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  Normative values of the nociceptive blink reflex habituation

  Michele Corrado, Elena Mazzotta, Gloria Vaghi, Francescantonio Cammarota, Federico Bighiani, Alessandro Antoniazzi, Daniele Martinelli, Maria Magdalena Pocora, Luca Martinis, Valentina Grillo, Sara Bottiroli, Armando Perrotta, Giuseppe Cosentino, Grazia Sances, Cristina Tassorelli, Roberto De Icco

  07-05-2024

  DOI https://doi.org/10.4081/cc.2024.15730

  • 2,902 abstract views
  • 641 PDF
  • 258 SUPPLEMENTARY MATERIAL

• OC09 | TOBACCO/NICOTINE-RELATED HEADACHE AS A CANDIDATE PHENOTYPE FOR ICHD-4: INSIGHTS FROM THE JASTIS STUDY, A JAPANESE CROSS-SECTIONAL ANALYSIS

  M. Katsuki^1|2, M. Romozzi^3|4, Y. Matsumori⁵, K. Moran², T. Ward², T. Tabuchi⁷ | ¹Nagaoka University of Technology, Japan; ²Insight Research Ireland Centre for Data Analytics, Ireland; ³Università Cattolica del Sacro Cuore, Italy; ⁴Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Italy; ⁵Sendai Headache and Neurology Clinic, Japan; ⁶Tohoku University, Japan

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.15947

  • 53 abstract views
  • 0 PDF

• Cyclic migraine. From pathophysiological understanding to therapeutic opportunities in patients with migraine attacks showing predictable periodicity

  Michele Viana, Giuseppe Nappi

  05-07-2016 Pages 26-29

  • 350 abstract views
  • 205 PDF (Italian)

• Drug resistance to triptans: a problem for thousands of people in Italy

  Sarah Cargnin, Salvatore Terrazzino, Ennio Pucci, Michele Viana

  05-07-2016 Pages 30-34

  • 1,024 abstract views
  • 4,209 PDF (Italian)

• PO-68 | Bipolar disorder spectrum and psychopathology in cluster headache compared to migraine: a cross-sectional study in a hospital headache clinic

  Isabella Getuli, Giada Giuliani, Chiara Zilli, Simone Preti, Gaia Chiecchi, Lorenzo Tarsitani, Marta Altieri | Dipartimento di Neuroscienze Umane, Sapienza Università di Roma, Italy

  Società Italiana per lo Studio delle Cefalee (SISC)

  06-11-2025

  DOI https://doi.org/10.4081/cc.2025.15891

  • 707 abstract views

• PO-07 | Psychological management of children treated at the Pediatric Headache Centre of Turin: preliminary analysis

  Emanuela Serri, Annachiara Lamberti Zanardi, Raffaella Mascolo, Barbara Lauria, Roberta Rossi, Sara Simona Racalbuto, Antonia Versace, Claudia Bondone | Department of Pediatric Emergency, Pediatric Headache Centre, Regina Margherita Children’s Hospital, Turin, Italy

  Società Italiana per lo Studio delle Cefalee (SISC)

  06-11-2025

  DOI https://doi.org/10.4081/cc.2025.15828

  • 429 abstract views

• P110 | IMPACT OF THE NORTH-EAST ITALIAN CHRONIC HEADACHE PROJECT ON WORKPLACE DISABILITY AND WORK PRODUCTIVITY IN PATIENTS TREATED WITH ATOGEPANT

  A. Granato¹, L. Bartole¹, C. Gonella¹, E. Fusco¹, M. Bonetti², A. Lodi³, A. Benussi¹ | ¹Clinical Unit of Neurology, Headache Centre, Department of Medicine, Surgery and Health Sciences, University of Trieste, Italy; ²DAD Area Giuliana, S.C. Distretto Trieste 1 e 2, ASUGI, University of Trieste, Italy; ³Funzione Organizzativa, Gestione Offerte Ambulatoriali, ASUGI, University of Trieste, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.16066

  • 17 abstract views
  • 0 PDF

• PO-03 | Intracranial incidental findings on brain magnetic resonance imaging (MRI) in a pediatric population with primary headache: our experience and management

  Fabiana Ursitti,¹ Filippo Tripodi,¹ Laura Papetti,¹ Giorgia Sforza,¹ Gabriele Monte,¹ Alessandro Borrelli,¹ Samuela Tarantino,¹ Martina Proietti Checchi,¹ Massimiliano Valeriani^1-3 | ¹Developmental Neurology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy; ²Child Neurology Unit, Systems Medicine Department, Tor Vergata University Hospital of Rome, Rome, Italy; ³Translational Pain Neuroscience and Precision Medicine, CNAP, Department of Health Science and Technology, School of Medicine, Aalborg University, Aalborg, Denmark

  Società Italiana per lo Studio delle Cefalee (SISC)

  06-11-2025

  DOI https://doi.org/10.4081/cc.2025.15824

  • 604 abstract views

• P095 | CLINICAL PREDICTORS OF SECONDARY HEADACHE IN THE EMERGENCY DEPARTMENT: AN EXPLORATORY MODEL OF A FOUR-VARIABLE BEDSIDE MODEL IN THE EMERGENCY DEPARTMENT

  V. Portera, P. Alonge, L. Baiamonte, A. Barresi, A. Calì, F. D'amico, A. Fiorentino, G. Giannetto, E. Lo Mauro, V. Di Stefano, C. Camarda, F. Brighina | Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), University of Palermo, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.16051

  • 18 abstract views
  • 0 PDF

• PO-58 | Pilot protocol to improve the booking and management network for chronic headache in secondary and tertiary care services

