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• OC-14 | Efficacy of eptinezumab during a migraine attack: preliminary data from an Italian multicenter real-world experience (the BEFREE study) Luisa Fofi,¹ Claudia Altamura,¹ Marilena Marcosano,¹ Alberto Doretti,² Francesca Pistoia,³ Antonio Granato,⁴ Simona Guerzoni,⁵ Michele Trimboli,⁶ Licia Grazzi,⁷ Danilo Antonio Montisano,⁷ Gianluca Avino,⁸ Gabriele Sebastianelli,⁹ Carla Fasano,¹⁰ Elisa Maria Piella,¹¹ Nicoletta Brunelli,¹ Luigi Francesco Iannone,^5,12 Fabrizio Vernieri¹ on behalf of the Italian Headache Registry (RICe) Study Group | ¹Neurosonology and Headache Unit, Fondazione Policlinico Campus Bio-Medico, Rome; ²IRCCS Istituto Auxologico Italiano - Department of Neurology and Laboratory of Neuroscience - Milan; ³University of L’Aquila; ⁴Headache Center, Neurology Clinic, University of Trieste, University Hospital of Trieste; ⁵AOU Policlinico di Modena; ⁶Azienda Ospedaliera-universitaria "Renato Dulbecco", Catanzaro; ⁷Headache Center, Neuroalgology Dpt, IRCCS Foundation "Carlo Besta" Neurological Institute, Milan; ⁸SOC Neurologia, Ospedale Santo Stefano, USL Toscana Centro, Prato; ⁹La Sapienza University of Rome Polo Pontino, Latina; ¹⁰Headache and Cerebrovascular Diseases Center, Neurology Unit 2, Careggi University Hospital, Florence; ¹¹Department of Neuroscience “Rita Levi Montalcini”, University of Turin; ¹²Università di Modena e Reggio Emilia, Italy

  Società Italiana per lo Studio delle Cefalee (SISC)

  06-11-2025

  https://doi.org/10.4081/cc.2025.15811

  242

• PO-41 | Eptinezumab for difficult-to-treat migraine: who responds and who needs more Alessandro Visentini,^1,2,3 Roberta Messina,^1,2,3 Ilaria Cetta,^1,2,3 Edorardo Ratto,¹ Laura Zanandrea,^1,3 Federica Genovese,^1,2,3 Irene Chinali,¹ Bruno Colombo,¹ Massimo Filippi^1,2,3 | ¹Neurology Unit and ²Neuroimaging Research Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy; ³Vita-Salute San Raffaele University, Milan, Italy

  Società Italiana per lo Studio delle Cefalee (SISC)

  06-11-2025

  https://doi.org/10.4081/cc.2025.15863

  172

• PO-43 | Eptinezumab in migraine patients unresponsive to prior subcutaneous CGRP(-R) monoclonal antibody treatment: a retrospective case series Elena Cresta, Irene Mattioli, Michele Di Pasquale, Alice Lanfranchi, Renata Rao, Alessandro Padovani | Neurology Unit and Headache Centre, Dipartimento di continuità di cura e fragilità, ASST Spedali Civili e Università degli studi di Brescia, Brescia, Italy

  Società Italiana per lo Studio delle Cefalee (SISC)

  06-11-2025

  https://doi.org/10.4081/cc.2025.15865

  177

• PO-14 | Pain catastrophizing in chronic migraine patients receiving eptinezumab treatment Alessandra Parisi,¹ Licia Grazzi,¹ Alberto Raggi,² Giulia Regonesi,¹ Montisano Danilo Antonio¹ | ¹Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano; ²Neurology, Public Health and Disability Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy

  Società Italiana per lo Studio delle Cefalee (SISC)

  06-11-2025

  https://doi.org/10.4081/cc.2025.15835

  210

• PO-19 | Unraveling the spectrum of migraine resistant to treatments: searching for novel biological PHEnotypes and theRApeutic approaches (SPHERA project) M. Giraudo,^1,2 R. De Icco,^1,2 G. Vaghi,^1,2 V. Grillo,^1,2 F. Bighiani,^1,2 M. Corrado,² A. Antoniazzi,^1,2 F. Cammarota,^1,2 B. Agostini,^1,2 A. Solfrizzi,^1,2 M. Allena,² E. Guaschino,² N. Ghiotto,² R. Greco,² C. Demartini,² A. Zanaboni,^1,2 M. Francavilla,^1,2 S. Facchetti,^1,2 G. Sances,² C. Tassorelli^1,2 | ¹Department of Brain and Behavioral Sciences, University of Pavia; ²Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy

  Società Italiana per lo Studio delle Cefalee (SISC)

  06-11-2025

  https://doi.org/10.4081/cc.2025.15840

  181

• OC-17 | Profiling miR-30a expression in patients with episodic and chronic migraine Elisa Rubino,^1,2 Elisa Maria Piella,¹ Giulia Cicilese,^1,3 Silvia Boschi,¹ Alberto Mario Chiarandon,¹ Elena Tamagno,^1,3 Michela Guglielmotto,^1,3 Innocenzo Rainero^1,2 | ¹Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Turin, Italy; ²Headache Center, Department of Neuroscience and Mental Health, AOU Città della Salute e della Scienza di Torino; ³Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano (TO), Italy

  Società Italiana per lo Studio delle Cefalee (SISC)

  06-11-2025

  https://doi.org/10.4081/cc.2025.15814

  87

• PO-82 | Integrated approach with detoxification, CGRP monoclonal antibodies and psychoeducational support in two patients with complex medication overuse headache Claudia Lanni,¹ Federica Papini,² Chiara Prevost,³ Alessandro Canessa,³ Lucia Testa,³ Cristoforo Comi,² Delfina Ferrandi³ | ¹Department of Psychology “Santi Antonio e Biagio”, University Hospital, Alessandria, Italy; ²Neurology Unit, Department of Transitional Medicine, University of Piemonte Orientale, and University Hospital “Maggiore della Carità”, Novara, Italy; ³Neurology Unit, “Santi Antonio e Biagio” University Hospital, Alessandria, Italy

  Società Italiana per lo Studio delle Cefalee (SISC)

  06-11-2025

  https://doi.org/10.4081/cc.2025.15906

  189