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• OC18 | LONG-TERM EFFECTIVENESS, SAFETY AND TOLERABILITY OF ATOGEPANT IN THE PREVENTION OF MIGRAINE: A MULTICENTRIC, PROSPECTIVE OBSERVATIONAL, REAL WORLD STUDY (THE 48-WEEK STAR STUDY)

  F. Vernieri^1|2, L. Francesco Iannone³, M. Marcosano^1|2, L. Fofi¹, F. Lo Castro⁴, G. Sebastianelli⁵, F. De Santis⁶, M. Corrado⁷, R. Ornello⁶, L. Grazzi⁸, D. Antonio Montisano⁸, F. De Cesaris⁹, A. Munafò⁹, G. Avino¹⁰, M. Trimboli¹¹, M. Albanese¹², A. Russo¹³, M. Silvestro¹³, G. Dalla Volta¹⁴, M. Romozzi¹⁵, P. Calabresi¹⁵, A. Boccalini⁴, P. Merlo¹⁶, M. Pia Prudenzano¹⁷, M. Rosaria Valente¹⁸, I. Rainero¹⁹, G. Giuliani²⁰, M. Altieri²⁰, A. Doretti²¹, G. Vaghi^7|22, F. Pistoia⁶, D. Ferrandi²³, S. Battistini²⁴, G. Coppola⁵, S. Guerzoni⁴, S. Sacco^6|25, C. Tassorelli^7|22, C. Altamura^1|2 | ¹Headache and Neurosonology Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy; ²Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Italy; ³Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy; ⁴Digital and Predictive Medicine, Pharmacology and Clinical Metabolic Toxicology-Headache Center and Drug Abuse-Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico Di Modena, Italy; ⁵Sapienza University of Rome, Department of Medico-Surgical Sciences and Biotechnologies, Polo Pontino, Latina, Italy; ⁶Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, Italy; ⁷Headache Science and Neurorehabilitation Centre, IRCCS Mondino Foundation, Pavia, Italy; ⁸Headache Center IRCCS Fondazione Istituto Neurologico "Carlo Besta", Italy; ⁹Headache center and clinical pharmacology, AOU Careggi, Firenze, Italy; ¹⁰Neurology Unit, Ospedale Santo Stefano, USL Toscana Centro, Prato, Italy; ¹¹Azienda Ospedaliera-universitaria "Renato Dulbecco", Catanzaro, Italy; ¹²Department of Systems Medicine, University of Rome Tor Vergata, Italy; ¹³Headache Center, Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Second University of Naples, Italy; ¹⁴U.O Neurologia, Istituto Clinico Città di Brescia, Gruppo San Donato, Italy; ¹⁵Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy; ¹⁶UO di Neurologia, Humanitas Gavazzeni, Bergamo, Italy; ¹⁷Clinica Neurologica "L. Amaducci", Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, Italy; ¹⁸Clinica Neurologica ASUFC, Dipartimento di Medicina DMED Università di Udine, Italy; ¹⁹Headache Center, Department of Neuroscience, University of Torino, Italy; ²⁰Department of Human Neuroscience, Sapienza University of Rome, Italy; ²¹IRCCS Istituto Auxologico Italiano, Milano, Italy; ²²Department of Brain and Behavioural Sciences, University of Pavia, Italy; ²³SC Neurologia, Azienda Ospedaliero Universitaria Santi Antonio e Biagio, Alessandria, Italy; ²⁴Department of Medical, Surgical and Neurological Sciences, University of Siena, Italy; ²⁵Neurology and Stroke Unit, ASL 1 Abruzzo, Avezzano-Sulmona-L’Aquila, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.15956

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• P079 | THE ROLE OF GUT MICROBIOTA IN MIGRAINE SUBJECTS TREATED WITH ANTI-CGRP MONOCLONAL ANTIBODIES: RESULTS THE SPHERA PROJECT

  F. Muscariello^1|2, G. Vaghi^1|2, R. Greco², V. Grillo^1|2, M. Corrado², F. Cammarota^1|2, B. Agostini^1|2, M. Giraudo^1|2, C. Angeli^1|2, M. Allena², E. Guaschino², N. Ghiotto², R. Ornello³, S. Sacco³, C. Demartini², M. Francavilla^1|2, S. Facchetti^1|2, V. Pazienza⁴, D. Sproviero², G. Sances², C. Tassorelli^1|2, R. De Icco^1|2 | ¹Department of Brain and Behavioral Sciences, University of Pavia, Italy; ²Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy; ³Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy; ⁴Division of Gastroenterology, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.16035

