FOR AUTHORS
2025: 39° Conference of the Italian Society for the Study of Headaches (SISC)
Published:
17 October 2025
SISC EXECUTIVE BOARD
President Marina de Tommaso
Vice President: Innocenzo Rainero
Secretary: Massimiliano Valeriani
Treasurer. Simona Guerzoni
Past President: Franco Granella
Counselors: Filippo Brighina, Edoardo Mampreso, Simona Sacco, Irene Toldo, Simone Vigneri, Catello Vollono Honorary Presidents: Pierangelo Geppetti, Vincenzo Guidetti, Giuseppe Nappi, Lorenzo Pinessi, Luigi Alberto Pini, Giorgio Zanchin
SCIENTIFIC COMMITTEE
Marina de Tommaso, Innocenzo Rainero, Franco Granella, Massimiliano Valeriani, Simona Guerzoni, Filippo Brighina, Edoardo Mampreso, Simona Sacco, Irene Toldo, Catello Vollono, Simone Vigneri, Pierangelo Geppetti, Anna Ambrosini, Paola Sarchielli, Antonio Russo, Gianluca Coppola, Grazia Sances, Paolo Calabresi
LOCAL ORGANIZING COMMITTEE
Franco Granella, Erica Curti, Elena Tsantes, Giusy Pipitone, Simona Guerzoni, Luigi Francesco lannone
SISC-Oral Communications
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OC-01 | Evolution of nitroglycerin-triggered premonitory symptoms in participants with migraine Gabriele Sebastianelli,1,2 Catarina Fernandes,1,3 Peter J. Goadsby,1 Nazia Karsan1 | 1NIHR King’s Clinical Research Facility, SLaM Biomedical Research Centre and Wolfson SPaRC, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, UK; 2Department of Medico-Surgical Sciences and Biotechnologies, Polo Pontino ICOT, Sapienza University of Rome, Latina, Italy; 3Neurology Department, Local Health Unit of Coimbra, Portugal
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OC-02 | Role of specific microRNAs in cluster headache: association with disease phenotype and neuropeptide levels A. Solfrizzi,1,2 F. Cammarota,1,2 R. De Icco,1,2 F. Bighiani,1,2 M. Corrado,2 G. Vaghi,1,2 A. Antoniazzi,1,2 V. Grillo,1,2 M. Giraudo,1,2 B. Agostini,1,2 R. Greco,2 C. Demartini,1,2 M. Francavilla,1,2 S. Franchini,1,2 M. Allena,2 G. Sances,2 C. Tassorelli1 | 1Department of Brain and Behavioral Sciences, University of Pavia; 2Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy
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OC-03 | Transcranial magnetic stimulation in patients with chronic migraine and medication overuse headache Elisa Maria Piella,1 Fabio Ferrandes,1 Gianluca Isoardo,1 Alberto Mario Chiarandon,1 Fausto Roveta,1 Alessia Agostinelli,1 Elisa Rubino,1,2 Innocenzo Rainero,1,2 | 1Department of Neuroscience “Rita Levi Montalcini”, University of Turin; 2Headache Center, Department of Neuroscience and Mental Health, AOU Città della Salute e della Scienza di Torino, Turin, Italy
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OC-04 | The chronopharmacology of atogepant in migraine prevention: a real-world evaluation of influence of timing of administration on effectiveness and tolerability Luigi Francesco Iannone,1,2 Gabriele Sebastianelli,3 Flavia Lo Castro,2 Federico De Santis,4 Michele Corrado,5 Marilena Marcosano,6,7 Raffaele Ornello,4 Licia Grazzi,8 Danilo Antonio Montisano,8 Francesco De Cesaris,9 Antonio Munafò,9 Gianluca Avino,10 Michele Trimboli,11 Maria Albanese,12 Antonio Russo,13 Giorgio Dalla Volta,14 Marina Romozzi,15 Paola Merlo,16 Luisa Fofi,6,7 Alberto Doretti,17 Gloria Vaghi,5 Francesca Pistoia,4 Delfina Ferrandi,18 Stefania Battistini,19 Gianluca Coppola,3 Simona Sacco,4 Simona Guerzoni,2 Claudia Altamura,6,7 Fabrizio Vernieri,6,7 On behalf of the Italian Headache Registry (RICe) Study Group | 1Department of Biomedical, Metabolic, and Neural Science, University of Modena and Reggio Emilia; 2Pharmacology and Clinical Metabolic Toxicology-Headache Center and Drug Abuse-Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico di Modena; 3Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino, Latina; 4Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila; 5Department of Brain and Behavioral Sciences, University of Pavia; Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia; 6Headache Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Roma; 7Neurology Unit, Università Campus Bio-Medico di Roma; 8Neuroalgology Unit and Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan; 9Headache center and Clinical Pharmacology, AOU Careggi, Florence; 10SOC Neurologia, Ospedale di Prato; 11Azienda Ospedaliera-universitaria "Renato Dulbecco", Catanzaro; 12Università Roma Tor Vergata, Roma; 13Università della Campania "Luigi Vanvitelli", Napoli; 14U.O Neurologia, Istituto Clinico Città di Brescia, Gruppo San Donato, Brescia; 15Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy; 16UO di Neurologia, Humanitas Gavazzeni, Bergamo; 17Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milano; 18Neurology Department, Azienda Ospedaliero Universitaria, Santi Antonio e Biagio e Cesare Arrigo, Alessandria; 19Department of Medical, Surgical and Neurological Sciences, University of Siena, Italy
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OC-05 | Mid-term effectiveness and tolerability of atogepant in the prevention of migraine: a real life, prospective, multicentric study (the STAR study) Fabrizio Vernieri,1 Luigi Francesco Iannone,2,3 Gabriele Sebastianelli,4 Flavia Lo Castro,2, Federico De Santis,5 Michele Corrado,6 Marilena Marcosano,1 Raffaele Ornello,5 Licia Grazzi,7 Danilo Antonio Montisano,7 Francesco De Cesaris,8 Antonio Munafò,8 Gianluca Avino,9 Michele Trimboli,10 Maria Albanese,11 Antonio Russo,12 Giorgio Dalla Volta,13 Marina Romozzi,14 Paola Merlo,15 Maria Pia Prudenzano,16 Maria Rosaria Valente,17 Innocenzo Rainero,18 Giada Giuliani,19 Luisa Fofi,1 Alberto Doretti,20 Gloria Vaghi,6 Francesca Pistoia,5 Delfina Ferrandi,21 Stefania Battistini,22 Simona Sacco,5 Simona Guerzoni,2 Claudia Altamura1 on behalf of the Italian Headache Registry (RICe) Study Group | 1Fondazione Policlinico Campus Bio-Medico, Roma; 2AOU Policlinico di Modena; 3Università di Modena e Reggio Emilia. 4Sapienza University of Rome Polo Pontino, Latina; 5University of L’Aquila; 6University of Pavia, Pavia, Italy and IRCCS Mondino Foundation, Pavia; 7IRCCS Istituto Neurologico Carlo Besta, Milano; 8AOU Careggi, Firenze; 9SOC Neurologia, Ospedale di Prato, Prato; 10Azienda Ospedaliera-universitaria "Renato Dulbecco", Catanzaro; 11Università Roma Tor Vergata, Roma; 12Università della Campania "Luigi Vanvitelli", Napoli; 13U.O Neurologia, Istituto Clinico Città di Brescia, Gruppo San Donato, Brescia; 14Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma; 15UO di Neurologia, Humanitas Gavazzeni, Bergamo; 16Clinica Neurologica "L. Amaducci", Azienda Ospedaliero-Universitaria Consorziale di Bari; 17Dipartimento di Neuroscienze, Azienda Sanitaria Universitaria Integrata di Udine; 18Dipartimento di Neuroscienze, Città della Salute e della Scienza di Torino; 19Centro per la diagnosi e terapia delle cefalee, Policlinico Umberto I, Roma; 20IRCCS Istituto Auxologico Italiano, Milano; 21AOU Alessandria; 22University of Siena, Siena, Italy
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OC-06 | Migraine in the elderly: a retrospective study in a tertiary headache center Giulia Paparella,1,2 Stefania Scannicchio,1 Annalisa Di Dio,1 Emmanuella Ladisa,1 Chiara Abbatantuono,1 Elena Ammendola,1 Katia Ricci,1 Giusy Tancredi,1 Livio Clemente,1 Marianna Diletta Delussi,3 Marina de Tommaso1 | 1Neurophysiopathology Unit, Department of Translational Biomedicine and Neuroscience (DiBraiN), University of Bari Aldo Moro, Bari; 2IRCCS Neuromed, Pozzilli (IS; 3Department of Education, Psychology, Communication (For.Psi.Com.), University of Bari Aldo Moro, Bari, Italy
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OC-07 | A retrospective analysis of headache and CADASIL association Danilo Antonio Montisano,1 Giulia Regonesi,1 Licia Grazzi,1 Alessandra Parisi,1 Alberto Raggi,2 Elisabetta Soldini,2 Giorgia Camarda,2 Matilde Leonardi,2 I. Canavero,3 E.M. Zacarias,3 Anna Bersano,3 Nicola Rifino3 | Fondazione IRCCS Istituto Neurologico Carlo Besta: 1SSD Centro Cefalee; 2SC Neurologia Salute Pubblica e Disabilità, 3SC Malattie Cerebrovascolari, Milan, Italy
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OC-08 | Daily eletriptan significantly improves treatment-resistant cluster headache: a case series Andrea Burgalassi,1 Antonio Munafò,2 Francesco De Cesaris,1 Giulia Vigani,2 Alberto Chiarugi1,2 | 1Headache Center and Clinical Pharmacology Unit, Careggi University Hospital, Florence; 2Section of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, Florence, Italy
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OC-09 | Atogepant in treatment-refractory chronic migraine: is a revision of current criteria for refractory migraine appropriate? Lorenzo Tartaglione, Marcello Silvestro, Ilaria Orologio, Marcella Marziani, Francesco Maurizio Chianese, Pasquale Sozio, Alessandro Tessitore, Gioacchino Tedeschi, Antonio Russo | Headache Center, Department of Advanced Medical and Surgical Sciences (DAMSS), University of Campania "Luigi Vanvitelli", Naples, Italy
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OC-10 | Assessing white matter hyperintensities in cluster headache: a distinct pathophysiological profile compared to migraine G. Giuliani,1 A. Viganò,2 C. Zilli,1 D. Chiffi,1 E. Vicenzini,1 V. Di Piero,1 M. Altieri1 | 1Department of Human Neuroscience, Sapienza University of Rome; 2IRCCS Fondazione Don Carlo Gnocchi, Milan, Italy
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OC-11 | Corneal nerve plexus impairment in patients with trigeminal neuralgia Daniel Litewczuk,1 Gianfranco De Stefano,1 Sabrina Compagno,2 Mattia D’Andrea,2 Ludovico Alisi,2 Marco Marenco,2 Giulia Di Stefano,1 Andrea Truini1 | 1Department of Human Neuroscience, Sapienza University of Rome, 2Department of Sense Organs, Sapienza University of Rome, Italy
