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PO-30 | A chronic migraine phenotype unveiling acromegaly: diagnostic pitfalls and the impact of timely treatment

Cinzia Rita Tamborino, Gianni Difonzo, Adriana Fallacara, Damiano Paolicelli, Maria Pia Prudenzano | Headache Center, “L. Amaducci” Neurological Clinic, Policlinico General Hospital, Bari, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15852
- 533 abstract views
PO-17 | A clinical guide to assess and manage altered pain sensitivity and cervical musculoskeletal impairments migraine patients. Part 1: Assessment and profiling

Stefano Di Antonio,^1,2 Lars Arendt-Nielsen,¹ Matteo Castaldo^1,3 | ¹Department of Health Science and Technology, Center for Pain and Neuroplasticity (CNAP), SMI, School of Medicine, Aalborg University, Aalborg, Denmark; ²Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal Child Health, University of Genoa; ³Department of Medicine and Surgery, Clinical Psychology, University of Parma, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15838
- 412 abstract views
PO-18 | A clinical guide to assess and manage altered pain sensitivity and cervical musculoskeletal impairments migraine patients. Part 2: individualised treatment

Matteo Castaldo,^1,2 Lars Arendt-Nielsen,¹ Stefano Di Antonio^1,3 | ¹Department of Health Science and Technology, Center for Pain and Neuroplasticity (CNAP), SMI, School of Medicine, Aalborg University, Aalborg, Denmark; ²Department of Medicine and Surgery, Clinical Psychology, University of Parma; ³Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal Child Health, University of Genoa, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15839
- 298 abstract views
PO-27 | A monitoring of intracranial hypertension through the valuation of optic nerve sheath diameter with bedside ultrasounds. A case report

Antonio Taglialatela,¹ Camilla Gaiga,¹ Simone Lorenzut,² Enrico Belgrado,² Mariarosaria Valente^1,3 | ¹Clinical Neurology Unit, Department of Head, neck and neurosurgery, Udine University Hospital, Udine; ²Neurology Unit, "Head, Neck and Neurosciences" Department, University Hospital of Udine; ³Department of Medical Area, University of Udine, Udine, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15849
- 335 abstract views
PO-70 | A nomogram for the prediction of response to anti-CGRP mAbs: the CGRP score

Marina Romozzi,¹ Ammar Lokhandwala,² Catello Vollono,¹ David García-Azorín,³ Giulia Vigani,⁴ Francesco De Cesaris,⁴ Claudia Altamura,⁵ Fabrizio Vernieri,⁵ Paolo Calabresi,¹ Sonia Di Tella,⁶ Luigi Francesco Iannone⁷ 1Dipartimento Universitario di Neuroscienze, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; 2Drexel University, Philadelphia, PA, USA; 3Hospital Universitario del Río Hortega, Valladolid, Headache Unit, Department of Neurology, Valladolid, Spain; 4Section of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, Florence, Italy; 5 Neurologia, Dipartimento di Medicina e Chirurgia, Università Campus Bio-Medico di Roma, Rome, Italy; 6Dipartimento di Psicologia, Università Cattolica del Sacro Cuore, Milan, Italy; 7Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15893
- 336 abstract views
PO-63 | Acceptance and commitment therapy in the management of chronic headache pain

E. Principe,¹ M. Pirrotta,¹ N. Fava,² C. Marchio,¹ L. M. Catalano,¹ D. Bosco,² R. Iannacchero,² Alcmeone group | ¹SPDC ASP Catanzaro, ²Centro Cefalee AOU R. Dulbecco Catanzaro, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15886
- 434 abstract views
PO-89 | Alcohol and headache: an update

Alessandro Panconesi,^1,2 Maria Letizia Bartolozzi¹ | ¹Headache Centre, Department of Neurology, Health Authority, Empoli; ²Clinical Research Institute Ecomedica, Empoli, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15913
- 740 abstract views
PO-85 | Alterations in gut microbiota and the endocannabinoid system in an animal model of chronic migraine

Sara Facchetti,^1,2 Chiara Demartini,¹ Miriam Francavilla,^1,2 Rosaria Greco,¹ Cristina Tassorelli^1,2 | ¹Section of Translational Neurovascular Research, IRCCS Mondino Foundation, Pavia, Italy; ²Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15909
- 598 abstract views
PO-36 | An atypical presentation of Tolosa-Hunt Syndrome: a case report

Marco Bolchini, Matteo Cortinovis, Paola Zavarise, Giulia Campana, Giorgio Dalla Volta | Neurology Unit and Headache Center, Istituto Clinico Città di Brescia, Brescia, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15858
- 860 abstract views
PO-25 | Antiepileptic medication in PRRT2 familial hemiplegic migraine: a case report

L. Bartole, A. Granato, G. Garascia, P. Manganotti | Clinical Unit of Neurology, Headache Centre, Department of Medicine, Surgery and Health Sciences, University of Trieste, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15847
- 755 abstract views
PO-76 | Atogepant reduces psychological dependence to acute treatments evaluated with the Leeds dependence questionnaire (LDQ): a prospective observational study

Luigi Francesco Iannone,^1,2 Marina Romozzi,^3,4 Alberto Boccalini,¹ Flavia Lo Castro,¹ Claudia Altamura,⁵ Fabrizio Vernieri,⁵ Simona Guerzoni¹ | ¹Digital and Predictive Medicine, Pharmacology and Clinical Metabolic Toxicology-Headache Center and Drug Abuse-Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico di Modena, Modena, Italy; ²Department of Biomedical, Metabolic, and Neural Science, University of Modena and Reggio Emilia, Modena, Italy; ³Dipartimento Universitario di Neuroscienze, Università Cattolica del Sacro Cuore, Rome, Italy; ⁴Neurologia, Dipartimento di Neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; ⁵Headache Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy; 6Università Campus Bio-Medico di Roma, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15900
- 399 abstract views
PO-73 | Auricular acupuncture as a complementary treatment for tension-type headache in women: a prospective study on efficacy and safety

Sergio Sorrenti,^1,2 Matteo Ciuffreda,¹ Emanuele Pisello,¹ Luca Brugiaferri,² Azzurra Federici,² Cristiano Piangatelli,³ Dario Galante⁴ | ¹U.O.C. Anestesia Rianimazione Terapia del Dolore, AST Ancona, Fabriano (AN), Italy; ²Scuola di Specializzazione in Anestesia Rianimazione, Terapia Intensiva e del Dolore, UNIVPM, Ancona, Italy; ³Direttore U.O.C. Anestesia Rianimazione Terapia del Dolore, AST Ancona, Fabriano (AN), Italy; ⁴Direttore U.O.C. Anestesia e Rianimazione, Cerignola (FG), Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15896
- 432 abstract views
PO-68 | Bipolar disorder spectrum and psychopathology in cluster headache compared to migraine: a cross-sectional study in a hospital headache clinic

Isabella Getuli, Giada Giuliani, Chiara Zilli, Simone Preti, Gaia Chiecchi, Lorenzo Tarsitani, Marta Altieri | Dipartimento di Neuroscienze Umane, Sapienza Università di Roma, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15891
- 707 abstract views
PO-45 | Botulinum toxin in clinical practice: a turning point for chronic migraine and MOH

Chiara Zilli, Davide Chiffi, Giada Giuliani, Francesca Traccitto, Mariangela Fratino, Marta Altieri | Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15867
- 239 abstract views
PO-88 | Can tamoxifen and metformin nullify efficacy of CGRP-mAbs migraine prophylaxis?

Patrizia Rossi,^1,2 Valentina Cima,² Alessandro Burlina² | ¹Headache Center, ²Neurology Department, San Bassiano Hospital, Bassano del Grappa (VI), Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15912
- 892 abstract views
PO-90 | CAPSULASE^® (PEA (palmitoylethanolamide), PHYTOSOME (quercetin from Sophora japonica L. 40% soy lecithin, microcrystalline cellulose, aerosil), CASPEROME (Boswellia serrata R., gum resin 40%, soy lecithin, microcrystalline cellulose, aerosil), bromelain 2

Ennio Pucci,¹ Ludovica Pucci,² Alberto Vercesio³ | ¹Department of Nervous System and Behavioral Sciences, University of Pavia; ²Nutritional biologist, Master in Nutritional and Clinical Dietetics, University of Pavia, Italy; ³Scientific Advisor

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15914
- 905 abstract views
PO-86 | CGRP, VIP and PACAP plasmatic levels in migraine patients before and after anti-CGRP(R) monoclonal antibodies prophylaxis

Alessia Bellotti,¹ Davide Chiasserini,² Alfredo Megaro,² Daniela Fruttini,³ Pierluigi Navarra,⁴ Giuseppe Tringali,⁴ Paolo Calabresi,⁵ Lucilla Parnetti,¹ Paola Sarchielli¹ | ¹Department of Medicine and Surgery, Section of Neurology, University of Perugia, Perugia, Italy; ²Department of Medicine and Surgery, Section of Physiology and Biochemistry, University of Perugia, Perugia, Italy; ³Department of Medicine and Surgery, Section of Internal Medicine, University of Perugia, Perugia, Italy; ⁴Department of Healthcare Surveillance and Bioethics, Section of Pharmacology, Catholic University Medical School, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy; ⁵Department of Medicine and Surgery, Section of Neurology, Catholic University Medical School, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy

