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PO-52 | Long-term efficacy of CGRP mAbs: new insights and current evidence Oreste Marsico,1 Marta Lioi,2 Rosario Iannacchero,3 Michele Trimboli3 | 1Department of Neuroscience, “Giovanni Paolo II” Hospital, Lamezia Terme, Catanzaro, Italy; 2Department of Neurology, Magna Graecia University, Catanzaro, Italy; 3Institute of Neurology, AOU Renato Dulbecco, Catanzaro, Italy
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PO-20 | Phenotypic description of a multigenerational family with PRRT2 gene mutation: a case series of six members affected by hemiplegic migraine and paroxysmal events Fabiana Cerulli,1 Costanza Sottani,1 Giulia Di Lazzaro,1,2 Paolo Calabresi,1,2 Anna Rita Bentivoglio,1,2 Catello Vollono1,3 | 1Dipartimento Universitario di Neuroscienze, Università Cattolica del Sacro Cuore, Rome; 2UOC Neurologia, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy; 3Neurofisiopatologia, Dipartimento di Scienze dell'invecchiamento, Neurologiche, Ortopediche e della Testa-Collo, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy
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OC-12 | The potential role of sleep quality in the relationship between glymphatic function and migraine frequency: insights from a cross-sectional study Maria Grazia Vittorini, Raffaele Ornello, Federico Salfi, Antonio Innocenzi, Federico De Santis, Federico Bruno, Francesca Pistoia, Michele Ferrara, Alessandra Splendiani, Simona Sacco | Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, Italy
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PO-72 | Stigma in migraine: preliminary results from the “Studio Emicrania Maugeri” Project Luca Giani, Christian Lunetta | Istituti Clinici Scientifici Maugeri IRCCS, Neurological Rehabilitation Unit of Milano Institute, Milan, Italy
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PO-39 | Leeds Dependence Questionnaire (LDQ) in migraine: diagnostic utility without predictive value for anti-CGRP (R) response Antonio Munafò,1 Andrea Burgalassi,1 Giulia Vigani,2 Francesco De Cesaris,1 Alberto Chiarugi1,2 | 1Headache Center and Clinical Pharmacology Unit, Careggi University Hospital, Florence, Italy; 2Section of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, Florence, Italy
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PO-07 | Psychological management of children treated at the Pediatric Headache Centre of Turin: preliminary analysis Emanuela Serri, Annachiara Lamberti Zanardi, Raffaella Mascolo, Barbara Lauria, Roberta Rossi, Sara Simona Racalbuto, Antonia Versace, Claudia Bondone | Department of Pediatric Emergency, Pediatric Headache Centre, Regina Margherita Children’s Hospital, Turin, Italy
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PO-92 QZU® (Kudzu e.s.: 200 mg of which Isoflavones: 80 mg and Puerarin: 60 mg; ComplexZyme vegan®: 40 mg) in the prophylaxys of migraine without aura: a retrospective observational study Ennio Pucci,1 Ludovica Pucci,2 Alberto Vercesi3 | 1Department of Nervous System and Behavioral Sciences, University of Pavia; 2Nutritional biologist, Master in Nutritional and Clinical Dietetics, University of Pavia, Italy; 3Scientific Advisor
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PO-58 | Pilot protocol to improve the booking and management network for chronic headache in secondary and tertiary care services A. Granato,1 L. Bartole,1 S. Centonze,2 A. Lodi,3 M. Lodi Zollia,3 P. Manganotti1 | 1Clinical Unit of Neurology, Headache Centre, Department of Medicine, Surgery and Health Sciences, ASUGI, University of Trieste, Trieste, Italy; 2Research & Innovation Unit, ASUGI, University of Trieste, Trieste, Italy; 3Funzione Organizzativa, Gestione Offerte Ambulatoriali, ASUGI, University of Trieste, Trieste, Italy
