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Confinia Cephalalgica, a peer-reviewed open access journal, focuses on publishing articles related to various aspects of headache medicine, including genetics, pathophysiology, diagnosis, imaging, management, epidemiology, pharmacology, and treatment. It covers both primary and secondary headaches, as well as other facial pains and their connections with systemic diseases. The journal aims to stay updated with rapidly evolving areas of medicine, such as digital health, gender medicine, and artificial intelligence, as applied to the field of headache medicine. |
Recent articles
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OC-02 | Role of specific microRNAs in cluster headache: association with disease phenotype and neuropeptide levels A. Solfrizzi,1,2 F. Cammarota,1,2 R. De Icco,1,2 F. Bighiani,1,2 M. Corrado,2 G. Vaghi,1,2 A. Antoniazzi,1,2 V. Grillo,1,2 M. Giraudo,1,2 B. Agostini,1,2 R. Greco,2 C. Demartini,1,2 M. Francavilla,1,2 S. Franchini,1,2 M. Allena,2 G. Sances,2 C. Tassorelli1 | 1Department of Brain and Behavioral Sciences, University of Pavia; 2Headache Science and Neurorehabilitation Unit, IRCCS Mondino Foundation, Pavia, Italy
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PO-10 | Differential diagnosis between symptomatic focal occipital epilepsy and headache: a case report Federica Molaschi,1 Barbara Lauria,2 Giulia Grasso,2 Cristina Vassia,2 Francesca Torta,3 Antonia Versace,2 Carlotta Canavese3 | 1University of Turin, SC U Child Neuropsychiatry, Regina Margherita Hospital, Turin; 2Department of Pediatric Emergency, Pediatric Headache Centre, Regina Margherita Children’s Hospital, Turin; 3Department of Child Pathology and Care “Regina Margherita”, SSD Pediatric Neurology, Regina Margherita Children’s Hospital, Turin, Italy
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PO-42 | OnaBotulinumtoxin-A in chronic migraine patients with short or long disease history and psychiatric comorbidities: preliminary data from an Italian multicentric study (the BACH Study) Fabrizio Vernieri,1,2 Marilena Marcosano,2 Licia Grazzi,3 Danilo Antonio Montisano,3 Raffaele Ornello,4 Simona Sacco,4 Chiara Rosignoli,4 Alberto Doretti,5 Maria Albanese,6 Giovanna Viticchi,7 Nicoletta Brunelli, Luigi d’Onofrio,2 Luisa Fofi,1 Claudia Altamura,1,2 Patrizio Pasqualetti8 | 1Fondazione Policlinico Campus Bio-Medico, Roma, Italy; 2Università Campus Bio-Medico di Roma, Italy; 3Istituto Neurologico Besta, Milano, Italy; 4Università degli Studi l’Aquila, Italy; 5Istituto Auxologico, Milano, Italy; 6Policlinico Tor Vergata, Roma, Italy; 7Università Politecnica Marche, Italy; 8Sapienza Università di Roma, Italy
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PO-73 | Auricular acupuncture as a complementary treatment for tension-type headache in women: a prospective study on efficacy and safety Sergio Sorrenti,1,2 Matteo Ciuffreda,1 Emanuele Pisello,1 Luca Brugiaferri,2 Azzurra Federici,2 Cristiano Piangatelli,3 Dario Galante4 | 1U.O.C. Anestesia Rianimazione Terapia del Dolore, AST Ancona, Fabriano (AN), Italy; 2Scuola di Specializzazione in Anestesia Rianimazione, Terapia Intensiva e del Dolore, UNIVPM, Ancona, Italy; 3Direttore U.O.C. Anestesia Rianimazione Terapia del Dolore, AST Ancona, Fabriano (AN), Italy; 4Direttore U.O.C. Anestesia e Rianimazione, Cerignola (FG), Italy
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OC-01 | Evolution of nitroglycerin-triggered premonitory symptoms in participants with migraine Gabriele Sebastianelli,1,2 Catarina Fernandes,1,3 Peter J. Goadsby,1 Nazia Karsan1 | 1NIHR King’s Clinical Research Facility, SLaM Biomedical Research Centre and Wolfson SPaRC, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, UK; 2Department of Medico-Surgical Sciences and Biotechnologies, Polo Pontino ICOT, Sapienza University of Rome, Latina, Italy; 3Neurology Department, Local Health Unit of Coimbra, Portugal
