Multidisciplinary research in neurosciences
Vol. 32 No. 3 (2022)

The diagnosis of Alzheimer’s disease: an update and current controversies

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Received: 28 November 2022
Published: 6 December 2022
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Alzheimer, diagnosi, biomarcatori, demenza mista

Authors

Alfredo Costa
alfredo.costa@unipv.it
1) Dipartimento di Scienze del Sistema Nervoso e del Comportamento, Università di Pavia. 2) Unità Complessa Neurologia del Comportamento e Centro Disturbi Cognitivi e Demenze (CDCD), Istituto Neurologico Nazionale IRCCS Mondino, Pavia., Italy.
Giulia Perini
1) Dipartimento di Scienze del Sistema Nervoso e del Comportamento, Università di Pavia. 2) Unità Complessa Neurologia del Comportamento e Centro Disturbi Cognitivi e Demenze (CDCD), Istituto Neurologico Nazionale IRCCS Mondino, Pavia., Italy.
Camillo Imbimbo
1) Dipartimento di Scienze del Sistema Nervoso e del Comportamento, Università di Pavia. 2) Unità Complessa Neurologia del Comportamento e Centro Disturbi Cognitivi e Demenze (CDCD), Istituto Neurologico Nazionale IRCCS Mondino, Pavia., Italy.
Lucia Scanu
1) Dipartimento di Scienze del Sistema Nervoso e del Comportamento, Università di Pavia. 2) Unità Complessa Neurologia del Comportamento e Centro Disturbi Cognitivi e Demenze (CDCD), Istituto Neurologico Nazionale IRCCS Mondino, Pavia., Italy.
Matteo Cotta Ramusino
1) Dipartimento di Scienze del Sistema Nervoso e del Comportamento, Università di Pavia. 2) Unità Complessa Neurologia del Comportamento e Centro Disturbi Cognitivi e Demenze (CDCD), Istituto Neurologico Nazionale IRCCS Mondino, Pavia., Italy.

 The chapter of the diagnosis of Alzheimer’s disease (AD), almost unchanged since the early 80’s, has been recognizing over the last years a revival of scientific and clinical  interest, following increasing advances, and currently represents one of the main developing fields of neurological research. In this review we report the most recent evidence in the field, mainly based on the use of neurobiological markers of disease, as well as  the current most debated issues, such as the impact of markers on the diagnostic workup and their incremental diagnostic value with respect to early diagnosis in typical cases and in those characterized by comorbidities or association with brain vascular pathology (mixed forms).

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1.
The diagnosis of Alzheimer’s disease: an update and current controversies. Confinia Cephalal [Internet]. 2022 Dec. 6 [cited 2026 Sep. 8];32(3):e2022023. Available from: https://www.confiniacephalalgica.com/site/article/view/13993

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