Societò Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15910
- 492 abstract views
PO-06 | Children’s headache through drawings: a narrative review and a portrait gallery

Floriana Ferro,^1,2 Caterina Gaspari,^1,2 Giulia Manfrè,^1,2 Federica Cernigliaro,¹ Daniela D’Agnano,³ Ruben Panzica,⁴ Edvige Correnti,² Maria Rosita Ruta,⁵ Francesca Marchese,⁵ Renata Pitino,² Maria Rita Capizzi,² Giuseppe Santangelo,² Antonella Versace,⁶ Vittorio Sciruicchio,³ Vincenzo Raieli² | ¹Child Neuropsychiatry Unit Department, Pro.MI.S.E. "G. D'Alessandro", University of Palermo; ²Child Neuropsychiatry Department, ISMEP, ARNAS Civico, Palermo; ³Children Epilepsy and EEG Center, San Paolo Hospital, ASL Bari, Bari; ⁴Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Messina; ⁵Child Neuropsychiatry Unit, ASP 6, Palermo; ⁶Pediatric Headache Center, Pediatric Emergency Dept, Regina Margherita Children's Hospital, Turin, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15842
- 398 abstract views
PO-31 | Could lamotrigine represent an effective treatment strategy in patients with migraine with aura? An observational study

M. Marziani, M. Silvestro, I. Orologio, L. Tartaglione, F.M. Chianese, A. Tessitore, A. Russo | Headache Centre, Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15853
- 3,948 abstract views
PO-46 | Diagnostic tests and headache misdiagnoses in individuals with resistant and refractory migraine – data from the REFINE study

Federico De Santis,¹ Chiara Rosignoli,¹ Agnese Onofri,¹ Mark Braschinsky,² Olga Sved,² Raquel Gil-Gouveia,^3,4 Renato Oliveira,³ Christian Lampl,⁵ Jakob Paungarttner,⁵ Paolo Martelletti,⁶ William David Wells-Gatnik,⁷ Isabel Pavao Martins,⁸ Dimos D Mitsikostas,⁹ Loukia Apostolakopoulou,⁹ Aynur Ozge,¹⁰ Dilan Bayar Narin,¹⁰ Patricia Pozo-Rosich,¹¹ Albert Munoz-Vendrell,¹¹ Maria Pia Prudenzano,¹² Martino Gentile,¹² Kristina Ryliskiene,¹³ Jurgita Vainauskiene,¹⁴ Margarita Sanchez-del-Rio,¹⁵ Fabrizio Vernieri,¹⁶ Gianmarco Iaccarino,¹⁶ Marta Waliszewska-Prosół,¹⁷ Sławomir Budrewicz,¹⁷ Marta Carnovali,¹⁸ Zaza Katsarava,¹⁸ Simona Sacco,¹ Raffaele Ornello¹ | ¹Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy; ²Department of Neurology and Neurosurgery, Institute of Clinical Medicine, Faculty of Medicine, University of Tartu and Neurology Clinic of Tartu University Hospital, Tartu, Estonia; ³Headache Center, Neurology Department, Hospital da Luz, Lisboa, Portugal; ⁴Center for Interdisciplinary Research in Health, Universidade Católica Portuguesa, Lisboa; ⁵Headache Medical Center, Seilerstaette Linz, Linz, Austria; ⁶Unitelma Sapienza University of Rome, Italy; ⁷Texas Tech University Health Sciences Center, El Paso TX, USA; ⁸Centro de Estudos Egas Moniz, Faculty of Medicine, University of Lisbon, Lisbon, Portugal; ⁹First Department of Neurology, Aeginition Hospital, National and Kapodistrian University of Athens, Athens, Greece; ¹⁰Department of Neurology, Mersin University Medical Faculty, Mersin, Turkey and NOROM Neuroscience and Neurotechnology Center of Excellence, Ankara, Turkey; ¹¹Headache Unit, Neurology Department, Vall d’Hebron University Hospital, Headache and Neurological Pain Research Group, VHIR, Barcelona, Spain; ¹²Headache Center, “I. Amaducci” Neurological Clinic, Policlinico General Hospital, Bari, Italy; ¹³Center of Neurology, Vilnius University, Vilnius, Lithuania; ¹⁴Center of Neurology, Kardiolitos klinikos, Vilnius, Lithuania; ¹⁵Department of Neurology, Clínica Universidad de Navarra, Madrid, Spain; ¹⁶Unit of Headache and Neurosonology, Fondazione Policlinico Campus Bio-Medico and Neurology, Università Campus Bio-Medico di Roma, Roma, Italy; ¹⁷Department of Neurology, Wroclaw Medical University, Wrocław, Poland; ¹⁸Department of Neurology, Christian Hospital Unna and University of Duisburg-Essen, Ruhr Metropolitan, Germany

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15868
- 431 abstract views
PO-10 | Differential diagnosis between symptomatic focal occipital epilepsy and headache: a case report

Federica Molaschi,¹ Barbara Lauria,² Giulia Grasso,² Cristina Vassia,² Francesca Torta,³ Antonia Versace,² Carlotta Canavese³ | ¹University of Turin, SC U Child Neuropsychiatry, Regina Margherita Hospital, Turin; ²Department of Pediatric Emergency, Pediatric Headache Centre, Regina Margherita Children’s Hospital, Turin; ³Department of Child Pathology and Care “Regina Margherita”, SSD Pediatric Neurology, Regina Margherita Children’s Hospital, Turin, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15831
- 661 abstract views
PO-15 | Disclosing somatosensory system alterations in trigeminal neuralgia

Gianfranco De Stefano, Daniel Litewczuk, Enrico Evangelisti, Giuseppe Di Pietro, Pietro Falco, Eleonora Galosi, Caterina Leone, Francesca Caramia, Andrea Truini, Giulia Di Stefano | Department of Human Neuroscience, Sapienza University of Rome, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15836
- 352 abstract views
PO-49 | Distress perception and mutuality in caregivers of migraine patients with depressive symptoms.: baseline evaluation of the observational prospective real-life MiDEAR study to evaluate the effectiveness of fremanezumab for reducing the caregivers’ burden a

C. Altamura,¹ L. Fofi,¹ R. Ornello,² G. Ceccardi,³ C. Aurilia,⁴ A. Montisano,⁵ I. Orologio,⁶ D. Mascarella,⁷ G. Viticchi,⁸ M. Marcosano,¹ N. Brunelli,¹ G. Del Mastro,¹ A. Onofri,² A. Lanfranchi,³ G. Fiorentini,⁴ M. Silvestro,⁶ V. Favoni,⁷ G. Egeo,⁴ M. Silvestrini,⁸ M. Peresson,⁹ S. Cevoli,⁷ A. Russo,⁶ R. Rao,³ L. Grazzi,⁵ S. Sacco,² F. Vernieri¹ | ¹Fondazione Policlinico Universitario Campus Bio-Medico, Rome; ²University of L'Aquila, L’Aquila; ³ASST Spedali Civili di Brescia, Brescia; ⁴IRCCS San Raffaele, Rome; ⁵IRCCS Fondazione istituto Neurologico Carlo Besta, Milan; ⁷IRCCS Istituto Delle Scienze Neurologiche di Bologna, Bologna; ⁶University of Campania; Caserta; ⁸Marche Polytechnic University, Ancona; ⁹San Pietro Fatebenefratelli Hospital, Rome, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15871
- 394 abstract views
PO-87 | Dual inhibition of FAAH and TRPV1 receptors counteracts nitroglycerin-induced migraine-like symptoms only in male rats

Miriam Francavilla,^1,2 Sara Facchetti,^1,2 Chiara Demartini,¹ Anna Maria Zanaboni,^1,2 Michela Palmisani,³ Valentina Franco,³ Rosaria Greco,¹ Cristina Tassorelli^1,2 | ¹Section of Translational Neurovascular Research, IRCCS Mondino Foundation, Pavia; ²Department of Brain and Behavioral Sciences, University of Pavia; ³Department of Internal Medicine and Therapeutics, Clinical and Experimental Pharmacology Unit, University of Pavia, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15911
- 423 abstract views
PO-57 | Early treatment with atogepant improves sleep quality without sleep-related adverse events: a prospective observational study

Alberto Boccalini,¹ Luigi Francesco Iannone,^1,2* Flavia Lo Castro,¹ Daria Brovia,¹ Marina Romozzi,^3,4 Fabrizio Vernieri,^5,6 Claudia Altamura,^5,6 Simona Guerzoni¹ | ¹Digital and Predictive Medicine, Pharmacology and Clinical Metabolic Toxicology-Headache Center and Drug Abuse-Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico di Modena, Modena, Italy; ²Department of Biomedical, Metabolic, and Neural Science, University of Modena and Reggio Emilia, Modena, Italy; ³Dipartimento Universitario di Neuroscienze, Università Cattolica del Sacro Cuore, Rome, Italy; ⁴Neurologia, Dipartimento di neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; ⁵Headache Unit, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy; ⁶Università Campus Bio-Medico di Roma, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15880
- 363 abstract views
PO-60 | Effectiveness of aerobic exercise, Mulligan technique, and myofascial release in migraine management: preliminary data from a randomized controlled trial