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PO-09 | When migraine turns severe: a case of aura that lasts too long Alessandra Fera,1 Erica Agosto,1 Giulia Grasso,2 Cristina Vassia,2 Francesca Feyles,2 Carlotta Canavese,3 Sara Racalbuto,2 Antonia Versace2 | 1Department of Public Health and Pediatrics, University of Turin; 2Department of Pediatric Emergency, Pediatric Headache Centre, Regina Margherita Children’s Hospital, Turin; 3Department of Child Pathology and Care “Regina Margherita”, SSD Pediatric Neurology, Regina Margherita Children’s Hospital, Turin, Italy
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PO-41 | Eptinezumab for difficult-to-treat migraine: who responds and who needs more Alessandro Visentini,1,2,3 Roberta Messina,1,2,3 Ilaria Cetta,1,2,3 Edorardo Ratto,1 Laura Zanandrea,1,3 Federica Genovese,1,2,3 Irene Chinali,1 Bruno Colombo,1 Massimo Filippi1,2,3 | 1Neurology Unit and 2Neuroimaging Research Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy; 3Vita-Salute San Raffaele University, Milan, Italy
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PO-72 | Stigma in migraine: preliminary results from the “Studio Emicrania Maugeri” Project Luca Giani, Christian Lunetta | Istituti Clinici Scientifici Maugeri IRCCS, Neurological Rehabilitation Unit of Milano Institute, Milan, Italy
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PO-08 | Long-term outcome in pediatric patients with headache S. Genta,1,2 M. Celario1,2, C. Brancaccio¹ ², G. Rossetto,1,2 C. Dusi,1,2 P. Baso,1,2 V. De Giorgis1,2 | 1Department of Child Neuropsychiatry, IRCCS Mondino, Pavia; 2University of Pavia, Italy
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PO-40 | Evaluating agreement between physician and ChatGPT in migraine prophylaxis selection: a pilot comparative study Simone Vigneri1, MatteoZanella2, Gianfranco Sindaco2, Alberto Merlin2, Maria Mazzullo2, Marco La Grua2, Valentina Paci2, Carmen Bertone2, Gilberto Pari2 1Santa Maria Maddalena Hospital, Neurology, Occhiobello, Italy; 2Santa Maria Maddalena Hospital, Pain Medicine, Occhiobello, Italy
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PO-71 | Is Doctor Google retiring? How Generative Artificial Intelligence is transforming the perception and management of headaches Matteo Bellamio,1 Sofia Zywicki,1 Rocco Quatrale,2 Giorgio Zanchin,3 Ferdinando Maggioni,3 Alberto Terrin1 | 1Centro Cefalee dell’Angelo, Neurology, Ospedale dell'Angelo, AULSS3 Serenissima, Mestre (VE), Italy; 2Neurology, Ospedale dell'Angelo, AULSS3 Serenissima, Mestre (VE), Italy; 3Neurology, University of Padua, Padua, Italy
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PO-07 | Psychological management of children treated at the Pediatric Headache Centre of Turin: preliminary analysis Emanuela Serri, Annachiara Lamberti Zanardi, Raffaella Mascolo, Barbara Lauria, Roberta Rossi, Sara Simona Racalbuto, Antonia Versace, Claudia Bondone | Department of Pediatric Emergency, Pediatric Headache Centre, Regina Margherita Children’s Hospital, Turin, Italy
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PO-39 | Leeds Dependence Questionnaire (LDQ) in migraine: diagnostic utility without predictive value for anti-CGRP (R) response Antonio Munafò,1 Andrea Burgalassi,1 Giulia Vigani,2 Francesco De Cesaris,1 Alberto Chiarugi1,2 | 1Headache Center and Clinical Pharmacology Unit, Careggi University Hospital, Florence, Italy; 2Section of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, Florence, Italy