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OC-12 | The potential role of sleep quality in the relationship between glymphatic function and migraine frequency: insights from a cross-sectional study Maria Grazia Vittorini, Raffaele Ornello, Federico Salfi, Antonio Innocenzi, Federico De Santis, Federico Bruno, Francesca Pistoia, Michele Ferrara, Alessandra Splendiani, Simona Sacco | Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, Italy
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OC-13 | Monoclonal antibodies targeting CGRP differently affect sleep and psychiatric comorbidities in reproductive and postmenopausal chronic migraine women Giulia Procopio, Letizia Curto, Antonia Di Chirico, Leonardo Troilo, Gabriele Siciliano, Filippo Baldacci, Sara Gori | Neurology Unit, Department of Clinical and Experimental Medicine, University of Pisa-AOUP, Pisa, Italy
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OC-14 | Efficacy of eptinezumab during a migraine attack: preliminary data from an Italian multicenter real-world experience (the BEFREE study) Luisa Fofi,1 Claudia Altamura,1 Marilena Marcosano,1 Alberto Doretti,2 Francesca Pistoia,3 Antonio Granato,4 Simona Guerzoni,5 Michele Trimboli,6 Licia Grazzi,7 Danilo Antonio Montisano,7 Gianluca Avino,8 Gabriele Sebastianelli,9 Carla Fasano,10 Elisa Maria Piella,11 Nicoletta Brunelli,1 Luigi Francesco Iannone,5,12 Fabrizio Vernieri1 on behalf of the Italian Headache Registry (RICe) Study Group | 1Neurosonology and Headache Unit, Fondazione Policlinico Campus Bio-Medico, Rome; 2IRCCS Istituto Auxologico Italiano - Department of Neurology and Laboratory of Neuroscience - Milan; 3University of L’Aquila; 4Headache Center, Neurology Clinic, University of Trieste, University Hospital of Trieste; 5AOU Policlinico di Modena; 6Azienda Ospedaliera-universitaria "Renato Dulbecco", Catanzaro; 7Headache Center, Neuroalgology Dpt, IRCCS Foundation "Carlo Besta" Neurological Institute, Milan; 8SOC Neurologia, Ospedale Santo Stefano, USL Toscana Centro, Prato; 9La Sapienza University of Rome Polo Pontino, Latina; 10Headache and Cerebrovascular Diseases Center, Neurology Unit 2, Careggi University Hospital, Florence; 11Department of Neuroscience “Rita Levi Montalcini”, University of Turin; 12Università di Modena e Reggio Emilia, Italy
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OC-15 | Electroencephalography recording during visual aura in migraine: results by quantitative analysis Salvatore Maria Lima,1 Massimo Gangitano,1 Vincenzo Di Stefano,1 Vincenzo Raieli,2 Filippo Brighina1 | 1Department of Biomedicine, Neuroscience, and advanced Diagnostic (BIND), University of Palermo; 2Child Neurology and Psychiatry Unit-ISMEP, "G. Di Cristina" Children's Hospital-ARNAS Civico, Palermo, Italy
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OC-16 | Network-level brain connectivity alterations in an animal model of migraine and the effects of olcegepant treatment Rosaria Greco,1 Gloria Castellazzi,1 Miriam Francavilla,1,2 Chiara Demartini,1 Sara Facchetti,1,2 Daniele Martinelli,1 Cristina Tassorelli1,2 | 1Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia; 2Department of Brain and Behavioral Sciences, University of Pavia, Italy
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OC-17 | Profiling miR-30a expression in patients with episodic and chronic migraine Elisa Rubino,1,2 Elisa Maria Piella,1 Giulia Cicilese,1,3 Silvia Boschi,1 Alberto Mario Chiarandon,1 Elena Tamagno,1,3 Michela Guglielmotto,1,3 Innocenzo Rainero1,2 | 1Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Turin, Italy; 2Headache Center, Department of Neuroscience and Mental Health, AOU Città della Salute e della Scienza di Torino; 3Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano (TO), Italy
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OC-18 | Effectiveness of fremanezumab up to 12 months in different subgroups of participants: results from the Italian analysis of the PEARL study Raffaele Ornello,1 Gisella Airola,2 Letizia Curto,3 Diletta Alivernini,4 Chiara Abagnale,5 Pinar Kokturk,6 Yan Tereshko7 | 1Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila; 2Department of Surgical Sciences, Women's Headache Center, University of Turin; 3Neurology Unit, Department of Clinical and Experimental Medicine, University of Pisa; 4Department of Neuroscience, Mental Health and Sensory Organs (NESMOS), Sapienza University of Rome; 5Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino ICOT, Latina, Italy; 6TEVA Pharmaceuticals Europe B.V., Haarlem, The Netherlands; 7Clinical Neurology, Department of Head-Neck and Neuroscience, Azienda Sanitaria Universitaria Friuli Centrale (ASU FC), Udine, Italy
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OC-19 | A multicenter, retrospective case series of trigeminal autonomic cephalalgias in children and adolescents Alessandro Borrelli,1 Vittorio Sciruicchio,2 Alessandro Ferretti,3 Irene Toldo,4 Antonia Versace,5 Elisabetta Tozzi,6 Agnese Onofri,7 Giorgia Sforza,1 Gabriele Monte,1 Fabiana Ursitti,1 Massimiliano Valeriani,1,8,9 Laura Papetti1 | 1Developmental Neurology Unit, IRCCS Bambino Gesù Children's Hospital, Rome; 2Children Epilepsy and EEG Center, San Paolo Hospital, ASL Bari;3Department of Neuroscience, Mental Health & Sense Organs (NESMOS), Faculty of Medicine & Psychology, Sant'Andrea Hospital, Rome; 4Pediatric Neurology and Neurophysiology Unit, Department of Woman's and Child Health, University of Padua; 5A.O.U. Città della Salute e della Scienza di Torino, Department of Pediatric Emergency, Regina Margherita Children's Hospital, Turin; 6Department of Clinical Medicine, Public Health, Life and Environmental Sciences, L'Aquila; 7Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy; 8Tor Vergata University of Rome, Systems Medicine Department, Rome, Italy; 9Aalborg University, Center for Sensory-Motor Interaction, Aalborg, Denmark
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OC-20 | The inflammatory burden index in pediatric migraine: a clinical study Carola Meo¹, Giulia Manfrè¹, Antonella Morea², Caterina Gaspari¹, Martina Tarantini², Maria Rosita Ruta³, Sofia D’Agostino¹, Edvige Correnti⁴, Daniela D’Agnano², Diletta Lopes⁴, Rosaria Nardello¹, Giuseppe Santangelo⁴, Vittorio Sciruicchio², Vincenzo Raieli⁴ | 1Child Neuropsychiatry Unit Department, Pro.M.I.S.E. "G. D'Alessandro", University of Palermo; 2Children Epilepsy and EEG Center, San Paolo Hospital, ASL Bari; 3Child Neuropsychiatry Unit, ASP 6 Palermo; 4Child Neuropsychiatry Department, ISMEP, ARNAS Civico, Palermo, Italy
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OC-21 | Coping and pain catastrophizing in migraine patients and their mothers: a comparison between mothers with and without migraine Martina Proietti Checchi,1 Samuela Tarantino,1 Fabiana Ursitti,1 Giorgia Sforza,1 Gabriele Monte,1 Alessandro Borrelli,1 Massimiliano Valeriani,1,2,3 Laura Papetti1 | 1Developmental Neurology, Bambino Gesù Children Hospital, IRCCS, Rome, Italy; 2Child Neurology and Psychiatry Unit, Tor Vergata University of Rome, Italy; 3Translational Pain Neuroscience and Precision Medicine, CNAP, Dept. of Health Science and Technology, School of Medicine, Aalborg University, Denmark
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OC-22 | Beyond headache: prevalence of atopy and other comorbidities in pediatric patients Erica Agosto,1 Alessandra Fera,1 Giulia Grasso,2 Barbara Lauria,2 Roberta Rossi,2 Cristina Vassia,2 Emanuele Castagno,2 Antonia Versace2 | 1Department of Public Health and Pediatrics, Postgraduate School of Pediatrics, University of Turin; 2Department of Pediatric Emergency, Pediatric Headache Centre, Regina Margherita Children’s Hospital, Turin, Italy
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OC-24 | A retrospective case-control study aimed at analyzing, through the administration of a questionnaire, the prevalence, clinical features and the risk factors for chronicity in a sample of 419 pediatric patients Alice Bonuccelli, Sara Mundo, Emma Iacopelli, Alessandro Orsini, Lorenza Marini, Diego Peroni | Neuropediatric, Pediatric Clinic, AOU Pisa, Italy
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SISC-Poster
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PO-02 | Migraine in youth: a double challenge to cognition and emotion Samuela Tarantino,1 Martina Proietti Checchi,1 Laura Papetti,1 Fabiana Ursitti,1 Gabriele Monte,1 Giorgia Sforza,1 Massimiliano Valeriani,1-3 | 1Developmental Neurology Unit, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy; 2Systems Medicine Department, Tor Vergata University of Rome, Rome, Italy; 3Translational Pain Neuroscience and Precision Medicine, CNAP, Dept. of Health Science and Technology, School of Medicine, Aalborg University, Denmark
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PO-03 | Intracranial incidental findings on brain magnetic resonance imaging (MRI) in a pediatric population with primary headache: our experience and management Fabiana Ursitti,1 Filippo Tripodi,1 Laura Papetti,1 Giorgia Sforza,1 Gabriele Monte,1 Alessandro Borrelli,1 Samuela Tarantino,1 Martina Proietti Checchi,1 Massimiliano Valeriani1-3 | 1Developmental Neurology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy; 2Child Neurology Unit, Systems Medicine Department, Tor Vergata University Hospital of Rome, Rome, Italy; 3Translational Pain Neuroscience and Precision Medicine, CNAP, Department of Health Science and Technology, School of Medicine, Aalborg University, Aalborg, Denmark