  A. Granato,¹ L. Bartole,¹ S. Centonze,² A. Lodi,³ M. Lodi Zollia,³ P. Manganotti¹ | ¹Clinical Unit of Neurology, Headache Centre, Department of Medicine, Surgery and Health Sciences, ASUGI, University of Trieste, Trieste, Italy; ²Research & Innovation Unit, ASUGI, University of Trieste, Trieste, Italy; ³Funzione Organizzativa, Gestione Offerte Ambulatoriali, ASUGI, University of Trieste, Trieste, Italy

  Società Italiana per lo Studio delle Cefalee (SISC)

  06-11-2025

  DOI https://doi.org/10.4081/cc.2025.15881

  • 273 abstract views

• OC-22 | Beyond headache: prevalence of atopy and other comorbidities in pediatric patients

  Erica Agosto,¹ Alessandra Fera,¹ Giulia Grasso,² Barbara Lauria,² Roberta Rossi,² Cristina Vassia,² Emanuele Castagno,² Antonia Versace² | ¹Department of Public Health and Pediatrics, Postgraduate School of Pediatrics, University of Turin; ²Department of Pediatric Emergency, Pediatric Headache Centre, Regina Margherita Children’s Hospital, Turin, Italy

  Società Italiana per lo Studio delle Cefalee (SISC)

  06-11-2025

  DOI https://doi.org/10.4081/cc.2025.15819

  • 340 abstract views
• 

  Efficacy and safety of greater occipital nerve block with a small volume of lidocaine and methylprednisolone in tertiary headache center

  Chiara Rosignoli, Agnese Onofri, Federico De Santis, Simona Sacco, Raffaele Ornello

  09-07-2024

  DOI https://doi.org/10.4081/cc.2024.15770

  • 5,157 abstract views
  • 687 PDF

• OC12 | HEADACHE-ATTRIBUTED BURDEN IN ITALIAN CHILDREN AND ADOLESCENTS: FINDINGS FROM THE REPICEF SCHOOL-BASED STUDY

  A. Onofri, C. Rosignoli, F. De Santis, R. Ornello, S. Sacco | Dipartimento di Scienze Cliniche Applicate e Biotecnologiche, Università degli Studi dell’Aquila, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.15950

  • 44 abstract views
  • 0 PDF

• OC-24 | A retrospective case-control study aimed at analyzing, through the administration of a questionnaire, the prevalence, clinical features and the risk factors for chronicity in a sample of 419 pediatric patients

  Alice Bonuccelli, Sara Mundo, Emma Iacopelli, Alessandro Orsini, Lorenza Marini, Diego Peroni | Neuropediatric, Pediatric Clinic, AOU Pisa, Italy

  Società Italiana per lo Studio delle Cefalee (SISC)

  06-11-2025

  DOI https://doi.org/10.4081/cc.2025.15821

  • 406 abstract views

• PO-06 | Children’s headache through drawings: a narrative review and a portrait gallery

  Floriana Ferro,^1,2 Caterina Gaspari,^1,2 Giulia Manfrè,^1,2 Federica Cernigliaro,¹ Daniela D’Agnano,³ Ruben Panzica,⁴ Edvige Correnti,² Maria Rosita Ruta,⁵ Francesca Marchese,⁵ Renata Pitino,² Maria Rita Capizzi,² Giuseppe Santangelo,² Antonella Versace,⁶ Vittorio Sciruicchio,³ Vincenzo Raieli² | ¹Child Neuropsychiatry Unit Department, Pro.MI.S.E. "G. D'Alessandro", University of Palermo; ²Child Neuropsychiatry Department, ISMEP, ARNAS Civico, Palermo; ³Children Epilepsy and EEG Center, San Paolo Hospital, ASL Bari, Bari; ⁴Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Messina; ⁵Child Neuropsychiatry Unit, ASP 6, Palermo; ⁶Pediatric Headache Center, Pediatric Emergency Dept, Regina Margherita Children's Hospital, Turin, Italy

  Società Italiana per lo Studio delle Cefalee (SISC)

  06-11-2025

  DOI https://doi.org/10.4081/cc.2025.15842

  • 398 abstract views

• P111 | THE LIGURIAN HEADACHE NETWORK: A SURVEY OF NINE HEADACHE CENTRES, RESOURCES AND CHALLENGES

  M. Grazzini¹, M. Del Sette¹, A. Schenone², M. Bandettini², F. Bandini³, F. Valguarnera⁴, A. Assini⁵, C. Solaro⁵, G. Silvestrelli⁶, E. Viani⁶, A. Sugo⁷, A. Coccia⁷, S. Nassani⁸, G. Sivori⁸, L. Benedetti⁹, E. Giorli⁹, E. Arena¹⁰, C. Finocchi¹⁰ | ¹Department of Neurology, IRCCS AOM San Martino Hospital, Genoa, Italy; ²Neurological Clinic DINOGMI, IRCCS AOM San Martino Hospital, Genoa, Italy; ³Department of Neurology, IRCCS AOM Villa Scassi, Genoa, Italy; ⁴Department of Neurology, Antero Micone Hospital, ATS liguriaArea 3, Head of the Headache Centre, Genoa, Italy; ⁵Department of Neurology, Ospedali Galliera, Genoa, Italy; ⁶Clinical Neurology and Stroke Centre, Emergency Department, Imperia Hospital, Italy; ⁷Department of Neurology, Santa Corona Hospital, Pietra Ligure, Italy; ⁸Department of Neurology, Tigullio Hospital, Lavagna, Italy; ⁹Department of Neurology, Sant'Andrea Hospital, La Spezia, Italy; ¹⁰Department of Neurology, San Paolo Hospital, Savona, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.16067

