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• P093 | GAINER-AI: PREDICTING ACUTE RIMEGEPANT RESPONSE IN MIGRAINE USING MACHINE LEARNING IN A MULTICENTER REAL-WORLD COHORT

  M. Romozzi^1|2, A. Lokhawandala³, G. Vaghi^4|5, G. Sebastianelli⁶, R. Ornello⁷, F. Casillo⁶, A. Russo⁸, M. Silvestro⁸, F. Pistoia⁹, G. Saporito⁹, G. Dalla Volta¹⁰, M. Bolchini¹⁰, A. Burgalassi¹¹, G. Vigani¹¹, D. Antonio Montisano¹², L. Grazzi¹², M. Pia Prudenzano¹³, D. Mascarella¹⁴, E. Mampreso¹⁵, G. Avino¹⁶, M. Valente¹⁷, G. Carlucci¹⁸, S. Guerzoni¹⁹, S. Battistini²⁰, A. Granato²¹, E. Maria Piella²², I. Rainero²², M. Albanese²³, M. Trimboli²⁴, A. Doretti²⁵, F. De Santis⁷, S. Sacco⁷, C. Tassorelli^4|5, S. Di Tella²⁶, C. Vollono^1|2, P. Calabresi^1|2, R. De Icco^4|5, L. Francesco Iannone²⁷ | ¹Dipartimento Universitario di Neuroscienze, Università Cattolica del Sacro Cuore, Rome, Italy; ²Neurologia, Dipartimento di neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; ³Drexel University, Philadelphia, USA; ⁴Department of Brain and Behavioral Sciences, University of Pavia, Italy; ⁵Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy; ⁶Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino, Latina, Italy; ⁷Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, Italy; ⁸Headache Centre, Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy; ⁹Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy; ¹⁰Headache Center of Clinical Neurology of Istituto Clinico Città Di Brescia, Italy; ¹¹Department of Health Sciences, University of Florence, Italy; ¹²Neuroalgology Unit and Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy; ¹³Headache Center, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, Italy; ¹⁴IRCCS Istituto Di Scienze Neurologiche Di Bologna, Programma Cefalee e Algie Facciali, Italy; ¹⁵Headache Centre, Neurology - Euganea, Health Unit, Padua, Italy; ¹⁶Neurology Unit, Ospedale Santo Stefano, USL Toscana Centro, Prato, Italy; ¹⁷Clinical Neurology, Azienda Sanitaria Universitaria Friuli Centrale, Presidio Ospedaliero Santa Maria Della Misericordia, Udine, Italy; ¹⁸NEUROFARBA Department, University of Florence - AOU Careggi, Italy; ¹⁹Digital and Predictive Medicine, Pharmacology, Clinical Metabolic Toxicology-Headache Center and Drug Abuse, Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico, Modena, Italy; ²⁰Department of Medical, Surgical and Neurological Sciences, University of Siena, Italy; ²¹Headache Centre, Clinical Unit of Neurology, School of Neurology, Department of Medicine, Surgery and Health Sciences, University Hospital and Health Services of Trieste, ASUGI, University of Trieste, Italy; ²²Department of Neurosciences “Rita Levi Montalcini”, University of Turin, Italy; ²³Unit of Neurology, Department of Systems Medicine, Tor Vergata University, Rome, Italy; Unit of Neurology - IRCCS Neuromed, Pozzilli (IS), Italy; ²⁴Headache Centre, Neurology Unit, AOU Renato Dulbecco, Catanzaro, Italy; ²⁵Department of Neurology- Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy; ²⁶Dipartimento di Psicologia, Università Cattolica del Sacro Cuore, Milan, Italy; ²⁷Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.16049

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• P082 | CHARACTERIZING SOCIAL COGNITION ACROSS MIGRAINE FREQUENCY USING THE STORY-BASED EMPATHY TASK AND THE READING THE MIND IN THE EYES TEST

  V. Batti¹, A. Mario Chiarandon¹, E. Maria Piella¹, A. Agostinelli¹, E. Rota³, I. Rainero^1|2, E. Rubino^1|2 | ¹Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Italy; ²Headache Center, Department of Neuroscience and Mental Health, University Hospital Città della Salute e della Scienza of Turin, Italy; ³Neurology Unit, S. Giacomo Hospital, ASL AL, Novi Ligure, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.16038

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• P025 | PAIN RELIEF AFTER 30 MINUTES PREDICTS COMPLETE ACUTE TREATMENT SUCCESS AT 12 HOURS: A REAL-WORLD ANALYSIS OF INTRAVENOUS EPTINEZUMAB INFUSION IN HIGHLY REFRACTORY MIGRAINE PATIENTS