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PO-04 | Mindfulness-based behavioral intervention for adolescents with high-frequency primary headaches: feasibility of a prospective multicenter study Beatrice Baldo,1 Giulia De Lorenzi,1 Valeria Marletta,1 Ilaria Bonemazzi,1 Alessia Raffagnato,2 Cristina Vassia,3 Emanuela Serri,3 Antonella Versace,4 Daniela D’Agnano,4 Vittorio Sciruicchio,4 Licia Grazzi,5 Irene Toldo1 | 1Juvenile Headache Center, Department of Woman’s and Child’s Health, University of Padua; 2Child and Adolescent Neuropsychiatric Unit, Department of Women's and Children's Health, University of Padua; 3Pediatric Headache Center, Department of Pediatric Emergency, Regina Margherita Children's Hospital, Turin; 4Children Epilepsy and EEG Center, San Paolo Hospital, ASL Bari; 5Neuroalgology Unit and Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
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PO-05 | Validation of the Italian version of the HARDSHIP Questionnaire in a school-based population Agnese Onofri,1 Chiara Rosignoli,1 Vittorio Trozzi,1 Martina D’Ambrosio,1 Benedetta Germani,1 Roberta Ciuffini,2 Raffaele Ornello,1 Simona Sacco1 | 1Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila; 2Department of Clinical Medicine, Public health, Life and Environmental Sciences, University of L’Aquila, Italy
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PO-06 | Children’s headache through drawings: a narrative review and a portrait gallery Floriana Ferro,1,2 Caterina Gaspari,1,2 Giulia Manfrè,1,2 Federica Cernigliaro,1 Daniela D’Agnano,3 Ruben Panzica,4 Edvige Correnti,2 Maria Rosita Ruta,5 Francesca Marchese,5 Renata Pitino,2 Maria Rita Capizzi,2 Giuseppe Santangelo,2 Antonella Versace,6 Vittorio Sciruicchio,3 Vincenzo Raieli2 | 1Child Neuropsychiatry Unit Department, Pro.MI.S.E. "G. D'Alessandro", University of Palermo; 2Child Neuropsychiatry Department, ISMEP, ARNAS Civico, Palermo; 3Children Epilepsy and EEG Center, San Paolo Hospital, ASL Bari, Bari; 4Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Messina; 5Child Neuropsychiatry Unit, ASP 6, Palermo; 6Pediatric Headache Center, Pediatric Emergency Dept, Regina Margherita Children's Hospital, Turin, Italy
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PO-07 | Psychological management of children treated at the Pediatric Headache Centre of Turin: preliminary analysis Emanuela Serri, Annachiara Lamberti Zanardi, Raffaella Mascolo, Barbara Lauria, Roberta Rossi, Sara Simona Racalbuto, Antonia Versace, Claudia Bondone | Department of Pediatric Emergency, Pediatric Headache Centre, Regina Margherita Children’s Hospital, Turin, Italy
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PO-08 | Long-term outcome in pediatric patients with headache S. Genta,1,2 M. Celario1,2, C. Brancaccio¹ ², G. Rossetto,1,2 C. Dusi,1,2 P. Baso,1,2 V. De Giorgis1,2 | 1Department of Child Neuropsychiatry, IRCCS Mondino, Pavia; 2University of Pavia, Italy
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PO-09 | When migraine turns severe: a case of aura that lasts too long Alessandra Fera,1 Erica Agosto,1 Giulia Grasso,2 Cristina Vassia,2 Francesca Feyles,2 Carlotta Canavese,3 Sara Racalbuto,2 Antonia Versace2 | 1Department of Public Health and Pediatrics, University of Turin; 2Department of Pediatric Emergency, Pediatric Headache Centre, Regina Margherita Children’s Hospital, Turin; 3Department of Child Pathology and Care “Regina Margherita”, SSD Pediatric Neurology, Regina Margherita Children’s Hospital, Turin, Italy
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PO-10 | Differential diagnosis between symptomatic focal occipital epilepsy and headache: a case report Federica Molaschi,1 Barbara Lauria,2 Giulia Grasso,2 Cristina Vassia,2 Francesca Torta,3 Antonia Versace,2 Carlotta Canavese3 | 1University of Turin, SC U Child Neuropsychiatry, Regina Margherita Hospital, Turin; 2Department of Pediatric Emergency, Pediatric Headache Centre, Regina Margherita Children’s Hospital, Turin; 3Department of Child Pathology and Care “Regina Margherita”, SSD Pediatric Neurology, Regina Margherita Children’s Hospital, Turin, Italy
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PO-11 | Resting state high-density EEG analysis reveals interictal subcortico-cortical linear and non-linear anomalies in subjects with migraine Gabriele Sebastianelli,1 Camillo Porcaro,2 Sara Gilli,1 Chiara Abagnale,1 Francesco Casillo,2 Giorgio Di Lorenzo,3 Gianluca Coppola1 | 1Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Polo Pontino ICOT, Latina; 2Department of Neuroscience (DNS) and Padova Neuroscience Center (PNC), University of Padova; 3Chair of Psychiatry, Department of Systems Medicine, Tor Vergata University of Rome, Italy
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PO-12 | The long-term efficacy on migraine of non-ketogenic low-carb diet after treatment with ketogenic diet Silvia Favaretto,1 Francesco Francini Pesenti2 | 1Headache centre, Neurology Unit, Department of Neuroscience, University Hospital of Padua; 2Department of Medicine (DIMED), Clinical Nutrition, University Hospital of Padua, Italy
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PO-13 | HD-EEG Delta connectivity rapidly alters after one month of atogepant in migraine patients Maria Albanese,1,2 Matteo Conti,1 Silvio Bagetta,1 Federico Carparelli,2 Vittoria Carla D’Agostino,2 Fabio Placidi,1,2 Alessandro Stefani,1,2 Nicola Biagio Mercuri,1-3 | 1Department of Systems Medicine, University of Rome Tor Vergata, Rome; 2Neurology Unit, Tor Vergata University Hospital, Rome; 3IRCCS Santa Lucia Foundation, Rome, Italy
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PO-14 | Pain catastrophizing in chronic migraine patients receiving eptinezumab treatment Alessandra Parisi,1 Licia Grazzi,1 Alberto Raggi,2 Giulia Regonesi,1 Montisano Danilo Antonio1 | 1Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano; 2Neurology, Public Health and Disability Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy
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PO-15 | Disclosing somatosensory system alterations in trigeminal neuralgia Gianfranco De Stefano, Daniel Litewczuk, Enrico Evangelisti, Giuseppe Di Pietro, Pietro Falco, Eleonora Galosi, Caterina Leone, Francesca Caramia, Andrea Truini, Giulia Di Stefano | Department of Human Neuroscience, Sapienza University of Rome, Italy
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PO-16 | Neurophysiological effects of atogepant in high-frequency episodic migraine B. Agostini,1,2 F. Cammarota,1,2 R. De Icco,1,2 V. Grillo,1,2 G. Vaghi,1,2 F. Bighiani1,2, M. Corrado,2 A. Antoniazzi,1,2 M. Giraudo,1,2 A. Solfrizzi,1,2 R. Greco,2 C. Demartini,1,2 A. Zanaboni,1,2 M. Francavilla,1,2 S. Facchetti,1,2 G. Sances,2 C. Tassorelli1,2 | 1Department of Brain and Behavioral Sciences, University of Pavia; 2Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy
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PO-17 | A clinical guide to assess and manage altered pain sensitivity and cervical musculoskeletal impairments migraine patients. Part 1: Assessment and profiling Stefano Di Antonio,1,2 Lars Arendt-Nielsen,1 Matteo Castaldo1,3 | 1Department of Health Science and Technology, Center for Pain and Neuroplasticity (CNAP), SMI, School of Medicine, Aalborg University, Aalborg, Denmark; 2Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal Child Health, University of Genoa; 3Department of Medicine and Surgery, Clinical Psychology, University of Parma, Italy
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PO-18 | A clinical guide to assess and manage altered pain sensitivity and cervical musculoskeletal impairments migraine patients. Part 2: individualised treatment Matteo Castaldo,1,2 Lars Arendt-Nielsen,1 Stefano Di Antonio1,3 | 1Department of Health Science and Technology, Center for Pain and Neuroplasticity (CNAP), SMI, School of Medicine, Aalborg University, Aalborg, Denmark; 2Department of Medicine and Surgery, Clinical Psychology, University of Parma; 3Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal Child Health, University of Genoa, Italy
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PO-19 | Unraveling the spectrum of migraine resistant to treatments: searching for novel biological PHEnotypes and theRApeutic approaches (SPHERA project) M. Giraudo,1,2 R. De Icco,1,2 G. Vaghi,1,2 V. Grillo,1,2 F. Bighiani,1,2 M. Corrado,2 A. Antoniazzi,1,2 F. Cammarota,1,2 B. Agostini,1,2 A. Solfrizzi,1,2 M. Allena,2 E. Guaschino,2 N. Ghiotto,2 R. Greco,2 C. Demartini,2 A. Zanaboni,1,2 M. Francavilla,1,2 S. Facchetti,1,2 G. Sances,2 C. Tassorelli1,2 | 1Department of Brain and Behavioral Sciences, University of Pavia; 2Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy
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PO-20 | Phenotypic description of a multigenerational family with PRRT2 gene mutation: a case series of six members affected by hemiplegic migraine and paroxysmal events Fabiana Cerulli,1 Costanza Sottani,1 Giulia Di Lazzaro,1,2 Paolo Calabresi,1,2 Anna Rita Bentivoglio,1,2 Catello Vollono1,3 | 1Dipartimento Universitario di Neuroscienze, Università Cattolica del Sacro Cuore, Rome; 2UOC Neurologia, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy; 3Neurofisiopatologia, Dipartimento di Scienze dell'invecchiamento, Neurologiche, Ortopediche e della Testa-Collo, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy
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PO-21 | Evaluating the impact of anti-CGRP monoclonal antibodies on retinal features in migraine patients: a retrospective optical coherence tomography study Chiara Serafini,1 Massimo Cesareo,2 Alessio Martucci,2 Marco Lombardo,2 Vittoria Carla D’Agostino,1 Alessandro Stefani,3 Carlo Nucci,2 Nicola Biagio Mercuri,1,3 Maria Albanese1,3 | 1Regional Referral Headache Center, Neurology Unit, Tor Vergata University Hospital, Rome, Italy 2Ophthalmology Unit, Department of Experimental Medicine, University of Rome “Tor Vergata”, Rome; 3Department of Systems Medicine, University of Rome “Tor Vergata”, Rome, Italy