Marco Bravi,^1,2 Fabio Santacaterina,^1,2 Federica Bressi,^1,2 Francesca Nasto,^1,2 Claudia Altamura,^1,2 Fabrizio Vernieri^1,2 | ¹Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Rome, Italy; ²Università Campus Bio-Medico di Roma, Rome, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15883
- 318 abstract views
PO-74 | Effectiveness of auricular acupuncture in the management of menstrual migraine: a pilot study

Sergio Sorrenti,^1,2 Matteo Ciuffreda,¹ Emanuele Pisello,¹ Luca Brugiaferri,² Azzurra Federici,² Cristiano Piangatelli,³ Dario Galante⁴ | ¹U.O.C. Anestesia Rianimazione Terapia del Dolore, AST Ancona, Fabriano (AN), Italy; ²Scuola di Specializzazione in Anestesia Rianimazione, Terapia Intensiva e del Dolore, UNIVPM, Ancona, Italy; ³Direttore U.O.C. Anestesia Rianimazione Terapia del Dolore, AST Ancona, Fabriano (AN), Italy; ⁴Direttore U.O.C. Anestesia e Rianimazione, Cerignola (FG), Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15898
- 574 abstract views
PO-44 | Effectiveness of fremanezumab as preventive treatment of migraine up to 24 months: response rates from the Italian analysis of the PEARL study

Alberto Doretti,¹ Anna Ambrosini,² Simone Braca,³ Florindo D’Onofrio,⁴ Elisa Maria Piella,⁵ Pinar Kokturk,⁶ Rosario Iannacchero⁷ | ¹Department of Neurology-Laboratory of Neuroscience, IRCCS, Istituto Auxologico Italiano, Milan, Italy; ²Mediterranean Neurological Institute NEUROMED IRCCS, Pozzilli (IS), Italy; ³Headache Centre, University of Naples “Federico II”, Naples, Italy; ⁴UOSD Stroke Unit, S.G. Moscati Hospital, Avellino, Italy; ⁵Neurosciences Department, University of Turin, Turin, Italy; ⁶Teva Netherlands B.V., Haarlem, The Netherlands; ⁷Department of Neurology, Headache Center, Regional Hospital “Pugliese-Ciaccio”, Catanzaro, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15866
- 270 abstract views
PO-50 | Enhanced integration and synergy in EEG- and fNIRS-based networks in migraine patients following three-month galcanezumab treatment: associations with long-term clinical effects

Giulia Paparella,^1,2 Marianna La Rocca,³ Livio Clemente,¹ Emmanuella Ladisa,¹ Chiara Abbatantuono,¹ Elena Ammendola,¹ Marianna Diletta Delussi,⁴ Katia Ricci,¹ Giusy Tancredi,¹ Antonio Lacalamita,³ Alfonso Monaco,³ Nicola Amoroso,⁵ Sebastiano Stramaglia,³ Roberto Bellotti,³ Marina de Tommaso¹ | ¹Neurophysiopathology Unit, Department of Translational Biomedicine and Neuroscience (DiBraiN), University of Bari Aldo Moro, Bari, Italy; ²IRCCS Neuromed, Pozzilli (IS), Italy; ³Interateneo Department of Physics "M. Merlin", University of Bari Aldo Moro, Bari, Italy; ⁴Department of Education, Psychology, Communication (For.Psi.Com.), University of Bari Aldo Moro, Bari, Italy; ⁵Department of Pharmacy–Drug Sciences, University of Bari Aldo Moro, Bari, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15872
- 220 abstract views
PO-41 | Eptinezumab for difficult-to-treat migraine: who responds and who needs more

Alessandro Visentini,^1,2,3 Roberta Messina,^1,2,3 Ilaria Cetta,^1,2,3 Edorardo Ratto,¹ Laura Zanandrea,^1,3 Federica Genovese,^1,2,3 Irene Chinali,¹ Bruno Colombo,¹ Massimo Filippi^1,2,3 | ¹Neurology Unit and ²Neuroimaging Research Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy; ³Vita-Salute San Raffaele University, Milan, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15863
- 447 abstract views
PO-43 | Eptinezumab in migraine patients unresponsive to prior subcutaneous CGRP(-R) monoclonal antibody treatment: a retrospective case series

Elena Cresta, Irene Mattioli, Michele Di Pasquale, Alice Lanfranchi, Renata Rao, Alessandro Padovani | Neurology Unit and Headache Centre, Dipartimento di continuità di cura e fragilità, ASST Spedali Civili e Università degli studi di Brescia, Brescia, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15865
- 466 abstract views
PO-40 | Evaluating agreement between physician and ChatGPT in migraine prophylaxis selection: a pilot comparative study

Simone Vigneri1, MatteoZanella2, Gianfranco Sindaco2, Alberto Merlin2, Maria Mazzullo2, Marco La Grua2, Valentina Paci2, Carmen Bertone2, Gilberto Pari2 1Santa Maria Maddalena Hospital, Neurology, Occhiobello, Italy; 2Santa Maria Maddalena Hospital, Pain Medicine, Occhiobello, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15862
- 362 abstract views
PO-21 | Evaluating the impact of anti-CGRP monoclonal antibodies on retinal features in migraine patients: a retrospective optical coherence tomography study

Chiara Serafini,¹ Massimo Cesareo,² Alessio Martucci,² Marco Lombardo,² Vittoria Carla D’Agostino,¹ Alessandro Stefani,³ Carlo Nucci,² Nicola Biagio Mercuri,^1,3 Maria Albanese^1,3 | ¹Regional Referral Headache Center, Neurology Unit, Tor Vergata University Hospital, Rome, Italy ²Ophthalmology Unit, Department of Experimental Medicine, University of Rome “Tor Vergata”, Rome; ³Department of Systems Medicine, University of Rome “Tor Vergata”, Rome, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15843
- 416 abstract views
PO-34 | Febrile headache in an immunosuppressed patient with autoimmune disease: a probable case of neurosarcoidosis

Giulia Settembrini, Giovanni Rinaldi, Marco Alabiso, Ilenia Corbelli, Paola Sarchielli | Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15856
- 342 abstract views
PO-48 | Flunarizine for preventive treatment of hemiplegic migraine during pregnancy: a case report

Andrea Burgalassi,¹ Antonio Munafò,² Francesco De Cesaris,¹ Giulia Vigani,² Alberto Chiarugi^1,2 | ¹Headache Center and Clinical Pharmacology Unit, Careggi University Hospital, Florence, Italy; ²Section of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, Florence, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15870
- 3,896 abstract views
PO-13 | HD-EEG Delta connectivity rapidly alters after one month of atogepant in migraine patients

Maria Albanese,^1,2 Matteo Conti,¹ Silvio Bagetta,¹ Federico Carparelli,² Vittoria Carla D’Agostino,² Fabio Placidi,^1,2 Alessandro Stefani,^1,2 Nicola Biagio Mercuri,^1-3 | ¹Department of Systems Medicine, University of Rome Tor Vergata, Rome; ²Neurology Unit, Tor Vergata University Hospital, Rome; ³IRCCS Santa Lucia Foundation, Rome, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15834
- 437 abstract views
PO-23 | Hemicrania continua-like headache in familial SDHD-related paragangliomas: a diagnostic challenge

A. Di Chirico, L. Curto, G. Procopio, L. Troilo, G. Siciliano, F. Baldacci, S. Gori | Neurology Unit, Department of Clinical and Experimental Medicine, University of Pisa-AOUP, Pisa, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15845
- 513 abstract views
PO-38 | Impact of atogepant on achieving best possible quality of life among patient global impression of change responders

Cristina Tassorelli,¹ Pranav Gandhi,² Molly Duan,² Karen Carr,² Kandavadivu Umashankar,² Jonathan Stokes,² Grace Forde,³ Tanya Bilchik,⁴ Martina Martini*, Rashmi Halker Singh⁵ | ¹University of Pavia, Pavia, Italy; ²AbbVie, North Chicago, IL, USA; ³North American Partners in Pain Management, North New Hyde Park, NY, USA; ⁴Department of Neurology, Yale School of Medicine, New Haven, CT, USA; ⁵Mayo Clinic, Phoenix, AZ, USA *Abbvie Srl, Rome, Italy.