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PO-26 | Optic nerve sheath ultrasound in idiopatic intracranial hypertension: early findings Francesca Cotichelli,1,2 Davide Mascarella1,1,2 Valentina Favoni,1 Gaia Patanè,1,2 Francesco Severi,1,2 Francesca Verna,1,2 Giulia Pierangeli,1,2 Sabina Cevoli1 | 1IRCCS Istituto delle Scienze Neurologiche di Bologna; 2DIBINEM, Department of Biomedical and Neuromotor Science, Alma Mater Studiorum, Bologna, Italy
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OC-18 | Effectiveness of fremanezumab up to 12 months in different subgroups of participants: results from the Italian analysis of the PEARL study Raffaele Ornello,1 Gisella Airola,2 Letizia Curto,3 Diletta Alivernini,4 Chiara Abagnale,5 Pinar Kokturk,6 Yan Tereshko7 | 1Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila; 2Department of Surgical Sciences, Women's Headache Center, University of Turin; 3Neurology Unit, Department of Clinical and Experimental Medicine, University of Pisa; 4Department of Neuroscience, Mental Health and Sensory Organs (NESMOS), Sapienza University of Rome; 5Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino ICOT, Latina, Italy; 6TEVA Pharmaceuticals Europe B.V., Haarlem, The Netherlands; 7Clinical Neurology, Department of Head-Neck and Neuroscience, Azienda Sanitaria Universitaria Friuli Centrale (ASU FC), Udine, Italy
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PO-78 | No changes in blood pressure assessed with the 24-hour Holter monitoring in patients treated with anti-CGRP monoclonal antibodies: a prospective observational study (SAFHYPER) Flavia Lo Castro,1 Niccolò Bonini,2 Luigi Francesco Iannone,1,3 Alberto Boccalini,1 Daria Brovia,1 Luca Pani,1,3 Giuseppe Boriani,2,3 Simona Guerzoni1 | 1Digital and Predictive Medicine, Pharmacology and Clinical Metabolic Toxicology-Headache Center and Drug Abuse-Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico di Modena, Modena, Italy; 2Cardiology Division, AOU Policlinico di Modena, Modena, Italy; 3Department of Biomedical, Metabolic, and Neural Science, University of Modena and Reggio Emilia, Modena, Italy
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PO-45 | Botulinum toxin in clinical practice: a turning point for chronic migraine and MOH Chiara Zilli, Davide Chiffi, Giada Giuliani, Francesca Traccitto, Mariangela Fratino, Marta Altieri | Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy
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PO-13 | HD-EEG Delta connectivity rapidly alters after one month of atogepant in migraine patients Maria Albanese,1,2 Matteo Conti,1 Silvio Bagetta,1 Federico Carparelli,2 Vittoria Carla D’Agostino,2 Fabio Placidi,1,2 Alessandro Stefani,1,2 Nicola Biagio Mercuri,1-3 | 1Department of Systems Medicine, University of Rome Tor Vergata, Rome; 2Neurology Unit, Tor Vergata University Hospital, Rome; 3IRCCS Santa Lucia Foundation, Rome, Italy