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PO-70 | A nomogram for the prediction of response to anti-CGRP mAbs: the CGRP score Marina Romozzi,1 Ammar Lokhandwala,2 Catello Vollono,1 David García-Azorín,3 Giulia Vigani,4 Francesco De Cesaris,4 Claudia Altamura,5 Fabrizio Vernieri,5 Paolo Calabresi,1 Sonia Di Tella,6 Luigi Francesco Iannone7 1Dipartimento Universitario di Neuroscienze, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; 2Drexel University, Philadelphia, PA, USA; 3Hospital Universitario del Río Hortega, Valladolid, Headache Unit, Department of Neurology, Valladolid, Spain; 4Section of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, Florence, Italy; 5 Neurologia, Dipartimento di Medicina e Chirurgia, Università Campus Bio-Medico di Roma, Rome, Italy; 6Dipartimento di Psicologia, Università Cattolica del Sacro Cuore, Milan, Italy; 7Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
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PO-06 | Children’s headache through drawings: a narrative review and a portrait gallery Floriana Ferro,1,2 Caterina Gaspari,1,2 Giulia Manfrè,1,2 Federica Cernigliaro,1 Daniela D’Agnano,3 Ruben Panzica,4 Edvige Correnti,2 Maria Rosita Ruta,5 Francesca Marchese,5 Renata Pitino,2 Maria Rita Capizzi,2 Giuseppe Santangelo,2 Antonella Versace,6 Vittorio Sciruicchio,3 Vincenzo Raieli2 | 1Child Neuropsychiatry Unit Department, Pro.MI.S.E. "G. D'Alessandro", University of Palermo; 2Child Neuropsychiatry Department, ISMEP, ARNAS Civico, Palermo; 3Children Epilepsy and EEG Center, San Paolo Hospital, ASL Bari, Bari; 4Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Messina; 5Child Neuropsychiatry Unit, ASP 6, Palermo; 6Pediatric Headache Center, Pediatric Emergency Dept, Regina Margherita Children's Hospital, Turin, Italy
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PO-38 | Impact of atogepant on achieving best possible quality of life among patient global impression of change responders Cristina Tassorelli,1 Pranav Gandhi,2 Molly Duan,2 Karen Carr,2 Kandavadivu Umashankar,2 Jonathan Stokes,2 Grace Forde,3 Tanya Bilchik,4 Martina Martini*, Rashmi Halker Singh5 | 1University of Pavia, Pavia, Italy; 2AbbVie, North Chicago, IL, USA; 3North American Partners in Pain Management, North New Hyde Park, NY, USA; 4Department of Neurology, Yale School of Medicine, New Haven, CT, USA; 5Mayo Clinic, Phoenix, AZ, USA *Abbvie Srl, Rome, Italy.
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PO-69 | Three-month atogepant treatment modulates dopaminergic-related functional connectivity in episodic migraine Davide Fedeli,1 Danilo Antonio Montisano,1 Greta Demichelis,1 Giuseppe Ciullo,1,2 Jean Paul Medina Carrion,1 Maria Grazia Bruzzone,1 Emilio Ciusani,1 Alessandra Erbetta,1 Marina Grisoli,1 Erika Guastafierro,1 Domenico D’Amico,1 Alberto Raggi,1 Anna Nigri,1 Licia Grazzi1 | 1Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy; 2University of Parma, Parma, Italy
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PO-05 | Validation of the Italian version of the HARDSHIP Questionnaire in a school-based population Agnese Onofri,1 Chiara Rosignoli,1 Vittorio Trozzi,1 Martina D’Ambrosio,1 Benedetta Germani,1 Roberta Ciuffini,2 Raffaele Ornello,1 Simona Sacco1 | 1Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila; 2Department of Clinical Medicine, Public health, Life and Environmental Sciences, University of L’Aquila, Italy
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PO-37 | Trigeminal autonomic cephalalgia as the initial presentation of a cerebral cavernous malformation: a rare case report Francesco Maurizio Chianese, Marcello Silvestro, Ilaria Orologio, Lorenzo Tartaglione, Marcella Marziani, Antonio Russo | Headache Centre, Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy
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PO-68 | Bipolar disorder spectrum and psychopathology in cluster headache compared to migraine: a cross-sectional study in a hospital headache clinic Isabella Getuli, Giada Giuliani, Chiara Zilli, Simone Preti, Gaia Chiecchi, Lorenzo Tarsitani, Marta Altieri | Dipartimento di Neuroscienze Umane, Sapienza Università di Roma, Italy
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PO-04 | Mindfulness-based behavioral intervention for adolescents with high-frequency primary headaches: feasibility of a prospective multicenter study Beatrice Baldo,1 Giulia De Lorenzi,1 Valeria Marletta,1 Ilaria Bonemazzi,1 Alessia Raffagnato,2 Cristina Vassia,3 Emanuela Serri,3 Antonella Versace,4 Daniela D’Agnano,4 Vittorio Sciruicchio,4 Licia Grazzi,5 Irene Toldo1 | 1Juvenile Headache Center, Department of Woman’s and Child’s Health, University of Padua; 2Child and Adolescent Neuropsychiatric Unit, Department of Women's and Children's Health, University of Padua; 3Pediatric Headache Center, Department of Pediatric Emergency, Regina Margherita Children's Hospital, Turin; 4Children Epilepsy and EEG Center, San Paolo Hospital, ASL Bari; 5Neuroalgology Unit and Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
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PO-36 | An atypical presentation of Tolosa-Hunt Syndrome: a case report Marco Bolchini, Matteo Cortinovis, Paola Zavarise, Giulia Campana, Giorgio Dalla Volta | Neurology Unit and Headache Center, Istituto Clinico Città di Brescia, Brescia, Italy
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PO-67 | Investigating plasma neurofilament light chain levels in patients with migraine: a cross-sectional study Elisa Maria Piella,1 Alberto Mario Chiarandon,1 Silvia Boschi,1 Fausto Roveta,1 Lucrezia Bonino,1 Giulia Gioiello,2 Giulia Montesano,2 Giulio Mengozzi,2 Innocenzo Rainero,1,3 Elisa Rubino1,3 | 1Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Turin, Italy; 2Clinical Biochemistry Laboratory “Baldi e Riberi”, A.O.U. Città della Salute e della Scienza di Torino, Turin, Italy; 3Headache Center, Department of Neuroscience and Mental Health, AOU Città della Salute e della Scienza di Torino, Turin, Italy
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PO-03 | Intracranial incidental findings on brain magnetic resonance imaging (MRI) in a pediatric population with primary headache: our experience and management Fabiana Ursitti,1 Filippo Tripodi,1 Laura Papetti,1 Giorgia Sforza,1 Gabriele Monte,1 Alessandro Borrelli,1 Samuela Tarantino,1 Martina Proietti Checchi,1 Massimiliano Valeriani1-3 | 1Developmental Neurology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy; 2Child Neurology Unit, Systems Medicine Department, Tor Vergata University Hospital of Rome, Rome, Italy; 3Translational Pain Neuroscience and Precision Medicine, CNAP, Department of Health Science and Technology, School of Medicine, Aalborg University, Aalborg, Denmark
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PO-35 | Treatment of chronic and episodic migraine with atogepant improves quality of life in patients with comorbid multiple sclerosis: the experience of the Headache Center at Spaziani Hospital, Frosinone Laura Borrello; Fabiana Marinelli; Maria Lorena Marziale; Ilaria Avallone; Fulvio Ferrante; Roberto De Simone | Neurology Unit, Headache Center, Multiple Sclerosis Center, UOC Pharmacy, Spaziani Hospital, Frosinone (FR), Italy