  L. Fofi¹, C. Altamura^1|2, M. Marcosano^1|2, L. d’Onofrio², A. Doretti³, F. Pistoia⁴, A. Granato⁵, S. Guerzoni⁶, M. Trimboli⁷, L. Grazzi⁸, D. Antonio Montisano⁸, G. Avino⁹, G. Sebastianelli¹⁰, C. Fasano¹¹, E. Maria Piella¹², P. Geppetti¹³, N. Brunelli¹, S. Lodico², L. Francesco Iannone¹⁴, F. Vernieri^1|2 | ¹Neurosonology and Headache Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy; ²Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Italy; ³Department of Neurology-Laboratory of Neuroscience, IRCCS, Istituto Auxologico Italiano, Milan, Italy; ⁴Department of Biotechnological and Applied Clinical Sciences, Neurological Institute, University of L’Aquila, Italy; ⁵Headache Center, Neurology Clinic, University Hospital of Trieste, University of Trieste, Italy; ⁶Digital and Predictive Medicine, Pharmacology and Clinical Metabolic Toxicology-Headache Center and Drug Abuse-Laboratory of Clinical Pharmacology and Pharmacogenomics, Department of Specialist Medicines, AOU Policlinico di Modena, Italy; ⁷Azienda Ospedaliera-Universitaria “Renato Dulbecco”, Catanzaro, Italy; ⁸Headache Center, Department of Neurology, IRCCS Foundation “Carlo Besta” Neurological Institute, Milan, Italy; ⁹SOC Neurologia, Ospedale Santo Stefano, USL Toscana Centro, Prato, Italy; ¹⁰Department of Medico-Surgical Sciences and Biotechnologies, Polo Pontino ICOT, Sapienza University of Rome, Latina, Italy; ¹¹Headache and Cerebrovascular Diseases Center, Neurology Unit 2, Careggi University Hospital, Florence, Italy; ¹²Department of Neurosciences “Rita Levi Montalcini”, University of Turin, Italy; ¹³Department of Molecular Pathobiology and Pain Research Center, College of Dentistry, New York University, NY, United States; ¹⁴Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.15981

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• OC03 | PLASMA PACAP-38 IS INCREASED IN MIGRAINE REGARDLESS OF CLINICAL PHENOTYPE: A CASE-CONTROL STUDY

  S. Boschi^1|2, A. Agostinelli^1|2, A. Panza^1|2, E. Maria Piella^1|2, V. Batti^1|2, I. Rainero^1|2, E. Rubino^1|2 | ¹Dipartimento di Neuroscienze "Rita Levi Montalcini", Università di Torino, Italy; ²Centro Cefalee, Dipartimento di Neuroscienze e Salute Mentale, AOU Città della Salute e della Scienza di Torino, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.15941

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• P048 | PLASMA GFAP LEVELS IN PATIENTS WITH MIGRAINE: LACK OF ASSOCIATION WITH CLINICAL PHENOTYPE AND DISEASE BURDEN

  A. Agostinelli¹, E. Rubino^1|2, S. Boschi¹, E. Maria Piella¹, A. Panza¹, A. Mario Chiarandon¹, F. Roveta¹, G. Gioiello³, S. Limoncelli³, G. Mengozzi³, I. Rainero^1|2 | ¹Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Italy; ²Headache Center, Department of Neuroscience and Mental Health, AOU Città della Salute e della Scienza di Torino, Italy; ³Clinical Biochemistry Laboratory “Baldi e Riberi”, AOU Città della Salute e della Scienza di Torino”, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.16004

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• P053 | LONG-TERM EFFECTIVENESS AND SAFETY OF FREMANEZUMAB FOR MIGRAINE PREVENTION: 24-MONTH OUTCOMES FROM THE ITALIAN COHORT OF THE PEARL STUDY

  S. Guerzoni¹, C. Aurilia², A. Doretti³, E. Maria Piella⁴, R. Ornello⁵, P. Kokturk⁶, M. Cepparulo⁷ | ¹Digital and Predictive Medicine, Pharmacology and Clinical Metabolic Toxicology- Headache Center and Drug Abuse, Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico di Modena, Italy; ²Headache and Pain Unit, IRCCS San Raffaele, Rome, Italy; ³Department of Neurology-Laboratory of Neuroscience, IRCCS, Istituto Auxologico Italiano, Milan, Italy; ⁴Neurosciences Department, University of Turin, Italy; ⁵Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, Italy; ⁶Teva Netherlands B.V., Haarlem, The Netherlands; ⁷Teva Italia Srl, Milan, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.16009

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