Catanzaro, Italy; ²Headache Center, “Renato Dulbecco” University Hospital, Catanzaro, Italy; ³Complex Operational Unit of Neurology, “Renato Dulbecco” University Hospital, Catanzaro, Italy; ⁴Psychiatric Service for Diagnosis and Care, Catanzaro, Italy

DOI https://doi.org/10.4081/cc.2026.16062
- 5 abstract views
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P107 | DIFFERENCES IN CLINICAL CHARACTERISTICS ACROSS LOW-FREQUENCY EPISODIC MIGRAINE, HIGH-FREQUENCY EPISODIC MIGRAINE, AND CHRONIC MIGRAINE: A CROSS-SECTIONAL OBSERVATIONAL STUDY

M. Del Sette¹, M. Grazzini¹, C. Finocchi², F. Tazza², E. Viani³, A. Coccia⁴, C. Solaro⁵, G. Poeta⁵, F. Valguarnera⁶, G. Sivori⁷, E. Giorli⁸, S. Di Antonio⁹, M. Bandettini⁹, A. Schenone⁹ | ¹U.O. Neurologia dell’IRCCS Azienda Ospedaliera Metropolitana Policlinico San Martino, Genova, Italy; ²S.C. Neurologia di Ponente, Ospedale San Paolo, Savona, Italy; ³Dipartimento Interaziendale Neuroscienze e Neuroriabilitazione Asl1/Asl2, Imperia, Italy; ⁴SC Neurologia, PO Ponente, Ospedale Santa Corona, Pietra Ligure (SV), Italy; ⁵S.C. Neurologia Ospedale Galliera, Genova, Italy; ⁶S.C. Neurologia IRCCS Azienda Ospedaliera Metropolitana Villa Scassi, Genova, Italy; ⁷S.C. Neurologia Ospedale di Lavagna, Genova, Italy; ⁸SC Neurologia Ospedale S. Andrea, La Spezia, Italy; ⁹U.O. Clinica Neurologica dell’IRCCS Azienda Ospedaliera Metropolitana Policlinico San Martino, Genova, Italy

DOI https://doi.org/10.4081/cc.2026.16063
- 6 abstract views
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P108 | CHARACTERISTIC OF PATIENTS ATTENDING TERTIARY HEADACHE CENTRES IN LIGURIA: A CROSS-SECTIONAL OBSERVATIONAL STUDY

M. Del Sette¹, M. Grazzini¹, C. Finocchi², F. Tazza², E. Viani³, A. Coccia⁴, C. Solaro⁵, G. Poeta⁵, F. Valguarnera⁶, G. Sivori⁷, E. Giorli⁸, S. Di Antonio⁹, M. Bandettini⁹, A. Schenone⁹ | ¹U.O. Neurologia dell’IRCCS Azienda Ospedaliera Metropolitana Policlinico San Martino, Genova, Italy; ²S.C. Neurologia di Ponente, Ospedale San Paolo, Savona, Italy; ³Dipartimento Interaziendale Neuroscienze e Neuroriabilitazione Asl1/Asl2, Imparia, Italy; ⁴SC Neurologia, PO Ponente, Ospedale Santa Corona, Pietra Ligure (SV), Italy; ⁵S.C. Neurologia Ospedale Galliera, Genova, Italy; ⁶S.C. Neurologia IRCCS Azienda Ospedaliera Metropolitana Villa Scassi, Genova, Italy; ⁷S.C. Neurologia Ospedale di Lavagna, Italy; ⁸SC Neurologia Ospedale S. Andrea, La Spezia, Italy; ⁹U.O. Clinica Neurologica dell’IRCCS Azienda Ospedaliera Metropolitana Policlinico San Martino, Genova, Italy

DOI https://doi.org/10.4081/cc.2026.16064
- 6 abstract views
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P109 | THE ROLE OF NEUROTICISM AND DEPRESSIVE SYMPTOMS IN MODULATING MIGRAINE BURDEN: A CROSS-SECTIONAL STUDY

I. Getuli, R. Serra, L. Contento, G. Giuliani, C. Zilli, L. Tarsitani, M. Altieri | Departiment of Human Neuroscience, Policlinico Umberto I Hospital, Sapienza University of Rome, Italy

DOI https://doi.org/10.4081/cc.2026.16065
- 8 abstract views
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P110 | IMPACT OF THE NORTH-EAST ITALIAN CHRONIC HEADACHE PROJECT ON WORKPLACE DISABILITY AND WORK PRODUCTIVITY IN PATIENTS TREATED WITH ATOGEPANT

A. Granato¹, L. Bartole¹, C. Gonella¹, E. Fusco¹, M. Bonetti², A. Lodi³, A. Benussi¹ | ¹Clinical Unit of Neurology, Headache Centre, Department of Medicine, Surgery and Health Sciences, University of Trieste, Italy; ²DAD Area Giuliana, S.C. Distretto Trieste 1 e 2, ASUGI, University of Trieste, Italy; ³Funzione Organizzativa, Gestione Offerte Ambulatoriali, ASUGI, University of Trieste, Italy

DOI https://doi.org/10.4081/cc.2026.16066
- 7 abstract views
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P111 | THE LIGURIAN HEADACHE NETWORK: A SURVEY OF NINE HEADACHE CENTRES, RESOURCES AND CHALLENGES

M. Grazzini¹, M. Del Sette¹, A. Schenone², M. Bandettini², F. Bandini³, F. Valguarnera⁴, A. Assini⁵, C. Solaro⁵, G. Silvestrelli⁶, E. Viani⁶, A. Sugo⁷, A. Coccia⁷, S. Nassani⁸, G. Sivori⁸, L. Benedetti⁹, E. Giorli⁹, E. Arena¹⁰, C. Finocchi¹⁰ | ¹Department of Neurology, IRCCS AOM San Martino Hospital, Genoa, Italy; ²Neurological Clinic DINOGMI, IRCCS AOM San Martino Hospital, Genoa, Italy; ³Department of Neurology, IRCCS AOM Villa Scassi, Genoa, Italy; ⁴Department of Neurology, Antero Micone Hospital, ATS liguriaArea 3, Head of the Headache Centre, Genoa, Italy; ⁵Department of Neurology, Ospedali Galliera, Genoa, Italy; ⁶Clinical Neurology and Stroke Centre, Emergency Department, Imperia Hospital, Italy; ⁷Department of Neurology, Santa Corona Hospital, Pietra Ligure, Italy; ⁸Department of Neurology, Tigullio Hospital, Lavagna, Italy; ⁹Department of Neurology, Sant'Andrea Hospital, La Spezia, Italy; ¹⁰Department of Neurology, San Paolo Hospital, Savona, Italy

DOI https://doi.org/10.4081/cc.2026.16067
- 4 abstract views
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P112 | HOW MUCH DO YOU KNOW ABOUT MIGRAINE? UNMET CHALLENGES IN HEADACHE EDUCATION

M. Marcosano^1|2, L. D’Onofrio^1|2, C. Altamura^1|2, L. Fofi^1|2, S. Lodico^1|2, F. Vernieri^1|2 | ¹Headache Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy; ²Neurology Unit, Università Campus Bio-Medico di Roma, Italy

DOI https://doi.org/10.4081/cc.2026.16068
- 5 abstract views
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