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15860
- 371 abstract views
PO-22 | Impact of sleep disorders on anti-CGRP monoclonal antibodies treatment response in migraine: a cross-sectional study

Costanza Sottani,¹ Valerio Brunetti,^1,2 Fabiana Cerulli,¹ Claudia Garattini,⁴ Gianluca Avino,⁵ Paolo Calabresi,^1,3 Catello Vollono^1,4 | ¹Università Cattolica del Sacro Cuore, Dipartimento di Neuroscienze, Rome; ²Stroke Unit, Fondazione Policlinico Agostino Gemelli IRCSS, Rome; ³UOC Neurologia, Fondazione Policlinico Agostino Gemelli IRCSS, Rome; ⁴UOC Neurofisiopatologia, Fondazione Policlinico Agostino Gemelli IRCSS, Rome; ⁵Unità di Neurologia, Ospedale Santo Stefano, Prato, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15844
- 307 abstract views
PO-24 | Inflammatory signatures of comorbid episodic migraine and endometriosis: a cytokine-based analysis

Maria Albanese,^1,2 Veronica Ceci,^3,4 Giulia Carrera,^4,5 Aikaterini Selntigia,⁶ Caterina Exacoustos,⁶ Marta Tiberi,⁴ Stefano Saracini,^3,4 Alessandro Matteocci,^4,7 Nicola Biagio Mercuri,^1,2,8 Valerio Chiurchiù^3,4 | ¹Department of Systems Medicine, University of Rome Tor Vergata, Rome; ²Regional Referral Headache Center, Neurology Unit, Tor Vergata University Hospital, Rome; ³Institute of Translational Pharmacology, National Research Council of Italy (CNR), Rome; ⁴Laboratory of Resolution of Neuroinflammation, IRCCS Santa Lucia Foundation, Rome; ⁵PhD Program in Neuroscience, Department of Systems Medicine, University of Rome Tor Vergata, Rome; ⁶Department of Surgical Sciences, Gynecological Unit, University of Rome Tor Vergata, Rome; ⁷PhD program in Immunology, Molecular Medicine and Applied biotechnologies, University of Rome Tor Vergata, Rome; ⁹Laboratory of Experimental Neuroscience, IRCCS Santa Lucia Foundation, Rome, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15846
- 344 abstract views
PO-84 | Inhibiting the peripheral degradation of anandamide reduces trigeminal hyperalgesia in a model of dural neurogenic inflammation via a CB1/CB2-independent mechanism

Chiara Demartini,¹ Rosaria Greco,¹ Miriam Francavilla,^1,2 Sara Facchetti,^1,2 Cristina Tassorelli^1,2 | ¹Section of Translational Neurovascular Research, IRCCS Mondino Foundation, Pavia, Italy; ²Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15908
- 417 abstract views
PO-82 | Integrated approach with detoxification, CGRP monoclonal antibodies and psychoeducational support in two patients with complex medication overuse headache

Claudia Lanni,¹ Federica Papini,² Chiara Prevost,³ Alessandro Canessa,³ Lucia Testa,³ Cristoforo Comi,² Delfina Ferrandi³ | ¹Department of Psychology “Santi Antonio e Biagio”, University Hospital, Alessandria, Italy; ²Neurology Unit, Department of Transitional Medicine, University of Piemonte Orientale, and University Hospital “Maggiore della Carità”, Novara, Italy; ³Neurology Unit, “Santi Antonio e Biagio” University Hospital, Alessandria, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15906
- 353 abstract views
PO-03 | Intracranial incidental findings on brain magnetic resonance imaging (MRI) in a pediatric population with primary headache: our experience and management

Fabiana Ursitti,¹ Filippo Tripodi,¹ Laura Papetti,¹ Giorgia Sforza,¹ Gabriele Monte,¹ Alessandro Borrelli,¹ Samuela Tarantino,¹ Martina Proietti Checchi,¹ Massimiliano Valeriani^1-3 | ¹Developmental Neurology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy; ²Child Neurology Unit, Systems Medicine Department, Tor Vergata University Hospital of Rome, Rome, Italy; ³Translational Pain Neuroscience and Precision Medicine, CNAP, Department of Health Science and Technology, School of Medicine, Aalborg University, Aalborg, Denmark

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15824
- 604 abstract views
PO-67 | Investigating plasma neurofilament light chain levels in patients with migraine: a cross-sectional study

Elisa Maria Piella,¹ Alberto Mario Chiarandon,¹ Silvia Boschi,¹ Fausto Roveta,¹ Lucrezia Bonino,¹ Giulia Gioiello,² Giulia Montesano,² Giulio Mengozzi,² Innocenzo Rainero,^1,3 Elisa Rubino^1,3 | ¹Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Turin, Italy; ²Clinical Biochemistry Laboratory “Baldi e Riberi”, A.O.U. Città della Salute e della Scienza di Torino, Turin, Italy; ³Headache Center, Department of Neuroscience and Mental Health, AOU Città della Salute e della Scienza di Torino, Turin, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15890
- 306 abstract views
PO-71 | Is Doctor Google retiring? How Generative Artificial Intelligence is transforming the perception and management of headaches

Matteo Bellamio,¹ Sofia Zywicki,¹ Rocco Quatrale,² Giorgio Zanchin,³ Ferdinando Maggioni,³ Alberto Terrin¹ | ¹Centro Cefalee dell’Angelo, Neurology, Ospedale dell'Angelo, AULSS3 Serenissima, Mestre (VE), Italy; ²Neurology, Ospedale dell'Angelo, AULSS3 Serenissima, Mestre (VE), Italy; ³Neurology, University of Padua, Padua, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15894
- 332 abstract views
PO-81 | Knowledge and misconceptions on headache disorders among healthcare workers: preliminary results from the Studio Emicrania Maugeri Study

Luca Giani, Christian Lunetta | Istituti Clinici Scientifici Maugeri IRCCS, Neurological Rehabilitation Unit of Milano Institute, Milan, Italy

Società Italiana per lo studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15905
- 411 abstract views
PO-39 | Leeds Dependence Questionnaire (LDQ) in migraine: diagnostic utility without predictive value for anti-CGRP (R) response

Antonio Munafò,¹ Andrea Burgalassi,¹ Giulia Vigani,² Francesco De Cesaris,¹ Alberto Chiarugi^1,2 | ¹Headache Center and Clinical Pharmacology Unit, Careggi University Hospital, Florence, Italy; ²Section of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, Florence, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15861
- 369 abstract views
PO-52 | Long-term efficacy of CGRP mAbs: new insights and current evidence

Oreste Marsico,¹ Marta Lioi,² Rosario Iannacchero,³ Michele Trimboli³ | ¹Department of Neuroscience, “Giovanni Paolo II” Hospital, Lamezia Terme, Catanzaro, Italy; ²Department of Neurology, Magna Graecia University, Catanzaro, Italy; ³Institute of Neurology, AOU Renato Dulbecco, Catanzaro, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15875
- 268 abstract views
PO-08 | Long-term outcome in pediatric patients with headache

S. Genta,^1,2 M. Celario^1,2, C. Brancaccio¹ ², G. Rossetto,^1,2 C. Dusi,^1,2 P. Baso,^1,2 V. De Giorgis^1,2 | ¹Department of Child Neuropsychiatry, IRCCS Mondino, Pavia; ²University of Pavia, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15829
- 430 abstract views
PO-53 | Managing chronic primaryhHeadache in Lombardy: insights from the ‘PERLA’ project

Grazia Sances,¹ Claudia Sulmona,¹ Natascia Ghiotto,¹ Daniele Martinelli,¹ Licia Grazzi,² Alberto Raggi,² Danilo Antonio Montisano,² Matilde Leonardi,² Giulia Gandini,² Renata Rao,³ Alessandro Padovani,³ Alessandro Amorosi,⁵ Cristina Tassorelli,^1,5 on behalf of Rete Regionale Cefalee Lombardia | ¹Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation Pavia, Italy; ²Headache Center, IRCCS Fondazione Istituto Neurologico Carlo Besta, Milan, Italy; ³ASST Spedali Civili di Brescia, Italy; ⁴Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy; ⁵Struttura Reti Clinico-Assistenziali e Organizzative e Ricerca, U.O. Polo Ospedaliero Direzione Generale Welfare, Regione Lombardia, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15876
- 231 abstract views
PO-02 | Migraine in youth: a double challenge to cognition and emotion

Samuela Tarantino,¹ Martina Proietti Checchi,¹ Laura Papetti,¹ Fabiana Ursitti,¹ Gabriele Monte,¹ Giorgia Sforza,¹ Massimiliano Valeriani,^1-3 | ¹Developmental Neurology Unit, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy; ²Systems Medicine Department, Tor Vergata University of Rome, Rome, Italy; ³Translational Pain Neuroscience and Precision Medicine, CNAP, Dept. of Health Science and Technology, School of Medicine, Aalborg University, Denmark

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15823
- 413 abstract views
PO-04 | Mindfulness-based behavioral intervention for adolescents with high-frequency primary headaches: feasibility of a prospective multicenter study

Beatrice Baldo,¹ Giulia De Lorenzi,¹ Valeria Marletta,¹ Ilaria Bonemazzi,¹ Alessia Raffagnato,² Cristina Vassia,³ Emanuela Serri,³ Antonella Versace,⁴ Daniela D’Agnano,⁴ Vittorio Sciruicchio,⁴ Licia Grazzi,⁵ Irene Toldo¹ | ¹Juvenile Headache Center, Department of Woman’s and Child’s Health, University of Padua; ²Child and Adolescent Neuropsychiatric Unit, Department of Women's and Children's Health, University of Padua; ³Pediatric Headache Center, Department of Pediatric Emergency, Regina Margherita Children's Hospital, Turin; ⁴Children Epilepsy and EEG Center, San Paolo Hospital, ASL Bari; ⁵Neuroalgology Unit and Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15825
- 428 abstract views
PO-75 | Network meta-analysis comparing efficacy and safety outcomes of atogepant, rimegepant, and galcanezumab in patients with episodic migraine after including CHALLENGE-MIG Trial

