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PO-59 | Questioning online survey-based physiotherapy treatment referral in headache treatment: differences in developed and developing countries D. Onan,1,2 A.K. Erdemoğlu,3 P. Gelener,4 S. Velioğlu,5 S. Ulutaş,6 N. Taşdemir,7 M. Waliszewska-Prosół,8 E. Ekizoğlu,9 M. Straburzyński,10 M. Kodounis,11 B. Raffaelli,12 C. Tana,13 F. De Cesaris,14 R. Messina,15 E.I. Sen,16 S. Ray,17 G. Sebastianelli,18 F. Granella,19 U. Pensato,20 S. Crema,21 S. Cevol,22 K. Chakravarty,23 M. Pia Prudenzano,24 A. Casalena,25 M. Romozzi,26 T. Takizawa,26 W. Rattanawong,27 A. Gantenbein,28 V. Favoni,29 C. Gaul,30 L.F.I. Iannone,31 B. Schäfer,23 D.A. Montisano,33 O. Grosu,34 A.B. de Oliveira,35 F. Puledda,36 V. Romanenko,37 I. Ros González,38 M. Castaldo,39 H. Al-Khazali,40 A. Hassan,41 D. Garcia-Azorin,42 L.-L. Hope Pan,43 R. Gil-Gouveia,44 M. Sanchez del Rio,45 M. Lisicki,46 H.W. Schytz,47 P. Anukoolwittaya,48 T. Mavridis,49 M. Lanteri-Minet,50 D.B. Swerts,51 C. Altamura,52 K. Hirata,53 M. Togha,54 M. Kyung Chu,55 T. Pongpitakmetha,56 M.-H. Bjørk,57 M. Minen,58 K. Skorobogatykh,59 D. Chowdhury,60 A.-M. Torgersen Dalgeir,61 J. Versijpt,62 P. Cras,63 A. Govaerts,64 A. Chiarugi,65 N. Vashchenko,59 L. Dobbels,66 T.S. Monteith,67 F. De Bruyne,68 E. Garay,67 S.L. Sava,69 Z. Salinas,67 M. Nordtveit,70 K. Delmotte,71 A. Gonzalez-Martinez,72 S. Debray,73 C. Deligianni,74 W. De Hertogh,75 R. Castien,76 E. Caronna,77 C. Valerija,78 F. Ahmed,79 G. De la Meilleure,80 L.L. Panneerchelvam,81 G.H. Bringeland,82 R. Ornello,2 S. Sacco2 | 1Yozgat Bozok University, Physiotherapy and Rehabilitation, Ankara, Turkey;2University of L'Aquila, Department of Biotechnological and Applied Clinical Sciences, L'Aquila, Italy;3Clinic of Prof. Dr. Ali Kemal Erdemoğlu, Neurology, Ankara, Turkey;4Elite Research and Surgical Hospital , Nicosia, Cyprus;5Karadeniz Technical University, Department of Neurology, Trabzon, Turkey;6Bahcesehir University, Department of Neurology, İstanbul, Turkey;7Ağrı İbrahim Çeçen University, Department of Neurology, Ağrı, Turkey;8Wroclaw Medical University, Wroclaw, Germany;9Istanbul University, Department of Neurology, Istanbul, Turkey;10University of Warmia and Mazury, Olsztyn, Poland;11National & Kapodistrian University of Athens, First Neurology Department, Eginitio Hospital, School of Medicine, Athens, Greece;12Charité Universitätsmedizin Berlin, Department of Neurology,Headache Center, Berlin, Germany;13SS Annunziata Hospital of Chieti, Chieti, Italy;14Centro Cefalee e Farmacologia Clinica - AOU Careggi , Florence, Italy;15Vita-Salute San Raffaele University, Milano, Italy;16Istanbul University Istanbul Faculty of Medicine, Department of Physical Medicine and Rehabilitation, İstanbul, Turkey;17Department of Neurology, PGIMER, Chandigarh, India;18Sapienza University of Rome, Latina, Italy;19University of Parma, Parma, Italy;20Humanitas University, Milan, Italy;21Fleni Hospital, Buenos Aires, Argentina;22University of Bologna, Bologna, Italy;23Post Graduate Institute Of Medical Education and Research, Chandigarh, India;24AOUC Policlinico, Centro Cefalee - Clinica Neurologica L Amaducci, Bari, Germany;25Centro Cefalee UOC Neurologia, Teramo, Italy;26Keio University School of Medicine, Tokyo, Japan;27King Mongkut's Institute of Technology Ladkrabang, Bangkok, Thailand;28ZURZACH Care, Zürich, Switzerland;30IRCCS Istituto delle scienze neurologiche di Bologna, Bologna, Italy;30Headache Center Frankfurt, Frankfurt, Germany;31Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy, Modena, Italy;32Migraine and Headache Clinic Königstein , Frankfurt, Germany;33SSD Centro Cefalee - Fondazione IRCCS Istituto Neurologico C.Besta, Milan, Italy;34Diomid Gherman Institute of Neurology and Neurosurgery, Kişinev, Moldova;35Center for Clinical and Epidemiological Research, University of Sao Paulo , Sao Paolo, Brazil;36King's College London, London, United Kingdom;37Vita Medical Clinic, Kyiv, Ukraine;38Hospital Clínico Universitario de Valladolid, Vallodolid, Spain;39Parma University, Parma, Italy;40Danish Headache Center, Copenhagen, Denmark;41Cairo University , Cairo, Egypt;42University of Valladolid, Valladolid, Spain;43Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan;44Hospital da Luz. Lisboa, Lisboa, Portugal;45Clinica Universidad de Navarra, Navarra, Spain;46Mercedes & Martín Ferreyra Institute for Medical Research, Córdoba, Argentina;47University of Copenhagen, Copenhagen, Denmark;48King Chulalongkorn Memorial Hospital, Bangkok, Thailand;49Tallaght University Hospital, Dublin, Ireland;50CHU Nice and Cote D'azur University, Nice, France;51Santa Casa de Sao Paolo, Sao Paolo, Brazil;52Fondazione Policlinico Universitario Campus BIo-Medico, Rome, Italy;53Dokkyo