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PO-22 | Impact of sleep disorders on anti-CGRP monoclonal antibodies treatment response in migraine: a cross-sectional study Costanza Sottani,1 Valerio Brunetti,1,2 Fabiana Cerulli,1 Claudia Garattini,4 Gianluca Avino,5 Paolo Calabresi,1,3 Catello Vollono1,4 | 1Università Cattolica del Sacro Cuore, Dipartimento di Neuroscienze, Rome; 2Stroke Unit, Fondazione Policlinico Agostino Gemelli IRCSS, Rome; 3UOC Neurologia, Fondazione Policlinico Agostino Gemelli IRCSS, Rome; 4UOC Neurofisiopatologia, Fondazione Policlinico Agostino Gemelli IRCSS, Rome; 5Unità di Neurologia, Ospedale Santo Stefano, Prato, Italy
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PO-23 | Hemicrania continua-like headache in familial SDHD-related paragangliomas: a diagnostic challenge A. Di Chirico, L. Curto, G. Procopio, L. Troilo, G. Siciliano, F. Baldacci, S. Gori | Neurology Unit, Department of Clinical and Experimental Medicine, University of Pisa-AOUP, Pisa, Italy
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PO-24 | Inflammatory signatures of comorbid episodic migraine and endometriosis: a cytokine-based analysis Maria Albanese,1,2 Veronica Ceci,3,4 Giulia Carrera,4,5 Aikaterini Selntigia,6 Caterina Exacoustos,6 Marta Tiberi,4 Stefano Saracini,3,4 Alessandro Matteocci,4,7 Nicola Biagio Mercuri,1,2,8 Valerio Chiurchiù3,4 | 1Department of Systems Medicine, University of Rome Tor Vergata, Rome; 2Regional Referral Headache Center, Neurology Unit, Tor Vergata University Hospital, Rome; 3Institute of Translational Pharmacology, National Research Council of Italy (CNR), Rome; 4Laboratory of Resolution of Neuroinflammation, IRCCS Santa Lucia Foundation, Rome; 5PhD Program in Neuroscience, Department of Systems Medicine, University of Rome Tor Vergata, Rome; 6Department of Surgical Sciences, Gynecological Unit, University of Rome Tor Vergata, Rome; 7PhD program in Immunology, Molecular Medicine and Applied biotechnologies, University of Rome Tor Vergata, Rome; 9Laboratory of Experimental Neuroscience, IRCCS Santa Lucia Foundation, Rome, Italy
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PO-25 | Antiepileptic medication in PRRT2 familial hemiplegic migraine: a case report L. Bartole, A. Granato, G. Garascia, P. Manganotti | Clinical Unit of Neurology, Headache Centre, Department of Medicine, Surgery and Health Sciences, University of Trieste, Italy
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PO-26 | Optic nerve sheath ultrasound in idiopatic intracranial hypertension: early findings Francesca Cotichelli,1,2 Davide Mascarella1,1,2 Valentina Favoni,1 Gaia Patanè,1,2 Francesco Severi,1,2 Francesca Verna,1,2 Giulia Pierangeli,1,2 Sabina Cevoli1 | 1IRCCS Istituto delle Scienze Neurologiche di Bologna; 2DIBINEM, Department of Biomedical and Neuromotor Science, Alma Mater Studiorum, Bologna, Italy
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PO-27 | A monitoring of intracranial hypertension through the valuation of optic nerve sheath diameter with bedside ultrasounds. A case report Antonio Taglialatela,1 Camilla Gaiga,1 Simone Lorenzut,2 Enrico Belgrado,2 Mariarosaria Valente1,3 | 1Clinical Neurology Unit, Department of Head, neck and neurosurgery, Udine University Hospital, Udine; 2Neurology Unit, "Head, Neck and Neurosciences" Department, University Hospital of Udine; 3Department of Medical Area, University of Udine, Udine, Italy
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PO-28 | Sex differences in the response to rimegepant for the treatment of acute migraine attacks – insights from the multicenter GAINER study Raffaele Ornello,1 Gloria Vaghi,2,3 Gabriele Sebastianelli,4 Francesco Casillo,4 Antonio Russo,5 Marcello Silvestro,5 Francesca Pistoia,1 Giorgio Dalla Volta,6 Matteo Cortinovis,6 Alberto Chiarugi,7 Danilo Antonio Montisano,8 Licia Grazzi,8 Maria Pia Prudenzano,9 Sabina Cevoli,10 Edoardo Mampreso,11 Gianluca Avino,12 Marina Romozzi,13 Mariarosaria Valente,14 Carla Fasano,15 Stefania Battistini,16 Antonio Granato,17 Elisa Maria Piella,18 Innocenzo Rainero,18 Federico De Santis,1 Simona Sacco,1 Maria Albanese,19 Michele Trimboli,20 Alberto Doretti,21 Cristina Tassorelli,2,3 Luigi Francesco Iannone,22 Roberto De Icco2,3 on behalf of the Italian Headache Registry (RICe) Study Group | 1Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila; 2Department of Brain and Behavioral Sciences, University of Pavia; 3Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia; 4Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino, Latina; 5Headache Centre, Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Naples; 6Headache Center of Clinical Neurology of Istituto Clinico "Città di Brescia", Brescia; 7Department of Health Sciences, University of Florence; 8Neuroalgology Unit and Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan; 9Headache Center, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari; 10IRCCS Istituto Di Scienze Neurologiche di Bologna, Programma Cefalee e Algie Facciali, Bologna; 11Headache Centre, Neurology - Euganea, Health Unit, Padua; 12Neurology Unit, Ospedale Santo Stefano, USL Toscana Centro, Prato; 13Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome; 14Clinical Neurology, Azienda Sanitaria Universitaria Friuli Centrale, Presidio Ospedaliero Santa Maria della Misericordia, Udine; 15Headache and Facial Pain Center Neurology, AOU Careggi, Florence; 16Department of Medical, Surgical and Neurological Sciences, University of Siena; 17Headache Centre, Clinical Unit of Neurology, School of Neurology, Department of Medicine, Surgery and Health Sciences, University Hospital and Health Services of Trieste, ASUGI, University of Trieste; 18Department of Neurosciences “Rita Levi Montalcini”, University of Turin; 19Department of Systems Medicine, University of Rome Tor Vergata, Rome; 20University Magna Graecia, Catanzaro; 21Department of Neuroscience - Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan; 22University of Modena and Reggio Emilia, Modena, Italy
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PO-29 | Spontaneous intracranial hypotension: a clinical and radiological observational study F. Verna, D. Mascarella, V. Favoni, G. Pierangeli, L. Cirillo, S. Cevoli | IRCCS Istituto delle Scienze Neurologiche di Bologna, Italia DIBINEM, Alma Mater Studiorum Bologna, Italy
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PO-30 | A chronic migraine phenotype unveiling acromegaly: diagnostic pitfalls and the impact of timely treatment Cinzia Rita Tamborino, Gianni Difonzo, Adriana Fallacara, Damiano Paolicelli, Maria Pia Prudenzano | Headache Center, “L. Amaducci” Neurological Clinic, Policlinico General Hospital, Bari, Italy
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PO-31 | Could lamotrigine represent an effective treatment strategy in patients with migraine with aura? An observational study M. Marziani, M. Silvestro, I. Orologio, L. Tartaglione, F.M. Chianese, A. Tessitore, A. Russo | Headache Centre, Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Italy
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PO-32 | Post-traumatic painful trigeminal neuropathy (13.1.2.3 - ICHD-3) following misguided gamma knife surgery: a case of diagnostic oversight with lasting consequences Marta Lioi,1 Laura Marino,1 Michele Trimboli2 | 1Department of Neurology, Magna Graecia University, Catanzaro, Italy; 2Institute of Neurology, AOU Renato Dulbecco, Catanzaro, Italy
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PO-33 | Visual hallucinations: a non-unique symptom Francesca Traccitto, Giada Giuliani, Davide Chiffi, Chiara Zilli, Mariangela Fratino, Marta Altieri | Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy
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PO-34 | Febrile headache in an immunosuppressed patient with autoimmune disease: a probable case of neurosarcoidosis Giulia Settembrini, Giovanni Rinaldi, Marco Alabiso, Ilenia Corbelli, Paola Sarchielli | Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Italy
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PO-35 | Treatment of chronic and episodic migraine with atogepant improves quality of life in patients with comorbid multiple sclerosis: the experience of the Headache Center at Spaziani Hospital, Frosinone Laura Borrello; Fabiana Marinelli; Maria Lorena Marziale; Ilaria Avallone; Fulvio Ferrante; Roberto De Simone | Neurology Unit, Headache Center, Multiple Sclerosis Center, UOC Pharmacy, Spaziani Hospital, Frosinone (FR), Italy
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PO-36 | An atypical presentation of Tolosa-Hunt Syndrome: a case report Marco Bolchini, Matteo Cortinovis, Paola Zavarise, Giulia Campana, Giorgio Dalla Volta | Neurology Unit and Headache Center, Istituto Clinico Città di Brescia, Brescia, Italy
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PO-37 | Trigeminal autonomic cephalalgia as the initial presentation of a cerebral cavernous malformation: a rare case report Francesco Maurizio Chianese, Marcello Silvestro, Ilaria Orologio, Lorenzo Tartaglione, Marcella Marziani, Antonio Russo | Headache Centre, Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy
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PO-38 | Impact of atogepant on achieving best possible quality of life among patient global impression of change responders Cristina Tassorelli,1 Pranav Gandhi,2 Molly Duan,2 Karen Carr,2 Kandavadivu Umashankar,2 Jonathan Stokes,2 Grace Forde,3 Tanya Bilchik,4 Martina Martini*, Rashmi Halker Singh5 | 1University of Pavia, Pavia, Italy; 2AbbVie, North Chicago, IL, USA; 3North American Partners in Pain Management, North New Hyde Park, NY, USA; 4Department of Neurology, Yale School of Medicine, New Haven, CT, USA; 5Mayo Clinic, Phoenix, AZ, USA *Abbvie Srl, Rome, Italy.