  • 15 abstract views
  • 0 PDF

• PO-23 | Hemicrania continua-like headache in familial SDHD-related paragangliomas: a diagnostic challenge

  A. Di Chirico, L. Curto, G. Procopio, L. Troilo, G. Siciliano, F. Baldacci, S. Gori | Neurology Unit, Department of Clinical and Experimental Medicine, University of Pisa-AOUP, Pisa, Italy

  Società Italiana per lo Studio delle Cefalee (SISC)

  06-11-2025

  DOI https://doi.org/10.4081/cc.2025.15845

  • 513 abstract views

• P062 | POST-DURAL PUNCTURE HEADACHE AFTER DIAGNOSTIC LUMBAR PUNCTURE: INCIDENCE, CLINICAL PRESENTATION, AND ASSOCIATED FACTORS IN A NEUROLOGICAL COHORT

  F. Innocenti^1|3, M. Romozzi^1|3, C. Vollono^1|3, P. Rossi^1|3, F. Signorelli^2|3, M. Mirabella^1|3, P. Calabresi^1|3, V. Nociti^1|3 | ¹Neurology Unit, Department of Neurosciences, Sense Organs and Thorax, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Italy; ²Neurosurgery Unit, Department of Neurosciences, Sense Organs and Thorax, Fondazione Policlinico Universitario A. Gemelli IRCCS, Italy; ³Department of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.16018

  • 18 abstract views
  • 0 PDF

• P001 | EFFECTS OF A MINDFULNESS-BASED INTERVENTION ON ADOLESCENTS WITH HIGH FREQUENCY PRIMARY HEADACHES: A PROSPECTIVE MULTICENTER STUDY

  I. Bonemazzi¹, B. Baldo¹, S. Contri¹, G. Coser¹, C. Del Vecchio¹, G. De Lorenzi¹, V. Marletta¹, A. Raffagnato², C. Vassia³, E. Serri³, D. D’Agnano⁴, A. Versace³, V. Sciruicchio⁴, L. Grazzi⁵, I. Toldo¹ | ¹Juvenile Headache Center, Department of Woman’s and Child’s Health, University of Padua, Italy; ²Child and Adolescent Neuropsychiatric Unit, Department of Women’s and Children’s Health, University of Padua, Italy; ³Pediatric Headache Center, Department of Pediatric Emergency, Regina Margherita Children’s Hospital, Turin, Italy; ⁴Children Epilepsy and EEG Center, San Paolo Hospital, ASL Bari, Italy; ⁵Neuroalgology Unit and Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.15957

  • 19 abstract views
  • 0 PDF

• P011 | PSYCHOLOGICAL CORRELATES IN ADOLESCENTS WITH CHRONIC AND NON-CHRONIC HEADACHE ATTENDING THE REGINA MARGHERITA CHILDREN’S HOSPITAL HEADACHE CENTER OF TURIN, ITALY (OIRM): A PRELIMINARY ANALYSIS

  S. Serri¹, A. Lamberti Zanardi¹, R. Mascolo¹, E. Agosto², A. Fera², E. Martinotti², R. Rossi¹, C. Bondone¹, A. Versace¹, S. Racalbuto¹ | ¹Department of Pediatric Emergency Pediatric Headache Centre, Regina Margherita Children’ s Hospital, Turin, Italy; ²Department of Public Health and Pediatrics, Postgraduate School of Pediatrics, University of Turin, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.15967

  • 15 abstract views
  • 0 PDF

• OC08 | HEADACHE OUTCOME AFTER MIDDLE-MENINGEAL ARTERY EMBOLIZATION IN SUBDURAL HEMATOMA

  F. Innocenti^1|3, M. Romozzi^1|3, M. Palermo, F. Tosto⁴, C. Vollono^1|3, P. Calabresi, H. Yuan, L. Francesco Iannone, F. Maria Polli, F. Signorelli, I. Valente, G. Garignano, A. Pedicelli | ¹Neurology Unit, Department of Neurosciences, Sense Organs and Thorax, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Italy; ²Neurosurgery Unit, Department of Neurosciences, Sense Organs and Thorax, Fondazione Policlinico Universitario A. Gemelli IRCCS, Italy; ³Department of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy; ⁴Department of Neuroscience, Giovanni Paolo II Hospital, Catanzaro, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.15946

  • 55 abstract views
  • 0 PDF

• OC-23 | The REPICEF Project: a school-based epidemiological study on primary headaches in children and adolescents

  Agnese Onofri,¹ Chiara Rosignoli,¹ Vittorio Trozzi,¹ Martina D’Ambrosio,¹ Benedetta Germani,¹ Roberta Ciuffini,² Raffaele Ornello,¹ Simona Sacco¹ | ¹Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila; ²Department of Clinical Medicine, Public health, Life and Environmental Sciences University of L’Aquila, Italy

  Società Italiana per lo Studio delle Cefalee (SISC)

  17-10-2025

  DOI https://doi.org/10.4081/cc.2025.15820

  • 215 abstract views

• P074 | EFFICACY OF REPETITIVE GREAT OCCIPITAL NERVE BLOCKS IN EPISODIC CLUSTER HEADACHE: A RETROSPECTIVE REAL-WORLD STUDY FROM A TERTIARY HEADACHE CENTER

  A. Taglialatela¹, E. Belgrado², C. Lettieri¹, G. Merlino^1|3, M. Valente^1|4, Y. Tereshko³ | ¹Clinical Neurology, Udine University Hospital, Italy; ²Neurology Unit, Department of Head-Neck and Neurosciences, Azienda Sanitaria Universitaria Friuli Centrale (ASU FC), Udine, Italy; ³Stroke Unit, Udine University Hospital, Italy; ⁴DMED, Udine University Hospital, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.16030