Medical University, Mibu, Tochigi, Japan;54Tehran University, Tehran, Iran;55Yonsei University, Seoul, South Korea;56Chulalongkorn University, Bangkok, Thailand;57University of Bergen , Bergen, Norway;58NYU Langone Health, New York, United States;59University Headache Clinic, Moscow, Russian Federation;60 G B Pant Institute of Post Graduate Medical Education and Research, New Delhi, India;61Haukeland University Hospital, NorHead, Bergen, Norway;62UZ Brussel, Brussel, Belgium;63Universiteit Antwerpen, Antwerpen, Belgium;64Rz Tienen, Tienen, Belgium;65University of Florence, Florence, Italy;Neurology Department İmelda Ziekenhuis, Bonheiden, Belgium;67University of Miami, Miami, United States;68University College Ghent, Ghent, Belgium;69University of Liège, Liege, Belgium;70Haukeland Universitetssykehus, Bergen, Norway;71Universitair Ziekenhuis Leuven, Leuven, Belgium;72Hospital Universitario de la Princesa e Instituto de Investigación Sanitaria Princesa, Madrid, Spain;73Europa Ziekenhuizen, Brussel, Belgium;74Athens Naval Hospital, Athens, Greece;75University of Antwerp , Antwerpen, Belgium;76Vrije Universiteit Amsterdam, Amsterdam, Netherlands;77Vall d'Hebron Hospital, Barcelona, Spain;78Private hospital, Riga, Latvia;79Hull University, Hull, United Kingdom;80VITAZ - General Hospital, Sint-Niklaas, Belgium;81James Cook University Hospital, Middlesbrough, United Kingdom; 82Haukeland University Hospital, Bergen, Norway
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PO-42 | OnaBotulinumtoxin-A in chronic migraine patients with short or long disease history and psychiatric comorbidities: preliminary data from an Italian multicentric study (the BACH Study) Fabrizio Vernieri,1,2 Marilena Marcosano,2 Licia Grazzi,3 Danilo Antonio Montisano,3 Raffaele Ornello,4 Simona Sacco,4 Chiara Rosignoli,4 Alberto Doretti,5 Maria Albanese,6 Giovanna Viticchi,7 Nicoletta Brunelli, Luigi d’Onofrio,2 Luisa Fofi,1 Claudia Altamura,1,2 Patrizio Pasqualetti8 | 1Fondazione Policlinico Campus Bio-Medico, Roma, Italy; 2Università Campus Bio-Medico di Roma, Italy; 3Istituto Neurologico Besta, Milano, Italy; 4Università degli Studi l’Aquila, Italy; 5Istituto Auxologico, Milano, Italy; 6Policlinico Tor Vergata, Roma, Italy; 7Università Politecnica Marche, Italy; 8Sapienza Università di Roma, Italy
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PO-44 | Effectiveness of fremanezumab as preventive treatment of migraine up to 24 months: response rates from the Italian analysis of the PEARL study Alberto Doretti,1 Anna Ambrosini,2 Simone Braca,3 Florindo D’Onofrio,4 Elisa Maria Piella,5 Pinar Kokturk,6 Rosario Iannacchero7 | 1Department of Neurology-Laboratory of Neuroscience, IRCCS, Istituto Auxologico Italiano, Milan, Italy; 2Mediterranean Neurological Institute NEUROMED IRCCS, Pozzilli (IS), Italy; 3Headache Centre, University of Naples “Federico II”, Naples, Italy; 4UOSD Stroke Unit, S.G. Moscati Hospital, Avellino, Italy; 5Neurosciences Department, University of Turin, Turin, Italy; 6Teva Netherlands B.V., Haarlem, The Netherlands; 7Department of Neurology, Headache Center, Regional Hospital “Pugliese-Ciaccio”, Catanzaro, Italy
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PO-57 | Early treatment with atogepant improves sleep quality without sleep-related adverse events: a prospective observational study Alberto Boccalini,1 Luigi Francesco Iannone,1,2* Flavia Lo Castro,1 Daria Brovia,1 Marina Romozzi,3,4 Fabrizio Vernieri,5,6 Claudia Altamura,5,6 Simona Guerzoni1 | 1Digital and Predictive Medicine, Pharmacology and Clinical Metabolic Toxicology-Headache Center and Drug Abuse-Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico di Modena, Modena, Italy; 2Department of Biomedical, Metabolic, and Neural Science, University of Modena and Reggio Emilia, Modena, Italy; 3Dipartimento Universitario di Neuroscienze, Università Cattolica del Sacro Cuore, Rome, Italy; 4Neurologia, Dipartimento di neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; 5Headache Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy; 6Università Campus Bio-Medico di Roma, Italy
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PO-76 | Atogepant reduces psychological dependence to acute treatments evaluated with the Leeds dependence questionnaire (LDQ): a prospective observational study Luigi Francesco Iannone,1,2 Marina Romozzi,3,4 Alberto Boccalini,1 Flavia Lo Castro,1 Claudia Altamura,5 Fabrizio Vernieri,5 Simona Guerzoni1 | 1Digital and Predictive Medicine, Pharmacology and Clinical Metabolic Toxicology-Headache Center and Drug Abuse-Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico di Modena, Modena, Italy; 2Department of Biomedical, Metabolic, and Neural Science, University of Modena and Reggio Emilia, Modena, Italy; 3Dipartimento Universitario di Neuroscienze, Università Cattolica del Sacro Cuore, Rome, Italy; 4Neurologia, Dipartimento di Neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; 5Headache Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy; 6Università Campus Bio-Medico di Roma, Italy