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PO-39 | Leeds Dependence Questionnaire (LDQ) in migraine: diagnostic utility without predictive value for anti-CGRP (R) response Antonio Munafò,1 Andrea Burgalassi,1 Giulia Vigani,2 Francesco De Cesaris,1 Alberto Chiarugi1,2 | 1Headache Center and Clinical Pharmacology Unit, Careggi University Hospital, Florence, Italy; 2Section of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, Florence, Italy
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PO-40 | Evaluating agreement between physician and ChatGPT in migraine prophylaxis selection: a pilot comparative study Simone Vigneri1, MatteoZanella2, Gianfranco Sindaco2, Alberto Merlin2, Maria Mazzullo2, Marco La Grua2, Valentina Paci2, Carmen Bertone2, Gilberto Pari2 1Santa Maria Maddalena Hospital, Neurology, Occhiobello, Italy; 2Santa Maria Maddalena Hospital, Pain Medicine, Occhiobello, Italy
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PO-41 | Eptinezumab for difficult-to-treat migraine: who responds and who needs more Alessandro Visentini,1,2,3 Roberta Messina,1,2,3 Ilaria Cetta,1,2,3 Edorardo Ratto,1 Laura Zanandrea,1,3 Federica Genovese,1,2,3 Irene Chinali,1 Bruno Colombo,1 Massimo Filippi1,2,3 | 1Neurology Unit and 2Neuroimaging Research Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy; 3Vita-Salute San Raffaele University, Milan, Italy
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PO-42 | OnaBotulinumtoxin-A in chronic migraine patients with short or long disease history and psychiatric comorbidities: preliminary data from an Italian multicentric study (the BACH Study) Fabrizio Vernieri,1,2 Marilena Marcosano,2 Licia Grazzi,3 Danilo Antonio Montisano,3 Raffaele Ornello,4 Simona Sacco,4 Chiara Rosignoli,4 Alberto Doretti,5 Maria Albanese,6 Giovanna Viticchi,7 Nicoletta Brunelli, Luigi d’Onofrio,2 Luisa Fofi,1 Claudia Altamura,1,2 Patrizio Pasqualetti8 | 1Fondazione Policlinico Campus Bio-Medico, Roma, Italy; 2Università Campus Bio-Medico di Roma, Italy; 3Istituto Neurologico Besta, Milano, Italy; 4Università degli Studi l’Aquila, Italy; 5Istituto Auxologico, Milano, Italy; 6Policlinico Tor Vergata, Roma, Italy; 7Università Politecnica Marche, Italy; 8Sapienza Università di Roma, Italy
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PO-43 | Eptinezumab in migraine patients unresponsive to prior subcutaneous CGRP(-R) monoclonal antibody treatment: a retrospective case series Elena Cresta, Irene Mattioli, Michele Di Pasquale, Alice Lanfranchi, Renata Rao, Alessandro Padovani | Neurology Unit and Headache Centre, Dipartimento di continuità di cura e fragilità, ASST Spedali Civili e Università degli studi di Brescia, Brescia, Italy
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PO-44 | Effectiveness of fremanezumab as preventive treatment of migraine up to 24 months: response rates from the Italian analysis of the PEARL study Alberto Doretti,1 Anna Ambrosini,2 Simone Braca,3 Florindo D’Onofrio,4 Elisa Maria Piella,5 Pinar Kokturk,6 Rosario Iannacchero7 | 1Department of Neurology-Laboratory of Neuroscience, IRCCS, Istituto Auxologico Italiano, Milan, Italy; 2Mediterranean Neurological Institute NEUROMED IRCCS, Pozzilli (IS), Italy; 3Headache Centre, University of Naples “Federico II”, Naples, Italy; 4UOSD Stroke Unit, S.G. Moscati Hospital, Avellino, Italy; 5Neurosciences Department, University of Turin, Turin, Italy; 6Teva Netherlands B.V., Haarlem, The Netherlands; 7Department of Neurology, Headache Center, Regional Hospital “Pugliese-Ciaccio”, Catanzaro, Italy
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PO-45 | Botulinum toxin in clinical practice: a turning point for chronic migraine and MOH Chiara Zilli, Davide Chiffi, Giada Giuliani, Francesca Traccitto, Mariangela Fratino, Marta Altieri | Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy
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PO-46 | Diagnostic tests and headache misdiagnoses in individuals with resistant and refractory migraine – data from the REFINE study Federico De Santis,1 Chiara Rosignoli,1 Agnese Onofri,1 Mark Braschinsky,2 Olga Sved,2 Raquel Gil-Gouveia,3,4 Renato Oliveira,3 Christian Lampl,5 Jakob Paungarttner,5 Paolo Martelletti,6 William David Wells-Gatnik,7 Isabel Pavao Martins,8 Dimos D Mitsikostas,9 Loukia Apostolakopoulou,9 Aynur Ozge,10 Dilan Bayar Narin,10 Patricia Pozo-Rosich,11 Albert Munoz-Vendrell,11 Maria Pia Prudenzano,12 Martino Gentile,12 Kristina Ryliskiene,13 Jurgita Vainauskiene,14 Margarita Sanchez-del-Rio,15 Fabrizio Vernieri,16 Gianmarco Iaccarino,16 Marta Waliszewska-Prosół,17 Sławomir Budrewicz,17 Marta Carnovali,18 Zaza Katsarava,18 Simona Sacco,1 Raffaele Ornello1 | 1Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy; 2Department of Neurology and Neurosurgery, Institute of Clinical Medicine, Faculty of Medicine, University of Tartu and Neurology Clinic of Tartu University Hospital, Tartu, Estonia; 3Headache Center, Neurology Department, Hospital da Luz, Lisboa, Portugal; 4Center for Interdisciplinary Research in Health, Universidade Católica Portuguesa, Lisboa; 5Headache Medical Center, Seilerstaette Linz, Linz, Austria; 6Unitelma Sapienza University of Rome, Italy; 7Texas Tech University Health Sciences Center, El Paso TX, USA; 8Centro de Estudos Egas Moniz, Faculty of Medicine, University of Lisbon, Lisbon, Portugal; 9First Department of Neurology, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece; 10Department of Neurology, Mersin University Medical Faculty, Mersin, Turkey and NOROM Neuroscience and Neurotechnology Center of Excellence, Ankara, Turkey; 11Headache Unit, Neurology Department, Vall d’Hebron University Hospital, Headache and Neurological Pain Research Group, VHIR, Barcelona, Spain; 12Headache Center, “I. Amaducci” Neurological Clinic, Policlinico General Hospital, Bari, Italy; 13Center of Neurology, Vilnius University, Vilnius, Lithuania; 14Center of Neurology, Kardiolitos klinikos, Vilnius, Lithuania; 15Department of Neurology, Clínica Universidad de Navarra, Madrid, Spain; 16Unit of Headache and Neurosonology, Fondazione Policlinico Campus Bio-Medico and Neurology, Università Campus Bio-Medico di Roma, Roma, Italy; 17Department of Neurology, Wroclaw Medical University, Wrocław, Poland; 18Department of Neurology, Christian Hospital Unna and University of Duisburg-Essen, Ruhr Metropolitan, Germany
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PO-47 | Systemic ozone treatment in chronic migraine: a focus on disability reduction and medication use Sergio Sorrenti,1,2 Matteo Ciuffreda,1 Emanuele Pisello,1 Luca Brugiaferri,2 Azzurra Federici,2 Cristiano Piangatelli,3 Dario Galante4 | 1U.O.C. Anestesia Rianimazione Terapia del Dolore, AST Ancona, Fabriano (AN), Italy; 2Scuola di Specializzazione in Anestesia Rianimazione, Terapia Intensiva e del Dolore, UNIVPM, Ancona, Italy; 3Direttore U.O.C. Anestesia Rianimazione Terapia del Dolore, AST Ancona, Fabriano (AN), Italy; 4Direttore U.O.C. Anestesia e Rianimazione, Cerignola (FG), Italy
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PO-48 | Flunarizine for preventive treatment of hemiplegic migraine during pregnancy: a case report Andrea Burgalassi,1 Antonio Munafò,2 Francesco De Cesaris,1 Giulia Vigani,2 Alberto Chiarugi1,2 | 1Headache Center and Clinical Pharmacology Unit, Careggi University Hospital, Florence, Italy; 2Section of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, Florence, Italy
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PO-49 | Distress perception and mutuality in caregivers of migraine patients with depressive symptoms.: baseline evaluation of the observational prospective real-life MiDEAR study to evaluate the effectiveness of fremanezumab for reducing the caregivers’ burden a C. Altamura,1 L. Fofi,1 R. Ornello,2 G. Ceccardi,3 C. Aurilia,4 A. Montisano,5 I. Orologio,6 D. Mascarella,7 G. Viticchi,8 M. Marcosano,1 N. Brunelli,1 G. Del Mastro,1 A. Onofri,2 A. Lanfranchi,3 G. Fiorentini,4 M. Silvestro,6 V. Favoni,7 G. Egeo,4 M. Silvestrini,8 M. Peresson,9 S. Cevoli,7 A. Russo,6 R. Rao,3 L. Grazzi,5 S. Sacco,2 F. Vernieri1 | 1Fondazione Policlinico Universitario Campus Bio-Medico, Rome; 2University of L'Aquila, L’Aquila; 3ASST Spedali Civili di Brescia, Brescia; 4IRCCS San Raffaele, Rome; 5IRCCS Fondazione istituto Neurologico Carlo Besta, Milan; 7IRCCS Istituto Delle Scienze Neurologiche di Bologna, Bologna; 6University of Campania; Caserta; 8Marche Polytechnic University, Ancona; 9San Pietro Fatebenefratelli Hospital, Rome, Italy
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PO-50 | Enhanced integration and synergy in EEG- and fNIRS-based networks in migraine patients following three-month galcanezumab treatment: associations with long-term clinical effects Giulia Paparella,1,2 Marianna La Rocca,3 Livio Clemente,1 Emmanuella Ladisa,1 Chiara Abbatantuono,1 Elena Ammendola,1 Marianna Diletta Delussi,4 Katia Ricci,1 Giusy Tancredi,1 Antonio Lacalamita,3 Alfonso Monaco,3 Nicola Amoroso,5 Sebastiano Stramaglia,3 Roberto Bellotti,3 Marina de Tommaso1 | 1Neurophysiopathology Unit, Department of Translational Biomedicine and Neuroscience (DiBraiN), University of Bari Aldo Moro, Bari, Italy; 2IRCCS Neuromed, Pozzilli (IS), Italy; 3Interateneo Department of Physics "M. Merlin", University of Bari Aldo Moro, Bari, Italy; 4Department of Education, Psychology, Communication (For.Psi.Com.), University of Bari Aldo Moro, Bari, Italy; 5Department of Pharmacy–Drug Sciences, University of Bari Aldo Moro, Bari, Italy
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PO-51 | Rimegepant combined with valproic acid and botulinum toxin in refractory hemiplegic migraine: a case report Gianni Difonzo, Cinzia Tamborino, Adriana Fallacara, Damiano Paolicelli, Maria Pia Prudenzano | Headache Center, “L. Amaducci” Neurological Clinic, Policlinico General Hospital, Bari, Italy