Jessica Ailani,¹ Pranav Gandhi,² Anjana Lalla,² Peter McAllister,³ Tanya Bilchik,⁴ Stephanie Nahas,⁵ David Rowe,⁶ Cristiano Piron,⁶ Kari Kelton,⁶ Raffaello Masselli*, Rashmi Halker Singh⁷ | ¹MedStar Health, Washington DC, USA; ²AbbVie, North Chicago, IL, USA; ³New England Institute for Neurology and Headache, Stamford, CT USA; ⁴Department of Neurology, Yale School of Medicine, New Haven, CT, USA; ⁵Department of Neurology, Thomas Jefferson University, Philadelphia, PA USA; ⁶Medical Decision Modeling Inc., Indianapolis, IN, USA; ⁷Mayo Clinic, Phoenix, AZ, USA *Abbvie Srl, Rome, Italy. This individual has been added to this publication author by-line, with the permission of the original authors, for the express purpose of conducting the presentation at a local congress or in a local language. He did not contribute to the content of the publication.

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15899
- 581 abstract views
PO-16 | Neurophysiological effects of atogepant in high-frequency episodic migraine

B. Agostini,^1,2 F. Cammarota,^1,2 R. De Icco,^1,2 V. Grillo,^1,2 G. Vaghi,^1,2 F. Bighiani^1,2, M. Corrado,² A. Antoniazzi,^1,2 M. Giraudo,^1,2 A. Solfrizzi,^1,2 R. Greco,² C. Demartini,^1,2 A. Zanaboni,^1,2 M. Francavilla,^1,2 S. Facchetti,^1,2 G. Sances,² C. Tassorelli^1,2 | ¹Department of Brain and Behavioral Sciences, University of Pavia; ²Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15837
- 319 abstract views
PO-78 | No changes in blood pressure assessed with the 24-hour Holter monitoring in patients treated with anti-CGRP monoclonal antibodies: a prospective observational study (SAFHYPER)

Flavia Lo Castro,¹ Niccolò Bonini,² Luigi Francesco Iannone,^1,3 Alberto Boccalini,¹ Daria Brovia,¹ Luca Pani,^1,3 Giuseppe Boriani,^2,3 Simona Guerzoni¹ | ¹Digital and Predictive Medicine, Pharmacology and Clinical Metabolic Toxicology-Headache Center and Drug Abuse-Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico di Modena, Modena, Italy; ²Cardiology Division, AOU Policlinico di Modena, Modena, Italy; ³Department of Biomedical, Metabolic, and Neural Science, University of Modena and Reggio Emilia, Modena, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15902
- 408 abstract views
PO-42 | OnaBotulinumtoxin-A in chronic migraine patients with short or long disease history and psychiatric comorbidities: preliminary data from an Italian multicentric study (the BACH Study)

Fabrizio Vernieri,^1,2 Marilena Marcosano,² Licia Grazzi,³ Danilo Antonio Montisano,³ Raffaele Ornello,⁴ Simona Sacco,⁴ Chiara Rosignoli,⁴ Alberto Doretti,⁵ Maria Albanese,⁶ Giovanna Viticchi,⁷ Nicoletta Brunelli, Luigi d’Onofrio,² Luisa Fofi,¹ Claudia Altamura,^1,2 Patrizio Pasqualetti⁸ | ¹Fondazione Policlinico Campus Bio-Medico, Roma, Italy; ²Università Campus Bio-Medico di Roma, Italy; ³Istituto Neurologico Besta, Milano, Italy; ⁴Università degli Studi l’Aquila, Italy; ⁵Istituto Auxologico, Milano, Italy; ⁶Policlinico Tor Vergata, Roma, Italy; ⁷Università Politecnica Marche, Italy; ⁸Sapienza Università di Roma, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15864
- 340 abstract views
PO-26 | Optic nerve sheath ultrasound in idiopatic intracranial hypertension: early findings

Francesca Cotichelli,^1,2 Davide Mascarella1,^1,2 Valentina Favoni,¹ Gaia Patanè,^1,2 Francesco Severi,^1,2 Francesca Verna,^1,2 Giulia Pierangeli,^1,2 Sabina Cevoli¹ | ¹IRCCS Istituto delle Scienze Neurologiche di Bologna; ²DIBINEM, Department of Biomedical and Neuromotor Science, Alma Mater Studiorum, Bologna, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15848
- 383 abstract views
PO-14 | Pain catastrophizing in chronic migraine patients receiving eptinezumab treatment

Alessandra Parisi,¹ Licia Grazzi,¹ Alberto Raggi,² Giulia Regonesi,¹ Montisano Danilo Antonio¹ | ¹Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano; ²Neurology, Public Health and Disability Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15835
- 413 abstract views
PO-54 | Patient perspectives on physiotherapy interventions for migraine: a pre- and post-intervention qualitative study

Zhiqi Liang,¹ Caitlin Scott,¹ Felix Cabrera Manrique,¹ Sumin Kim,¹ Chun Shun Lee,¹ Bixiang Cheng,¹ Chun Yiu Kwok,¹ Matteo Castaldo² | ¹University of Queensland; ²Parma University, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15877
- 393 abstract views
PO-01 | Pediatric nummular headaches: a case series and physiopathological and nosography considerations

Carola Meo¹*, Sofia D’Agostino¹*, Antonella Morea²*, Martina Tarantini²*, Giuseppe Giglia³, Maria Rosita Ruta⁴, Edvige Correnti⁵, Daniela D’Agnano², Giuseppe Santangelo⁵, Vittorio Sciruicchio², Vincenzo Raieli⁵ (*These authors contributed equally) | ¹Child Neuropsychiatry Unit Department, Pro.M.I.S.E. "G. D'Alessandro", University of Palermo, Palermo, Italy; ²Children Epilepsy and EEG Center, San Paolo Hospital, ASL Bari, Bari, Italy; ³Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), Section of Human Physiology, University of Palermo, Palermo; ⁴Child Neuropsychiatry Unit, ASP 6, Palermo; ⁵Child Neuropsychiatry Department, ISMEP, ARNAS Civico, Palermo, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

17-10-2025

DOI https://doi.org/10.4081/cc.2025.15822
- 360 abstract views
PO-20 | Phenotypic description of a multigenerational family with PRRT2 gene mutation: a case series of six members affected by hemiplegic migraine and paroxysmal events

Fabiana Cerulli,¹ Costanza Sottani,¹ Giulia Di Lazzaro,^1,2 Paolo Calabresi,^1,2 Anna Rita Bentivoglio,^1,2 Catello Vollono^1,3 | ¹Dipartimento Universitario di Neuroscienze, Università Cattolica del Sacro Cuore, Rome; ²UOC Neurologia, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy; 3Neurofisiopatologia, Dipartimento di Scienze dell'invecchiamento, Neurologiche, Ortopediche e della Testa-Collo, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15841
- 451 abstract views
PO-58 | Pilot protocol to improve the booking and management network for chronic headache in secondary and tertiary care services

A. Granato,¹ L. Bartole,¹ S. Centonze,² A. Lodi,³ M. Lodi Zollia,³ P. Manganotti¹ | ¹Clinical Unit of Neurology, Headache Centre, Department of Medicine, Surgery and Health Sciences, ASUGI, University of Trieste, Trieste, Italy; ²Research & Innovation Unit, ASUGI, University of Trieste, Trieste, Italy; ³Funzione Organizzativa, Gestione Offerte Ambulatoriali, ASUGI, University of Trieste, Trieste, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15881
- 273 abstract views
PO-32 | Post-traumatic painful trigeminal neuropathy (13.1.2.3 - ICHD-3) following misguided gamma knife surgery: a case of diagnostic oversight with lasting consequences

Marta Lioi,¹ Laura Marino,¹ Michele Trimboli² | ¹Department of Neurology, Magna Graecia University, Catanzaro, Italy; ²Institute of Neurology, AOU Renato Dulbecco, Catanzaro, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15854
- 554 abstract views
PO-66 | Predicting the evolution to resistant and refractory migraine: a machine learning analysis from the REFINE Study