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PO-66 | Predicting the evolution to resistant and refractory migraine: a machine learning analysis from the REFINE Study Chiara Rosignoli,1 Raffaele Ornello,1 Daniele Lozzi,2 Enrico Mattei,2 Federico De Santis,1 Agnese Onofri,1 Mark Braschinsky,3 Christian Lampl,4 Isabel Pavão Martins,5 Paolo Martelletti,6 Dimos Mitsikostas,7 Raquel Gil-Gouveia,8 Maria Pia Prudenzano,9 Kristina Ryliskiene,10 Margarita Sanchez del Rio,11 Patricia Pozo-Rosich,12 Aynur Özge,13 Fabrizio Vernieri,14 Marta Waliszewska-Prosół,15 Zaza Katsarava,16 Giuseppe Placidi,2 Simona Sacco1 | 1Dept. of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy; 2A²VI-lab, Dept. MeSVA University of L’Aquila; 3Dept. of Neurology and Neurosurgery, Institute of Clinical Medicine, Faculty of Medicine, University of Tartu, Estonia; 4Headache Medical Center, Seilerstaette Linz, Austria. Center; 5Headache Center, Hospital da Luz, Lisbon, Portugal; 6School of Health, Unitelma Sapienza University of Rome, Italy; 7First Dept of Neurology, Aeginition Hospital, National and Kapodistrian University of Athens, Greece; 8Centro de Estudos Egas Moniz, Faculty of Medicine, University of Lisbon, Portugal; 9Headache Center, Amaducci Neurological Clinic, Policlinico General Hospital, Bari, Italy; 10Center of Neurology, Vilnius University, Lithuania; 11Dept. of Neurology, Clínica Universidad de Navarra, Madrid, Spain; 12Neurology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain; 13Dept. of Neurology, Mersin University Medical Faculty, Mersin, Turkey; 14Università Policlinico Campus Bio-Medico, Rome, Italy; 15Dept. of Neurology, Wroclaw Medical University, Wrocław, Poland; 16Dept of Neurology, Christian Hospital Unna and University of Duisburg-Essen, Ruhr Metropolitan, Germany
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PO-02 | Migraine in youth: a double challenge to cognition and emotion Samuela Tarantino,1 Martina Proietti Checchi,1 Laura Papetti,1 Fabiana Ursitti,1 Gabriele Monte,1 Giorgia Sforza,1 Massimiliano Valeriani,1-3 | 1Developmental Neurology Unit, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy; 2Systems Medicine Department, Tor Vergata University of Rome, Rome, Italy; 3Translational Pain Neuroscience and Precision Medicine, CNAP, Dept. of Health Science and Technology, School of Medicine, Aalborg University, Denmark
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PO-34 | Febrile headache in an immunosuppressed patient with autoimmune disease: a probable case of neurosarcoidosis Giulia Settembrini, Giovanni Rinaldi, Marco Alabiso, Ilenia Corbelli, Paola Sarchielli | Clinica Neurologica, Ospedale Santa Maria della Misericordia, Università degli Studi di Perugia, Italy
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PO-01 | Pediatric nummular headaches: a case series and physiopathological and nosography considerations Carola Meo¹*, Sofia D’Agostino¹*, Antonella Morea²*, Martina Tarantini²*, Giuseppe Giglia³, Maria Rosita Ruta⁴, Edvige Correnti⁵, Daniela D’Agnano², Giuseppe Santangelo⁵, Vittorio Sciruicchio², Vincenzo Raieli⁵ (*These authors contributed equally) | 1Child Neuropsychiatry Unit Department, Pro.M.I.S.E. "G. D'Alessandro", University of Palermo, Palermo, Italy; 2Children Epilepsy and EEG Center, San Paolo Hospital, ASL Bari, Bari, Italy; 3Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), Section of Human Physiology, University of Palermo, Palermo; 4Child Neuropsychiatry Unit, ASP 6, Palermo; 5Child Neuropsychiatry Department, ISMEP, ARNAS Civico, Palermo, Italy
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OC-23 | The REPICEF Project: a school-based epidemiological study on primary headaches in children and adolescents Agnese Onofri,1 Chiara Rosignoli,1 Vittorio Trozzi,1 Martina D’Ambrosio,1 Benedetta Germani,1 Roberta Ciuffini,2 Raffaele Ornello,1 Simona Sacco1 | 1Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila; 2Department of Clinical Medicine, Public health, Life and Environmental Sciences University of L’Aquila, Italy
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Normative values of the nociceptive blink reflex habituation
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