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PO-52 | Long-term efficacy of CGRP mAbs: new insights and current evidence Oreste Marsico,1 Marta Lioi,2 Rosario Iannacchero,3 Michele Trimboli3 | 1Department of Neuroscience, “Giovanni Paolo II” Hospital, Lamezia Terme, Catanzaro, Italy; 2Department of Neurology, Magna Graecia University, Catanzaro, Italy; 3Institute of Neurology, AOU Renato Dulbecco, Catanzaro, Italy
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PO-53 | Managing chronic primaryhHeadache in Lombardy: insights from the ‘PERLA’ project Grazia Sances,1 Claudia Sulmona,1 Natascia Ghiotto,1 Daniele Martinelli,1 Licia Grazzi,2 Alberto Raggi,2 Danilo Antonio Montisano,2 Matilde Leonardi,2 Giulia Gandini,2 Renata Rao,3 Alessandro Padovani,3 Alessandro Amorosi,5 Cristina Tassorelli,1,5 on behalf of Rete Regionale Cefalee Lombardia | 1Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation Pavia, Italy; 2Headache Center, IRCCS Fondazione Istituto Neurologico Carlo Besta, Milan, Italy; 3ASST Spedali Civili di Brescia, Italy; 4Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy; 5Struttura Reti Clinico-Assistenziali e Organizzative e Ricerca, U.O. Polo Ospedaliero Direzione Generale Welfare, Regione Lombardia, Italy
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PO-54 | Patient perspectives on physiotherapy interventions for migraine: a pre- and post-intervention qualitative study Zhiqi Liang,1 Caitlin Scott,1 Felix Cabrera Manrique,1 Sumin Kim,1 Chun Shun Lee,1 Bixiang Cheng,1 Chun Yiu Kwok,1 Matteo Castaldo2 | 1University of Queensland; 2Parma University, Italy
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PO-55 | What patients want: a qualitative study on an information resource on migraine Matteo Castaldo,1 Zhiqi Liang,2 Gina Williams,2 Shayne Watson,2 Caitlyn Haynes,2 Zoe Diamond2 | 1Parma University; 2University of Queensland
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PO-56 | The role of bilateral greater occipital nerve block in resistant chronic migraine with medication overuse Leonardo Troilo, Letizia Curto, Giulia Procopio, Antonia Di Chirico, Gabriele Siciliano, Sara Gori, Filippo Baldacci | Neurology Unit, Department of Clinical and Experimental Medicine, University of Pisa-AOUP, Pisa, Italy
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PO-57 | Early treatment with atogepant improves sleep quality without sleep-related adverse events: a prospective observational study Alberto Boccalini,1 Luigi Francesco Iannone,1,2* Flavia Lo Castro,1 Daria Brovia,1 Marina Romozzi,3,4 Fabrizio Vernieri,5,6 Claudia Altamura,5,6 Simona Guerzoni1 | 1Digital and Predictive Medicine, Pharmacology and Clinical Metabolic Toxicology-Headache Center and Drug Abuse-Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico di Modena, Modena, Italy; 2Department of Biomedical, Metabolic, and Neural Science, University of Modena and Reggio Emilia, Modena, Italy; 3Dipartimento Universitario di Neuroscienze, Università Cattolica del Sacro Cuore, Rome, Italy; 4Neurologia, Dipartimento di neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; 5Headache Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy; 6Università Campus Bio-Medico di Roma, Italy
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PO-58 | Pilot protocol to improve the booking and management network for chronic headache in secondary and tertiary care services A. Granato,1 L. Bartole,1 S. Centonze,2 A. Lodi,3 M. Lodi Zollia,3 P. Manganotti1 | 1Clinical Unit of Neurology, Headache Centre, Department of Medicine, Surgery and Health Sciences, ASUGI, University of Trieste, Trieste, Italy; 2Research & Innovation Unit, ASUGI, University of Trieste, Trieste, Italy; 3Funzione Organizzativa, Gestione Offerte Ambulatoriali, ASUGI, University of Trieste, Trieste, Italy
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PO-59 | Questioning online survey-based physiotherapy treatment referral in headache treatment: differences in developed and developing countries D. Onan,1,2 A.K. Erdemoğlu,3 P. Gelener,4 S. Velioğlu,5 S. Ulutaş,6 N. Taşdemir,7 M. Waliszewska-Prosół,8 E. Ekizoğlu,9 M. Straburzyński,10 M. Kodounis,11 B. Raffaelli,12 C. Tana,13 F. De Cesaris,14 R. Messina,15 E.I. Sen,16 S. Ray,17 G. Sebastianelli,18 F. Granella,19 U. Pensato,20 S. Crema,21 S. Cevol,22 K. Chakravarty,23 M. Pia Prudenzano,24 A. Casalena,25 M. Romozzi,26 T. Takizawa,26 W. Rattanawong,27 A. Gantenbein,28 V. Favoni,29 C. Gaul,30 L.F.I. Iannone,31 B. Schäfer,23 D.A. Montisano,33 O. Grosu,34 A.B. de Oliveira,35 F. Puledda,36 V. Romanenko,37 I. Ros González,38 M. Castaldo,39 H. Al-Khazali,40 A. Hassan,41 D. Garcia-Azorin,42 L.-L. Hope Pan,43 R. Gil-Gouveia,44 M. Sanchez del Rio,45 M. Lisicki,46 H.W. Schytz,47 P. Anukoolwittaya,48 T. Mavridis,49 M. Lanteri-Minet,50 D.B. Swerts,51 C. Altamura,52 K. Hirata,53 M. Togha,54 M. Kyung Chu,55 T. Pongpitakmetha,56 M.-H. Bjørk,57 M. Minen,58 K. Skorobogatykh,59 D. Chowdhury,60 A.-M. Torgersen Dalgeir,61 J. Versijpt,62 P. Cras,63 A. Govaerts,64 A. Chiarugi,65 N. Vashchenko,59 L. Dobbels,66 T.S. Monteith,67 F. De Bruyne,68 E. Garay,67 S.L. Sava,69 Z. Salinas,67 M. Nordtveit,70 K. Delmotte,71 A. Gonzalez-Martinez,72 S. Debray,73 C. Deligianni,74 W. De Hertogh,75 R. Castien,76 E. Caronna,77 C. Valerija,78 F. Ahmed,79 G. De la Meilleure,80 L.L. Panneerchelvam,81 G.H. Bringeland,82 R. Ornello,2 S. Sacco2 | 1Yozgat Bozok University, Physiotherapy and Rehabilitation, Ankara, Turkey;2University of L'Aquila, Department of Biotechnological and Applied Clinical Sciences, L'Aquila, Italy;3Clinic of Prof. Dr. Ali Kemal Erdemoğlu, Neurology, Ankara, Turkey;4Elite Research and Surgical Hospital , Nicosia, Cyprus;5Karadeniz Technical University, Department of Neurology, Trabzon, Turkey;6Bahcesehir University, Department of Neurology, İstanbul, Turkey;7Ağrı İbrahim Çeçen University, Department of Neurology, Ağrı, Turkey;8Wroclaw Medical University, Wroclaw, Germany;9Istanbul University, Department of Neurology, Istanbul, Turkey;10University of Warmia and Mazury, Olsztyn, Poland;11National & Kapodistrian University of Athens, First Neurology Department, Eginitio Hospital, School of Medicine, Athens, Greece;12Charité Universitätsmedizin Berlin, Department of Neurology,Headache Center, Berlin, Germany;13SS Annunziata Hospital of Chieti, Chieti, Italy;14Centro Cefalee e Farmacologia Clinica - AOU Careggi , Florence, Italy;15Vita-Salute San Raffaele University, Milano, Italy;16Istanbul University Istanbul Faculty of Medicine, Department of Physical Medicine and Rehabilitation, İstanbul, Turkey;17Department of Neurology, PGIMER, Chandigarh, India;18Sapienza University of Rome, Latina, Italy;19University of Parma, Parma, Italy;20Humanitas University, Milan, Italy;21Fleni Hospital, Buenos Aires, Argentina;22University of Bologna, Bologna, Italy;23Post Graduate Institute Of Medical Education and Research, Chandigarh, India;24AOUC Policlinico, Centro Cefalee - Clinica Neurologica L Amaducci, Bari, Germany;25Centro Cefalee UOC Neurologia, Teramo, Italy;26Keio University School of Medicine, Tokyo, Japan;27King Mongkut's Institute of Technology Ladkrabang, Bangkok, Thailand;28ZURZACH Care, Zürich, Switzerland;30IRCCS Istituto delle scienze neurologiche di Bologna, Bologna, Italy;30Headache Center Frankfurt, Frankfurt, Germany;31Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy, Modena, Italy;32Migraine and Headache Clinic Königstein , Frankfurt, Germany;33SSD Centro Cefalee - Fondazione IRCCS Istituto Neurologico C.Besta, Milan, Italy;34Diomid Gherman Institute of Neurology and Neurosurgery, Kişinev, Moldova;35Center for Clinical and Epidemiological Research, University of Sao Paulo , Sao Paolo, Brazil;36King's College London, London, United Kingdom;37Vita Medical Clinic, Kyiv, Ukraine;38Hospital Clínico Universitario de Valladolid, Vallodolid, Spain;39Parma University, Parma, Italy;40Danish Headache Center, Copenhagen, Denmark;41Cairo University , Cairo, Egypt;42University of Valladolid, Valladolid, Spain;43Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan;44Hospital da Luz. Lisboa, Lisboa, Portugal;45Clinica Universidad de Navarra, Navarra, Spain;46Mercedes & Martín Ferreyra Institute for Medical Research, Córdoba, Argentina;47University of Copenhagen, Copenhagen, Denmark;48King Chulalongkorn Memorial Hospital, Bangkok, Thailand;49Tallaght University Hospital, Dublin, Ireland;50CHU Nice and Cote D'azur University, Nice, France;51Santa Casa de Sao Paolo, Sao Paolo, Brazil;52Fondazione Policlinico Universitario Campus BIo-Medico, Rome, Italy;53Dokkyo Medical University, Mibu, Tochigi, Japan;54Tehran University, Tehran, Iran;55Yonsei University, Seoul, South Korea;56Chulalongkorn University, Bangkok, Thailand;57University of Bergen , Bergen, Norway;58NYU Langone Health, New York, United States;59University Headache Clinic, Moscow, Russian Federation;60 G B Pant Institute of Post Graduate Medical Education and Research, New Delhi, India;61Haukeland University Hospital, NorHead, Bergen, Norway;62UZ Brussel, Brussel, Belgium;63Universiteit Antwerpen, Antwerpen, Belgium;64Rz Tienen, Tienen, Belgium;65University of Florence, Florence, Italy;Neurology Department İmelda Ziekenhuis, Bonheiden, Belgium;67University of Miami, Miami, United States;68University College Ghent, Ghent, Belgium;69University of Liège, Liege, Belgium;70Haukeland Universitetssykehus, Bergen, Norway;71Universitair Ziekenhuis Leuven, Leuven, Belgium;72Hospital Universitario de la Princesa e Instituto de Investigación Sanitaria Princesa, Madrid, Spain;73Europa Ziekenhuizen, Brussel, Belgium;74Athens Naval Hospital, Athens, Greece;75University of Antwerp , Antwerpen, Belgium;76Vrije Universiteit Amsterdam, Amsterdam, Netherlands;77Vall d'Hebron Hospital, Barcelona, Spain;78Private hospital, Riga, Latvia;79Hull University, Hull, United Kingdom;80VITAZ - General Hospital, Sint-Niklaas, Belgium;81James Cook University Hospital, Middlesbrough, United Kingdom; 82Haukeland University Hospital, Bergen, Norway
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PO-60 | Effectiveness of aerobic exercise, Mulligan technique, and myofascial release in migraine management: preliminary data from a randomized controlled trial Marco Bravi,1,2 Fabio Santacaterina,1,2 Federica Bressi,1,2 Francesca Nasto,1,2 Claudia Altamura,1,2 Fabrizio Vernieri1,2 | 1Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Rome, Italy; 2Università Campus Bio-Medico di Roma, Rome, Italy