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PO-53 | Managing chronic primaryhHeadache in Lombardy: insights from the ‘PERLA’ project Grazia Sances,1 Claudia Sulmona,1 Natascia Ghiotto,1 Daniele Martinelli,1 Licia Grazzi,2 Alberto Raggi,2 Danilo Antonio Montisano,2 Matilde Leonardi,2 Giulia Gandini,2 Renata Rao,3 Alessandro Padovani,3 Alessandro Amorosi,5 Cristina Tassorelli,1,5 on behalf of Rete Regionale Cefalee Lombardia | 1Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation Pavia, Italy; 2Headache Center, IRCCS Fondazione Istituto Neurologico Carlo Besta, Milan, Italy; 3ASST Spedali Civili di Brescia, Italy; 4Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy; 5Struttura Reti Clinico-Assistenziali e Organizzative e Ricerca, U.O. Polo Ospedaliero Direzione Generale Welfare, Regione Lombardia, Italy
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PO-50 | Enhanced integration and synergy in EEG- and fNIRS-based networks in migraine patients following three-month galcanezumab treatment: associations with long-term clinical effects Giulia Paparella,1,2 Marianna La Rocca,3 Livio Clemente,1 Emmanuella Ladisa,1 Chiara Abbatantuono,1 Elena Ammendola,1 Marianna Diletta Delussi,4 Katia Ricci,1 Giusy Tancredi,1 Antonio Lacalamita,3 Alfonso Monaco,3 Nicola Amoroso,5 Sebastiano Stramaglia,3 Roberto Bellotti,3 Marina de Tommaso1 | 1Neurophysiopathology Unit, Department of Translational Biomedicine and Neuroscience (DiBraiN), University of Bari Aldo Moro, Bari, Italy; 2IRCCS Neuromed, Pozzilli (IS), Italy; 3Interateneo Department of Physics "M. Merlin", University of Bari Aldo Moro, Bari, Italy; 4Department of Education, Psychology, Communication (For.Psi.Com.), University of Bari Aldo Moro, Bari, Italy; 5Department of Pharmacy–Drug Sciences, University of Bari Aldo Moro, Bari, Italy
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PO-70 | A nomogram for the prediction of response to anti-CGRP mAbs: the CGRP score Marina Romozzi,1 Ammar Lokhandwala,2 Catello Vollono,1 David García-Azorín,3 Giulia Vigani,4 Francesco De Cesaris,4 Claudia Altamura,5 Fabrizio Vernieri,5 Paolo Calabresi,1 Sonia Di Tella,6 Luigi Francesco Iannone7 1Dipartimento Universitario di Neuroscienze, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; 2Drexel University, Philadelphia, PA, USA; 3Hospital Universitario del Río Hortega, Valladolid, Headache Unit, Department of Neurology, Valladolid, Spain; 4Section of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, Florence, Italy; 5 Neurologia, Dipartimento di Medicina e Chirurgia, Università Campus Bio-Medico di Roma, Rome, Italy; 6Dipartimento di Psicologia, Università Cattolica del Sacro Cuore, Milan, Italy; 7Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
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PO-86 | CGRP, VIP and PACAP plasmatic levels in migraine patients before and after anti-CGRP(R) monoclonal antibodies prophylaxis Alessia Bellotti,1 Davide Chiasserini,2 Alfredo Megaro,2 Daniela Fruttini,3 Pierluigi Navarra,4 Giuseppe Tringali,4 Paolo Calabresi,5 Lucilla Parnetti,1 Paola Sarchielli1 | 1Department of Medicine and Surgery, Section of Neurology, University of Perugia, Perugia, Italy; 2Department of Medicine and Surgery, Section of Physiology and Biochemistry, University of Perugia, Perugia, Italy; 3Department of Medicine and Surgery, Section of Internal Medicine, University of Perugia, Perugia, Italy; 4Department of Healthcare Surveillance and Bioethics, Section of Pharmacology, Catholic University Medical School, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy; 5Department of Medicine and Surgery, Section of Neurology, Catholic University Medical School, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy
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PO-74 | Effectiveness of auricular acupuncture in the management of menstrual migraine: a pilot study Sergio Sorrenti,1,2 Matteo Ciuffreda,1 Emanuele Pisello,1 Luca Brugiaferri,2 Azzurra Federici,2 Cristiano Piangatelli,3 Dario Galante4 | 1U.O.C. Anestesia Rianimazione Terapia del Dolore, AST Ancona, Fabriano (AN), Italy; 2Scuola di Specializzazione in Anestesia Rianimazione, Terapia Intensiva e del Dolore, UNIVPM, Ancona, Italy; 3Direttore U.O.C. Anestesia Rianimazione Terapia del Dolore, AST Ancona, Fabriano (AN), Italy; 4Direttore U.O.C. Anestesia e Rianimazione, Cerignola (FG), Italy