  • 16 abstract views
  • 0 PDF

• PO-10 | Differential diagnosis between symptomatic focal occipital epilepsy and headache: a case report

  Federica Molaschi,¹ Barbara Lauria,² Giulia Grasso,² Cristina Vassia,² Francesca Torta,³ Antonia Versace,² Carlotta Canavese³ | ¹University of Turin, SC U Child Neuropsychiatry, Regina Margherita Hospital, Turin; ²Department of Pediatric Emergency, Pediatric Headache Centre, Regina Margherita Children’s Hospital, Turin; ³Department of Child Pathology and Care “Regina Margherita”, SSD Pediatric Neurology, Regina Margherita Children’s Hospital, Turin, Italy

  Società Italiana per lo Studio delle Cefalee (SISC)

  06-11-2025

  DOI https://doi.org/10.4081/cc.2025.15831

  • 661 abstract views

• PO-30 | A chronic migraine phenotype unveiling acromegaly: diagnostic pitfalls and the impact of timely treatment

  Cinzia Rita Tamborino, Gianni Difonzo, Adriana Fallacara, Damiano Paolicelli, Maria Pia Prudenzano | Headache Center, “L. Amaducci” Neurological Clinic, Policlinico General Hospital, Bari, Italy

  Società Italiana per lo Studio delle Cefalee (SISC)

  06-11-2025

  DOI https://doi.org/10.4081/cc.2025.15852

  • 533 abstract views
• 

  New-onset cervical pain followed by ophthalmoplegia revealing cavernous sinus meningioma

  Matteo Palermo, Marina Romozzi, Vittoria Viglione, Francesco Innocenti, Flavia Felici, Solange Fugger, Federico Tosto

  23-09-2026

  DOI https://doi.org/10.4081/cc.2026.15930

  • 170 abstract views
  • 133 PDF
  • 96 VIDEO

• PO-59 | Questioning online survey-based physiotherapy treatment referral in headache treatment: differences in developed and developing countries

