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• P015 | IMPROVING DISTRESS PERCEPTION IN CAREGIVERS OF MIGRAINE PATIENTS WITH DEPRESSIVE SYMPTOMS TREATED WITH FREMANEZUMAB. THE OBSERVATIONAL PROSPECTIVE REAL-LIFE MI-DEAR STUDY

  C. Altamura^1|2, L. Fofi¹, C. Aurilia³, E. Cresta⁴, A. Onofri⁵, A. Montisano⁶, M. Silvastro⁷, V. Favoni⁸, G. Viticchi⁹, M. Marcosano¹, G. Egeo³, M. Bartolini⁹, M. Peresson¹⁰, M. Cepparulo¹¹, A. Russo⁷, S. Cevoli⁸, R. Rao^4|12, L. Grazzi⁶, S. Sacco⁵, F. Vernieri^1|2 | ¹Neurosonology and Headache Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy; ²Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Italy; ³Headache and Pain Unit, IRCCS San Raffaele Roma, Italy; ⁴Department of Frailty and Care, Neurology Unit, Headache Center, ASST Spedali Civili, Brescia, Italy; ⁵Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy; ⁶Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy; ⁷Inter-departmental Program of Headache Medicine and Primary Pain Syndromes, Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, University of Campania “Luigi Vanvitelli”, Naples, Italy; ⁸Programma cefalee e algie facciali, IRCCS Istituto delle Scienze Neurologiche di Bologna, Italy; ⁹Neurological Clinic, Marche Polytechnic University, Ancona, Italy; ¹⁰Headache Unit, San Pietro Fatebenefratelli Hospital, Rome, Italy; ¹¹Teva Italia Srl, Milan, Italy; ¹²Department of Clinical and Experimental Sciences (DSCS), University of Brescia, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.15971

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• P053 | LONG-TERM EFFECTIVENESS AND SAFETY OF FREMANEZUMAB FOR MIGRAINE PREVENTION: 24-MONTH OUTCOMES FROM THE ITALIAN COHORT OF THE PEARL STUDY

  S. Guerzoni¹, C. Aurilia², A. Doretti³, E. Maria Piella⁴, R. Ornello⁵, P. Kokturk⁶, M. Cepparulo⁷ | ¹Digital and Predictive Medicine, Pharmacology and Clinical Metabolic Toxicology- Headache Center and Drug Abuse, Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico di Modena, Italy; ²Headache and Pain Unit, IRCCS San Raffaele, Rome, Italy; ³Department of Neurology-Laboratory of Neuroscience, IRCCS, Istituto Auxologico Italiano, Milan, Italy; ⁴Neurosciences Department, University of Turin, Italy; ⁵Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, Italy; ⁶Teva Netherlands B.V., Haarlem, The Netherlands; ⁷Teva Italia Srl, Milan, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.16009

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• P105 | PATIENT DEPRESSIVE SYMPTOMS AND RECIPROCITY INFLUENCE DISTRESS IN THE CAREGIVER OF PATIENTS WITH MIGRAINE: INSIGHTS FROM THE MIDEAR OBSERVATIONAL COHORT STUDY

  C. Altamura^1|2, L. Fofi¹, C. Aurilia³, E. Cresta⁴, A. Onofri⁵, A. Montisano⁶, M. Silvastro⁷, V. Favoni⁸, G. Viticchi⁹, M. Marcosano¹, G. Egeo³, M. Bartolini⁹, M. Peresson¹⁰, M. Cepparulo¹¹, A. Russo⁷, S. Cevoli⁸, R. Rao^4|12, L. Grazzi⁶, S. Sacco⁵, F. Vernieri^1|2 | ¹Neurosonology and Headache Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy; ²Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Italy; ³Headache and Pain Unit, IRCCS San Raffaele Roma, Italy; ⁴Department of Frailty and Care, Neurology Unit, Headache Center, ASST Spedali Civili, Brescia, Italy; ⁵Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy; ⁶Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy; ⁷Inter-departmental Program of Headache Medicine and Primary Pain Syndromes, Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, University of Campania “Luigi Vanvitelli”, Naples, Italy; ⁸Programma cefalee e algie facciali, IRCCS Istituto delle Scienze Neurologiche di Bologna, Italy; ⁹Neurological Clinic, Marche Polytechnic University, Ancona, Italy; ¹⁰Headache Unit, San Pietro Fatebenefratelli Hospital, Rome, Italy; ¹¹Teva Italia Srl, Milan, Italy; ¹²Department of Clinical and Experimental Sciences (DSCS), University of Brescia, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.16061

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• P041 | WHO TAKES CARE OF PATIENTS SUFFERING FROM MIGRAINE? THE CAREGIVER’S IDENTIKIT STUDY. A MI-DEAR SUB-ANALYSIS

  L. Fofi¹, C. Altamura^1|2, L. D'Onofrio¹, C. Aurilia³, E. Cresta⁴, A. Onofri⁵, A. Montisano⁶, M. Silvestro⁷, V. Favoni⁸, G. Viticchi⁹, M. Marcosano¹, G. Egeo³, M. Bartolini⁹, M. Peresson¹⁰, M. Cepparulo¹¹, A. Russo⁷, S. Cevoli⁸, R. Rao^4|12, L. Grazzi⁶, S. Sacco⁵, F. Vernieri^1|2 | ¹Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Italy; ²Neurosonology and Headache Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy; ³Headache and Pain Unit, IRCCS San Raffaele Roma, Italy; ⁴Department of Frailty and Care, Neurology Unit, Headache Center, ASST Spedali Civili, Brescia, Italy; ⁵Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy; ⁶Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy; ⁷Inter-departmental Program of Headache Medicine and Primary Pain Syndromes, Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, University of Campania “Luigi Vanvitelli”, Naples, Italy; ⁸Programma cefalee e algie facciali, IRCCS Istituto delle Scienze Neurologiche di Bologna, Italy; ⁹Neurological Clinic, Marche Polytechnic University, Ancona, Italy; ¹⁰Headache Unit, San Pietro Fatebenefratelli Hospital, Rome, Italy; ¹¹Teva Italia Srl, Milan, Italy; ¹²Department of Clinical and Experimental Sciences (DSCS), University of Brescia, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.15997

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