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PO-47 | Systemic ozone treatment in chronic migraine: a focus on disability reduction and medication use Sergio Sorrenti,1,2 Matteo Ciuffreda,1 Emanuele Pisello,1 Luca Brugiaferri,2 Azzurra Federici,2 Cristiano Piangatelli,3 Dario Galante4 | 1U.O.C. Anestesia Rianimazione Terapia del Dolore, AST Ancona, Fabriano (AN), Italy; 2Scuola di Specializzazione in Anestesia Rianimazione, Terapia Intensiva e del Dolore, UNIVPM, Ancona, Italy; 3Direttore U.O.C. Anestesia Rianimazione Terapia del Dolore, AST Ancona, Fabriano (AN), Italy; 4Direttore U.O.C. Anestesia e Rianimazione, Cerignola (FG), Italy
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PO-73 | Auricular acupuncture as a complementary treatment for tension-type headache in women: a prospective study on efficacy and safety Sergio Sorrenti,1,2 Matteo Ciuffreda,1 Emanuele Pisello,1 Luca Brugiaferri,2 Azzurra Federici,2 Cristiano Piangatelli,3 Dario Galante4 | 1U.O.C. Anestesia Rianimazione Terapia del Dolore, AST Ancona, Fabriano (AN), Italy; 2Scuola di Specializzazione in Anestesia Rianimazione, Terapia Intensiva e del Dolore, UNIVPM, Ancona, Italy; 3Direttore U.O.C. Anestesia Rianimazione Terapia del Dolore, AST Ancona, Fabriano (AN), Italy; 4Direttore U.O.C. Anestesia e Rianimazione, Cerignola (FG), Italy
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PO-46 | Diagnostic tests and headache misdiagnoses in individuals with resistant and refractory migraine – data from the REFINE study Federico De Santis,1 Chiara Rosignoli,1 Agnese Onofri,1 Mark Braschinsky,2 Olga Sved,2 Raquel Gil-Gouveia,3,4 Renato Oliveira,3 Christian Lampl,5 Jakob Paungarttner,5 Paolo Martelletti,6 William David Wells-Gatnik,7 Isabel Pavao Martins,8 Dimos D Mitsikostas,9 Loukia Apostolakopoulou,9 Aynur Ozge,10 Dilan Bayar Narin,10 Patricia Pozo-Rosich,11 Albert Munoz-Vendrell,11 Maria Pia Prudenzano,12 Martino Gentile,12 Kristina Ryliskiene,13 Jurgita Vainauskiene,14 Margarita Sanchez-del-Rio,15 Fabrizio Vernieri,16 Gianmarco Iaccarino,16 Marta Waliszewska-Prosół,17 Sławomir Budrewicz,17 Marta Carnovali,18 Zaza Katsarava,18 Simona Sacco,1 Raffaele Ornello1 | 1Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy; 2Department of Neurology and Neurosurgery, Institute of Clinical Medicine, Faculty of Medicine, University of Tartu and Neurology Clinic of Tartu University Hospital, Tartu, Estonia; 3Headache Center, Neurology Department, Hospital da Luz, Lisboa, Portugal; 4Center for Interdisciplinary Research in Health, Universidade Católica Portuguesa, Lisboa; 5Headache Medical Center, Seilerstaette Linz, Linz, Austria; 6Unitelma Sapienza University of Rome, Italy; 7Texas Tech University Health Sciences Center, El Paso TX, USA; 8Centro de Estudos Egas Moniz, Faculty of Medicine, University of Lisbon, Lisbon, Portugal; 9First Department of Neurology, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece; 10Department of Neurology, Mersin University Medical Faculty, Mersin, Turkey and NOROM Neuroscience and Neurotechnology Center of Excellence, Ankara, Turkey; 11Headache Unit, Neurology Department, Vall d’Hebron University Hospital, Headache and Neurological Pain Research Group, VHIR, Barcelona, Spain; 12Headache Center, “I. Amaducci” Neurological Clinic, Policlinico General Hospital, Bari, Italy; 13Center of Neurology, Vilnius University, Vilnius, Lithuania; 14Center of Neurology, Kardiolitos klinikos, Vilnius, Lithuania; 15Department of Neurology, Clínica Universidad de Navarra, Madrid, Spain; 16Unit of Headache and Neurosonology, Fondazione Policlinico Campus Bio-Medico and Neurology, Università Campus Bio-Medico di Roma, Roma, Italy; 17Department of Neurology, Wroclaw Medical University, Wrocław, Poland; 18Department of Neurology, Christian Hospital Unna and University of Duisburg-Essen, Ruhr Metropolitan, Germany
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PO-66 | Predicting the evolution to resistant and refractory migraine: a machine learning analysis from the REFINE Study Chiara Rosignoli,1 Raffaele Ornello,1 Daniele Lozzi,2 Enrico Mattei,2 Federico De Santis,1 Agnese Onofri,1 Mark Braschinsky,3 Christian Lampl,4 Isabel Pavão Martins,5 Paolo Martelletti,6 Dimos Mitsikostas,7 Raquel Gil-Gouveia,8 Maria Pia Prudenzano,9 Kristina Ryliskiene,10 Margarita Sanchez del Rio,11 Patricia Pozo-Rosich,12 Aynur Özge,13 Fabrizio Vernieri,14 Marta Waliszewska-Prosół,15 Zaza Katsarava,16 Giuseppe Placidi,2 Simona Sacco1 | 1Dept. of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy; 2A²VI-lab, Dept. MeSVA University of L’Aquila; 3Dept. of Neurology and Neurosurgery, Institute of Clinical Medicine, Faculty of Medicine, University of Tartu, Estonia; 4Headache Medical Center, Seilerstaette Linz, Austria. Center; 5Headache Center, Hospital da