  D. Onan,^1,2 A.K. Erdemoğlu,³ P. Gelener,⁴ S. Velioğlu,⁵ S. Ulutaş,⁶ N. Taşdemir,⁷ M. Waliszewska-Prosół,⁸ E. Ekizoğlu,⁹ M. Straburzyński,¹⁰ M. Kodounis,¹¹ B. Raffaelli,¹² C. Tana,¹³ F. De Cesaris,¹⁴ R. Messina,¹⁵ E.I. Sen,¹⁶ S. Ray,¹⁷ G. Sebastianelli,¹⁸ F. Granella,¹⁹ U. Pensato,²⁰ S. Crema,²¹ S. Cevol,²² K. Chakravarty,²³ M. Pia Prudenzano,²⁴ A. Casalena,²⁵ M. Romozzi,²⁶ T. Takizawa,²⁶ W. Rattanawong,²⁷ A. Gantenbein,²⁸ V. Favoni,²⁹ C. Gaul,³⁰ L.F.I. Iannone,³¹ B. Schäfer,²³ D.A. Montisano,³³ O. Grosu,³⁴ A.B. de Oliveira,³⁵ F. Puledda,³⁶ V. Romanenko,³⁷ I. Ros González,³⁸ M. Castaldo,³⁹ H. Al-Khazali,⁴⁰ A. Hassan,⁴¹ D. Garcia-Azorin,⁴² L.-L. Hope Pan,⁴³ R. Gil-Gouveia,⁴⁴ M. Sanchez del Rio,⁴⁵ M. Lisicki,⁴⁶ H.W. Schytz,⁴⁷ P. Anukoolwittaya,⁴⁸ T. Mavridis,⁴⁹ M. Lanteri-Minet,⁵⁰ D.B. Swerts,⁵¹ C. Altamura,⁵² K. Hirata,⁵³ M. Togha,⁵⁴ M. Kyung Chu,⁵⁵ T. Pongpitakmetha,⁵⁶ M.-H. Bjørk,⁵⁷ M. Minen,⁵⁸ K. Skorobogatykh,⁵⁹ D. Chowdhury,⁶⁰ A.-M. Torgersen Dalgeir,⁶¹ J. Versijpt,⁶² P. Cras,⁶³ A. Govaerts,⁶⁴ A. Chiarugi,⁶⁵ N. Vashchenko,⁵⁹ L. Dobbels,⁶⁶ T.S. Monteith,⁶⁷ F. De Bruyne,⁶⁸ E. Garay,⁶⁷ S.L. Sava,⁶⁹ Z. Salinas,⁶⁷ M. Nordtveit,⁷⁰ K. Delmotte,⁷¹ A. Gonzalez-Martinez,⁷² S. Debray,⁷³ C. Deligianni,⁷⁴ W. De Hertogh,⁷⁵ R. Castien,⁷⁶ E. Caronna,⁷⁷ C. Valerija,⁷⁸ F. Ahmed,⁷⁹ G. De la Meilleure,⁸⁰ L.L. Panneerchelvam,⁸¹ G.H. Bringeland,⁸² R. Ornello,² S. Sacco² | ¹Yozgat Bozok University, Physiotherapy and Rehabilitation, Ankara, Turkey;²University of L'Aquila, Department of Biotechnological and Applied Clinical Sciences, L'Aquila, Italy;³Clinic of Prof. Dr. Ali Kemal Erdemoğlu, Neurology, Ankara, Turkey;⁴Elite Research and Surgical Hospital , Nicosia, Cyprus;⁵Karadeniz Technical University, Department of Neurology, Trabzon, Turkey;⁶Bahcesehir University, Department of Neurology, İstanbul, Turkey;⁷Ağrı İbrahim Çeçen University, Department of Neurology, Ağrı, Turkey;⁸Wroclaw Medical University, Wroclaw, Germany;⁹Istanbul University, Department of Neurology, Istanbul, Turkey;¹⁰University of Warmia and Mazury, Olsztyn, Poland;¹¹National & Kapodistrian University of Athens, First Neurology Department, Eginitio Hospital, School of Medicine, Athens, Greece;¹²Charité Universitätsmedizin Berlin, Department of Neurology,Headache Center, Berlin, Germany;¹³SS Annunziata Hospital of Chieti, Chieti, Italy;¹⁴Centro Cefalee e Farmacologia Clinica - AOU Careggi , Florence, Italy;¹⁵Vita-Salute San Raffaele University, Milano, Italy;¹⁶Istanbul University Istanbul Faculty of Medicine, Department of Physical Medicine and Rehabilitation, İstanbul, Turkey;¹⁷Department of Neurology, PGIMER, Chandigarh, India;¹⁸Sapienza University of Rome, Latina, Italy;¹⁹University of Parma, Parma, Italy;²⁰Humanitas University, Milan, Italy;²¹Fleni Hospital, Buenos Aires, Argentina;²²University of Bologna, Bologna, Italy;²³Post Graduate Institute Of Medical Education and Research, Chandigarh, India;²⁴AOUC Policlinico, Centro Cefalee - Clinica Neurologica L Amaducci, Bari, Germany;²⁵Centro Cefalee UOC Neurologia, Teramo, Italy;²⁶Keio University School of Medicine, Tokyo, Japan;²⁷King Mongkut's Institute of Technology Ladkrabang, Bangkok, Thailand;²⁸ZURZACH Care, Zürich, Switzerland;³⁰IRCCS Istituto delle scienze neurologiche di Bologna, Bologna, Italy;³⁰Headache Center Frankfurt, Frankfurt, Germany;³¹Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy, Modena, Italy;³²Migraine and Headache Clinic Königstein , Frankfurt, Germany;³³SSD Centro Cefalee - Fondazione IRCCS Istituto Neurologico C.Besta, Milan, Italy;³⁴Diomid Gherman Institute of Neurology and Neurosurgery, Kişinev, Moldova;³⁵Center for Clinical and Epidemiological Research, University of Sao Paulo , Sao Paolo, Brazil;³⁶King's College London, London, United Kingdom;³⁷Vita Medical Clinic, Kyiv, Ukraine;³⁸Hospital Clínico Universitario de Valladolid, Vallodolid, Spain;³⁹Parma University, Parma, Italy;⁴⁰Danish Headache Center, Copenhagen, Denmark;⁴¹Cairo University , Cairo, Egypt;⁴²University of Valladolid, Valladolid, Spain;⁴³Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan;⁴⁴Hospital da Luz. Lisboa, Lisboa, Portugal;⁴⁵Clinica Universidad de Navarra, Navarra, Spain;⁴⁶Mercedes & Martín Ferreyra Institute for Medical Research, Córdoba, Argentina;⁴⁷University of Copenhagen, Copenhagen, Denmark;⁴⁸King Chulalongkorn Memorial Hospital, Bangkok, Thailand;⁴⁹Tallaght University Hospital, Dublin, Ireland;⁵⁰CHU Nice and Cote D'azur University, Nice, France;⁵¹Santa Casa de Sao Paolo, Sao Paolo, Brazil;⁵²Fondazione Policlinico Universitario Campus BIo-Medico, Rome, Italy;⁵³Dokkyo Medical University, Mibu, Tochigi, Japan;⁵⁴Tehran University, Tehran, Iran;⁵⁵Yonsei University, Seoul, South Korea;⁵⁶Chulalongkorn University, Bangkok, Thailand;⁵⁷University of Bergen , Bergen, Norway;⁵⁸NYU Langone Health, New York, United States;⁵⁹University Headache Clinic, Moscow, Russian Federation;⁶⁰ G B Pant Institute of Post Graduate Medical Education and Research, New Delhi, India;⁶¹Haukeland University Hospital, NorHead, Bergen, Norway;⁶²UZ Brussel, Brussel, Belgium;⁶³Universiteit Antwerpen, Antwerpen, Belgium;⁶⁴Rz Tienen, Tienen, Belgium;⁶⁵University of Florence, Florence, Italy;Neurology Department İmelda Ziekenhuis, Bonheiden, Belgium;⁶⁷University of Miami, Miami, United States;⁶⁸University College Ghent, Ghent, Belgium;⁶⁹University of Liège, Liege, Belgium;⁷⁰Haukeland Universitetssykehus, Bergen, Norway;⁷¹Universitair Ziekenhuis Leuven, Leuven, Belgium;⁷²Hospital Universitario de la Princesa e Instituto de Investigación Sanitaria Princesa, Madrid, Spain;⁷³Europa Ziekenhuizen, Brussel, Belgium;⁷⁴Athens Naval Hospital, Athens, Greece;⁷⁵University of Antwerp , Antwerpen, Belgium;⁷⁶Vrije Universiteit Amsterdam, Amsterdam, Netherlands;⁷⁷Vall d'Hebron Hospital, Barcelona, Spain;⁷⁸Private hospital, Riga, Latvia;⁷⁹Hull University, Hull, United Kingdom;⁸⁰VITAZ - General Hospital, Sint-Niklaas, Belgium;⁸¹James Cook University Hospital, Middlesbrough, United Kingdom; ⁸²Haukeland University Hospital, Bergen, Norway