Chiara Rosignoli,¹ Raffaele Ornello,¹ Daniele Lozzi,² Enrico Mattei,² Federico De Santis,¹ Agnese Onofri,¹ Mark Braschinsky,³ Christian Lampl,⁴ Isabel Pavão Martins,⁵ Paolo Martelletti,⁶ Dimos Mitsikostas,⁷ Raquel Gil-Gouveia,⁸ Maria Pia Prudenzano,⁹ Kristina Ryliskiene,¹⁰ Margarita Sanchez del Rio,¹¹ Patricia Pozo-Rosich,¹² Aynur Özge,¹³ Fabrizio Vernieri,¹⁴ Marta Waliszewska-Prosół,¹⁵ Zaza Katsarava,¹⁶ Giuseppe Placidi,² Simona Sacco¹ | ¹Dept. of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy; ²A²VI-lab, Dept. MeSVA University of L’Aquila; ³Dept. of Neurology and Neurosurgery, Institute of Clinical Medicine, Faculty of Medicine, University of Tartu, Estonia; ⁴Headache Medical Center, Seilerstaette Linz, Austria. Center; ⁵Headache Center, Hospital da Luz, Lisbon, Portugal; ⁶School of Health, Unitelma Sapienza University of Rome, Italy; ⁷First Dept of Neurology, Aeginition Hospital, National and Kapodistrian University of Athens, Greece; ⁸Centro de Estudos Egas Moniz, Faculty of Medicine, University of Lisbon, Portugal; ⁹Headache Center, Amaducci Neurological Clinic, Policlinico General Hospital, Bari, Italy; ¹⁰Center of Neurology, Vilnius University, Lithuania; ¹¹Dept. of Neurology, Clínica Universidad de Navarra, Madrid, Spain; ¹²Neurology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain; ¹³Dept. of Neurology, Mersin University Medical Faculty, Mersin, Turkey; ¹⁴Università Policlinico Campus Bio-Medico, Rome, Italy; ¹⁵Dept. of Neurology, Wroclaw Medical University, Wrocław, Poland; ¹⁶Dept of Neurology, Christian Hospital Unna and University of Duisburg-Essen, Ruhr Metropolitan, Germany

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15889
- 319 abstract views
PO-62 | Preventive migraine treatment in patients under 25: a 24-month observational study on adherence, therapeutic switching, and prescription determinant factors

Marilena Marcosano,¹ Nicoletta Brunelli,¹ Luisa Fofi,¹ Laura Papetti,² Fabiana Ursitti,² Massimiliano Valeriani,² Fabrizio Vernieri,¹ Claudia Altamura¹ | ¹Headache and Neurosonology Unit, Fondazione Policlinico Campus Biomedico di Rome, Rome, Italy; ²Developmental Neurology, Bambino Gesù Children Hospital, IRCCS, Rome, Italy

Società Italiana per lo studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15885
- 224 abstract views
PO-07 | Psychological management of children treated at the Pediatric Headache Centre of Turin: preliminary analysis

Emanuela Serri, Annachiara Lamberti Zanardi, Raffaella Mascolo, Barbara Lauria, Roberta Rossi, Sara Simona Racalbuto, Antonia Versace, Claudia Bondone | Department of Pediatric Emergency, Pediatric Headache Centre, Regina Margherita Children’s Hospital, Turin, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15828
- 429 abstract views
PO-59 | Questioning online survey-based physiotherapy treatment referral in headache treatment: differences in developed and developing countries

D. Onan,^1,2 A.K. Erdemoğlu,³ P. Gelener,⁴ S. Velioğlu,⁵ S. Ulutaş,⁶ N. Taşdemir,⁷ M. Waliszewska-Prosół,⁸ E. Ekizoğlu,⁹ M. Straburzyński,¹⁰ M. Kodounis,¹¹ B. Raffaelli,¹² C. Tana,¹³ F. De Cesaris,¹⁴ R. Messina,¹⁵ E.I. Sen,¹⁶ S. Ray,¹⁷ G. Sebastianelli,¹⁸ F. Granella,¹⁹ U. Pensato,²⁰ S. Crema,²¹ S. Cevol,²² K. Chakravarty,²³ M. Pia Prudenzano,²⁴ A. Casalena,²⁵ M. Romozzi,²⁶ T. Takizawa,²⁶ W. Rattanawong,²⁷ A. Gantenbein,²⁸ V. Favoni,²⁹ C. Gaul,³⁰ L.F.I. Iannone,³¹ B. Schäfer,²³ D.A. Montisano,³³ O. Grosu,³⁴ A.B. de Oliveira,³⁵ F. Puledda,³⁶ V. Romanenko,³⁷ I. Ros González,³⁸ M. Castaldo,³⁹ H. Al-Khazali,⁴⁰ A. Hassan,⁴¹ D. Garcia-Azorin,⁴² L.-L. Hope Pan,⁴³ R. Gil-Gouveia,⁴⁴ M. Sanchez del Rio,⁴⁵ M. Lisicki,⁴⁶ H.W. Schytz,⁴⁷ P. Anukoolwittaya,⁴⁸ T. Mavridis,⁴⁹ M. Lanteri-Minet,⁵⁰ D.B. Swerts,⁵¹ C. Altamura,⁵² K. Hirata,⁵³ M. Togha,⁵⁴ M. Kyung Chu,⁵⁵ T. Pongpitakmetha,⁵⁶ M.-H. Bjørk,⁵⁷ M. Minen,⁵⁸ K. Skorobogatykh,⁵⁹ D. Chowdhury,⁶⁰ A.-M. Torgersen Dalgeir,⁶¹ J. Versijpt,⁶² P. Cras,⁶³ A. Govaerts,⁶⁴ A. Chiarugi,⁶⁵ N. Vashchenko,⁵⁹ L. Dobbels,⁶⁶ T.S. Monteith,⁶⁷ F. De Bruyne,⁶⁸ E. Garay,⁶⁷ S.L. Sava,⁶⁹ Z. Salinas,⁶⁷ M. Nordtveit,⁷⁰ K. Delmotte,⁷¹ A. Gonzalez-Martinez,⁷² S. Debray,⁷³ C. Deligianni,⁷⁴ W. De Hertogh,⁷⁵ R. Castien,⁷⁶ E. Caronna,⁷⁷ C. Valerija,⁷⁸ F. Ahmed,⁷⁹ G. De la Meilleure,⁸⁰ L.L. Panneerchelvam,⁸¹ G.H. Bringeland,⁸² R. Ornello,² S. Sacco² | ¹Yozgat Bozok University, Physiotherapy and Rehabilitation, Ankara, Turkey;²University of L'Aquila, Department of Biotechnological and Applied Clinical Sciences, L'Aquila, Italy;³Clinic of Prof. Dr. Ali Kemal Erdemoğlu, Neurology, Ankara, Turkey;⁴Elite Research and Surgical Hospital , Nicosia, Cyprus;⁵Karadeniz Technical University, Department of Neurology, Trabzon, Turkey;⁶Bahcesehir University, Department of Neurology, İstanbul, Turkey;⁷Ağrı İbrahim Çeçen University, Department of Neurology, Ağrı, Turkey;⁸Wroclaw Medical University, Wroclaw, Germany;⁹Istanbul University, Department of Neurology, Istanbul, Turkey;¹⁰University of Warmia and Mazury, Olsztyn, Poland;¹¹National & Kapodistrian University of Athens, First Neurology Department, Eginitio Hospital, School of Medicine, Athens, Greece;¹²Charité Universitätsmedizin Berlin, Department of Neurology,Headache Center, Berlin, Germany;¹³SS Annunziata Hospital of Chieti, Chieti, Italy;¹⁴Centro Cefalee e Farmacologia Clinica - AOU Careggi , Florence, Italy;¹⁵Vita-Salute San Raffaele University, Milano, Italy;¹⁶Istanbul University Istanbul Faculty of Medicine, Department of Physical Medicine and Rehabilitation, İstanbul, Turkey;¹⁷Department of Neurology, PGIMER, Chandigarh, India;¹⁸Sapienza University of Rome, Latina, Italy;¹⁹University of Parma, Parma, Italy;²⁰Humanitas University, Milan, Italy;²¹Fleni Hospital, Buenos Aires, Argentina;²²University of Bologna, Bologna, Italy;²³Post Graduate Institute Of Medical Education and Research, Chandigarh, India;²⁴AOUC Policlinico, Centro Cefalee - Clinica Neurologica L Amaducci, Bari, Germany;²⁵Centro Cefalee UOC Neurologia, Teramo, Italy;²⁶Keio University School of Medicine, Tokyo, Japan;²⁷King Mongkut's Institute of Technology Ladkrabang, Bangkok, Thailand;²⁸ZURZACH Care, Zürich, Switzerland;³⁰IRCCS Istituto delle scienze neurologiche di Bologna, Bologna, Italy;³⁰Headache Center Frankfurt, Frankfurt, Germany;³¹Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy, Modena, Italy;³²Migraine and Headache Clinic Königstein , Frankfurt, Germany;³³SSD Centro Cefalee - Fondazione IRCCS Istituto Neurologico C.Besta, Milan, Italy;³⁴Diomid Gherman Institute of Neurology and Neurosurgery, Kişinev, Moldova;³⁵Center for Clinical and Epidemiological Research, University of Sao Paulo , Sao Paolo, Brazil;³⁶King's College London, London, United Kingdom;³⁷Vita Medical Clinic, Kyiv, Ukraine;³⁸Hospital Clínico Universitario de Valladolid, Vallodolid, Spain;³⁹Parma University, Parma, Italy;⁴⁰Danish Headache Center, Copenhagen, Denmark;⁴¹Cairo University , Cairo, Egypt;⁴²University of Valladolid, Valladolid, Spain;⁴³Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan;⁴⁴Hospital da Luz. Lisboa, Lisboa, Portugal;⁴⁵Clinica Universidad de Navarra, Navarra, Spain;⁴⁶Mercedes & Martín Ferreyra Institute for Medical Research, Córdoba, Argentina;⁴⁷University of Copenhagen, Copenhagen, Denmark;⁴⁸King Chulalongkorn Memorial Hospital, Bangkok, Thailand;⁴⁹Tallaght University Hospital, Dublin, Ireland;⁵⁰CHU Nice and Cote D'azur University, Nice, France;⁵¹Santa Casa de Sao Paolo, Sao Paolo, Brazil;⁵²Fondazione Policlinico Universitario Campus BIo-Medico, Rome, Italy;⁵³Dokkyo Medical University, Mibu, Tochigi, Japan;⁵⁴Tehran University, Tehran, Iran;⁵⁵Yonsei University, Seoul, South Korea;⁵⁶Chulalongkorn University, Bangkok, Thailand;⁵⁷University of Bergen , Bergen, Norway;⁵⁸NYU Langone Health, New York, United States;⁵⁹University Headache Clinic, Moscow, Russian Federation;⁶⁰ G B Pant Institute of Post Graduate Medical Education and Research, New Delhi, India;⁶¹Haukeland University Hospital, NorHead, Bergen, Norway;⁶²UZ Brussel, Brussel, Belgium;⁶³Universiteit Antwerpen, Antwerpen, Belgium;⁶⁴Rz Tienen, Tienen, Belgium;⁶⁵University of Florence, Florence, Italy;Neurology Department İmelda Ziekenhuis, Bonheiden, Belgium;⁶⁷University of Miami, Miami, United States;⁶⁸University College Ghent, Ghent, Belgium;⁶⁹University of Liège, Liege, Belgium;⁷⁰Haukeland Universitetssykehus, Bergen, Norway;⁷¹Universitair Ziekenhuis Leuven, Leuven, Belgium;⁷²Hospital Universitario de la Princesa e Instituto de Investigación Sanitaria Princesa, Madrid, Spain;⁷³Europa Ziekenhuizen, Brussel, Belgium;⁷⁴Athens Naval Hospital, Athens, Greece;⁷⁵University of Antwerp , Antwerpen, Belgium;⁷⁶Vrije Universiteit Amsterdam, Amsterdam, Netherlands;⁷⁷Vall d'Hebron Hospital, Barcelona, Spain;⁷⁸Private hospital, Riga, Latvia;⁷⁹Hull University, Hull, United Kingdom;⁸⁰VITAZ - General Hospital, Sint-Niklaas, Belgium;⁸¹James Cook University Hospital, Middlesbrough, United Kingdom; ⁸²Haukeland University Hospital, Bergen, Norway