Luz, Lisbon, Portugal; 6School of Health, Unitelma Sapienza University of Rome, Italy; 7First Dept of Neurology, Aeginition Hospital, National and Kapodistrian University of Athens, Greece; 8Centro de Estudos Egas Moniz, Faculty of Medicine, University of Lisbon, Portugal; 9Headache Center, Amaducci Neurological Clinic, Policlinico General Hospital, Bari, Italy; 10Center of Neurology, Vilnius University, Lithuania; 11Dept. of Neurology, Clínica Universidad de Navarra, Madrid, Spain; 12Neurology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain; 13Dept. of Neurology, Mersin University Medical Faculty, Mersin, Turkey; 14Università Policlinico Campus Bio-Medico, Rome, Italy; 15Dept. of Neurology, Wroclaw Medical University, Wrocław, Poland; 16Dept of Neurology, Christian Hospital Unna and University of Duisburg-Essen, Ruhr Metropolitan, Germany
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PO-65 | The complexity of chronic headache: towards tailored therapies through a multidimensional assessment Silvia Favaretto,1 Giulia Demo,2 Veronica Rizzato,2 Elisabetta Patron,2,3,4 Sara Bianconi,2 Stèphanie Maldera,2 Giulia Buodo,2,3 | 1UOC Clinica Neurologica, Azienda Ospedale-Università Padova, Padua, Italy; 2Centro di Ateneo Servizi Clinici Universitari Psicologici (SCUP), University of Padua, Italy; 3Department of General Psychology, University of Padua, Padova, Italy; 4Padua Neuroscience Center (PNC), University of Padua, Padova, Italy
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PO-58 | Pilot protocol to improve the booking and management network for chronic headache in secondary and tertiary care services A. Granato,1 L. Bartole,1 S. Centonze,2 A. Lodi,3 M. Lodi Zollia,3 P. Manganotti1 | 1Clinical Unit of Neurology, Headache Centre, Department of Medicine, Surgery and Health Sciences, ASUGI, University of Trieste, Trieste, Italy; 2Research & Innovation Unit, ASUGI, University of Trieste, Trieste, Italy; 3Funzione Organizzativa, Gestione Offerte Ambulatoriali, ASUGI, University of Trieste, Trieste, Italy
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PO-83 | Serum diamine oxidase activity in patients with cluster headache: a cross-sectional case–control study Silvia Boschi,1 Elisa Maria Piella,1 Tilde Manetta,3 Paola Merlach,3 Alberto Mario Chiarandon,1 Alessia Agostinelli,1 Barbara Donati Morello,3 Giulio Mengozzi,3 Innocenzo Rainero,1,2 Elisa Rubino,1,2 | 1Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Turin, Italy; 2Headache Center, Department of Neuroscience and Mental Health, AOU Città della Salute e della Scienza di Torino, Turin, Italy; 3Department of Laboratory Medicine, Città della Salute e della Scienza University Hospital, Turin, Italy
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OC-22 | Beyond headache: prevalence of atopy and other comorbidities in pediatric patients Erica Agosto,1 Alessandra Fera,1 Giulia Grasso,2 Barbara Lauria,2 Roberta Rossi,2 Cristina Vassia,2 Emanuele Castagno,2 Antonia Versace2 | 1Department of Public Health and Pediatrics, Postgraduate School of Pediatrics, University of Turin; 2Department of Pediatric Emergency, Pediatric Headache Centre, Regina Margherita Children’s Hospital, Turin, Italy
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PO-82 | Integrated approach with detoxification, CGRP monoclonal antibodies and psychoeducational support in two patients with complex medication overuse headache Claudia Lanni,1 Federica Papini,2 Chiara Prevost,3 Alessandro Canessa,3 Lucia Testa,3 Cristoforo Comi,2 Delfina Ferrandi3 | 1Department of Psychology “Santi Antonio e Biagio”, University Hospital, Alessandria, Italy; 2Neurology Unit, Department of Transitional Medicine, University of Piemonte Orientale, and University Hospital “Maggiore della Carità”, Novara, Italy; 3Neurology Unit, “Santi Antonio e Biagio” University Hospital, Alessandria, Italy
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PO-61 | Social cognition in interictal episodic and chronic migraine: a cross-sectional study Chiara Abbatantuono,1* Delussi Marianna,2* Clemente Livio,1 Giulia Paparella,1 Stefania Scannicchio,1 Annalisa Di Dio,1 Elena Ammendola,1 Giusy Tancredi,1 Emmanuella Ladisa,1 Giulia Paparella,1,3 Marina de Tommaso1 (*Equally Contributed) | 1Neurophysiopathology Unit, Department of Translational Biomedicine and Neuroscience (DiBraiN), University of Bari Aldo Moro (IT), Bari, Italy; 2Department of Education, Psychology, Communication (For.Psi.Com.), University of Bari Aldo Moro (IT), Bari, Italy; 3IRCCS Neuromed Pozzilli (IS), Italy