  Società Italiana per lo studio delle Cefalee (SISC)

  06-11-2025

  DOI https://doi.org/10.4081/cc.2025.15882

  • 325 abstract views

• OC-07 | A retrospective analysis of headache and CADASIL association

  Danilo Antonio Montisano,¹ Giulia Regonesi,¹ Licia Grazzi,¹ Alessandra Parisi,¹ Alberto Raggi,² Elisabetta Soldini,² Giorgia Camarda,² Matilde Leonardi,² I. Canavero,³ E.M. Zacarias,³ Anna Bersano,³ Nicola Rifino³ | Fondazione IRCCS Istituto Neurologico Carlo Besta: ¹SSD Centro Cefalee; ²SC Neurologia Salute Pubblica e Disabilità, ³SC Malattie Cerebrovascolari, Milan, Italy

  Società Italiana per lo Studio delle Cefalee (SISC)

  06-11-2025

  DOI https://doi.org/10.4081/cc.2025.15804

  • 405 abstract views

• P108 | CHARACTERISTIC OF PATIENTS ATTENDING TERTIARY HEADACHE CENTRES IN LIGURIA: A CROSS-SECTIONAL OBSERVATIONAL STUDY

  M. Del Sette¹, M. Grazzini¹, C. Finocchi², F. Tazza², E. Viani³, A. Coccia⁴, C. Solaro⁵, G. Poeta⁵, F. Valguarnera⁶, G. Sivori⁷, E. Giorli⁸, S. Di Antonio⁹, M. Bandettini⁹, A. Schenone⁹ | ¹U.O. Neurologia dell’IRCCS Azienda Ospedaliera Metropolitana Policlinico San Martino, Genova, Italy; ²S.C. Neurologia di Ponente, Ospedale San Paolo, Savona, Italy; ³Dipartimento Interaziendale Neuroscienze e Neuroriabilitazione Asl1/Asl2, Imparia, Italy; ⁴SC Neurologia, PO Ponente, Ospedale Santa Corona, Pietra Ligure (SV), Italy; ⁵S.C. Neurologia Ospedale Galliera, Genova, Italy; ⁶S.C. Neurologia IRCCS Azienda Ospedaliera Metropolitana Villa Scassi, Genova, Italy; ⁷S.C. Neurologia Ospedale di Lavagna, Italy; ⁸SC Neurologia Ospedale S. Andrea, La Spezia, Italy; ⁹U.O. Clinica Neurologica dell’IRCCS Azienda Ospedaliera Metropolitana Policlinico San Martino, Genova, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.16064

  • 16 abstract views
  • 0 PDF

• P030 | PREMONITORY EPISODES WITHOUT HEADACHE DURING ANTI-CGRP PREVENTIVE TREATMENTS: A CROSS-SECTIONAL MULTICENTER STUDY

  A. Munafò¹, G. Sebastianelli^2|3, P. Amarsena², F. Greenwood², S. Maniataki², A. Burgalassi¹, G. Vigani¹, D. Moreno², F. Puledda², N. Karsan², F. De Cesaris¹, A. Chiarugi¹, P. Goadsby^2|4 | ¹Headache Center and Clinical Pharmacology Unit, Careggi University Hospital, Florence, Italy; ²NIHR King’s Clinical Research Facility, SLaM Biomedical Research Centre and Wolfson SPaRC, Institute of Psychiatry, Psychology and Neurosceince, King’s College London, UK; ³Department of Medico-Surgical Sciences and Biotechnologies, Polo Pontino, Sapeinza University of Rome, Latina, Italy; ⁴Division of Biomedcial Sciences, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.15986

  • 42 abstract views
  • 0 PDF

• P099 | PHYSIOTHERAPY INTERVENTIONS FOR TENSION-TYPE HEADACHE: EffECT ON FREQUENCY, DURATION, PAIN INTENSITY, USE OF MEDICATION AND DISABILITY. A SYSTEMATIC REVIEW WITH META-ANALYSIS

  S. Di Antonio^1|2|3, L. Bottazzi², M. Mazzoni⁵, M. Bandettini³, E. Pelosin², C. Cosentino², M. Castaldo^1|6|7 | ¹Department of Health Science and Technology, Center for Pain and Neuroplasticity (CNAP), SMI, School of Medicine, Aalborg University, Denmark; ²Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Genoa, Italy; ³IRCCS Azienda Ospedaliera Metropolitana, Genoa, Italy; ⁵ATS area 3 (ex ASL3) Health Protection Agency - Rehabilitation Department Genoa, Italy; ⁶Headache Center, Department of Medicine and Surgery, University of Parma, Italy; ⁷Clinical Psychophysiology and Clinical Neuropsychology Labs, University of Parma, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.16055

  • 15 abstract views
  • 0 PDF
• 

  Migraine prodromal symptoms and their clinical manifestations: an observational multicenter study

  Marco Bolchini, Matteo Cortinovis, Paola Merlo, Alessandro Viganò, Valentina Rebecchi, Sara Mazza, Michele Gennuso, Natascia Ghiotto, Elena Guaschino, Grazia Sances, Giorgio Dalla Volta

  24-06-2026

  DOI https://doi.org/10.4081/cc.2026.15926

  • 787 abstract views
  • 374 PDF

• PO-05 | Validation of the Italian version of the HARDSHIP Questionnaire in a school-based population

  Agnese Onofri,¹ Chiara Rosignoli,¹ Vittorio Trozzi,¹ Martina D’Ambrosio,¹ Benedetta Germani,¹ Roberta Ciuffini,² Raffaele Ornello,¹ Simona Sacco¹ | ¹Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila; ²Department of Clinical Medicine, Public health, Life and Environmental Sciences, University of L’Aquila, Italy