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• OC01 | DECODING THE BIOCHEMICAL SIGNATURE OF TREATMENT-RESISTANT MIGRAINE: SEARCHING FOR DISEASE PHENOTYPES AND NOVEL THERAPEUTIC TARGETS

  B. Agostini^1|2, R. Greco², G. Vaghi^1|2, V. Grillo^1|2, M. Corrado², F. Cammarota^1|2, C. Angeli^1|2, F. Muscariello^1|2, M. Giraudo^1|2, M. Allena², E. Guaschino², N. Ghiotto², C. Demartini², M. Francavilla^1|2, S. Facchetti^1|2, V. Franco^2|3, G. Sances², C. Tassorelli^1|2, R. De Icco^1|2 | ¹Department of Brain and Behavioral Sciences, University of Pavia, Italy; ²Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy; ³Department of Internal Medicine and Therapeutics, University of Pavia, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.15939

  • 2 abstract views
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• P089 | PRELIMINARY VALIDATION OF THE ITALIAN VERSION OF THE UTAH PHOTOPHOBIA SYMPTOM IMPACT SCALE (UPSIS-2) IN PATIENTS WITH MIGRAINE

  A.M. Chiarandon¹, E.M. Piella¹, V. Batti¹, G. Sebastianelli², F. Ferrandes¹, M. Corrado³, M. Romozzi⁴, F. De Santis⁵, C. Fasano⁶, F. Lazzerini⁷, L. F. Iannone⁸, A. Munafò⁹, R. Ornello¹⁰, E. Rubino^1|11, I. Rainero^1|11 | ¹Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Italy; ²Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Polo Pontino, Latina, Italy; ³Department of Brain and Behavioral Sciences, University of Pavia, Italy; ⁴Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome; Università Cattolica del Sacro Cuore, Rome, Italy; ⁵Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, Italy; ⁶Headache and Cerebrovascular Diseases Center, Neurology Unit 2, Careggi University Hospital, Florence, Italy; ⁷Department of Humanities, University of Turin, Italy; ⁸Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy; ⁹Headache center and Clinical pharmacology unit, AOU Careggi, Florence, Italy; ¹⁰Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy; ¹¹Headache Center, Department of Neuroscience and Mental Health, City of Health and Science of Turin, Italy, on behalf of SISC Junior Group

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.16045

  • 2 abstract views
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• P036 | ROLE OF SPECIFIC MICRORNAS IN CLUSTER HEADACHE: ASSOCIATION WITH DISEASE PHENOTYPE AND NEUROPEPTIDE LEVELS

  C. Angeli^1|2, R. De Icco^1|2, M. Corrado², G. Vaghi^1|2, F. Cammarota^1|2, V. Grillo^1|2, M. Giraudo^1|2, B. Agostini^1|2, F. Muscariello^1|2, R. Greco², C. Demartini^1|2, M. Francavilla^1|2, S. Franchini^1|2, M. Allena², G. Sances², C. Tassorelli^1|2 | ¹Department of Brain and Behavioural Sciences, University of Pavia, Italy; ²Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.15992

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• OC06 | UNRAVELING THE SPECTRUM OF MIGRAINE RESISTANT TO TREATMENT: THE ROLE OF MRI RESTING-STATE FUNCTIONAL CONNECTIVITY IN MIGRAINE SUBJECTS TREATED WITH ANTI-CGRP MONOCLONAL ANTIBODIES

  M. Giraudo^1|2, D. Martinelli², G. Vaghi^1|2, G. Castellazzi², M. Corrado², F. Cammarota^1|2, B. Agostini^1|2, F. Muscariello^1|2, C. Angeli^1|2, V. Grillo^1|2, R. Greco², C. Demartini^1|2, M. Francavilla^1|2, S. Facchetti^1|2, A. Pichiecchio^1|3, M. Allena², E. Guaschino², N. Ghiotto², G. Sances², C. Tassorelli^1|2, R. De Icco^1|2 | ¹Department of Brain and Behavioral Sciences, University of Pavia, Italy; ²Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy; ³Neuroradiology Department, IRCCS Mondino Foundation, Pavia, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.15944

  • 1 abstract views
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