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PO-67 | Investigating plasma neurofilament light chain levels in patients with migraine: a cross-sectional study Elisa Maria Piella,1 Alberto Mario Chiarandon,1 Silvia Boschi,1 Fausto Roveta,1 Lucrezia Bonino,1 Giulia Gioiello,2 Giulia Montesano,2 Giulio Mengozzi,2 Innocenzo Rainero,1,3 Elisa Rubino1,3 | 1Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Turin, Italy; 2Clinical Biochemistry Laboratory “Baldi e Riberi”, A.O.U. Città della Salute e della Scienza di Torino, Turin, Italy; 3Headache Center, Department of Neuroscience and Mental Health, AOU Città della Salute e della Scienza di Torino, Turin, Italy
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PO-79 | Survey on adherence and tolerability of atogepant used as migraine preventive treatment D.A. Montisano,1 G. Vaghi,2,3 A. Paris,1 R. De Icco,2,3 B. Agostini,2,3 M. Giraudo,2,3 A. Solfrizzi,2,3 C. Tassorelli,2,3 G. Sances,3 L. Grazzi | 1Fondazione IRCCS C.Besta Istituto Neurologico, SSD Headache Center, Milan, Italy; 2University of Pavia, Department of Brain and Behavioral Sciences, Pavia, Italy; 3IRCCS Mondino Foundation, Headache Science & Neurorehabilitation Unit, Pavia, Italy
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PO-01 | Pediatric nummular headaches: a case series and physiopathological and nosography considerations Carola Meo¹*, Sofia D’Agostino¹*, Antonella Morea²*, Martina Tarantini²*, Giuseppe Giglia³, Maria Rosita Ruta⁴, Edvige Correnti⁵, Daniela D’Agnano², Giuseppe Santangelo⁵, Vittorio Sciruicchio², Vincenzo Raieli⁵ (*These authors contributed equally) | 1Child Neuropsychiatry Unit Department, Pro.M.I.S.E. "G. D'Alessandro", University of Palermo, Palermo, Italy; 2Children Epilepsy and EEG Center, San Paolo Hospital, ASL Bari, Bari, Italy; 3Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), Section of Human Physiology, University of Palermo, Palermo; 4Child Neuropsychiatry Unit, ASP 6, Palermo; 5Child Neuropsychiatry Department, ISMEP, ARNAS Civico, Palermo, Italy
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PO-52 | Long-term efficacy of CGRP mAbs: new insights and current evidence Oreste Marsico,1 Marta Lioi,2 Rosario Iannacchero,3 Michele Trimboli3 | 1Department of Neuroscience, “Giovanni Paolo II” Hospital, Lamezia Terme, Catanzaro, Italy; 2Department of Neurology, Magna Graecia University, Catanzaro, Italy; 3Institute of Neurology, AOU Renato Dulbecco, Catanzaro, Italy
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PO-78 | No changes in blood pressure assessed with the 24-hour Holter monitoring in patients treated with anti-CGRP monoclonal antibodies: a prospective observational study (SAFHYPER) Flavia Lo Castro,1 Niccolò Bonini,2 Luigi Francesco Iannone,1,3 Alberto Boccalini,1 Daria Brovia,1 Luca Pani,1,3 Giuseppe Boriani,2,3 Simona Guerzoni1 | 1Digital and Predictive Medicine, Pharmacology and Clinical Metabolic Toxicology-Headache Center and Drug Abuse-Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico di Modena, Modena, Italy; 2Cardiology Division, AOU Policlinico di Modena, Modena, Italy; 3Department of Biomedical, Metabolic, and Neural Science, University of Modena and Reggio Emilia, Modena, Italy
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PO-71 | Is Doctor Google retiring? How Generative Artificial Intelligence is transforming the perception and management of headaches Matteo Bellamio,1 Sofia Zywicki,1 Rocco Quatrale,2 Giorgio Zanchin,3 Ferdinando Maggioni,3 Alberto Terrin1 | 1Centro Cefalee dell’Angelo, Neurology, Ospedale dell'Angelo, AULSS3 Serenissima, Mestre (VE), Italy; 2Neurology, Ospedale dell'Angelo, AULSS3 Serenissima, Mestre (VE), Italy; 3Neurology, University of Padua, Padua, Italy
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OC-04 | The chronopharmacology of atogepant in migraine prevention: a real-world evaluation of influence of timing of administration on effectiveness and tolerability Luigi Francesco Iannone,1,2 Gabriele Sebastianelli,3 Flavia Lo Castro,2 Federico De Santis,4 Michele Corrado,5 Marilena Marcosano,6,7 Raffaele Ornello,4 Licia Grazzi,8 Danilo Antonio Montisano,8 Francesco De Cesaris,9 Antonio Munafò,9 Gianluca Avino,10 Michele Trimboli,11 Maria Albanese,12 Antonio Russo,13 Giorgio Dalla Volta,14 Marina Romozzi,15 Paola Merlo,16 Luisa Fofi,6,7 Alberto Doretti,17 Gloria Vaghi,5 Francesca Pistoia,4 Delfina Ferrandi,18 Stefania Battistini,19 Gianluca Coppola,3 Simona Sacco,4 Simona Guerzoni,2 Claudia Altamura,6,7 Fabrizio Vernieri,6,7 On behalf of the Italian Headache Registry (RICe) Study Group | 1Department of Biomedical, Metabolic, and Neural Science, University of Modena and Reggio Emilia; 2Pharmacology and Clinical Metabolic Toxicology-Headache Center and Drug Abuse-Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico di Modena; 3Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino, Latina; 4Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila; 