Società Italiana per lo studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15882
- 325 abstract views
PO-92 QZU^® (Kudzu e.s.: 200 mg of which Isoflavones: 80 mg and Puerarin: 60 mg; ComplexZyme vegan^®: 40 mg) in the prophylaxys of migraine without aura: a retrospective observational study

Ennio Pucci,¹ Ludovica Pucci,² Alberto Vercesi³ | ¹Department of Nervous System and Behavioral Sciences, University of Pavia; ²Nutritional biologist, Master in Nutritional and Clinical Dietetics, University of Pavia, Italy; ³Scientific Advisor

Società Italiana per lo studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15916
- 1,474 abstract views
PO-80 | Real-world effectiveness of atogepant for the preventive treatment of migraine in a cohort of multi -refractory patients: a single center study

M. De Luca,¹ L. Ferraù,¹ A. Cafarchio,² M.S. Adragna,¹ M. Autunno¹ | ¹Unit of Neurology and Neuromuscular Diseases, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy; ²Department of Medicine and Health Sciences “Vincenzo Tibero” DIMES, University of Molise, Campobasso, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15904
- 365 abstract views
PO-77 | Real-world evidence of Atogepant efficacy in patients unresponsive to anti-CGRP monoclonals

Matteo Cortinovis, Marco Bolchini, Paola Zavarise, Giulia Campana, Giorgio Dalla Volta | Headache Center, Istituto Clinico Città di Brescia, Gruppo San Donato, Brescia, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15901
- 634 abstract views
PO-91 | Real-world evidence of CGRP dual blockade: clinical and biomarker insights from combined therapy in chronic migraine

Laura Marino,¹ Marta Lioi¹, Rosario Iannacchero,² Michele Trimboli² | ¹Department of Neurology, Magna Graecia University, Catanzaro; ²Institute of Neurology, AOU Renato Dulbecco, Catanzaro, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15915
- 714 abstract views
PO-11 | Resting state high-density EEG analysis reveals interictal subcortico-cortical linear and non-linear anomalies in subjects with migraine

Gabriele Sebastianelli,¹ Camillo Porcaro,² Sara Gilli,¹ Chiara Abagnale,¹ Francesco Casillo,² Giorgio Di Lorenzo,³ Gianluca Coppola¹ | ¹Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Polo Pontino ICOT, Latina; ²Department of Neuroscience (DNS) and Padova Neuroscience Center (PNC), University of Padova; ³Chair of Psychiatry, Department of Systems Medicine, Tor Vergata University of Rome, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15832
- 370 abstract views
PO-51 | Rimegepant combined with valproic acid and botulinum toxin in refractory hemiplegic migraine: a case report

Gianni Difonzo, Cinzia Tamborino, Adriana Fallacara, Damiano Paolicelli, Maria Pia Prudenzano | Headache Center, “L. Amaducci” Neurological Clinic, Policlinico General Hospital, Bari, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15874
- 788 abstract views
PO-83 | Serum diamine oxidase activity in patients with cluster headache: a cross-sectional case–control study

Silvia Boschi,¹ Elisa Maria Piella,¹ Tilde Manetta,³ Paola Merlach,³ Alberto Mario Chiarandon,¹ Alessia Agostinelli,¹ Barbara Donati Morello,³ Giulio Mengozzi,³ Innocenzo Rainero,^1,2 Elisa Rubino,^1,2 | ¹Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Turin, Italy; ²Headache Center, Department of Neuroscience and Mental Health, AOU Città della Salute e della Scienza di Torino, Turin, Italy; ³Department of Laboratory Medicine, Città della Salute e della Scienza University Hospital, Turin, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15907
- 588 abstract views
PO-28 | Sex differences in the response to rimegepant for the treatment of acute migraine attacks – insights from the multicenter GAINER study

Raffaele Ornello,¹ Gloria Vaghi,^2,3 Gabriele Sebastianelli,⁴ Francesco Casillo,⁴ Antonio Russo,⁵ Marcello Silvestro,⁵ Francesca Pistoia,¹ Giorgio Dalla Volta,⁶ Matteo Cortinovis,⁶ Alberto Chiarugi,⁷ Danilo Antonio Montisano,⁸ Licia Grazzi,⁸ Maria Pia Prudenzano,⁹ Sabina Cevoli,¹⁰ Edoardo Mampreso,¹¹ Gianluca Avino,¹² Marina Romozzi,¹³ Mariarosaria Valente,¹⁴ Carla Fasano,¹⁵ Stefania Battistini,¹⁶ Antonio Granato,¹⁷ Elisa Maria Piella,¹⁸ Innocenzo Rainero,¹⁸ Federico De Santis,¹ Simona Sacco,¹ Maria Albanese,¹⁹ Michele Trimboli,²⁰ Alberto Doretti,²¹ Cristina Tassorelli,^2,3 Luigi Francesco Iannone,²² Roberto De Icco^2,3 on behalf of the Italian Headache Registry (RICe) Study Group | ¹Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila; ²Department of Brain and Behavioral Sciences, University of Pavia; ³Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia; ⁴Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino, Latina; ⁵Headache Centre, Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Naples; ⁶Headache Center of Clinical Neurology of Istituto Clinico "Città di Brescia", Brescia; ⁷Department of Health Sciences, University of Florence; ⁸Neuroalgology Unit and Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan; ⁹Headache Center, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari; ¹⁰IRCCS Istituto Di Scienze Neurologiche di Bologna, Programma Cefalee e Algie Facciali, Bologna; ¹¹Headache Centre, Neurology - Euganea, Health Unit, Padua; ¹²Neurology Unit, Ospedale Santo Stefano, USL Toscana Centro, Prato; ¹³Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome; ¹⁴Clinical Neurology, Azienda Sanitaria Universitaria Friuli Centrale, Presidio Ospedaliero Santa Maria della Misericordia, Udine; ¹⁵Headache and Facial Pain Center Neurology, AOU Careggi, Florence; ¹⁶Department of Medical, Surgical and Neurological Sciences, University of Siena; ¹⁷Headache Centre, Clinical Unit of Neurology, School of Neurology, Department of Medicine, Surgery and Health Sciences, University Hospital and Health Services of Trieste, ASUGI, University of Trieste; ¹⁸Department of Neurosciences “Rita Levi Montalcini”, University of Turin; ¹⁹Department of Systems Medicine, University of Rome Tor Vergata, Rome; ²⁰University Magna Graecia, Catanzaro; ²¹Department of Neuroscience - Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan; ²²University of Modena and Reggio Emilia, Modena, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15850
- 494 abstract views
PO-61 | Social cognition in interictal episodic and chronic migraine: a cross-sectional study