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PO-61 | Social cognition in interictal episodic and chronic migraine: a cross-sectional study Chiara Abbatantuono,1* Delussi Marianna,2* Clemente Livio,1 Giulia Paparella,1 Stefania Scannicchio,1 Annalisa Di Dio,1 Elena Ammendola,1 Giusy Tancredi,1 Emmanuella Ladisa,1 Giulia Paparella,1,3 Marina de Tommaso1 (*Equally Contributed) | 1Neurophysiopathology Unit, Department of Translational Biomedicine and Neuroscience (DiBraiN), University of Bari Aldo Moro (IT), Bari, Italy; 2Department of Education, Psychology, Communication (For.Psi.Com.), University of Bari Aldo Moro (IT), Bari, Italy; 3IRCCS Neuromed Pozzilli (IS), Italy
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PO-62 | Preventive migraine treatment in patients under 25: a 24-month observational study on adherence, therapeutic switching, and prescription determinant factors Marilena Marcosano,1 Nicoletta Brunelli,1 Luisa Fofi,1 Laura Papetti,2 Fabiana Ursitti,2 Massimiliano Valeriani,2 Fabrizio Vernieri,1 Claudia Altamura1 | 1Headache and Neurosonology Unit, Fondazione Policlinico Campus Biomedico di Rome, Rome, Italy; 2Developmental Neurology, Bambino Gesù Children Hospital, IRCCS, Rome, Italy
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PO-63 | Acceptance and commitment therapy in the management of chronic headache pain E. Principe,1 M. Pirrotta,1 N. Fava,2 C. Marchio,1 L. M. Catalano,1 D. Bosco,2 R. Iannacchero,2 Alcmeone group | 1SPDC ASP Catanzaro, 2Centro Cefalee AOU R. Dulbecco Catanzaro, Italy
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PO-64 | Telemedicine in a second level headache clinic of Azienda Sanitaria Locale Roma 1: a lesson learned from the SarsCov2 pandemic Teresa Catarci | ASL Roma 1, Rome, Italy
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PO-65 | The complexity of chronic headache: towards tailored therapies through a multidimensional assessment Silvia Favaretto,1 Giulia Demo,2 Veronica Rizzato,2 Elisabetta Patron,2,3,4 Sara Bianconi,2 Stèphanie Maldera,2 Giulia Buodo,2,3 | 1UOC Clinica Neurologica, Azienda Ospedale-Università Padova, Padua, Italy; 2Centro di Ateneo Servizi Clinici Universitari Psicologici (SCUP), University of Padua, Italy; 3Department of General Psychology, University of Padua, Padova, Italy; 4Padua Neuroscience Center (PNC), University of Padua, Padova, Italy
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PO-66 | Predicting the evolution to resistant and refractory migraine: a machine learning analysis from the REFINE Study Chiara Rosignoli,1 Raffaele Ornello,1 Daniele Lozzi,2 Enrico Mattei,2 Federico De Santis,1 Agnese Onofri,1 Mark Braschinsky,3 Christian Lampl,4 Isabel Pavão Martins,5 Paolo Martelletti,6 Dimos Mitsikostas,7 Raquel Gil-Gouveia,8 Maria Pia Prudenzano,9 Kristina Ryliskiene,10 Margarita Sanchez del Rio,11 Patricia Pozo-Rosich,12 Aynur Özge,13 Fabrizio Vernieri,14 Marta Waliszewska-Prosół,15 Zaza Katsarava,16 Giuseppe Placidi,2 Simona Sacco1 | 1Dept. of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy; 2A²VI-lab, Dept. MeSVA University of L’Aquila; 3Dept. of Neurology and Neurosurgery, Institute of Clinical Medicine, Faculty of Medicine, University of Tartu, Estonia; 4Headache Medical Center, Seilerstaette Linz, Austria. Center; 5Headache Center, Hospital da Luz, Lisbon, Portugal; 6School of Health, Unitelma Sapienza University of Rome, Italy; 7First Dept of Neurology, Aeginition Hospital, National and Kapodistrian University of Athens, Greece; 8Centro de Estudos Egas Moniz, Faculty of Medicine, University of Lisbon, Portugal; 9Headache Center, Amaducci Neurological Clinic, Policlinico General Hospital, Bari, Italy; 10Center of Neurology, Vilnius University, Lithuania; 11Dept. of Neurology, Clínica Universidad de Navarra, Madrid, Spain; 12Neurology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain; 13Dept. of Neurology, Mersin University Medical Faculty, Mersin, Turkey; 14Università Policlinico Campus Bio-Medico, Rome, Italy; 15Dept. of Neurology, Wroclaw Medical University, Wrocław, Poland; 16Dept of Neurology, Christian Hospital Unna and University of Duisburg-Essen, Ruhr Metropolitan, Germany
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PO-67 | Investigating plasma neurofilament light chain levels in patients with migraine: a cross-sectional study Elisa Maria Piella,1 Alberto Mario Chiarandon,1 Silvia Boschi,1 Fausto Roveta,1 Lucrezia Bonino,1 Giulia Gioiello,2 Giulia Montesano,2 Giulio Mengozzi,2 Innocenzo Rainero,1,3 Elisa Rubino1,3 | 1Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Turin, Italy; 2Clinical Biochemistry Laboratory “Baldi e Riberi”, A.O.U. Città della Salute e della Scienza di Torino, Turin, Italy; 3Headache Center, Department of Neuroscience and Mental Health, AOU Città della Salute e della Scienza di Torino, Turin, Italy
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PO-68 | Bipolar disorder spectrum and psychopathology in cluster headache compared to migraine: a cross-sectional study in a hospital headache clinic Isabella Getuli, Giada Giuliani, Chiara Zilli, Simone Preti, Gaia Chiecchi, Lorenzo Tarsitani, Marta Altieri | Dipartimento di Neuroscienze Umane, Sapienza Università di Roma, Italy
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PO-69 | Three-month atogepant treatment modulates dopaminergic-related functional connectivity in episodic migraine Davide Fedeli,1 Danilo Antonio Montisano,1 Greta Demichelis,1 Giuseppe Ciullo,1,2 Jean Paul Medina Carrion,1 Maria Grazia Bruzzone,1 Emilio Ciusani,1 Alessandra Erbetta,1 Marina Grisoli,1 Erika Guastafierro,1 Domenico D’Amico,1 Alberto Raggi,1 Anna Nigri,1 Licia Grazzi1 | 1Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy; 2University of Parma, Parma, Italy
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PO-70 | A nomogram for the prediction of response to anti-CGRP mAbs: the CGRP score Marina Romozzi,1 Ammar Lokhandwala,2 Catello Vollono,1 David García-Azorín,3 Giulia Vigani,4 Francesco De Cesaris,4 Claudia Altamura,5 Fabrizio Vernieri,5 Paolo Calabresi,1 Sonia Di Tella,6 Luigi Francesco Iannone7 1Dipartimento Universitario di Neuroscienze, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; 2Drexel University, Philadelphia, PA, USA; 3Hospital Universitario del Río Hortega, Valladolid, Headache Unit, Department of Neurology, Valladolid, Spain; 4Section of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, Florence, Italy; 5 Neurologia, Dipartimento di Medicina e Chirurgia, Università Campus Bio-Medico di Roma, Rome, Italy; 6Dipartimento di Psicologia, Università Cattolica del Sacro Cuore, Milan, Italy; 7Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
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PO-71 | Is Doctor Google retiring? How Generative Artificial Intelligence is transforming the perception and management of headaches Matteo Bellamio,1 Sofia Zywicki,1 Rocco Quatrale,2 Giorgio Zanchin,3 Ferdinando Maggioni,3 Alberto Terrin1 | 1Centro Cefalee dell’Angelo, Neurology, Ospedale dell'Angelo, AULSS3 Serenissima, Mestre (VE), Italy; 2Neurology, Ospedale dell'Angelo, AULSS3 Serenissima, Mestre (VE), Italy; 3Neurology, University of Padua, Padua, Italy
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PO-72 | Stigma in migraine: preliminary results from the “Studio Emicrania Maugeri” Project Luca Giani, Christian Lunetta | Istituti Clinici Scientifici Maugeri IRCCS, Neurological Rehabilitation Unit of Milano Institute, Milan, Italy
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PO-73 | Auricular acupuncture as a complementary treatment for tension-type headache in women: a prospective study on efficacy and safety Sergio Sorrenti,1,2 Matteo Ciuffreda,1 Emanuele Pisello,1 Luca Brugiaferri,2 Azzurra Federici,2 Cristiano Piangatelli,3 Dario Galante4 | 1U.O.C. Anestesia Rianimazione Terapia del Dolore, AST Ancona, Fabriano (AN), Italy; 2Scuola di Specializzazione in Anestesia Rianimazione, Terapia Intensiva e del Dolore, UNIVPM, Ancona, Italy; 3Direttore U.O.C. Anestesia Rianimazione Terapia del Dolore, AST Ancona, Fabriano (AN), Italy; 4Direttore U.O.C. Anestesia e Rianimazione, Cerignola (FG), Italy
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PO-74 | Effectiveness of auricular acupuncture in the management of menstrual migraine: a pilot study Sergio Sorrenti,1,2 Matteo Ciuffreda,1 Emanuele Pisello,1 Luca Brugiaferri,2 Azzurra Federici,2 Cristiano Piangatelli,3 Dario Galante4 | 1U.O.C. Anestesia Rianimazione Terapia del Dolore, AST Ancona, Fabriano (AN), Italy; 2Scuola di Specializzazione in Anestesia Rianimazione, Terapia Intensiva e del Dolore, UNIVPM, Ancona, Italy; 3Direttore U.O.C. Anestesia Rianimazione Terapia del Dolore, AST Ancona, Fabriano (AN), Italy; 4Direttore U.O.C. Anestesia e Rianimazione, Cerignola (FG), Italy
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PO-75 | Network meta-analysis comparing efficacy and safety outcomes of atogepant, rimegepant, and galcanezumab in patients with episodic migraine after including CHALLENGE-MIG Trial Jessica Ailani,1 Pranav Gandhi,2 Anjana Lalla,2 Peter McAllister,3 Tanya Bilchik,4 Stephanie Nahas,5 David Rowe,6 Cristiano Piron,6 Kari Kelton,6 Raffaello Masselli*, Rashmi Halker Singh7 | 1MedStar Health, Washington DC, USA; 2AbbVie, North Chicago, IL, USA; 3New England Institute for Neurology and Headache, Stamford, CT USA; 4Department of Neurology, Yale School of Medicine, New Haven, CT, USA; 5Department of Neurology, Thomas Jefferson University, Philadelphia, PA USA; 6Medical Decision Modeling Inc., Indianapolis, IN, USA; 7Mayo Clinic, Phoenix, AZ, USA *Abbvie Srl, Rome, Italy. This individual has been added to this publication author by-line, with the permission of the original authors, for the express purpose of conducting the presentation at a local congress or in a local language. He did not contribute to the content of the publication.