  Società Italiana per lo Studio delle Cefalee (SISC)

  06-11-2025

  DOI https://doi.org/10.4081/cc.2025.15826

  • 351 abstract views

• PO-04 | Mindfulness-based behavioral intervention for adolescents with high-frequency primary headaches: feasibility of a prospective multicenter study

  Beatrice Baldo,¹ Giulia De Lorenzi,¹ Valeria Marletta,¹ Ilaria Bonemazzi,¹ Alessia Raffagnato,² Cristina Vassia,³ Emanuela Serri,³ Antonella Versace,⁴ Daniela D’Agnano,⁴ Vittorio Sciruicchio,⁴ Licia Grazzi,⁵ Irene Toldo¹ | ¹Juvenile Headache Center, Department of Woman’s and Child’s Health, University of Padua; ²Child and Adolescent Neuropsychiatric Unit, Department of Women's and Children's Health, University of Padua; ³Pediatric Headache Center, Department of Pediatric Emergency, Regina Margherita Children's Hospital, Turin; ⁴Children Epilepsy and EEG Center, San Paolo Hospital, ASL Bari; ⁵Neuroalgology Unit and Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy

  Società Italiana per lo Studio delle Cefalee (SISC)

  06-11-2025

  DOI https://doi.org/10.4081/cc.2025.15825

  • 428 abstract views

• P112 | HOW MUCH DO YOU KNOW ABOUT MIGRAINE? UNMET CHALLENGES IN HEADACHE EDUCATION

  M. Marcosano^1|2, L. D’Onofrio^1|2, C. Altamura^1|2, L. Fofi^1|2, S. Lodico^1|2, F. Vernieri^1|2 | ¹Headache Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy; ²Neurology Unit, Università Campus Bio-Medico di Roma, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.16068

  • 17 abstract views
  • 0 PDF

• P004 | SECONDARY HEADACHE IN THE PEDIATRIC EMERGENCY DEPARTEMENT: THE CRUCIAL ROLE OF MEDICAL HISTORY

  C. Ferraris¹, C. Minero², S. Belluca², B. Lauria², G. Grasso², R. Rossi², C. Vassia², P. Lacroce³, C. Bondone², A. Versace² | ¹Department of Public Health and Pediatrics, Residency Program in Pediatrics, University of Turin, Italy; ²Department of Pediatric Emergency – Pediatric Headache Center, Regina Margherita Children's Hospital, Turin, Italy; ³Department of Pediatric Neurosurgery, Regina Margherita Children's Hospital, Turin, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.15960

  • 16 abstract views
  • 0 PDF

• PO-53 | Managing chronic primaryhHeadache in Lombardy: insights from the ‘PERLA’ project

  Grazia Sances,¹ Claudia Sulmona,¹ Natascia Ghiotto,¹ Daniele Martinelli,¹ Licia Grazzi,² Alberto Raggi,² Danilo Antonio Montisano,² Matilde Leonardi,² Giulia Gandini,² Renata Rao,³ Alessandro Padovani,³ Alessandro Amorosi,⁵ Cristina Tassorelli,^1,5 on behalf of Rete Regionale Cefalee Lombardia | ¹Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation Pavia, Italy; ²Headache Center, IRCCS Fondazione Istituto Neurologico Carlo Besta, Milan, Italy; ³ASST Spedali Civili di Brescia, Italy; ⁴Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy; ⁵Struttura Reti Clinico-Assistenziali e Organizzative e Ricerca, U.O. Polo Ospedaliero Direzione Generale Welfare, Regione Lombardia, Italy

  Società Italiana per lo Studio delle Cefalee (SISC)

  06-11-2025

  DOI https://doi.org/10.4081/cc.2025.15876

  • 231 abstract views

• P096 | VALIDATION OF A STRUCTURED PRE-VISIT QUESTIONNAIRE FOR HEADACHE SPECIALIST CONSULTATIONS

  V. Portera, P. Alonge, A. Torrente, I. Cutrò, A. Meli, A. Vignoli, C. Camarda, F. Brighina | Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), University of Palermo, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.16052

  • 17 abstract views
  • 0 PDF

• P088 | SLEEP-CIRCADIAN MECHANISMS AND CGRP SIGNALING IN TACS AND HYPNIC HEADACHE: A SYSTEMATIC REVIEW

  A. Boccalini¹, C. Benatti², L. Pani^2|3, F. Tascedda⁴, L. Francesco Iannone² | ¹Department of Addiction Services, ULSS 9 Scaligera, Verona, Italy; ²Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy; ³Department of Psychiatry and Behavioral Sciences, University of Miami, USA; ⁴Department of Life Sciences, University of Modena and Reggio Emilia, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.16044

  • 24 abstract views
  • 0 PDF

• P006 | PAIN MANAGEMENT FOR ACUTE PRIMARY HEADACHE IN A PEDIATRIC EMERGENCY DEPARTMENT: A RETROSPECTIVE STUDY

  G. Monte¹, M. Roversi², L. Papetti¹, F. Ursitti¹, G. Sforza¹, S. Cristaldi², U. Raucci⁴, M. Valeriani¹ | ¹Developmental Neurology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy; ²Pediatric Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy; ³Institute for the Child and Adolescent Health, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.15962

  • 17 abstract views
  • 0 PDF

• PO-83 | Serum diamine oxidase activity in patients with cluster headache: a cross-sectional case–control study