Chiara Abbatantuono,^1* Delussi Marianna,^2* Clemente Livio,¹ Giulia Paparella,¹ Stefania Scannicchio,¹ Annalisa Di Dio,¹ Elena Ammendola,¹ Giusy Tancredi,¹ Emmanuella Ladisa,¹ Giulia Paparella,^1,3 Marina de Tommaso¹ (*Equally Contributed) | ¹Neurophysiopathology Unit, Department of Translational Biomedicine and Neuroscience (DiBraiN), University of Bari Aldo Moro (IT), Bari, Italy; ²Department of Education, Psychology, Communication (For.Psi.Com.), University of Bari Aldo Moro (IT), Bari, Italy; ³IRCCS Neuromed Pozzilli (IS), Italy

Soocietà Italiana per lo studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15884
- 201 abstract views
PO-29 | Spontaneous intracranial hypotension: a clinical and radiological observational study

F. Verna, D. Mascarella, V. Favoni, G. Pierangeli, L. Cirillo, S. Cevoli | IRCCS Istituto delle Scienze Neurologiche di Bologna, Italia DIBINEM, Alma Mater Studiorum Bologna, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15851
- 343 abstract views
PO-72 | Stigma in migraine: preliminary results from the “Studio Emicrania Maugeri” Project

Luca Giani, Christian Lunetta | Istituti Clinici Scientifici Maugeri IRCCS, Neurological Rehabilitation Unit of Milano Institute, Milan, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15895
- 378 abstract views
PO-79 | Survey on adherence and tolerability of atogepant used as migraine preventive treatment

D.A. Montisano,¹ G. Vaghi,^2,3 A. Paris,¹ R. De Icco,^2,3 B. Agostini,^2,3 M. Giraudo,^2,3 A. Solfrizzi,^2,3 C. Tassorelli,^2,3 G. Sances,³ L. Grazzi | ¹Fondazione IRCCS C.Besta Istituto Neurologico, SSD Headache Center, Milan, Italy; ²University of Pavia, Department of Brain and Behavioral Sciences, Pavia, Italy; ³IRCCS Mondino Foundation, Headache Science & Neurorehabilitation Unit, Pavia, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15903
- 356 abstract views
PO-47 | Systemic ozone treatment in chronic migraine: a focus on disability reduction and medication use

Sergio Sorrenti,^1,2 Matteo Ciuffreda,¹ Emanuele Pisello,¹ Luca Brugiaferri,² Azzurra Federici,² Cristiano Piangatelli,³ Dario Galante⁴ | ¹U.O.C. Anestesia Rianimazione Terapia del Dolore, AST Ancona, Fabriano (AN), Italy; ²Scuola di Specializzazione in Anestesia Rianimazione, Terapia Intensiva e del Dolore, UNIVPM, Ancona, Italy; ³Direttore U.O.C. Anestesia Rianimazione Terapia del Dolore, AST Ancona, Fabriano (AN), Italy; ⁴Direttore U.O.C. Anestesia e Rianimazione, Cerignola (FG), Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15869
- 862 abstract views
PO-64 | Telemedicine in a second level headache clinic of Azienda Sanitaria Locale Roma 1: a lesson learned from the SarsCov2 pandemic

Teresa Catarci | ASL Roma 1, Rome, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15887
- 235 abstract views
PO-65 | The complexity of chronic headache: towards tailored therapies through a multidimensional assessment

Silvia Favaretto,¹ Giulia Demo,² Veronica Rizzato,² Elisabetta Patron,^2,3,4 Sara Bianconi,² Stèphanie Maldera,² Giulia Buodo,^2,3 | ¹UOC Clinica Neurologica, Azienda Ospedale-Università Padova, Padua, Italy; ²Centro di Ateneo Servizi Clinici Universitari Psicologici (SCUP), University of Padua, Italy; ³Department of General Psychology, University of Padua, Padova, Italy; ⁴Padua Neuroscience Center (PNC), University of Padua, Padova, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15888
- 240 abstract views
PO-12 | The long-term efficacy on migraine of non-ketogenic low-carb diet after treatment with ketogenic diet

Silvia Favaretto,¹ Francesco Francini Pesenti² | ¹Headache centre, Neurology Unit, Department of Neuroscience, University Hospital of Padua; ²Department of Medicine (DIMED), Clinical Nutrition, University Hospital of Padua, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15833
- 702 abstract views
PO-56 | The role of bilateral greater occipital nerve block in resistant chronic migraine with medication overuse

Leonardo Troilo, Letizia Curto, Giulia Procopio, Antonia Di Chirico, Gabriele Siciliano, Sara Gori, Filippo Baldacci | Neurology Unit, Department of Clinical and Experimental Medicine, University of Pisa-AOUP, Pisa, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15879
- 282 abstract views
PO-69 | Three-month atogepant treatment modulates dopaminergic-related functional connectivity in episodic migraine

Davide Fedeli,¹ Danilo Antonio Montisano,¹ Greta Demichelis,¹ Giuseppe Ciullo,^1,2 Jean Paul Medina Carrion,¹ Maria Grazia Bruzzone,¹ Emilio Ciusani,¹ Alessandra Erbetta,¹ Marina Grisoli,¹ Erika Guastafierro,¹ Domenico D’Amico,¹ Alberto Raggi,¹ Anna Nigri,¹ Licia Grazzi¹ | ¹Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy; ²University of Parma, Parma, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15892
- 327 abstract views
PO-35 | Treatment of chronic and episodic migraine with atogepant improves quality of life in patients with comorbid multiple sclerosis: the experience of the Headache Center at Spaziani Hospital, Frosinone

Laura Borrello; Fabiana Marinelli; Maria Lorena Marziale; Ilaria Avallone; Fulvio Ferrante; Roberto De Simone | Neurology Unit, Headache Center, Multiple Sclerosis Center, UOC Pharmacy, Spaziani Hospital, Frosinone (FR), Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15857
- 373 abstract views
PO-37 | Trigeminal autonomic cephalalgia as the initial presentation of a cerebral cavernous malformation: a rare case report

Francesco Maurizio Chianese, Marcello Silvestro, Ilaria Orologio, Lorenzo Tartaglione, Marcella Marziani, Antonio Russo | Headache Centre, Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15859
- 480 abstract views
PO-19 | Unraveling the spectrum of migraine resistant to treatments: searching for novel biological PHEnotypes and theRApeutic approaches (SPHERA project)

M. Giraudo,^1,2 R. De Icco,^1,2 G. Vaghi,^1,2 V. Grillo,^1,2 F. Bighiani,^1,2 M. Corrado,² A. Antoniazzi,^1,2 F. Cammarota,^1,2 B. Agostini,^1,2 A. Solfrizzi,^1,2 M. Allena,² E. Guaschino,² N. Ghiotto,² R. Greco,² C. Demartini,² A. Zanaboni,^1,2 M. Francavilla,^1,2 S. Facchetti,^1,2 G. Sances,² C. Tassorelli^1,2 | ¹Department of Brain and Behavioral Sciences, University of Pavia; ²Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15840
- 474 abstract views
PO-05 | Validation of the Italian version of the HARDSHIP Questionnaire in a school-based population

Agnese Onofri,¹ Chiara Rosignoli,¹ Vittorio Trozzi,¹ Martina D’Ambrosio,¹ Benedetta Germani,¹ Roberta Ciuffini,² Raffaele Ornello,¹ Simona Sacco¹ | ¹Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila; ²Department of Clinical Medicine, Public health, Life and Environmental Sciences, University of L’Aquila, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15826
- 351 abstract views
PO-33 | Visual hallucinations: a non-unique symptom

Francesca Traccitto, Giada Giuliani, Davide Chiffi, Chiara Zilli, Mariangela Fratino, Marta Altieri | Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15855
- 351 abstract views
PO-55 | What patients want: a qualitative study on an information resource on migraine

Matteo Castaldo,¹ Zhiqi Liang,² Gina Williams,² Shayne Watson,² Caitlyn Haynes,² Zoe Diamond² | ¹Parma University; ²University of Queensland

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15878
- 225 abstract views
PO-09 | When migraine turns severe: a case of aura that lasts too long

Alessandra Fera,¹ Erica Agosto,¹ Giulia Grasso,² Cristina Vassia,² Francesca Feyles,² Carlotta Canavese,³ Sara Racalbuto,² Antonia Versace² | ¹Department of Public Health and Pediatrics, University of Turin; ²Department of Pediatric Emergency, Pediatric Headache Centre, Regina Margherita Children’s Hospital, Turin; ³Department of Child Pathology and Care “Regina Margherita”, SSD Pediatric Neurology, Regina Margherita Children’s Hospital, Turin, Italy

Società Italiana per lo Studio delle Cefalee (SISC)

06-11-2025

DOI https://doi.org/10.4081/cc.2025.15830
- 621 abstract views

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