5Department of Brain and Behavioral Sciences, University of Pavia; Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia; 6Headache Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Roma; 7Neurology Unit, Università Campus Bio-Medico di Roma; 8Neuroalgology Unit and Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan; 9Headache center and Clinical Pharmacology, AOU Careggi, Florence; 10SOC Neurologia, Ospedale di Prato; 11Azienda Ospedaliera-universitaria "Renato Dulbecco", Catanzaro; 12Università Roma Tor Vergata, Roma; 13Università della Campania "Luigi Vanvitelli", Napoli; 14U.O Neurologia, Istituto Clinico Città di Brescia, Gruppo San Donato, Brescia; 15Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy; 16UO di Neurologia, Humanitas Gavazzeni, Bergamo; 17Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milano; 18Neurology Department, Azienda Ospedaliero Universitaria, Santi Antonio e Biagio e Cesare Arrigo, Alessandria; 19Department of Medical, Surgical and Neurological Sciences, University of Siena, Italy
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OC-23 | The REPICEF Project: a school-based epidemiological study on primary headaches in children and adolescents Agnese Onofri,1 Chiara Rosignoli,1 Vittorio Trozzi,1 Martina D’Ambrosio,1 Benedetta Germani,1 Roberta Ciuffini,2 Raffaele Ornello,1 Simona Sacco1 | 1Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila; 2Department of Clinical Medicine, Public health, Life and Environmental Sciences University of L’Aquila, Italy
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PO-05 | Validation of the Italian version of the HARDSHIP Questionnaire in a school-based population Agnese Onofri,1 Chiara Rosignoli,1 Vittorio Trozzi,1 Martina D’Ambrosio,1 Benedetta Germani,1 Roberta Ciuffini,2 Raffaele Ornello,1 Simona Sacco1 | 1Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila; 2Department of Clinical Medicine, Public health, Life and Environmental Sciences, University of L’Aquila, Italy
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PO-24 | Inflammatory signatures of comorbid episodic migraine and endometriosis: a cytokine-based analysis Maria Albanese,1,2 Veronica Ceci,3,4 Giulia Carrera,4,5 Aikaterini Selntigia,6 Caterina Exacoustos,6 Marta Tiberi,4 Stefano Saracini,3,4 Alessandro Matteocci,4,7 Nicola Biagio Mercuri,1,2,8 Valerio Chiurchiù3,4 | 1Department of Systems Medicine, University of Rome Tor Vergata, Rome; 2Regional Referral Headache Center, Neurology Unit, Tor Vergata University Hospital, Rome; 3Institute of Translational Pharmacology, National Research Council of Italy (CNR), Rome; 4Laboratory of Resolution of Neuroinflammation, IRCCS Santa Lucia Foundation, Rome; 5PhD Program in Neuroscience, Department of Systems Medicine, University of Rome Tor Vergata, Rome; 6Department of Surgical Sciences, Gynecological Unit, University of Rome Tor Vergata, Rome; 7PhD program in Immunology, Molecular Medicine and Applied biotechnologies, University of Rome Tor Vergata, Rome; 9Laboratory of Experimental Neuroscience, IRCCS Santa Lucia Foundation, Rome, Italy
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PO-69 | Three-month atogepant treatment modulates dopaminergic-related functional connectivity in episodic migraine Davide Fedeli,1 Danilo Antonio Montisano,1 Greta Demichelis,1 Giuseppe Ciullo,1,2 Jean Paul Medina Carrion,1 Maria Grazia Bruzzone,1 Emilio Ciusani,1 Alessandra Erbetta,1 Marina Grisoli,1 Erika Guastafierro,1 Domenico D’Amico,1 Alberto Raggi,1 Anna Nigri,1 Licia Grazzi1 | 1Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy; 2University of Parma, Parma, Italy
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PO-62 | Preventive migraine treatment in patients under 25: a 24-month observational study on adherence, therapeutic switching, and prescription determinant factors Marilena Marcosano,1 Nicoletta Brunelli,1 Luisa Fofi,1 Laura Papetti,2 Fabiana Ursitti,2 Massimiliano Valeriani,2 Fabrizio Vernieri,1 Claudia Altamura1 | 1Headache and Neurosonology Unit, Fondazione Policlinico Campus Biomedico di Rome, Rome, Italy; 2Developmental Neurology, Bambino Gesù Children Hospital, IRCCS, Rome, Italy
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OC-21 | Coping and pain catastrophizing in migraine patients and their mothers: a comparison between mothers with and without migraine Martina Proietti Checchi,1 Samuela Tarantino,1 Fabiana Ursitti,1 Giorgia Sforza,1 Gabriele Monte,1 Alessandro Borrelli,1 Massimiliano Valeriani,1,2,3 Laura Papetti1 | 1Developmental Neurology, Bambino Gesù Children Hospital, IRCCS, Rome, Italy; 2Child Neurology and Psychiatry Unit, Tor Vergata University of Rome, Italy; 3Translational Pain Neuroscience and Precision Medicine, CNAP, Dept. of Health Science and Technology, School of Medicine, Aalborg University, Denmark