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OC-05 | Mid-term effectiveness and tolerability of atogepant in the prevention of migraine: a real life, prospective, multicentric study (the STAR study) Fabrizio Vernieri,1 Luigi Francesco Iannone,2,3 Gabriele Sebastianelli,4 Flavia Lo Castro,2, Federico De Santis,5 Michele Corrado,6 Marilena Marcosano,1 Raffaele Ornello,5 Licia Grazzi,7 Danilo Antonio Montisano,7 Francesco De Cesaris,8 Antonio Munafò,8 Gianluca Avino,9 Michele Trimboli,10 Maria Albanese,11 Antonio Russo,12 Giorgio Dalla Volta,13 Marina Romozzi,14 Paola Merlo,15 Maria Pia Prudenzano,16 Maria Rosaria Valente,17 Innocenzo Rainero,18 Giada Giuliani,19 Luisa Fofi,1 Alberto Doretti,20 Gloria Vaghi,6 Francesca Pistoia,5 Delfina Ferrandi,21 Stefania Battistini,22 Simona Sacco,5 Simona Guerzoni,2 Claudia Altamura1 on behalf of the Italian Headache Registry (RICe) Study Group | 1Fondazione Policlinico Campus Bio-Medico, Roma; 2AOU Policlinico di Modena; 3Università di Modena e Reggio Emilia. 4Sapienza University of Rome Polo Pontino, Latina; 5University of L’Aquila; 6University of Pavia, Pavia, Italy and IRCCS Mondino Foundation, Pavia; 7IRCCS Istituto Neurologico Carlo Besta, Milano; 8AOU Careggi, Firenze; 9SOC Neurologia, Ospedale di Prato, Prato; 10Azienda Ospedaliera-universitaria "Renato Dulbecco", Catanzaro; 11Università Roma Tor Vergata, Roma; 12Università della Campania "Luigi Vanvitelli", Napoli; 13U.O Neurologia, Istituto Clinico Città di Brescia, Gruppo San Donato, Brescia; 14Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma; 15UO di Neurologia, Humanitas Gavazzeni, Bergamo; 16Clinica Neurologica "L. Amaducci", Azienda Ospedaliero-Universitaria Consorziale di Bari; 17Dipartimento di Neuroscienze, Azienda Sanitaria Universitaria Integrata di Udine; 18Dipartimento di Neuroscienze, Città della Salute e della Scienza di Torino; 19Centro per la diagnosi e terapia delle cefalee, Policlinico Umberto I, Roma; 20IRCCS Istituto Auxologico Italiano, Milano; 21AOU Alessandria; 22University of Siena, Siena, Italy
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PO-65 | The complexity of chronic headache: towards tailored therapies through a multidimensional assessment Silvia Favaretto,1 Giulia Demo,2 Veronica Rizzato,2 Elisabetta Patron,2,3,4 Sara Bianconi,2 Stèphanie Maldera,2 Giulia Buodo,2,3 | 1UOC Clinica Neurologica, Azienda Ospedale-Università Padova, Padua, Italy; 2Centro di Ateneo Servizi Clinici Universitari Psicologici (SCUP), University of Padua, Italy; 3Department of General Psychology, University of Padua, Padova, Italy; 4Padua Neuroscience Center (PNC), University of Padua, Padova, Italy
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PO-32 | Post-traumatic painful trigeminal neuropathy (13.1.2.3 - ICHD-3) following misguided gamma knife surgery: a case of diagnostic oversight with lasting consequences Marta Lioi,1 Laura Marino,1 Michele Trimboli2 | 1Department of Neurology, Magna Graecia University, Catanzaro, Italy; 2Institute of Neurology, AOU Renato Dulbecco, Catanzaro, Italy
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OC-24 | A retrospective case-control study aimed at analyzing, through the administration of a questionnaire, the prevalence, clinical features and the risk factors for chronicity in a sample of 419 pediatric patients Alice Bonuccelli, Sara Mundo, Emma Iacopelli, Alessandro Orsini, Lorenza Marini, Diego Peroni | Neuropediatric, Pediatric Clinic, AOU Pisa, Italy
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PO-84 | Inhibiting the peripheral degradation of anandamide reduces trigeminal hyperalgesia in a model of dural neurogenic inflammation via a CB1/CB2-independent mechanism Chiara Demartini,1 Rosaria Greco,1 Miriam Francavilla,1,2 Sara Facchetti,1,2 Cristina Tassorelli1,2 | 1Section of Translational Neurovascular Research, IRCCS Mondino Foundation, Pavia, Italy; 2Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy
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PO-51 | Rimegepant combined with valproic acid and botulinum toxin in refractory hemiplegic migraine: a case report Gianni Difonzo, Cinzia Tamborino, Adriana Fallacara, Damiano Paolicelli, Maria Pia Prudenzano | Headache Center, “L. Amaducci” Neurological Clinic, Policlinico General Hospital, Bari, Italy
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PO-19 | Unraveling the spectrum of migraine resistant to treatments: searching for novel biological PHEnotypes and theRApeutic approaches (SPHERA project) M. Giraudo,1,2 R. De Icco,1,2 G. Vaghi,1,2 V. Grillo,1,2 F. Bighiani,1,2 M. Corrado,2 A. Antoniazzi,1,2 F. Cammarota,1,2 B. Agostini,1,2 A. Solfrizzi,1,2 M. Allena,2 E. Guaschino,2 N. Ghiotto,2 R. Greco,2 C. Demartini,2 A. Zanaboni,1,2 M. Francavilla,1,2 S. Facchetti,1,2 G. Sances,2 C. Tassorelli1,2 | 1Department of Brain and Behavioral Sciences, University of Pavia; 2Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy
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OC-11 | Corneal nerve plexus impairment in patients with trigeminal neuralgia Daniel Litewczuk,1 Gianfranco De Stefano,1 Sabrina Compagno,2 Mattia D’Andrea,2 Ludovico Alisi,2 Marco Marenco,2 Giulia Di Stefano,1 Andrea Truini1 | 1Department of Human Neuroscience, Sapienza University of Rome, 2Department of Sense Organs, Sapienza University of Rome, Italy
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PO-71 | Is Doctor Google retiring? How Generative Artificial Intelligence is transforming the perception and management of headaches Matteo Bellamio,1 Sofia Zywicki,1 Rocco Quatrale,2 Giorgio Zanchin,3 Ferdinando Maggioni,3 Alberto Terrin1 | 1Centro Cefalee dell’Angelo, Neurology, Ospedale dell'Angelo, AULSS3 Serenissima, Mestre (VE), Italy; 2Neurology, Ospedale dell'Angelo, AULSS3 Serenissima, Mestre (VE), Italy; 3Neurology, University of Padua, Padua, Italy
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PO-38 | Impact of atogepant on achieving best possible quality of life among patient global impression of change responders Cristina Tassorelli,1 Pranav Gandhi,2 Molly Duan,2 Karen Carr,2 Kandavadivu Umashankar,2 Jonathan Stokes,2 Grace Forde,3 Tanya Bilchik,4 Martina Martini*, Rashmi Halker Singh5 | 1University of Pavia, Pavia, Italy; 2AbbVie, North Chicago, IL, USA; 3North American Partners in Pain Management, North New Hyde Park, NY, USA; 4Department of Neurology, Yale School of Medicine, New Haven, CT, USA; 5Mayo Clinic, Phoenix, AZ, USA *Abbvie Srl, Rome, Italy.
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PO-06 | Children’s headache through drawings: a narrative review and a portrait gallery Floriana Ferro,1,2 Caterina Gaspari,1,2 Giulia Manfrè,1,2 Federica Cernigliaro,1 Daniela D’Agnano,3 Ruben Panzica,4 Edvige Correnti,2 Maria Rosita Ruta,5 Francesca Marchese,5 Renata Pitino,2 Maria Rita Capizzi,2 Giuseppe Santangelo,2 Antonella Versace,6 Vittorio Sciruicchio,3 Vincenzo Raieli2 | 1Child Neuropsychiatry Unit Department, Pro.MI.S.E. "G. D'Alessandro", University of Palermo; 2Child Neuropsychiatry Department, ISMEP, ARNAS Civico, Palermo; 3Children Epilepsy and EEG Center, San Paolo Hospital, ASL Bari, Bari; 4Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Messina; 5Child Neuropsychiatry Unit, ASP 6, Palermo; 6Pediatric Headache Center, Pediatric Emergency Dept, Regina Margherita Children's Hospital, Turin, Italy
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