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• P039 | GUT-BRAIN AXIS ALTERATIONS IN A NITROGLYCERIN MODEL OF MIGRAINE: FROM MICROBIOTA DYSBIOSIS TO TRIGEMINAL SENSITIZATION

  C. Demartini¹, S. Facchetti^1|2, M. Francavilla¹, S. Baldi³, S. Bertorello³, G. Bartolucci⁴, E. Niccolai³, A. Amedei³, R. Greco¹, C. Tassorelli^1|2 | ¹Section of Translational Neurovascular Research, IRCCS Mondino Foundation, Pavia, Italy; ²Department of Brain and Behavioral Sciences, University of Pavia, Italy; ³Department of Experimental and Clinical Medicine, University of Florence, Italy; ⁴Department of Neuroscience, Psychology, Drug Research and Child Health NEUROFARBA, University of Florence, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.15995

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• P052 | A PATIENT-SPECIFIC HUMAN TRIGEMINAL NEURON MODEL FOR THE STUDY OF MIGRAINE MECHANISMS

  R. Greco¹, M. Bordoni², J. Cazzola³, F. De Luca⁴, M. Francavilla¹, C. Demartini¹, S. Facchetti¹, O. Pansarasa², G. Vaghi¹, R. De Icco^1|5, G. Biella³, C. Tassorelli^1|5 | ¹Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy; ²Cellular Models and Neuroepigenetics Section, IRCCS Mondino Foundation, Pavia, Italy; ³Laboratory of Biophysics and Physiology of Ion Channels, University of Pavia, Italy; ⁴Laboratory of Cell Biology and Neurobiology, University of Pavia, Italy; ⁵Behavioral Sciences, Department of Brain, University of Pavia, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.16008

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• OC01 | DECODING THE BIOCHEMICAL SIGNATURE OF TREATMENT-RESISTANT MIGRAINE: SEARCHING FOR DISEASE PHENOTYPES AND NOVEL THERAPEUTIC TARGETS

  B. Agostini^1|2, R. Greco², G. Vaghi^1|2, V. Grillo^1|2, M. Corrado², F. Cammarota^1|2, C. Angeli^1|2, F. Muscariello^1|2, M. Giraudo^1|2, M. Allena², E. Guaschino², N. Ghiotto², C. Demartini², M. Francavilla^1|2, S. Facchetti^1|2, V. Franco^2|3, G. Sances², C. Tassorelli^1|2, R. De Icco^1|2 | ¹Department of Brain and Behavioral Sciences, University of Pavia, Italy; ²Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy; ³Department of Internal Medicine and Therapeutics, University of Pavia, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.15939

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• P036 | ROLE OF SPECIFIC MICRORNAS IN CLUSTER HEADACHE: ASSOCIATION WITH DISEASE PHENOTYPE AND NEUROPEPTIDE LEVELS

  C. Angeli^1|2, R. De Icco^1|2, M. Corrado², G. Vaghi^1|2, F. Cammarota^1|2, V. Grillo^1|2, M. Giraudo^1|2, B. Agostini^1|2, F. Muscariello^1|2, R. Greco², C. Demartini^1|2, M. Francavilla^1|2, S. Franchini^1|2, M. Allena², G. Sances², C. Tassorelli^1|2 | ¹Department of Brain and Behavioural Sciences, University of Pavia, Italy; ²Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.15992

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• OC06 | UNRAVELING THE SPECTRUM OF MIGRAINE RESISTANT TO TREATMENT: THE ROLE OF MRI RESTING-STATE FUNCTIONAL CONNECTIVITY IN MIGRAINE SUBJECTS TREATED WITH ANTI-CGRP MONOCLONAL ANTIBODIES

  M. Giraudo^1|2, D. Martinelli², G. Vaghi^1|2, G. Castellazzi², M. Corrado², F. Cammarota^1|2, B. Agostini^1|2, F. Muscariello^1|2, C. Angeli^1|2, V. Grillo^1|2, R. Greco², C. Demartini^1|2, M. Francavilla^1|2, S. Facchetti^1|2, A. Pichiecchio^1|3, M. Allena², E. Guaschino², N. Ghiotto², G. Sances², C. Tassorelli^1|2, R. De Icco^1|2 | ¹Department of Brain and Behavioral Sciences, University of Pavia, Italy; ²Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy; ³Neuroradiology Department, IRCCS Mondino Foundation, Pavia, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.15944

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• P042 | INHIBITION OF PEA DEGRADATION VIA NAAA BLOCKADE MODULATES MIGRAINE-RELATED PATHWAYS WITHOUT REVERSED TRIGEMINAL HYPERALGESIA IN FEMALE RATS IN THE NTG-BASED MIGRAINE MODEL

  M. Francavilla¹, S. Facchetti^1|2, C. Demartini¹, J. Stefania Cusme Valle^1|2, R. Greco¹, C. Tassorelli^1|2 | ¹Section of Translational Neurovascular Research, IRCCS Mondino Foundation, Pavia, Italy; ²Department of Brain and Behavioral Sciences, University of Pavia, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.15998

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• P040 | PROBIOTIC SUPPLEMENTATION ALLEVIATES MIGRAINE-LIKE PAIN BY RESTORING INTESTINAL BARRIER INTEGRITY AND ENDOCANNABINOID HOMEOSTASIS

  S. Facchetti^1|2, C. Demartini¹, M. Francavilla¹, B. Marfella³, L. Cristino³, R. Greco¹, C. Tassorelli^1|2 | ¹Section of Translational Neurovascular Research, IRCCS Mondino Foundation, Pavia, Italy; ²Department of Brain and Behavioral Sciences, University of Pavia, Italy; ³Istituto di Chimica Biomolecolare del CNR, Pozzuoli (NA), Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.15996

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• P079 | THE ROLE OF GUT MICROBIOTA IN MIGRAINE SUBJECTS TREATED WITH ANTI-CGRP MONOCLONAL ANTIBODIES: RESULTS THE SPHERA PROJECT

  F. Muscariello^1|2, G. Vaghi^1|2, R. Greco², V. Grillo^1|2, M. Corrado², F. Cammarota^1|2, B. Agostini^1|2, M. Giraudo^1|2, C. Angeli^1|2, M. Allena², E. Guaschino², N. Ghiotto², R. Ornello³, S. Sacco³, C. Demartini², M. Francavilla^1|2, S. Facchetti^1|2, V. Pazienza⁴, D. Sproviero², G. Sances², C. Tassorelli^1|2, R. De Icco^1|2 | ¹Department of Brain and Behavioral Sciences, University of Pavia, Italy; ²Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy; ³Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy; ⁴Division of Gastroenterology, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.16035

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