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PO-76 | Atogepant reduces psychological dependence to acute treatments evaluated with the Leeds dependence questionnaire (LDQ): a prospective observational study Luigi Francesco Iannone,1,2 Marina Romozzi,3,4 Alberto Boccalini,1 Flavia Lo Castro,1 Claudia Altamura,5 Fabrizio Vernieri,5 Simona Guerzoni1 | 1Digital and Predictive Medicine, Pharmacology and Clinical Metabolic Toxicology-Headache Center and Drug Abuse-Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico di Modena, Modena, Italy; 2Department of Biomedical, Metabolic, and Neural Science, University of Modena and Reggio Emilia, Modena, Italy; 3Dipartimento Universitario di Neuroscienze, Università Cattolica del Sacro Cuore, Rome, Italy; 4Neurologia, Dipartimento di Neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; 5Headache Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy; 6Università Campus Bio-Medico di Roma, Italy
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PO-77 | Real-world evidence of Atogepant efficacy in patients unresponsive to anti-CGRP monoclonals Matteo Cortinovis, Marco Bolchini, Paola Zavarise, Giulia Campana, Giorgio Dalla Volta | Headache Center, Istituto Clinico Città di Brescia, Gruppo San Donato, Brescia, Italy
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PO-78 | No changes in blood pressure assessed with the 24-hour Holter monitoring in patients treated with anti-CGRP monoclonal antibodies: a prospective observational study (SAFHYPER) Flavia Lo Castro,1 Niccolò Bonini,2 Luigi Francesco Iannone,1,3 Alberto Boccalini,1 Daria Brovia,1 Luca Pani,1,3 Giuseppe Boriani,2,3 Simona Guerzoni1 | 1Digital and Predictive Medicine, Pharmacology and Clinical Metabolic Toxicology-Headache Center and Drug Abuse-Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico di Modena, Modena, Italy; 2Cardiology Division, AOU Policlinico di Modena, Modena, Italy; 3Department of Biomedical, Metabolic, and Neural Science, University of Modena and Reggio Emilia, Modena, Italy
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PO-79 | Survey on adherence and tolerability of atogepant used as migraine preventive treatment D.A. Montisano,1 G. Vaghi,2,3 A. Paris,1 R. De Icco,2,3 B. Agostini,2,3 M. Giraudo,2,3 A. Solfrizzi,2,3 C. Tassorelli,2,3 G. Sances,3 L. Grazzi | 1Fondazione IRCCS C.Besta Istituto Neurologico, SSD Headache Center, Milan, Italy; 2University of Pavia, Department of Brain and Behavioral Sciences, Pavia, Italy; 3IRCCS Mondino Foundation, Headache Science & Neurorehabilitation Unit, Pavia, Italy
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PO-80 | Real-world effectiveness of atogepant for the preventive treatment of migraine in a cohort of multi -refractory patients: a single center study M. De Luca,1 L. Ferraù,1 A. Cafarchio,2 M.S. Adragna,1 M. Autunno1 | 1Unit of Neurology and Neuromuscular Diseases, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy; 2Department of Medicine and Health Sciences “Vincenzo Tibero” DIMES, University of Molise, Campobasso, Italy
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PO-81 | Knowledge and misconceptions on headache disorders among healthcare workers: preliminary results from the Studio Emicrania Maugeri Study Luca Giani, Christian Lunetta | Istituti Clinici Scientifici Maugeri IRCCS, Neurological Rehabilitation Unit of Milano Institute, Milan, Italy
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PO-82 | Integrated approach with detoxification, CGRP monoclonal antibodies and psychoeducational support in two patients with complex medication overuse headache Claudia Lanni,1 Federica Papini,2 Chiara Prevost,3 Alessandro Canessa,3 Lucia Testa,3 Cristoforo Comi,2 Delfina Ferrandi3 | 1Department of Psychology “Santi Antonio e Biagio”, University Hospital, Alessandria, Italy; 2Neurology Unit, Department of Transitional Medicine, University of Piemonte Orientale, and University Hospital “Maggiore della Carità”, Novara, Italy; 3Neurology Unit, “Santi Antonio e Biagio” University Hospital, Alessandria, Italy
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PO-83 | Serum diamine oxidase activity in patients with cluster headache: a cross-sectional case–control study Silvia Boschi,1 Elisa Maria Piella,1 Tilde Manetta,3 Paola Merlach,3 Alberto Mario Chiarandon,1 Alessia Agostinelli,1 Barbara Donati Morello,3 Giulio Mengozzi,3 Innocenzo Rainero,1,2 Elisa Rubino,1,2 | 1Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Turin, Italy; 2Headache Center, Department of Neuroscience and Mental Health, AOU Città della Salute e della Scienza di Torino, Turin, Italy; 3Department of Laboratory Medicine, Città della Salute e della Scienza University Hospital, Turin, Italy
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PO-84 | Inhibiting the peripheral degradation of anandamide reduces trigeminal hyperalgesia in a model of dural neurogenic inflammation via a CB1/CB2-independent mechanism Chiara Demartini,1 Rosaria Greco,1 Miriam Francavilla,1,2 Sara Facchetti,1,2 Cristina Tassorelli1,2 | 1Section of Translational Neurovascular Research, IRCCS Mondino Foundation, Pavia, Italy; 2Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy
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PO-85 | Alterations in gut microbiota and the endocannabinoid system in an animal model of chronic migraine Sara Facchetti,1,2 Chiara Demartini,1 Miriam Francavilla,1,2 Rosaria Greco,1 Cristina Tassorelli1,2 | 1Section of Translational Neurovascular Research, IRCCS Mondino Foundation, Pavia, Italy; 2Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy
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PO-86 | CGRP, VIP and PACAP plasmatic levels in migraine patients before and after anti-CGRP(R) monoclonal antibodies prophylaxis Alessia Bellotti,1 Davide Chiasserini,2 Alfredo Megaro,2 Daniela Fruttini,3 Pierluigi Navarra,4 Giuseppe Tringali,4 Paolo Calabresi,5 Lucilla Parnetti,1 Paola Sarchielli1 | 1Department of Medicine and Surgery, Section of Neurology, University of Perugia, Perugia, Italy; 2Department of Medicine and Surgery, Section of Physiology and Biochemistry, University of Perugia, Perugia, Italy; 3Department of Medicine and Surgery, Section of Internal Medicine, University of Perugia, Perugia, Italy; 4Department of Healthcare Surveillance and Bioethics, Section of Pharmacology, Catholic University Medical School, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy; 5Department of Medicine and Surgery, Section of Neurology, Catholic University Medical School, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy
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PO-87 | Dual inhibition of FAAH and TRPV1 receptors counteracts nitroglycerin-induced migraine-like symptoms only in male rats Miriam Francavilla,1,2 Sara Facchetti,1,2 Chiara Demartini,1 Anna Maria Zanaboni,1,2 Michela Palmisani,3 Valentina Franco,3 Rosaria Greco,1 Cristina Tassorelli1,2 | 1Section of Translational Neurovascular Research, IRCCS Mondino Foundation, Pavia; 2Department of Brain and Behavioral Sciences, University of Pavia; 3Department of Internal Medicine and Therapeutics, Clinical and Experimental Pharmacology Unit, University of Pavia, Italy
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PO-88 | Can tamoxifen and metformin nullify efficacy of CGRP-mAbs migraine prophylaxis? Patrizia Rossi,1,2 Valentina Cima,2 Alessandro Burlina2 | 1Headache Center, 2Neurology Department, San Bassiano Hospital, Bassano del Grappa (VI), Italy
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PO-89 | Alcohol and headache: an update Alessandro Panconesi,1,2 Maria Letizia Bartolozzi1 | 1Headache Centre, Department of Neurology, Health Authority, Empoli; 2Clinical Research Institute Ecomedica, Empoli, Italy
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PO-90 | CAPSULASE® (PEA (palmitoylethanolamide), PHYTOSOME (quercetin from Sophora japonica L. 40% soy lecithin, microcrystalline cellulose, aerosil), CASPEROME (Boswellia serrata R., gum resin 40%, soy lecithin, microcrystalline cellulose, aerosil), bromelain 2 Ennio Pucci,1 Ludovica Pucci,2 Alberto Vercesio3 | 1Department of Nervous System and Behavioral Sciences, University of Pavia; 2Nutritional biologist, Master in Nutritional and Clinical Dietetics, University of Pavia, Italy; 3Scientific Advisor
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PO-91 | Real-world evidence of CGRP dual blockade: clinical and biomarker insights from combined therapy in chronic migraine Laura Marino,1 Marta Lioi1, Rosario Iannacchero,2 Michele Trimboli2 | 1Department of Neurology, Magna Graecia University, Catanzaro; 2Institute of Neurology, AOU Renato Dulbecco, Catanzaro, Italy
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PO-92 QZU® (Kudzu e.s.: 200 mg of which Isoflavones: 80 mg and Puerarin: 60 mg; ComplexZyme vegan®: 40 mg) in the prophylaxys of migraine without aura: a retrospective observational study Ennio Pucci,1 Ludovica Pucci,2 Alberto Vercesi3 | 1Department of Nervous System and Behavioral Sciences, University of Pavia; 2Nutritional biologist, Master in Nutritional and Clinical Dietetics, University of Pavia, Italy; 3Scientific Advisor
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