  Silvia Boschi,¹ Elisa Maria Piella,¹ Tilde Manetta,³ Paola Merlach,³ Alberto Mario Chiarandon,¹ Alessia Agostinelli,¹ Barbara Donati Morello,³ Giulio Mengozzi,³ Innocenzo Rainero,^1,2 Elisa Rubino,^1,2 | ¹Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Turin, Italy; ²Headache Center, Department of Neuroscience and Mental Health, AOU Città della Salute e della Scienza di Torino, Turin, Italy; ³Department of Laboratory Medicine, Città della Salute e della Scienza University Hospital, Turin, Italy

  Società Italiana per lo Studio delle Cefalee (SISC)

  06-11-2025

  DOI https://doi.org/10.4081/cc.2025.15907

  • 588 abstract views
• 

  Sex and gender differences in the epidemiology, clinical features, and pathophysiology of trigeminal autonomic cephalalgias

  Selene Attorre, Andrea Burgalassi, Giulia Vigani, Francesco De Cesaris, Marina Romozzi, Luigi Francesco Iannone

  09-10-2024

  DOI https://doi.org/10.4081/cc.2024.15775

  • 3,071 abstract views
  • 808 PDF

• PO-81 | Knowledge and misconceptions on headache disorders among healthcare workers: preliminary results from the Studio Emicrania Maugeri Study

  Luca Giani, Christian Lunetta | Istituti Clinici Scientifici Maugeri IRCCS, Neurological Rehabilitation Unit of Milano Institute, Milan, Italy

  Società Italiana per lo studio delle Cefalee (SISC)

  06-11-2025

  DOI https://doi.org/10.4081/cc.2025.15905

  • 411 abstract views

• P032 | IMPROVEMENT IN DEPRESSIVE AND ANXIETY SYMPTOMS DURING EPTINEZUMAB TREATMENT: A POST-HOC ANALYSIS FROM THE TACHIS STUDY

  E.M. Piella¹, A.M. Chiarandon¹, V. Batti¹, D.A. Montisano², L. F. Iannone³, C. Fasano⁴, G. Sebastianelli⁵, G. Coppola⁵, D. Ferrandi⁶, C. Lanni⁷, M.P. Prudenzano⁸, M. De Tommaso⁹, P. Merlo¹⁰, A. Viganò¹⁰, F. De Cesaris¹¹, A. Chiarugi¹¹, A. Munafò¹¹, F. Pistoia¹², R. Ornello¹², S. Sacco¹², A. Doretti¹³, L. Grazzi², F. Lo Castro¹⁴, R. Allamprese¹⁴, R. De Icco^15|16, G. Vaghi^15|16, C. Tassorelli^15|16, G. Avino¹⁷, M. Romozzi¹⁸, C. Vollono¹⁸, P. Calabresi¹⁸, S. Battistini¹⁹, A. Rufa¹⁹, M. Albanese²⁰, M. Trimboli²¹, G. Carlucci⁴, M. Silvestro²², A. Russo²², M. Valente²³, L. Fofi²⁴, M. Marcosano²⁴, P. Geppetti²⁵, C. Altamura²⁴, F. Vernieri²⁴, E. Rubino¹, I. Rainero¹, S. Guerzoni¹⁴ | ¹Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Italy; ²Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy; ³Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy; ⁴NEUROFARBA Department, University of Florence - Neurologia, AOU Careggi, Italy; ⁵Sapienza University of Rome, Department of Medico-Surgical Sciences and Biotechnologies, Polo Pontino, Latina, Italy; ⁶AOU Alessandria, SC Neurologia, Italy; ⁷Psicologia AOU Alessandria, Italy; ⁸Clinica Neurologica "L. Amaducci", Azienda Ospedaliero-Universitaria Consorziale di Bari, Italy; ⁹Neurophysiopathology Unit, Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Italy; ¹⁰UO di Neurologia, Humanitas Gavazzeni, Bergamo, Italy; ¹¹Headache center and Clinical pharmacology unit, AOU Careggi, Florence, Italy; ¹²Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy; ¹³Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milano, Italy; ¹⁴Digital and Predictive Medicine, Pharmacology, Clinical Metabolic Toxicology-Headache Center and Drug Abuse, Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico, Modena, Italy; ¹⁵Department of Brain and Behavioral Sciences, University of Pavia, Italy; ¹⁶Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy; ¹⁷SOC Neurologia, Ospedale di Prato, Italy; ¹⁸Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy; ¹⁹Department of Medical, Surgical and Neurological Sciences, University of Siena, Italy; ²⁰Unit of Neurology, Department of Systems Medicine, University of Rome Tor Vergata, Italy; ²¹Headache Center, Unit of Neurology, AOU Renato Dulbecco, Catanzaro, Italy; ²²Inter-departmental Program of Headache Medicine and Primary Pain Syndromes, Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Naples, Italy; ²³DMED, University of Udine and Clinical Neurology, Udine University Hospital, Italy; ²⁴Fondazione Policlinico Universitario Campus Bio-Medico, Roma e Università Campus Bio-Medico di Roma, Italy; ²⁵Department of Molecular Pathobiology and Pain Research Center, College of Dentistry, New York University, NY, USA

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.15988

  • 16 abstract views
  • 0 PDF

• P007 | PRIMARY HEADACHES IN ITALIAN CHILDREN AND ADOLESCENTS: EPIDEMIOLOGY AND CLINICAL PROFILE FROM THE REPICEF STUDY

  A. Onofri, C. Rosignoli, F. De Santis, R. Ornello, S. Sacco | Dipartimento di Scienze Cliniche Applicate e Biotecnologiche, Università degli Studi dell’Aquila, Italy

  03-11-2026

  DOI https://doi.org/10.4081/cc.2026.15963

  • 17 abstract views
  • 0 PDF