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• PO-57 | Early treatment with atogepant improves sleep quality without sleep-related adverse events: a prospective observational study Alberto Boccalini,¹ Luigi Francesco Iannone,^1,2* Flavia Lo Castro,¹ Daria Brovia,¹ Marina Romozzi,^3,4 Fabrizio Vernieri,^5,6 Claudia Altamura,^5,6 Simona Guerzoni¹ | ¹Digital and Predictive Medicine, Pharmacology and Clinical Metabolic Toxicology-Headache Center and Drug Abuse-Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico di Modena, Modena, Italy; ²Department of Biomedical, Metabolic, and Neural Science, University of Modena and Reggio Emilia, Modena, Italy; ³Dipartimento Universitario di Neuroscienze, Università Cattolica del Sacro Cuore, Rome, Italy; ⁴Neurologia, Dipartimento di neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; ⁵Headache Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy; ⁶Università Campus Bio-Medico di Roma, Italy

  Società Italiana per lo Studio delle Cefalee (SISC)

  06-11-2025

  https://doi.org/10.4081/cc.2025.15880

  106

• OC-12 | The potential role of sleep quality in the relationship between glymphatic function and migraine frequency: insights from a cross-sectional study Maria Grazia Vittorini, Raffaele Ornello, Federico Salfi, Antonio Innocenzi, Federico De Santis, Federico Bruno, Francesca Pistoia, Michele Ferrara, Alessandra Splendiani, Simona Sacco | Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, Italy

  Società Italiana per lo Studio delle Cefalee (SISC)

  06-11-2025

  https://doi.org/10.4081/cc.2025.15809

  227

• PO-22 | Impact of sleep disorders on anti-CGRP monoclonal antibodies treatment response in migraine: a cross-sectional study Costanza Sottani,¹ Valerio Brunetti,^1,2 Fabiana Cerulli,¹ Claudia Garattini,⁴ Gianluca Avino,⁵ Paolo Calabresi,^1,3 Catello Vollono^1,4 | ¹Università Cattolica del Sacro Cuore, Dipartimento di Neuroscienze, Rome; ²Stroke Unit, Fondazione Policlinico Agostino Gemelli IRCSS, Rome; ³UOC Neurologia, Fondazione Policlinico Agostino Gemelli IRCSS, Rome; ⁴UOC Neurofisiopatologia, Fondazione Policlinico Agostino Gemelli IRCSS, Rome; ⁵Unità di Neurologia, Ospedale Santo Stefano, Prato, Italy

  Società Italiana per lo Studio delle Cefalee (SISC)

  06-11-2025

  https://doi.org/10.4081/cc.2025.15844

  118

• OC-13 | Monoclonal antibodies targeting CGRP differently affect sleep and psychiatric comorbidities in reproductive and postmenopausal chronic migraine women Giulia Procopio, Letizia Curto, Antonia Di Chirico, Leonardo Troilo, Gabriele Siciliano, Filippo Baldacci, Sara Gori | Neurology Unit, Department of Clinical and Experimental Medicine, University of Pisa-AOUP, Pisa, Italy

  Società Italiana per lo Studio delle Cefalee (SISC)

  06-11-2025

  https://doi.org/10.4081/cc.2025.15810

  247
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  The effectiveness of mindfulness as a complementary therapy in headache patients: a preliminary interventional study

  Emanuela Principe, Melissa Pirrotta, Nicola Fava, Carmen Marchio, Laura Maria Catalano, Rosario Iannacchero, Domenico Bosco

  16-12-2025

  https://doi.org/10.4081/cc.2025.15788

  41

  PDF: 38

• PO-47 | Systemic ozone treatment in chronic migraine: a focus on disability reduction and medication use Sergio Sorrenti,^1,2 Matteo Ciuffreda,¹ Emanuele Pisello,¹ Luca Brugiaferri,² Azzurra Federici,² Cristiano Piangatelli,³ Dario Galante⁴ | ¹U.O.C. Anestesia Rianimazione Terapia del Dolore, AST Ancona, Fabriano (AN), Italy; ²Scuola di Specializzazione in Anestesia Rianimazione, Terapia Intensiva e del Dolore, UNIVPM, Ancona, Italy; ³Direttore U.O.C. Anestesia Rianimazione Terapia del Dolore, AST Ancona, Fabriano (AN), Italy; ⁴Direttore U.O.C. Anestesia e Rianimazione, Cerignola (FG), Italy

  Società Italiana per lo Studio delle Cefalee (SISC)

  06-11-2025

  https://doi.org/10.4081/cc.2025.15869

  79