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PO-81 | Knowledge and misconceptions on headache disorders among healthcare workers: preliminary results from the Studio Emicrania Maugeri Study Luca Giani, Christian Lunetta | Istituti Clinici Scientifici Maugeri IRCCS, Neurological Rehabilitation Unit of Milano Institute, Milan, Italy
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PO-48 | Flunarizine for preventive treatment of hemiplegic migraine during pregnancy: a case report Andrea Burgalassi,1 Antonio Munafò,2 Francesco De Cesaris,1 Giulia Vigani,2 Alberto Chiarugi1,2 | 1Headache Center and Clinical Pharmacology Unit, Careggi University Hospital, Florence, Italy; 2Section of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, Florence, Italy
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PO-03 | Intracranial incidental findings on brain magnetic resonance imaging (MRI) in a pediatric population with primary headache: our experience and management Fabiana Ursitti,1 Filippo Tripodi,1 Laura Papetti,1 Giorgia Sforza,1 Gabriele Monte,1 Alessandro Borrelli,1 Samuela Tarantino,1 Martina Proietti Checchi,1 Massimiliano Valeriani1-3 | 1Developmental Neurology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy; 2Child Neurology Unit, Systems Medicine Department, Tor Vergata University Hospital of Rome, Rome, Italy; 3Translational Pain Neuroscience and Precision Medicine, CNAP, Department of Health Science and Technology, School of Medicine, Aalborg University, Aalborg, Denmark
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PO-41 | Eptinezumab for difficult-to-treat migraine: who responds and who needs more Alessandro Visentini,1,2,3 Roberta Messina,1,2,3 Ilaria Cetta,1,2,3 Edorardo Ratto,1 Laura Zanandrea,1,3 Federica Genovese,1,2,3 Irene Chinali,1 Bruno Colombo,1 Massimo Filippi1,2,3 | 1Neurology Unit and 2Neuroimaging Research Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy; 3Vita-Salute San Raffaele University, Milan, Italy
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PO-80 | Real-world effectiveness of atogepant for the preventive treatment of migraine in a cohort of multi -refractory patients: a single center study M. De Luca,1 L. Ferraù,1 A. Cafarchio,2 M.S. Adragna,1 M. Autunno1 | 1Unit of Neurology and Neuromuscular Diseases, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy; 2Department of Medicine and Health Sciences “Vincenzo Tibero” DIMES, University of Molise, Campobasso, Italy
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PO-02 | Migraine in youth: a double challenge to cognition and emotion Samuela Tarantino,1 Martina Proietti Checchi,1 Laura Papetti,1 Fabiana Ursitti,1 Gabriele Monte,1 Giorgia Sforza,1 Massimiliano Valeriani,1-3 | 1Developmental Neurology Unit, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy; 2Systems Medicine Department, Tor Vergata University of Rome, Rome, Italy; 3Translational Pain Neuroscience and Precision Medicine, CNAP, Dept. of Health Science and Technology, School of Medicine, Aalborg University, Denmark
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PO-21 | Evaluating the impact of anti-CGRP monoclonal antibodies on retinal features in migraine patients: a retrospective optical coherence tomography study Chiara Serafini,1 Massimo Cesareo,2 Alessio Martucci,2 Marco Lombardo,2 Vittoria Carla D’Agostino,1 Alessandro Stefani,3 Carlo Nucci,2 Nicola Biagio Mercuri,1,3 Maria Albanese1,3 | 1Regional Referral Headache Center, Neurology Unit, Tor Vergata University Hospital, Rome, Italy 2Ophthalmology Unit, Department of Experimental Medicine, University of Rome “Tor Vergata”, Rome; 3Department of Systems Medicine, University of Rome “Tor Vergata”, Rome, Italy
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PO-40 | Evaluating agreement between physician and ChatGPT in migraine prophylaxis selection: a pilot comparative study Simone Vigneri1, MatteoZanella2, Gianfranco Sindaco2, Alberto Merlin2, Maria Mazzullo2, Marco La Grua2, Valentina Paci2, Carmen Bertone2, Gilberto Pari2 1Santa Maria Maddalena Hospital, Neurology, Occhiobello, Italy; 2Santa Maria Maddalena Hospital, Pain Medicine, Occhiobello, Italy
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PO-60 | Effectiveness of aerobic exercise, Mulligan technique, and myofascial release in migraine management: preliminary data from a randomized controlled trial Marco Bravi,1,2 Fabio Santacaterina,1,2 Federica Bressi,1,2 Francesca Nasto,1,2 Claudia Altamura,1,2 Fabrizio Vernieri1,2 | 1Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Rome, Italy; 2Università Campus Bio-Medico di Roma, Rome, Italy
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